AG73
AG73 is a polypeptide. AG73 is derived from the G domain of the Laminin α1 chain. AG73 binds heparin, Syndecan-1 and Syndecan-4. AG73 promotes the adhesion of various cells, induces the differentiation of salivary gland acinar cells, stimulates neurite outgrowth, secretion of matrix metalloproteinases and angiogenesis. AG73 retains its angiogenic activity when conjugated to chitosan membranes. AG73 can be used in the research of melanoma and ischemic injury.
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- CAS No.: 170655-66-0
- Formule: C64H120N24O17
- Masse moléculaire:1497.82
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
AG73 (200 μg/mL) completely inhibits the formation of cellular networks by mouse melanoma (B16F10) cells on Matrigel[1].
AG73 binds to immobilized biotinylated heparin with a Kd of 6.4 μM[1].
AG73 (1-100 μg/mL; 2 days) stimulates angiogenesis sprouting from 13-day-incubated chick embryo aortic rings in a dose-dependent manner[2].
AG73 (0.1-100 μg; 18 h) promotes axonal growth in 71% of PC12 cells when used at a substrate coating concentration of 100 μg[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
AG73 (1 mg/mL per mouse; s.c.; single dose) promotes vessel cell migration and angiogenesis in vivo, resulting in a mean of 55 endothelial cells per field in the subcutaneous Cultrex BME plug assay[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:unspecified strain (fertilized eggs)[2]
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Dosage:0.5 μg per coverslip
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Administration:topical application; single dose
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Result:Induced a positive angiogenic response (vessels radiating from the coverslip center) in 55.5% of treated eggs.
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Animal Model:unspecified strain[2]
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Dosage:1 mg/mL per mouse
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Administration:s.c.; single dose
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Result:Showed an intermediate color between the poorly vascularized control/AG73T plugs and the ECGS-treated positive control plugs.
Confirmed significantly more migrated endothelial cells, with a mean of ~55 endothelial cells per field.
Chemical Information
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CAS No. 170655-66-0
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Masse moléculaire 1497.82
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Formule C64H120N24O17
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Sequence
Arg-Lys-Arg-Leu-Gln-Val-Gln-Leu-Ser-Ile-Arg-Thr
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Sequence Shortening
RKRLQVQLSIRT
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Hoffman MP, et al. Cell type-specific differences in glycosaminoglycans modulate the biological activity of a heparin-binding peptide (RKRLQVQLSIRT) from the G domain of the laminin alpha1 chain. J Biol Chem. 2001;276(25):22077-22085. [Content Brief]
[2]. Mochizuki M, et al. Angiogenic activity of syndecan-binding laminin peptide AG73 (RKRLQVQLSIRT). Arch Biochem Biophys. 2007;459(2):249-255. [Content Brief]
[3]. Weeks BS, et al. Laminin-1 and the RKRLQVQLSIRT laminin-1 alpha1 globular domain peptide stimulate matrix metalloproteinase secretion by PC12 cells. Exp Cell Res. 1998;243(2):375-382. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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