Chrysomycin A
Based on 1 Customer Validation
Chrysomycin A (Chr-A), an antibiotic, can be obtained from Streptomyces. Chrysomycin A exhibits antitumor and anti-tuberculous and MRSA activities. As for glioblastoma, Chrysomycin A inhibits the proliferation, migration, and invasion of cancer cells through the Akt/GSK-3β/β-catenin signaling pathway.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 82196-88-1
- Formula: C28H28O9
- Molecular Weight:508.52
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chrysomycin A (0.2-1.8 μM; 48 h) has anti-glioblastoma efficacy, and inhibits cell viability in U251 and U87-MG human glioblastoma, as well as migration and invasion[1].
Chrysomycin A (0.2-1.8 μM; 48 h) inhibits Akt/GSK-3β/β-Catenin signaling pathway in U251 and U87-MG cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U251 and U87-MG human glioblastoma
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Concentration:0.2, 0.4 and 0.8 μM for U251; 0.2, 0.6 and 1.8 μM for U87-MG
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Incubation Time:48 hours
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Result:Inhibited U251 and U87-MG with 0.475 μM and 1.77 μM, respectively.
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Cell Line:U251 and U87-MG human glioblastoma
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Concentration:0.2, 0.4 and 0.8 μM for U251; 0.2, 0.6 and 1.8 μM for U87-MG
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Incubation Time:48 hours
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Result:Significantly downregulated the expression of slug and MMP2.
Significantly decreased the protein expression of PI3K-p85, p-PI3K-p85, Akt and p-Akt, as well as c-Myc, cyclin D1.
Chemical Information
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CAS No. 82196-88-1
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Appearance Solid
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Molecular Weight 508.52
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Formula C28H28O9
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Color Light yellow to yellow
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SMILES
O=C1C2=CC(C=C)=CC(OC)=C2C3=CC(OC)=C4C(O)=CC=C([C@H]5[C@@H]([C@]([C@H]([C@@H](C)O5)O)(C)O)O)C4=C3O1
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Synonyms
Chr-A
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Initial Source
marine-derived strain Streptomyces sp. 891
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Chrysomycin A Related Classifications
HY-126771 Related Classifications
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