Glue02
Glue02 is a CCNK molecular glue degrader with a DC50 < 0.1 μM. Glue02 binds to the kinase domain of CDK12, promotes the formation of a ternary complex between CDK12 and the DDB1-CUL4-RBX1 E3 ubiquitin ligase complex, converts CDK12 into a substrate-specific receptor, and induces polyubiquitination and proteasomal degradation of CCNK. Glue02 inhibits cancer cell proliferation. Glue02 can be used in cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 2034581-68-3
- Formula: C15H15N7OS
- Molecular Weight:341.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
CCNK < 0.1 μM (DC50) |
In Vitro
Glue02 inhibits cancer cell proliferation through degradation of CCNK, IC50 < 2 μM (Grade A)[1].
Glue02 binds the CDK12 kinase domain and promotes the formation of a ternary complex between CDK12 and DDB1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- MTT Cell Proliferation Assay
Chemical Information
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CAS No. 2034581-68-3
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Molecular Weight 341.39
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Formula C15H15N7OS
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SMILES
CC1=CN=C(NC(C2CN(C3=NC=NC(N4C=CC=N4)=C3)C2)=O)S1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glue02 Related Classifications
HY-190178 Related Classifications
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Keywords
- Glue02
- 2034581-68-3
- Glue 02
- Glue-02
- molecular glue
- molecular glue degrader
- CDK12 ligand
- CDK12
- CCNK degrader
- Cyclin K degrader
- CCNK
- Cyclin K
- DDB1
- CUL4
- protein degrader
- targeted protein degradation
- ubiquitin-proteasome pathway
- E3 ubiquitin ligase
- CRL4
- anticancer agent
- pyrazolopyrimidine
- azetidine
- thiazole
- trifluoromethyl
- Inhibitor
- inhibitor
- inhibit