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Referencia número: HY-114894

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2C07

2C07 is a mutant Ras (K-Ras^M72C, H-Ras^M72C) inhibitor. 2C07 blocks the activation of PI3K through allosteric Ras modification. 2C07 binds to the modified switch II pocket (S-IIG) of Ras in both GDP- and GTP-bound states, stabilizes the GDP-bound state, disrupts the polar interactions of the canonical GTP-bound state, and inhibits SOS binding and nucleotide exchange. 2C07 can be used in cancer-related research.

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No. CAS: 2230185-95-0
Fòrmula: C₁₉H₂₅F₃N₄O₂S₂
Peso molecular:462.55

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Please store the product under the recommended conditions in the Certificate of Analysis.

2C07 Chemical Structure

No. CAS: 2230185-95-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Ras :

Ver todos los productos específicos de isoformas PI3K :

In Vitro

2C07 selectively binds to the engineered Cys72 residue in truncated K-Ras^M72C GDP and truncated H-Ras^M72C GppNHp with βME₅₀ values of 2.53 mM and 1.10 mM, respectively, and does not modify wild-type Ras constructs^[1].
2C07 binds to the switch-II groove (S-IIG) of truncated K-Ras^M72C GDP and truncated H-Ras^M72C in both GDP and GppNHp states, inducing a modified switch-II pocket conformation and, in the GppNHp state, altering switch I positioning and Mg²⁺ coordination^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2230185-95-0
Peso molecular 462.55
Fòrmula C₁₉H₂₅F₃N₄O₂S₂
SMILES

O=C(NCCCSSCCN(C)C)C1=C(N(N=C1)C2=CC=C(C=C2)OC)C(F)(F)F
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Gentile DR, et al. Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States. Cell chemical biology. 2017 Dec 21;24(12):1455-1466.e14. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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2C07

Ver todos los productos específicos de isoformas Ras

Ver todos los productos específicos de isoformas PI3K