Vescalagin
Vescalagin is a hexahydroxyphenol. Vescalagin is isolable from Camu-camu (Myrciaria dubia) and immature wax apple fruits. Vescalagin exhibits inhibitory activity against a variety of enzymes, with a Ki value of 5.87 nM against AChE, 3.89 nM against BChE, 11.75 nM against hCA I, 16.23 nM against hCA II, and 16.08 nM against α-glucosidase. Vescalagin inhibits hCA I, hCA II and α-glucosidase in a non-competitive manner. Vescalagin downregulates JNK/p38 MAPK to protect pancreatic β-cells and improve insulin secretion in methylglyoxal-treated rats. Vescalagin reduces hyperglycemia and hypertriglyceridemia in rats fed a high-fructose diet. Vescalagin possesses anti-inflammatory and antioxidant properties.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 36001-47-5
- Formule: C41H26O26
- Masse moléculaire:934.63
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
|
AChE 5.87 nM (Ki) |
BChE 3.89 nM (Ki) |
hCA I 11.75 nM (Ki) |
hCA II 16.23 nM (Ki) |
α‑glucosidase 16.08 nM (Ki) |
Vescalagin is an inhibitor of acetylcholinesterase (AChE) with a Ki value of 5.87 nM[1].
Vescalagin is an inhibitor of butyrylcholinesterase (BChE) with a Ki value of 3.89 nM[1].
Vescalagin acts as a non-competitive inhibitor of α-glucosidase with a Ki value of 16.08 nM[1].
Vescalagin acts as a non-competitive inhibitor of hCA I with a Ki value of 11.75 nM[1].
Vescalagin acts as a non-competitive inhibitor of hCA II with a Ki value of 16.23 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Vescalagin reduces hyperglycemia and hypertriglyceridemia in rats fed a high-fructose diet[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 36001-47-5
-
Masse moléculaire 934.63
-
Formule C41H26O26
-
SMILES
OC1=C(O)C(O)=C(C2=C3C=C(O)C(O)=C2O)C=C1C(OC[C@](OC(C4=C(C5=C6C(C7=C(C(O[C@@]8([H])[C@@H]9O)=O)C9=C(O)C(O)=C7O)=C(O)C(O)=C5O)C(O)=C(O)C(O)=C4)=O)([H])[C@@]([C@@H]8OC6=O)([H])OC3=O)=O
-
Structure Classification
-
Initial Source
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz