Hdac7 - histone deacetylase 7 Gene

Also Known as HD7; HD7a; Hdac7a; mFLJ00062; 5830434K02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56233

About Hdac7

Chromosome 15: 97,690,545-97,742,383 reverse strand.GRCm39:CM001008.3

This gene has 13 transcripts (splice variants), 263 orthologues, 10 paralogues and is associated with 16 phenotypes. Broad expression in thymus adult (RPKM 141.4), lung adult (RPKM 54.7) and 16 other tissues.

Summary

Enables chromatin binding activity and transcription corepressor activity. Acts upstream of or within cell-cell junction assembly; negative regulation of transcription by RNA polymerase II; and vasculogenesis. Predicted to be located in cytosol and nucleus. Predicted to be part of histone deacetylase complex. Is expressed in adrenal gland; embryo; eye; inner ear; and otocyst. Orthologous to human HDAC7 (histone deacetylase 7). [provided by Alliance of Genome Resources, Apr 2022]

Hdac7 Products (9)

mRNA Protein Name
NM_001204276.1 NP_001191205.1 histone deacetylase 7 isoform 2
NM_019572.3 NP_062518.2 histone deacetylase 7 isoform 4
NM_001378971.1 NP_001365900.1 histone deacetylase 7 isoform 9
NM_001204277.1 NP_001191206.1 histone deacetylase 7 isoform 3
NM_001204280.1 NP_001191209.1 histone deacetylase 7 isoform 7
NM_001204281.1 NP_001191210.1 histone deacetylase 7 isoform 8
NM_001204275.1 NP_001191204.1 histone deacetylase 7 isoform 1
NM_001204279.1 NP_001191208.1 histone deacetylase 7 isoform 6
NM_001204278.1 NP_001191207.1 histone deacetylase 7 isoform 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables chromatin binding IDA
IDA: Inferred from direct assay
16109736 MGI
enables histone deacetylase activity IDA
IDA: Inferred from direct assay
10640276 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10640276 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
10640276 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within cell-cell junction assembly IMP
IMP: Inferred from mutant phenotype
16873063 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16260608 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10640276 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
16873063 MGI
Cellular Component GO Annotation Evidence Références Source
is active in nucleus IDA
IDA: Inferred from direct assay
10640276 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac7 Protein Structure

PHA03247

PHA03247: cl33720 (121 - 524)

HDAC7

HDAC7: cd10008 (543 - 918)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 975 a.a.
Protein Preferred Names Protein Names

histone deacetylase 7

  • histone deacetylase 7A

Hdac7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
Hdac7 Q8C2B3 Ywhae Mus musculus P62259
Pull Down
16956611
Intra
Hdac7 Q8C2B3 Ywhae Mus musculus P62259
CoIP
11585834
Intra
Hdac7 Q8C2B3 Ywhae Mus musculus P62259
Pull Down
15166223
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Nom du produit Effect
Pureté Rare Diseases
HY-10221 Vorinostat Inhibitor 99.96% Yes
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes

Clinical Phase

Bioactive Molecules (6)
Cat. No. Nom du produit Effect
Pureté Phase
HY-150109 Puzerinostat mesylate Inhibitor 99.45% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1
HY-15994 Citarinostat Inhibitor 99.55% Phase 1

Pre-clinical Phase

Bioactive Molecules (43)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-18361 TMP195 Inhibitor 99.82% Unkown
HY-13428 Tubacin Inhibitor 98.71% Unkown
HY-N6735 Apicidin Inhibitor 99.87% Unkown
HY-18360 TMP269 Inhibitor 98.16% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Unkown
HY-119939 CHDI-390576 Inhibitor 98.10% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-126330 SS-208 Inhibitor 99.00% Unkown
HY-N5084 Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside Inhibitor 98.92% Unkown
HY-169259 HDAC9-IN-1 Inhibitor 95.13% Unkown
HY-135714 Bavarostat Inhibitor 99.51% Unkown
HY-149285 NT160 Inhibitor 99.58% Unkown
HY-148624 CHDI-00484077 Inhibitor 98.38% Unkown
HY-149208 HDAC-IN-53 Inhibitor 95.73% Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-162319 Tubulin/HDAC-IN-4 Inhibitor / Unkown
HY-184574 HDAC-IN-104 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-180224 HDAC6-IN-70 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-159172 HDAC3-IN-4 Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-162630 HDAC6-IN-44 Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-180811 ALK/HDAC-IN-2 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-178104 HDAC-IN-93 Inhibitor / Unkown
HY-150774 HDAC6/HSP90-IN-2 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-179227 HDAC6 ligand-7 Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac7 NCBI NCBI:51564