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Traf6 - TNF receptor-associated factor 6 Gene

Also Known as 2310003F17Rik; C630032O20Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22034

Summary

This gene encodes a member of the TNF Receptor associated factor (TRAF) family of adaptor proteins that mediate signaling events from members of the TNF Receptor and Toll/IL-1 receptor families to activate transcription factors such as NF-kappa-B and AP-1. The product of this gene is essential for perinatal and postnatal survival. Mice deficient in this protein exhibit osteopetrosis and defective in development of epidermal appendixes, normal B cell differentiation, lymph node organogenesis, interleukin-1 signaling, lipopolysaccharide signaling and neural tube closure. This protein possesses ubiquitin Ligase activity. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Traf6 Products (2)

mRNA	Protein	Name
NM_001303273.1	NP_001290202.1	TNF receptor-associated factor 6
NM_009424.3	NP_033450.2	TNF receptor-associated factor 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8910514	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	15361868	MGI
enables ubiquitin protein ligase activity	IGI IGI: Inferred from genetic interaction	22863753	MGI
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	23042151	MGI
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	16252010	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within T-helper 1 type immune response	IMP IMP: Inferred from mutant phenotype	14499111	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	15705807	MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II	IMP IMP: Inferred from mutant phenotype	14499111	MGI
involved in bone remodeling	IMP IMP: Inferred from mutant phenotype	10421844	MGI
involved in bone resorption	IMP IMP: Inferred from mutant phenotype	10215628	MGI
involved in canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	17633018	MGI
acts upstream of or within cell development	IMP IMP: Inferred from mutant phenotype	15705807	MGI
acts upstream of or within immune response	IMP IMP: Inferred from mutant phenotype	15705807	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	27996060	MGI
involved in interleukin-1-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	10421844	MGI
involved in interleukin-17-mediated signaling pathway	IDA IDA: Inferred from direct assay	19825828	MGI
involved in interleukin-17-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	19825828	MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway	IGI IGI: Inferred from genetic interaction	26458771	MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	26458771	MGI
acts upstream of or within myeloid dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	14499111	MGI
involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	11007897	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	14699584	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	10215628	MGI
involved in osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	10421844	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	20345905	MGI
involved in positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	10421844	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IGI IGI: Inferred from genetic interaction	22863753	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	15322147	MGI
acts upstream of or within positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	14499111	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	14499111	MGI
involved in positive regulation of lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	10215628	MGI
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	15361868	MGI
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	16252010	MGI
involved in protein polyubiquitination	IMP IMP: Inferred from mutant phenotype	19825828	MGI
acts upstream of or within protein ubiquitination	IDA IDA: Inferred from direct assay	23042151	MGI
acts upstream of or within protein ubiquitination	IGI IGI: Inferred from genetic interaction	22095711	MGI
acts upstream of or within regulation of immunoglobulin production	IDA IDA: Inferred from direct assay	12958312	MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	28973854	MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IEP IEP: Inferred from expression pattern	28973854	MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	28973854	MGI
acts upstream of or within signal transduction	IDA IDA: Inferred from direct assay	12958312	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
part of CD40 receptor complex	IDA IDA: Inferred from direct assay	20614026	MGI
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	20614026	MGI
located in cytosol	IDA IDA: Inferred from direct assay	16831874	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	28973854	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	28973854	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	28973854	MGI
located in lipid droplet	IDA IDA: Inferred from direct assay	21435586	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
TNF receptor-associated factor 6	E3 ubiquitin-protein ligase TRAF6 RING-type E3 ubiquitin transferase TRAF6

Traf6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	Traf6	P70196	Trafd1	Mus musculus	Q3UDK1	Pull Down	16221674
Intra	Traf6	P70196	Rps27a	Mus musculus	P62991	Anti Bait CoIP	19091944
Intra	Traf6	P70196	Rps27a	Mus musculus	P62991	Anti Bait CoIP	19815506
Intra	Traf6	P70196	Rps27a	Mus musculus	P62991	Anti Bait CoIP	18083102
Intra	Traf6	P70196	Rps27a	Mus musculus	P62991	Anti Bait CoIP	19131965
Intra	Traf6	P70196	Nr0b2	Mus musculus	Q62227	Anti Bait CoIP	21725320
Intra	Traf6	P70196	Map3k3	Mus musculus	Q61084	Anti Bait CoIP	16362041
Intra	Traf6	P70196	Map3k3	Mus musculus	Q61084	CoIP	14661019
Intra	Traf6	P70196	Irak1	Mus musculus	Q62406-1	Y2H	15102471
Intra	Traf6	P70196	Cd40	Mus musculus	P27512	Y2H	8910514
Intra	Traf6	P70196	Cd40	Mus musculus	P27512	Pull Down	8910514
Intra	Traf6	P70196	Ecsit	Mus musculus	Q9QZH6	Y2H	15102471
Intra	Traf6	P70196	Ecsit	Mus musculus	Q9QZH6	Y2H	10465784
Intra	Traf6	P70196	Traf3ip2	Mus musculus	Q8C0E5	Anti Tag CoIP	12459498
Intra	Traf6	P70196	Ern1	Mus musculus	Q9EQY0	Anti Bait CoIP	23942232
Intra	Traf6	P70196	Ern1	Mus musculus	Q9EQY0	Anti Tag CoIP	23942232
Intra	Traf6	P70196	Traf3ip2	Mus musculus	Q8N7N6	Y2H	15102471
Intra	Traf6	P70196	Irak3	Mus musculus	Q8K4B2	Y2H	15102471
Intra	Traf6	P70196	Tnfrsf11a	Mus musculus	O35305	Y2H	10097072
Cross	Traf6	P70196	TIFA	Homo sapiens	Q96CG3	Anti Tag CoIP	15047173

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-B1829A	Dexamethasone phosphate disodium		99.94%	Yes
HY-B1829AR	Dexamethasone phosphate disodium (Standard)		99.88%	Unkown

Pre-clinical Phase

Bioactive Molecules (26)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-120934	C25-140	Inhibitor	99.92%	Unkown
HY-110247	TRAF-STOP inhibitor 6877002	Inhibitor	99.67%	Unkown
HY-N0481	Roburic acid		99.93%	Unkown
HY-N1431	Tabersonine		98.13%	Unkown
HY-N0026	2'-Acetylacteoside	Inhibitor	99.73%	Unkown
HY-142026	Vitisin A		96%	Unkown
HY-N0320	Salvianolic acid D		95.15%	Unkown
HY-P3709A	TRAF6 peptide TFA	Inhibitor	98.20%	Unkown
HY-W013636C	2-Ketoglutaric acid potassium	Inhibitor	98.0%	Unkown
HY-125025	SMI 6860766	Inhibitor	/	Unkown
HY-164670	D228	Inhibitor	99.77%	Unkown
HY-NP134	Flagellin from S. typhimurium		95%	Unkown
HY-P3709	TRAF6 peptide	Inhibitor	/	Unkown
HY-B1829	Dexamethasone phosphate		98.89%	Yes
HY-RS23098	Traf6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-155801	CRX 527		/	Unkown
HY-176220	GPX4-AUTAC		/	Unkown
HY-184160	Mcl1 Degrader-1		/	Unkown
HY-P11001	RANK-derived TRAF6 inhibitor	Inhibitor	/	Unkown
HY-P11002	PTD	Control	/	Unkown
HY-P3708	TRAF6 control peptide	Control	/	Unkown
HY-RS14975	TRAF6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174520	Human TLR8 mRNA		/	Unkown
HY-B1829R	Dexamethasone phosphate (Standard)		/	Unkown
HY-N1431A	Tabersonine hydrochloride		98.55%	Unkown
HY-RS16663	Traf6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Traf6	NCBI	NCBI:7189