MAX - MYC associated factor X Gene
Also Known as bHLHd4
Species: Homo sapiens
About MAX
This gene has 20 transcripts (splice variants), 283 orthologues and is associated with 89 phenotypes. Ubiquitous expression in spleen (RPKM 18.6), lymph node (RPKM 17.0) and 25 other tissues.
Summary
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with Other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and Apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
MAX Products (29)
| mRNA | Protein | Name |
|---|---|---|
| NM_001271068.2 | NP_001257997.1 | protein max isoform g |
| NM_001271069.2 | NP_001257998.1 | protein max isoform h |
| NM_001320415.2 | NP_001307344.1 | protein max isoform i |
| NM_001407094.1 | NP_001394023.1 | protein max isoform a |
| NM_001407095.1 | NP_001394024.1 | protein max isoform b |
| NM_001407096.1 | NP_001394025.1 | protein max isoform j |
| NM_001407097.1 | NP_001394026.1 | protein max isoform j |
| NM_001407098.1 | NP_001394027.1 | protein max isoform k |
| NM_001407099.1 | NP_001394028.1 | protein max isoform l |
| NM_001407100.1 | NP_001394029.1 | protein max isoform l |
| NM_001407101.1 | NP_001394030.1 | protein max isoform l |
| NM_001407102.1 | NP_001394031.1 | protein max isoform l |
| NM_001407103.1 | NP_001394032.1 | protein max isoform c |
| NM_001407104.1 | NP_001394033.1 | protein max isoform c |
| NM_001407105.1 | NP_001394034.1 | protein max isoform i |
| NM_001407106.1 | NP_001394035.1 | protein max isoform i |
| NM_001407107.1 | NP_001394036.1 | protein max isoform i |
| NM_001407108.1 | NP_001394037.1 | protein max isoform m |
| NM_001407109.1 | NP_001394038.1 | protein max isoform m |
| NM_001407110.1 | NP_001394039.1 | protein max isoform m |
| NM_001407111.1 | NP_001394040.1 | protein max isoform n |
| NM_001407112.1 | NP_001394041.1 | protein max isoform n |
| NM_001407113.1 | NP_001394042.1 | protein max isoform g |
| NM_001407114.1 | NP_001394043.1 | protein max isoform o |
| NM_002382.5 | NP_002373.3 | protein max isoform a |
| NM_145112.3 | NP_660087.1 | protein max isoform b |
| NM_145113.3 | NP_660088.1 | protein max isoform c |
| NM_145114.3 | NP_660089.1 | protein max isoform d |
| NM_197957.4 | NP_932061.1 | protein max isoform f |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in negative regulation of transcription by RNA polymerase II |
IDA
IDA: Inferred from direct assay
|
8521822 | GOA |
| involved in positive regulation of DNA-templated transcription |
IDA
IDA: Inferred from direct assay
|
8425218 | GOA |
| involved in regulation of transcription by RNA polymerase II |
IDA
IDA: Inferred from direct assay
|
8425218 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of MLL1 complex |
IDA
IDA: Inferred from direct assay
|
15960975 | GOA |
| part of Mad-Max complex |
IPI
IPI: Inferred from physical interaction
|
12553908 | GOA |
| part of Myc-Max complex |
IPI
IPI: Inferred from physical interaction
|
12553908 | GOA |
| part of RNA polymerase II transcription regulator complex |
IDA
IDA: Inferred from direct assay
|
8425219 | GOA |
| located in chromatin |
IDA
IDA: Inferred from direct assay
|
12837246 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
10723141 | GOA |
| part of protein-DNA complex |
IDA
IDA: Inferred from direct assay
|
9399572 | GOA |
| part of protein-DNA complex |
IMP
IMP: Inferred from mutant phenotype
|
16171389 | GOA |
MAX Protein Structure
HLH: Helix-loop-helix DNA-binding domain (24 - 74)
- 0
- 100
- 160 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
protein max |
|
MAX Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
MAX | P61244 | UNC45A | Homo sapiens | Q9H3U1 | 31515488 | |
|
Intra
|
MAX | P61244 | UNC45A | Homo sapiens | Q9H3U1 | 25416956 | |
|
Intra
|
MAX | P61244 | VRK3 | Homo sapiens | Q8IV63 | 25609649 | |
|
Intra
|
MAX | P61244 | MECP2 | Homo sapiens | P51608 | 25609649 | |
|
Intra
|
MAX | P61244 | LIG3 | Homo sapiens | P49916 | 25609649 | |
|
Intra
|
MAX | P61244 | FOXK2 | Homo sapiens | Q01167 | 25609649 | |
|
Intra
|
MAX | P61244 | FOXK2 | Homo sapiens | Q01167 | 25609649 | |
|
Intra
|
MAX | P61244 | MGA | Homo sapiens | Q8IWI9 | 27705803 | |
|
Intra
|
MAX | P61244 | MGA | Homo sapiens | Q8IWI9 | 33961781 | |
|
Intra
|
MAX | P61244 | MGA | Homo sapiens | Q8IWI9 | 25609649 | |
|
Intra
|
MAX | P61244 | MGA | Homo sapiens | Q8IWI9 | 21988832 | |
|
Intra
|
MAX | P61244 | MGA | Homo sapiens | Q8IWI9 | 24981860 | |
|
Intra
|
MAX | P61244 | MACROH2A1 | Homo sapiens | O75367 | 25609649 | |
|
Intra
|
MAX | P61244 | TFAP2A | Homo sapiens | P05549 | 25609649 | |
|
Intra
|
MAX | P61244 | EEF1D | Homo sapiens | P29692 | 25609649 | |
|
Intra
|
MAX | P61244 | MYC | Homo sapiens | P01106 | 32296183 | |
|
Intra
|
MAX | P61244 | MYC | Homo sapiens | P01106 | 24951594 | |
|
Intra
|
MAX | P61244 | MYC | Homo sapiens | P01106 | 17418410 | |
|
Intra
|
MAX | P61244 | MYC | Homo sapiens | P01106 | 20691906 | |
|
Intra
|
MAX | P61244 | MYC | Homo sapiens | P01106 | 32296183 | |
|
Intra
|
MAX | P61244 | MYC | Homo sapiens | P01106 | 33961781 | |
|
Intra
|
MAX | P61244 | MYC | Homo sapiens | P01106 | 9184233 | |
|
Intra
|
MAX | P61244 | MYC | Homo sapiens | P01106 | 27705803 | |
|
Intra
|
MAX | P61244 | MYC | Homo sapiens | P01106 | 18620061 | |
|
Intra
|
MAX | P61244 | MYC | Homo sapiens | P01106 | 21988832 | |
|
Intra
|
MAX | P61244 | MYC | Homo sapiens | P01106 | 20691906 | |
|
Intra
|
MAX | P61244 | MYC | Homo sapiens | P01106 | 25609649 | |
|
Intra
|
MAX | P61244 | MYC | Homo sapiens | P01106 | 12821782 | |
|
Intra
|
MAX | P61244 | MYC | Homo sapiens | P01106 | 17157259 | |
|
Intra
|
MAX | P61244 | L3MBTL2 | Homo sapiens | Q969R5 | 33961781 | |
|
Intra
|
MAX | P61244 | L3MBTL2 | Homo sapiens | Q969R5 | 25609649 | |
|
Intra
|
MAX | P61244 | L3MBTL2 | Homo sapiens | Q969R5 | 27705803 | |
|
Intra
|
MAX | P61244 | PLEKHF2 | Homo sapiens | Q9H8W4 | 16189514 | |
|
Intra
|
MAX | P61244 | PLEKHF2 | Homo sapiens | Q9H8W4 | 32296183 | |
|
Intra
|
MAX | P61244 | PLEKHF2 | Homo sapiens | Q9H8W4 | 32296183 | |
|
Intra
|
MAX | P61244 | PLEKHF2 | Homo sapiens | Q9H8W4 | 32296183 | |
|
Intra
|
MAX | P61244 | E2F6 | Homo sapiens | O75461 | 27705803 | |
|
Intra
|
MAX | P61244 | E2F6 | Homo sapiens | O75461 | 33961781 | |
|
Intra
|
MAX | P61244 | E2F6 | Homo sapiens | O75461 | 25609649 | |
|
Intra
|
MAX | P61244 | TFDP1 | Homo sapiens | Q14186 | 25609649 | |
|
Intra
|
MAX | P61244 | TFDP1 | Homo sapiens | Q14186 | 33961781 | |
|
Intra
|
MAX | P61244 | TFDP1 | Homo sapiens | Q14186 | 27705803 | |
|
Intra
|
MAX | P61244 | MXI1 | Homo sapiens | P50539 | 25416956 | |
|
Intra
|
MAX | P61244 | MXI1 | Homo sapiens | P50539 | 25416956 | |
|
Intra
|
MAX | P61244 | MXI1 | Homo sapiens | P50539 | 25416956 | |
|
Intra
|
MAX | P61244 | MXI1 | Homo sapiens | P50539 | 27705803 | |
|
Intra
|
MAX | P61244 | MXI1 | Homo sapiens | P50539 | 33961781 | |
|
Intra
|
MAX | P61244 | MXI1 | Homo sapiens | P50539 | 9184233 | |
|
Intra
|
MAX | P61244 | MXI1 | Homo sapiens | P50539 | 16189514 | |
|
Intra
|
MAX | P61244 | MXI1 | Homo sapiens | P50539 | 25609649 | |
|
Intra
|
MAX | P61244 | MNT | Homo sapiens | Q99583 | 33961781 | |
|
Intra
|
MAX | P61244 | MNT | Homo sapiens | Q99583 | 25609649 | |
|
Intra
|
MAX | P61244 | MNT | Homo sapiens | Q99583 | 27705803 | |
|
Intra
|
MAX | P61244 | MNT | Homo sapiens | Q99583 | 9184233 | |
|
Intra
|
MAX | P61244 | MXD1 | Homo sapiens | Q05195 | 27705803 | |
|
Intra
|
MAX | P61244 | MXD1 | Homo sapiens | Q05195 | 33961781 | |
|
Intra
|
MAX | P61244 | XRCC1 | Homo sapiens | P18887 | 25609649 |
Recombinant MAX Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70388 | MAX Protein, Human (His) | P61244-2 (M1-S151) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P73832 | MAX Protein, Human (sf9, His-GST) | P61244-1/NP_002373 (M1-S160) | ≥ 85%, as determined by reducing SDS-PAGE. |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Hereditary Paraganglioma-Pheochromocytoma Syndromes |
|
|
| Pheochromocytoma |
|
|
| Bap1 Tumor Predisposition Syndrome |
|
|
| Inherited Cancer-Predisposing Syndrome |
|
|
| Paraganglioma |
|
|
| Spastic Paraplegia 84, Autosomal Recessive |
|
|
| Spastic Paraplegia 85, Autosomal Recessive |
|
|
| Spastic Paraplegia 86, Autosomal Recessive |
|
|
| Esophagus Leiomyoma |
|
|
| Persistent Generalized Lymphadenopathy |
|
|
| Multiple Endocrine Neoplasia, Type Iia |
|
|
| Duodenal Somatostatinoma |
|
|
| Sweeney-Cox Syndrome |
|
|
| Malignant Pheochromocytoma |
|
|
| Adrenal Medulla Cancer |
|
|
| Peripheral Nervous System Benign Neoplasm |
|
|
| Autonomic Nervous System Benign Neoplasm |
|
|
| Lung Cancer |
|
|
| Paraganglioma And Gastric Stromal Sarcoma |
|
|
| Von Hippel-Lindau Syndrome |
|
|
| Williams-Beuren Syndrome |
|
|
| Neurofibromatosis, Type I |
|
|
| Neuroblastoma |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | MAX | VGNC | VGNC:74667 |
| Rattus norvegicus | MAX | RGD | RGD:621101 |
| Felis catus | MAX | VGNC | VGNC:80920 |
| Canis familiaris | MAX | VGNC | VGNC:43045 |
| Mus musculus | MAX | MGD | MGI:96921 |
| Bos taurus | MAX | VGNC | VGNC:31269 |
| Others | MAX | NCBI |