Carteolol
Based on 2 publication(s) in Google Scholar
Carteolol is a non-selective β-adrenoceptor antagonist. Carteolol induces apoptosis via a caspase activated and mitochondrial-dependent pathway. Carteolol can be used for glaucoma research.
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- CAS No.: 51781-06-7
- Formule: C16H24N2O3
- Masse moléculaire:292.37
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Carteolol
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Activité biologique
Carteolol (0-2%; 0-28 hours; HCECs) has cytotoxicity and decreases cell viability in a dose- and time-dependent manner[1].
Carteolol (0.25%; 4-12 hours; HCECs) induces apoptosis and necroptotic protein expression in HCECs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCECs
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Concentration:0.00390625-2%
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Incubation Time:0, 2, 4, 8, 16, 20,24 and 28 hours
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Result:Decreased cell viability with the concentrations above 0.0015625% in a dose- and time-dependent manner.
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Cell Line:HCECs
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Concentration:0.25%
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Incubation Time:4, 8 and 12 hours
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Result:Dampened expression of the anti-apoptotic protein Bcl-2 and Bcl-xL, enhanced expression of the pro-apoptotic proteins Bax and Bad, and mitochondrial-released pro-apoptotic proteins Cyt.c and AIF.
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Cell Line:HCECs
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Concentration:0.25%
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Incubation Time:4, 8 and 12 hours
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Result:Increased the number of G1 phase of the cell cycle, whereas decreased S phase.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 51781-06-7
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Masse moléculaire 292.37
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Formule C16H24N2O3
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SMILES
O=C1NC2=C(C(OCC(O)CNC(C)(C)C)=CC=C2)CC1
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Synonyms
OPC-1085
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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ACS Omega
Computational and Experimental Approaches Identify Beta-Blockers as Potential SARS-CoV-2 Spike Inhibitors. [Abstract]2022 Aug 8;7(32):27950-27958. PMID: 35983371 -
J Pharm Biomed Anal
Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]2021 Feb 20:195:113870. PMID: 33453569
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Carteolol Related Classifications
HY-17495 Related Classifications
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