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Cat. No.: HY-162985

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JHD205

JHD205 is a CDK4/6 inhibitor that induces apoptosis and DNA damage. JHD205 inhibits DNA repair by upregulating Caspase3 and p-H2AX. JHD205 has superior potency to Abemaciclib (HY-16297A) in a xenograft chick embryo breast cancer model..

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Formule: C₃₂H₄₀F₂N₈O
Masse moléculaire:590.71

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Please store the product under the recommended conditions in the Certificate of Analysis.

JHD205 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

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Chemical Information

Masse moléculaire 590.71
Formule C₃₂H₄₀F₂N₈O
SMILES

COC1=CC(N2CCC(CC2)N3CCN(CC3)C)=CC=C1NC4=NC(C5=CC(F)=C6C(N(C(C)=N6)C(C)C)=C5)=C(C=N4)F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

Cell Assay

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Ji J, et al. JHD205, A Novel Abemaciclib Derivative, Exerts Antitumor Effects on Breast Cancer by CDK4/6. Anticancer Agents Med Chem. 2024;24(6):400-411. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Protocole
Pureté et documentation
Références

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JHD205

Voir tous les produits spécifiques à Isoform CDK