LQ23
LQ23 is a selective inhibitor for CDC2-like kinase 2 (CLK2) with an IC50 of 1.4 nM. LQ23 exhibits anti-inflammatory activity.
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- CAS No.: 2997615-62-8
- Formule: C24H24N4OS
- Masse moléculaire:416.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 1.4 nM (CLK2), 2.1 nM (CLK1), 3.2 nM (CLK4), 21.7 nM (DYRK1A), >100 nM (CLK3)
LQ23 (10-100 nM) dose-dependently inhibits SR protein phosphorylation in chondrocytes, and thereby regulates the selective cleavage of genes[1].
LQ23 (10-100 nM) dose-dependently inhibits CHIR99021-stimulated Wnt-signaling in HEK-293T cells with IC50 of 2.9 μM[1].
LQ23 (30 nM) ameliorates osteoarthritis through promotes the bone mesenchymal stem cells (BMSC) differentation into chondrocytes and suppresses the cartilage degradation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Chondrocytes
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Concentration:10-100 nM
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Incubation Time:1 h
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Result:Reduced phosphorylated SRSF4, SRSF5 and SRSF6.
Reduced levels of β-catenin and c myc.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MIA-/ACLT-pMMx-induced osteoarthritis in Sprague-Dawley rats model[1]
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Dosage:1.5 μg/ kg
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Administration:Single IA injection
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Result:Ameliorated the surface of the articular cartilage and the cell arrangement, reduced the thickness of the synovium, increased the gap between the femur and the tibia.
Reduced the levels of inflammatory cytokines and catabolic enzymes.
Chemical Information
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CAS No. 2997615-62-8
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Masse moléculaire 416.54
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Formule C24H24N4OS
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SMILES
N[C@H](COC1=CC(C2=CC=C(C3=C2)NN=C3C#CC4=CSC=C4)=CN=C1)CC(C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LQ23 Related Classifications
HY-162398 Related Classifications
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