ERBB3 - erb-b2 receptor tyrosine kinase 3 Gene

Also Known as HER3; FERLK; LCCS2; VSCN1; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2065

About ERBB3

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:56,080,108-56,103,505 (from NCBI)

This gene has 33 transcripts (splice variants), 280 orthologues, 53 paralogues and is associated with 134 phenotypes. Broad expression in small intestine (RPKM 41.0), duodenum (RPKM 39.7) and 17 other tissues.

Summary

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of Receptor Tyrosine Kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with Other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

ERBB3 Products (4)

mRNA	Protein	Name
NM_001005915.1	NP_001005915.1	receptor tyrosine-protein kinase erbB-3 isoform s precursor
XM_047428500.1	XP_047284456.1	receptor tyrosine-protein kinase erbB-3 isoform X1
NM_001982.4	NP_001973.2	receptor tyrosine-protein kinase erbB-3 isoform 1 precursor
XM_047428501.1	XP_047284457.1	receptor tyrosine-protein kinase erbB-3 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ErbB-3 class receptor binding	IPI IPI: Inferred from physical interaction	12000754	GOA
enables growth factor binding	IPI IPI: Inferred from physical interaction	11389077	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21575594	GOA
enables neuregulin binding	IDA IDA: Inferred from direct assay	20682778	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7556068	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	7556068	GOA
enables protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	7556068	GOA
NOT enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7556068	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	27353365	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell surface receptor protein tyrosine kinase signaling pathway	IDA IDA: Inferred from direct assay	7556068	GOA
involved in extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	17701904	GOA
involved in negative regulation of cell adhesion	IDA IDA: Inferred from direct assay	7556068	GOA
involved in negative regulation of secretion	IDA IDA: Inferred from direct assay	10559227	GOA
involved in negative regulation of signal transduction	IDA IDA: Inferred from direct assay	11389077	GOA
involved in neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17701904	GOA
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	7556068	GOA
involved in regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11389077	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	10572067	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ERBB3:ERBB2 complex	IDA IDA: Inferred from direct assay	12000754	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	12646923	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	11389077	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERBB3 Protein Structure

Recep_L_domain

Furin-like

Recep_L_domain

GF_recep_IV

Pkinase_Tyr

0
300
600
900
1200
1342 a.a.

Protein Preferred Names	Protein Names
receptor tyrosine-protein kinase erbB-3	human epidermal growth factor receptor 3 proto-oncogene-like protein c-ErbB-3 tyrosine kinase-type cell surface receptor HER3 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

ERBB3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ERBB3	P21860	RASA1	Homo sapiens	P20936	Protein Array	16273093
Intra	ERBB3	P21860	ABL2	Homo sapiens	P42684	Protein Array	16273093
Intra	ERBB3	P21860	TNS3	Homo sapiens	Q68CZ2	Protein Array	16273093
Intra	ERBB3	P21860	PIK3CA	Homo sapiens	P42336	TAP	24189400
Intra	ERBB3	P21860	PIK3CA	Homo sapiens	P42336	Anti Bait CoIP	19411071
Intra	ERBB3	P21860	NRG1	Homo sapiens	Q02297-7	Comig Non-Denat Gel	7592681
Intra	ERBB3	P21860	NRG1	Homo sapiens	Q02297-7	Solution Sedimentation	7592681
Intra	ERBB3	P21860	EGFR	Homo sapiens	P00533	Anti Bait CoIP	23866081
Intra	ERBB3	P21860	EGFR	Homo sapiens	P00533	Anti Bait CoIP	10572067
Intra	ERBB3	P21860	EGFR	Homo sapiens	P00533	TAP	24189400
Intra	ERBB3	P21860	EGFR	Homo sapiens	P00533	Anti Bait CoIP	31862538
Intra	ERBB3	P21860	HCK	Homo sapiens	P08631	Protein Array	16273093
Intra	ERBB3	P21860	PIK3R2	Homo sapiens	O00459	Protein Array	16273093
Intra	ERBB3	P21860	PIK3R2	Homo sapiens	O00459	TAP	24189400
Intra	ERBB3	P21860	PIK3R2	Homo sapiens	O00459	Pull Down	16729043
Intra	ERBB3	P21860	HSP90AB1	Homo sapiens	P08238	TAP	24189400
Intra	ERBB3	P21860	RIN1	Homo sapiens	Q13671	Ub Reconstruction	31980649
Intra	ERBB3	P21860	RIN1	Homo sapiens	Q13671	Protein Array	16273093
Intra	ERBB3	P21860	GRB2	Homo sapiens	P62993	Pull Down	16729043
Intra	ERBB3	P21860	GRB2	Homo sapiens	P62993	TAP	24189400
Intra	ERBB3	P21860	GRB2	Homo sapiens	P62993	Ub Reconstruction	24658140
Intra	ERBB3	P21860	SRC	Homo sapiens	P12931	Protein Array	16273093
Intra	ERBB3	P21860	ERBB2	Homo sapiens	P04626	PLA	23436906
Intra	ERBB3	P21860	ERBB2	Homo sapiens	P04626	Beta Galactosidase	17148612
Intra	ERBB3	P21860	ERBB2	Homo sapiens	P04626	PLA	23688700
Intra	ERBB3	P21860	ERBB2	Homo sapiens	P04626	Anti Bait CoIP	21075308
Intra	ERBB3	P21860	ERBB2	Homo sapiens	P04626	Anti Bait CoIP	10572067
Intra	ERBB3	P21860	ERBB2	Homo sapiens	P04626	Crosslink	19411071
Intra	ERBB3	P21860	ERBB2	Homo sapiens	P04626	Anti Bait CoIP	19411071
Intra	ERBB3	P21860	ERBB2	Homo sapiens	P04626	Photoaffinity Labelling	21278786
Intra	ERBB3	P21860	SYK	Homo sapiens	P43405	Protein Array	16273093
Intra	ERBB3	P21860	SH2B3	Homo sapiens	Q9UQQ2	Protein Array	16273093
Intra	ERBB3	P21860	SHC1	Homo sapiens	P29353	BioID	35384245
Intra	ERBB3	P21860	SHC1	Homo sapiens	P29353	TAP	24189400
Intra	ERBB3	P21860	SHC1	Homo sapiens	P29353	Pull Down	16729043
Intra	ERBB3	P21860	SHC1	Homo sapiens	P29353	Protein Array	16273093
Intra	ERBB3	P21860	SHC3	Homo sapiens	Q92529	Protein Array	16273093
Intra	ERBB3	P21860	PLCG1	Homo sapiens	P19174	Protein Array	16273093
Intra	ERBB3	P21860	PIK3R1	Homo sapiens	P27986	Anti Bait CoIP	21075308
Intra	ERBB3	P21860	PIK3R1	Homo sapiens	P27986	Anti Bait CoIP	20227043
Intra	ERBB3	P21860	PIK3R1	Homo sapiens	P27986	Anti Bait CoIP	21278786
Intra	ERBB3	P21860	PIK3R1	Homo sapiens	P27986	Anti Bait CoIP	10572067
Intra	ERBB3	P21860	PIK3R1	Homo sapiens	P27986	Protein Array	16273093
Intra	ERBB3	P21860	PIK3R1	Homo sapiens	P27986	TAP	24189400
Intra	ERBB3	P21860	PIK3R3	Homo sapiens	Q92569	Protein Array	16273093
Intra	ERBB3	P21860	PIK3R3	Homo sapiens	Q92569	TAP	24189400
Intra	ERBB3	P21860	ERBB4	Homo sapiens	Q15303	Anti Bait CoIP	10572067
Intra	ERBB3	P21860	ERBB4	Homo sapiens	Q15303	Anti Bait CoIP	20227043
Intra	ERBB3	P21860	CRKL	Homo sapiens	P46109	Protein Array	16273093
Intra	ERBB3	P21860	TNS2	Homo sapiens	Q63HR2	Protein Array	16273093
Intra	ERBB3	P21860	GRB7	Homo sapiens	Q14451	TAP	24189400
Intra	ERBB3	P21860	GRB7	Homo sapiens	Q14451	Competition Binding	9516479
Intra	ERBB3	P21860	GRB7	Homo sapiens	Q14451	Protein Array	16273093

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ERBB3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70322	HER3 Protein, Human (HEK293, Fc)	P21860-1 (S20-T643)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70323	HER3 Protein, Human (312a.a, HEK293, Fc)	P21860-3 (S20-F331)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72375	HER3 Protein, Human (Biotinylated, HEK293, His-Avi)	P21860-1 (S20-T643)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72625	HER3 Protein, Human (HEK293, His)	P21860-1 (S20-T643)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74893	HER3 Protein, Human (sf9, His-GST)	P21860-1/NP_001973.2 (P730-S1065)	≥ 75%, as determined by reducing SDS-PAGE.
HY-P74894	HER3 Protein, Human (Biotinylated, HEK293, Fc)	P21860-1 (S20-T643)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77554	HER3 Protein, Human (Biotinylated, HEK293, His)	P21860-1/NP_001973.2 (S20-T643)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72625A	HER3 Protein, Human (HEK293, His, solution)	P21860-1 (S20-T643)	≥ 95%, as determined by reducing SDS-PAGE.

ERBB3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80659	C-erbB-3/HER3 Antibody (YA457)	WB, IHC-P, FC	Human, Mouse
HY-P80659A	C-erbB-3/HER3 Antibody (YA457)(PBS only)	WB, IHC-P, FC	Human, Mouse
HY-P810612	Phospho-HER3/ErbB3 (Tyr1222) Antibody (YA9874)	WB, IHC-P	Human
HY-P810613	Phospho-ErbB3/HER3 (Tyr1289) Antibody (YA9875)	WB, ICC/IF	Human
HY-P84183	C-erbB-3/HER3 Antibody (YA3880)	WB, ICC/IF, ELISA	Human
HY-P84183A	C-erbB-3/HER3 Antibody (YA3880)(PBS only)	WB, ICC/IF, ELISA	Human
HY-P86321	C-erbB-3/HER3 Antibody (YA6013)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Lethal Congenital Contracture Syndrome	Lccs Lethal Congenital Contracture Syndrome 1
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Bladder Urothelial Carcinoma	Bladder Transitional Cell Carcinoma Transitional Cell Carcinoma Of Bladder Transitional Cell Carcinoma Of The Bladder Urinary Bladder Urothelial Carcinoma Urothelial Bladder Carcinoma Carcinoma Transitional Cell Bladder Tcc - [Transitional Cell Carcinoma] Of Bladder
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Vallecula Cancer	Malignant Tumor Of Vallecula
Gallbladder Signet Ring Cell Adenocarcinoma	Signet Ring Cell Carcinoma Of The Gallbladder
Acoustic Neuroma	Neurofibromatosis Type 2 Vestibular Schwannoma Bilateral Acoustic Neurofibromatosis Nf2 Acoustic Neurilemoma Acoustic Neurinoma Cerebellopontine Angle Tumor Neurofibromatosis Central Type Neurofibromatosis Type Ii Vestibular Neurilemmoma Acoustic Tumor Neurinoma Of The Acoustic Nerve Acoustic Neurinoma Bilateral Acoustic Schwannomas Bilateral Banf Central Neurofibromatosis Familial Acoustic Neuromas Neurofibromatosis 2 Neurofibromatosis Type 2 Merlin Schwannoma, Acoustic, Bilateral Neuroma Acoustic Neuroma, Acoustic Familial Acoustic Neuroma Familial Vestibular Schwannoma Neurofibromatosis, Central Type Nf2 - [Neurofibromatosis Type 2]
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Pancreatic Adenocarcinoma	Adenocarcinoma Of Pancreas Adenocarcinoma Of The Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Clivus Chondroid Chordoma	Chondroid Chordoma Of The Clivus
Erythroleukemia
Cervical Cancer	Cervical Cancer, Somatic Neoplasm Of Uterine Cervix Cervix Cancer Uterine Cervical Neoplasm Cervical Neoplasm Cervix Uteri Cancer Tumor Of The Cervix Uteri CERCA Uterine Cervical Cancer Neoplasms Cervical Uterine Cervical Neoplasms Cervical Cancers Cancer, Cervical, Somatic Malignant Tumor Of Cervix Cervix Carcinoma
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Head And Neck Cancer Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Cancer, Head/Neck Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Keratoconjunctivitis Sicca	Kcs Dry Eye Syndromes Keratitis Sicca Xerophthalmia
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Uterine Carcinosarcoma	Carcinosarcoma Of The Corpus Uteri Mixed Mullerian Sarcoma Of Uterus Malignant Mixed Müllerian Tumor Of The Corpus Uteri Malignant Mixed Müllerian Tumor Of Corpus Uteri Mixed Müllerian Cancer Of Corpus Uteri Malignant Mixed Mullerian Tumor Of The Corpus Uteri Mixed Mullerian Cancer Of Corpus Uteri Uterine Corpus Carcinosarcoma
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Clear Cell Sarcoma	Sarcoma, Clear Cell Adult Soft Part Clear Cell Sarcoma Clear Cell Sarcoma Of Soft Parts Malignant Melanoma Of Soft Parts Malignant Melanoma Of Soft Tissues Melanoma, Malignant, Of Soft Parts Sarcoma Clear Cell
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Ganglioneuroma
Gastroesophageal Adenocarcinoma	Gastric And Esophageal Adenocarcinoma Gastro-Esophageal Adenocarcinoma
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Gastroesophageal Junction Adenocarcinoma	Adenocarcinoma Of Cardioesophageal Junction Adenocarcinoma Of Gastroesophageal Junction Adenocarcinoma Of The Gastroesophageal Junction
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hypoganglionosis	Intestinal Hypoganglionosis
Acneiform Dermatitis	Dermatitis Acneiform
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Ovary Transitional Cell Carcinoma	Malignant Ovarian Transitional Cell Neoplasm Ovarian Transitional Cell Cancer Ovarian Transitional Cell Neoplasm Transitional Cell Carcinoma Of Ovary Ovarian Transitional Cell Carcinoma Malignant Ovarian Transitional Cell Tumor Ovarian Transitional Cell Tumor
Gastric Adenocarcinoma	Adenocarcinoma Of Stomach Stomach Adenocarcinoma Adenocarcinoma Gastric Intestinal Type Adenocarcinoma Of Unspecified Site Diffuse Type Adenocarcinoma Of Unspecified Site
Neurogenic Bladder	Neurogenic Dysfunction Of The Urinary Bladder Neurogenic Urinary Bladder Disorder Neuropathic Bladder Bladder Neurogenic Urinary Bladder, Neurogenic Neurogenic Urinary Bladder
Lethal Congenital Contracture Syndrome 2	LCCS2 Lethal Congenital Contractural Syndrome 2 Multiple Contracture Syndrome, Israeli-Bedouin Type Multiple Contracture Syndrome, Israeli Bedouin Type A Multiple Contracture Syndrome, Israeli Bedouin Type Lethal Congenital Contracture Syndrome Type 2 Israeli Bedouin Multiple Contracture Syndrome Type A Contracture Syndrome, Lethal, Congenital, Type 2
Squamous Blepharitis
Ganglioneuroblastoma
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Colonic Benign Neoplasm	Colon Neoplasm Colonic Mass Colonic Tumor Neoplasm Of Colon Neoplasm Of The Colon Colonic Neoplasms Colon Cancer Colon Carcinoma Nos Colonic Cancer Metastatic Colon Cancer Nos
Erythroleukemia, Familial	FERLK Erythroleukemia, Familial, Susceptibility To Di Guglielmo Disease, Familial Leukemia, Acute Myelogenous, M6 {Erythroleukemia, Familial, Susceptibility To} Acute Erythroblastic Leukemia
Mucinous Lung Adenocarcinoma
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Congenital Megacolon Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against Hirschsprung'S Disease Congenital Intestinal Aganglionosis HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Visceral Neuropathy, Familial, 1, Autosomal Recessive	VSCN1 Intestinal Pseudoobstruction Due To Neuronal Disease Argyrophil Myenteric Plexus, Deficiency Of Pseudoobstruction, Chronic Idiopathic Intestinal, Neuronal Type
Parkinson Disease 2, Autosomal Recessive Juvenile	Young-Onset Parkinson Disease PARK2 Pdj Autosomal Recessive Juvenile Parkinson Disease 2 Epdf Parkinson Disease, Juvenile, Type 2 Parkinson'S Disease 2 Autosomal Recessive Juvenile Parkinson Disease Early-Onset Parkinson Disease Parkinson Disease 2 Parkinson Disease, Juvenile, Autosomal Recessive Parkinsonism, Early-Onset, With Diurnal Fluctuation Autosomal Recessive Juvenile Parkinson'S Disease 2 Jp Juvenile Parkinsonism Parkinson Disease Autosomal Recessive, Early Onset Parkinsonism, Early Onset, With Diurnal Fluctuation Yopd Autosomal Recessive Early-Onset Parkinson Disease Type 2 Chromosome 6-Linked Autosomal Recessive Parkinsonism Early-Onset Parkinsonism With Diurnal Fluctuation Parkinsonism Young Adult Onset Parkinson Disease, Type 2 Parkinsonism, Juvenile
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Female Breast Cancer	Female Breast Carcinoma Carcinoma Of Female Breast Mammary Carcinoma Of Female Breast Malignant Neoplasm Of Female Breast
Gallbladder Cancer	Gallbladder Carcinoma Gallbladder Neoplasm Malignant Neoplasm Of Gallbladder Malignant Tumour Of Gallbladder Gallbladder Ca Localized Malignant Gallbladder Neoplasm Malignant Tumor Of The Gallbladder Tumor Of The Gallbladder Cancer Of The Gallbladder Carcinoma Gallbladder Carcinoma Of Gallbladder Gallbladder Neoplasms Malignant Neoplasm Of Gallbladder Localized Cancer Of Gallbladder Primary Malignant Neoplasm Of Gallbladder
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Combined Oxidative Phosphorylation Deficiency 13	COXPD13 Combined Oxidative Phosphorylation Defect Type 13 Combined Oxidative Phosphorylation Deficiency, Type 13
Breast Ductal Carcinoma	Ductal Breast Carcinoma Duct Carcinoma Carcinoma, Ductal Mammary Ductal Carcinoma Ductal Carcinoma
Bronchiectasis 2
Childhood Medulloblastoma	Medulloblastoma, Childhood Pediatric Medulloblastoma Medulloblastoma Childhood

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-B0426A	Olopatadine hydrochloride	99.83%	Unkown
HY-W062109	Olopatadine	98.94%	Unkown
HY-B0426AR	Olopatadine hydrochloride (Standard)	/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-118998	TX2-121-1	Inhibitor	/	Phase 3
HY-13050	Sapitinib	Inhibitor	99.93%	Phase 2

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99275	Patritumab	Inhibitor	99.28%	Phase 3
HY-P99672	Istiratumab	Inhibitor	98.45%	Phase 2
HY-P991240	CDX-3379	Inhibitor	99.38%	Phase 2
HY-P991524	MM-111	Inhibitor	/	Phase 2
HY-P99304	Lumretuzumab	Inhibitor	≥99.0%	Phase 1
HY-P991244	REGN-1400	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100848	TX1-85-1	Inhibitor	99.65%	Unkown
HY-18609	PD158780	Inhibitor	99.47%	Unkown
HY-E70715	ERBB2 775YVMA776 Recombinant Human Active Protein Kinase		/	Unkown
HY-13050A	Sapitinib fumarate	Inhibitor	/	Unkown
HY-B0426AS2	Olopatadine-d6 hydrochloride		/	Unkown
HY-RS04469	ERBB3 Human Pre-designed siRNA Set A		/	Unkown
HY-RS04470	Erbb3 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS04471	Erbb3 Rat Pre-designed siRNA Set A		/	Unkown
HY-W062109S	Olopatadine-d6		/	Unkown
HY-B0426AS	Olopatadine-d3 hydrochloride		/	Unkown

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991159	Ruzaltatug	Inhibitor	95.69%	Unkown
HY-P992128	Rinumafusp alfa	Inhibitor	97.09%	Unkown
HY-P991241	Anti-ERBB3/HER3 (29Z6)	Inhibitor	/	Unkown
HY-P991243	MP-RM-1	Inhibitor	96.29%	Unkown
HY-P991245	Anti-ERBB3/HER3 (SGP1)	Inhibitor	/	Unkown
HY-P991983	DB-1310 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ERBB3	RGD	RGD:69323
Felis catus	ERBB3	VGNC	VGNC:83875
Mus musculus	ERBB3	MGD	MGI:95411
Bos taurus	ERBB3	VGNC	VGNC:28564
Canis familiaris	ERBB3	VGNC	VGNC:54147
Macaca mulatta	ERBB3	VGNC	VGNC:108514
Others	ERBB3	NCBI