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Dacinostat

(Synonyms: NVP-LAQ824; LAQ824)
7 Cited Publications
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Based on 7 publication(s) in Google Scholar

Dacinostat is a potent HDAC inhibitor, with an IC50 of 32 nM; Dacinostat also inhibits HDAC1 with an IC50 of 9 nM, and used in cancer research.

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  • Pureté: 98.45%
  • CAS No.: 404951-53-7
  • Formule: C22H25N3O3
  • Masse moléculaire:379.45
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Dacinostat Chemical Structure
    Dacinostat Chemical Structure
  • Experimental Validation Results for Dacinostat
  • Experimental Validation Results for Dacinostat
  • Experimental Validation Results for Dacinostat
  • Experimental Validation Results for Dacinostat
  • Experimental Validation Results for Dacinostat
CAS No.: 404951-53-7
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Cell Proliferation/Viability AssayApoptosis AnalysisWBFlow CytometryIn Vivo Efficacy Study
  • Cell Proliferation/Viability Assay
  • Apoptosis Analysis
  • WB
  • Flow Cytometry
  • In Vivo Efficacy Study

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  • Dacinostat Chemical Structure
    Dacinostat Chemical Structure
    1/16
  • 1/16

    Dacinostat purchased from MedChemExpress. Usage Cited in: Exp Hematol Oncol. 2019 Nov 15;8:30. [Abstract]

    Customer Validation
     The dose response curves (based on MTT assays) for cell viability of Daoy and D283 cells after treated with Dacinostat for 48 h at the indicated concentrations.

  • 1/16

    Dacinostat purchased from MedChemExpress. Usage Cited in: Exp Hematol Oncol. 2019 Nov 15;8:30. [Abstract]

    Customer Validation
     Daoy and D283 cells were treated with Dacinostat (0.1 µM for Daoy cells, 0.01 µM for D283 cells) for 24 h and 48 h, respectively. Apoptosis was analyzed with flow cytometry.

  • 1/16

    Dacinostat purchased from MedChemExpress. Usage Cited in: Exp Hematol Oncol. 2019 Nov 15;8:30. [Abstract]

    Customer Validation
     Dacinostat induce the cleavage of caspase-3 and PARP. Daoy and D283 cells were treated with Dacinostat (0.05, 0.1, 0.2 μM) for 24 h and 48 h, respectively.

  • 1/16

    Dacinostat purchased from MedChemExpress. Usage Cited in: Exp Hematol Oncol. 2019 Nov 15;8:30. [Abstract]

    Customer Validation
     Daoy and D283 cells were treated with dacinostat (0.1 µM for Daoy cells, 0.01 µM for D283 cells) for 24 h and 48 h, respectively. The cell cycle distribution was analyzed by flow cytometry.

  • 1/16

    Dacinostat purchased from MedChemExpress. Usage Cited in: Exp Hematol Oncol. 2019 Nov 15;8:30. [Abstract]

    Customer Validation
     Tumor volumes during treatment were measured using calipers treated with Dacinostat (20 mg/kg, i.p.).

  • Dacinostat