Referencia número: HY-15763

Biologically Validated

Erastin

Name: Erastin
Brand: MedChemExpress
SKU: HY-15763
Price: 50.00 USD
Availability: InStock
Rating: 5 (905 reviews)

905 Cited Publications

Revisión del cliente

Based on 905 publication(s) in Google Scholar

Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation.

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Pureza : 99.91%
No. CAS: 571203-78-6
Fòrmula: C₃₀H₃₁ClN₄O₄
Peso molecular:547.04

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years

* The compound is unstable in solutions, freshly prepared is recommended.

Erastin Chemical Structure

No. CAS: 571203-78-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- MCE Validation Data
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (905)
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
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Descripciòn

IC₅₀ & Target

VDAC2

VDAC3

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MCE Validation Data

HT-1080 cells were seeded at 8,000 cells/well in a 96-well plate and were cultured overnight. Then, cells were treated with Erastin (HY-15763) (0-400 nM) for 24 h, and the cell viability was assayed by CCK-8 kit (HY-K0301). The results indicated that Erastin inhibits the cell viability.
HT-1080 cells were seeded at 60000 cells/well in a 24 well plate and were cultured overnight. Then, cells were treated with Erastin (HY-15763) (0-100 nM) for 24 h, and the expression of GPX-4 was measured. The results indicated that Erastin inhibits GPX-4 expression. Primary antibody: GPX-4 antibody (HY-P80450), GAPDH antibody (HY-P80137).
HT-1080 cells were seeded at 8000 cells/well in a 96 well plate and were cultured overnight. Then, cells are treated with 200 nM Erastin (HY-15763) in the presence or absence of Ferrostatin-1 (HY-100579) (Fer-1, 0.5 μM) for 24 h. The results indicated that Fer-1 inhibits the ferroptosis induced by Erastin.

Cellular Effect

Cell Line	Type	Value	Description	References
A673	EC₅₀	30 μM Compound: erastin	Induction of cell death in human A673 cells Induction of cell death in human A673 cells	[PMID: 17568748]
B16	IC₅₀	5 μM Compound: Erastin	Cytotoxicity against mouse B16 cells assessed as inhibition of cell viability measured after 24 hrs by MTT assay Cytotoxicity against mouse B16 cells assessed as inhibition of cell viability measured after 24 hrs by MTT assay	[PMID: 38306267]
BJ	EC₅₀	10 μM Compound: erastin	Induction of cell death in TERT expressing human BJ cells Induction of cell death in TERT expressing human BJ cells	[PMID: 17568748]
BJ	EC₅₀	6 μM Compound: erastin	Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes	[PMID: 17568748]
BJ	IC₅₀	0.9 μM Compound: erastin	Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells in presence of MEK inhibitor 2 by trypan blue exclusion method Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells in presence of MEK inhibitor 2 by trypan blue exclusion method	[PMID: 17568748]
BJ	IC₅₀	0.9 μM Compound: erastin	Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells in presence of PD-98059 by trypan blue exclusion method Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells in presence of PD-98059 by trypan blue exclusion method	[PMID: 17568748]
BJ	IC₅₀	2 μM Compound: erastin	Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells in presence of MEK 1/2 inhibitor by trypan blue exclusion method Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes cells in presence of MEK 1/2 inhibitor by trypan blue exclusion method	[PMID: 17568748]
BJ	IC₅₀	2.6 μM Compound: erastin	Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes in presence of MEK inhibitor by trypan blue exclusion method Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes in presence of MEK inhibitor by trypan blue exclusion method	[PMID: 17568748]
BJ	IC₅₀	31.2 μM Compound: erastin	Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes in presence of U0126 by trypan blue exclusion method Induction of cell death in human BJ cells expressing TERT, LT, ST and RAS G12V mutant genes in presence of U0126 by trypan blue exclusion method	[PMID: 17568748]
C-33-A	EC₅₀	0.6 μM Compound: erastin	Induction of cell death in human C33A cells Induction of cell death in human C33A cells	[PMID: 17568748]
Calu-1	IC₅₀	0.14 μM Compound: 4	Induction of ferroptosis in human Calu-1 cells assessed as inhibition of (cystine-glutamate antiporter) system Xc- mediated cystine transport Induction of ferroptosis in human Calu-1 cells assessed as inhibition of (cystine-glutamate antiporter) system Xc- mediated cystine transport	[PMID: 36332549]
Calu-1	IC₅₀	4 μM Compound: erastin	Inhibition of human Calu1 cells expressing KRAS with activating mutations by trypan blue exclusion assay Inhibition of human Calu1 cells expressing KRAS with activating mutations by trypan blue exclusion assay	[PMID: 17568748]
CCF-STTG1	IC₅₀	200 nM Compound: ERA	Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometry Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometry	[PMID: 26231156]
HeLa	EC₅₀	0.6 μM Compound: erastin	Induction of cell death in human HeLa cells Induction of cell death in human HeLa cells	[PMID: 17568748]
HOS	EC₅₀	17 μM Compound: erastin	Induction of cell death in human HOS cells Induction of cell death in human HOS cells	[PMID: 17568748]
HT-1080	EC₅₀	2 μM Compound: erastin	Induction of cell death in human HT1080 cells Induction of cell death in human HT1080 cells	[PMID: 17568748]
HT-1080	IC₅₀	0.2 μM Compound: 4	Induction of ferroptosis in human HT-1080 cells assessed as inhibition of (cystine-glutamate antiporter) system Xc- mediated cystine transport Induction of ferroptosis in human HT-1080 cells assessed as inhibition of (cystine-glutamate antiporter) system Xc- mediated cystine transport	[PMID: 36332549]
HT-1080	IC₅₀	1 μM Compound: erastin	Induction of cell death in human HT1080 cells in presence of PD-98059 by trypan blue exclusion method Induction of cell death in human HT1080 cells in presence of PD-98059 by trypan blue exclusion method	[PMID: 17568748]
HT-1080	IC₅₀	1.3 μM Compound: erastin	Induction of cell death in human HT1080 cells in presence of MEK inhibitor 2 by trypan blue exclusion method Induction of cell death in human HT1080 cells in presence of MEK inhibitor 2 by trypan blue exclusion method	[PMID: 17568748]
HT-1080	IC₅₀	1.52 μM Compound: Erastin	Lethality in human HT-1080 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay Lethality in human HT-1080 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay	[PMID: 36410168]
HT-1080	IC₅₀	2.5 μM Compound: erastin	Induction of cell death in human HT1080 cells in presence of MEK inhibitor by trypan blue exclusion method Induction of cell death in human HT1080 cells in presence of MEK inhibitor by trypan blue exclusion method	[PMID: 17568748]
HT-1080	IC₅₀	3.4 μM Compound: erastin	Induction of cell death in human HT1080 cells in presence of U0126 by trypan blue exclusion method Induction of cell death in human HT1080 cells in presence of U0126 by trypan blue exclusion method	[PMID: 17568748]
HT-1080	IC₅₀	6 μM Compound: erastin	Induction of cell death in human HT1080 cells in presence of MEK 1/2 inhibitor by trypan blue exclusion method Induction of cell death in human HT1080 cells in presence of MEK 1/2 inhibitor by trypan blue exclusion method	[PMID: 17568748]
HT-29	IC₅₀	20.89 μM Compound: Erastin	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38422700]
LNCaP	EC₅₀	6 μM Compound: erastin	Induction of cell death in human LNCaP cells Induction of cell death in human LNCaP cells	[PMID: 17568748]
MC-38	IC₅₀	0.5 μM Compound: Erastin	Cytotoxicity against mouse MC-38 cells assessed as reduction in cell viability incubated for 24 hrs by MTS assay Cytotoxicity against mouse MC-38 cells assessed as reduction in cell viability incubated for 24 hrs by MTS assay	[PMID: 38306267]
MES-SA	EC₅₀	3 μM Compound: erastin	Induction of cell death in human MES-SA cells Induction of cell death in human MES-SA cells	[PMID: 17568748]
SJSA-1	EC₅₀	12 μM Compound: erastin	Induction of cell death in human SJSA1 cells Induction of cell death in human SJSA1 cells	[PMID: 17568748]
SK-ES1	EC₅₀	7 μM Compound: erastin	Induction of cell death in human SK-ES-1 cells Induction of cell death in human SK-ES-1 cells	[PMID: 17568748]
SK-LMS-1	EC₅₀	6 μM Compound: erastin	Induction of cell death in human SKLMS1 cells Induction of cell death in human SKLMS1 cells	[PMID: 17568748]
SK-N-MC	EC₅₀	10 μM Compound: erastin	Induction of cell death in human SK-N-MC cells Induction of cell death in human SK-N-MC cells	[PMID: 17568748]
SVR	EC₅₀	2.5 μM Compound: erastin	Induction of cell death in human SVR cells Induction of cell death in human SVR cells	[PMID: 17568748]
TC-32	EC₅₀	8 μM Compound: erastin	Induction of cell death in human TC32 cells Induction of cell death in human TC32 cells	[PMID: 17568748]
U2OS	EC₅₀	6 μM Compound: erastin	Induction of cell death in human U2OS cells Induction of cell death in human U2OS cells	[PMID: 17568748]
U-937	EC₅₀	10 μM Compound: erastin	Induction of cell death in human U937 cells Induction of cell death in human U937 cells	[PMID: 17568748]

In Vitro

Erastin (10 μM; 24 h) triggers ferroptosis in ectopic endometrial stromal cells (EESCs), and increases the total ROS level at 9 h^[1].
Erastin shorts mitochondria and increases membrane density in EESCs^[1].
Erastin (10 μM; 9 h) decreases the mRNA expression levels of iron-related proteins, such FPN (iron exporter) in EESCs. However, FPN overexpression significantly inhibits erastin-induced ferroptosis in EESCs^[1].
Erastin (10 μM; 24 h) induces mitochondrial permeability transition pore (mPTP) opening in HT-29 colorectal cancer cells^[2].
Erastin (30 μM; 72 h) significantly inhibits the growth of HT-29 colorectal cancer cells^[2].
The molecular mechanism by which Erastin induces ferroptosis is related to genes regulating iron or mitochondrial fatty acid metabolism. Includes ribosomal protein L8, iron response element binding protein 2 (IREB2), ATP synthase F0 complex subunit C3, citrate synthase, tetrapeptide repeat domain 35, and acyl-CoA synthetase family member 2 (ACSF2)^[3].
Note:
1. Different cell lines may have different sensitivity to a same compound. As reported, A549, HCT116, HepG2, H1299 cells may be insensitive to Erastin^[3]^[4]^[5].
2. Erastin is unstable in solution. Freshly prepared is recommended.

Ferroptosis-sensitive Cell Lines

Ferroptosis-sensitive Cells	Test Conditions
SKOV3^[6]	5-20 μM; 1-7 days
OVCA429^[6]	5-20 μM; 1-7 days
MCF10A-RAS^[7]	0-30 μM; 48 h
HT-22 neuron^[8]	500 nM; 16 h
NCI-H508^[9]	0.1-10 μM; 48 h
LoVo^[9]	0.1-10 μM; 48 h
LS513^[9]	0.1-10 μM; 48 h
SW480^[9]	0.1-10 μM; 48 h
SW620^[9]	0.1-10 μM; 48 h
SW1116^[9]	0.1-10 μM; 48 h
DLD-1^[9]	0.1-10 μM; 48 h
Caco-2^[9]	0.1-10 μM; 48 h
SW837^[10]	0-40 μM; 24 h
Pfa1^[11]	0.1-5 μM; 48 h
HT-1080^[12]	0.1-5 μM; 48 h
MAD-MB-231^[13]	0-100 μM; 72 h; IC₅₀: 9.55 μM
HCC1937^[13]	0-100 μM; 72 h; IC₅₀: 11.58 μM

Ferroptosis-insensitive Cell Lines

Ferroptosis-insensitive Cells	Test Conditions
HCT116^[11]	0-40 μM; 24 h
SW48^[11]	0-40 μM; 24 h
HepG2^[5]	0-20 μM; 24 h
MDA-MB-436^[13]	0.1-25 μM; 24 h
HT-29^[13]	0.1-25 μM; 24 h
U-373^[13]	0.1-25 μM; 24 h

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Normal endometrial stromal cells (NESCs) and endometrial stromal cells (EESCs)
Concentration:

0, 0.5, 0.8, 1, 1.5, 2, 2.5, 5, 10 μM
Incubation Time:

24 hours
Result:

Induced cell detachment and overt death in EESCs, but not NESCs.

Apoptosis Analysis^[1]

Cell Line:

EESCs infected with adenovirus expressing FPN cDNA (co-incubation for 24 hr)
Concentration:

0, 0.5, 1.5, 2.5, 5 and 2.5 μM
Incubation Time:

24 hours
Result:

Induced ferroptosis by decreasing the levels of total ROS and lipid ROS. And reversed by the overexpression of FPN in adenovirus-infected cells.

In Vivo

Erastin can be used in animal modeling to construct ferroptosis induction model.

Erastin (40 mg/kg; i.p.; once every 3 days for 2 weeks) suppresses endometriotic implants in the mouse endometriosis model, indicating Erastin regresses ectopic lesions by trigging ferroptosis^[1].
Erastin (10 mg/kg, 30 mg/kg; i.p.; once daily for 4 weeks) suppresses HT-29 xenograft growth in SCID mice, with more potent efficacy under 30 mg/kg treatment^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mouse model of endometriosis^[1]
Dosage:

40 mg/kg
Administration:

Intraperitoneal injection; once every 3 days for 2 weeks
Result:

Showed little impact on body weight of mice and hair of mice displayed neat and glossy.
Reduced the volume of ectopic lesions.

Chemical Information

No. CAS 571203-78-6
Appearance Solid
Peso molecular 547.04
Fòrmula C₃₀H₃₁ClN₄O₄
Color White to off-white
SMILES

O=C1N(C2=CC=CC=C2OCC)C(C(N3CCN(C(COC4=CC=C(Cl)C=C4)=O)CC3)C)=NC5=C1C=CC=C5
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years

* The compound is unstable in solutions, freshly prepared is recommended.

Publications (905)

All Bio/Physico-chemical AssayCell Migration/Invasion AssayOthersCell Imaging/StainingELISAIn Vivo Efficacy StudyFlow CytometryIHCHistological Imaging/StainingApoptosis AnalysisRT-PCRIFWBCell Proliferation/Viability Assay

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Journal Impact Factor

Nature

Catabolism of extracellular glutathione supplies cysteine to support tumours. [Abstract]

2026 May;653(8115):933-941. PMID: 41851454

Erastin purchased from MedChemExpress. Usage Cited in: Nature. 2026 May;653(8115):933-941. [Abstract]

HCC-1806 cells were grown in 6-well plates and treated with Erastin (15 μM) for 72 h in different culture media, and relative cell numbers were determined.
Cancer Cell

Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma. [Abstract]

2026 Feb 9;44(2):383-404.e18. PMID: 41544627
Cell

Stabilizing MARCH7 as a ferro-guardian against ferroptosis. [Abstract]

2026 Jun 11;189(12):3553-3570.e30. PMID: 42049018

Erastin purchased from MedChemExpress. Usage Cited in: Cell. 2026 Jun 11;189(12):3553-3570.e30. [Abstract]

Viability of HeLa cells stably expressing empty vector, MARCH7-WT, or MARCH7-WI with Erastin (10 μM) or Fer-1 (5 μM) treatment for 24 h.

Erastin purchased from MedChemExpress. Usage Cited in: Cell. 2026 Jun 11;189(12):3553-3570.e30. [Abstract]

Levels of Fe²⁺ in the control and MARCHF7-KD HeLa cells after treated with Erastin (10 μM) or Erastin (10 μM) and DFO (80 μM) for 24 h.

Erastin purchased from MedChemExpress. Usage Cited in: Cell. 2026 Jun 11;189(12):3553-3570.e30. [Abstract]

Levels of cellular Fe²⁺ in the control and MARCHF7-KD HT-1080 cells detected by flow cytometry under Erastin (10 μM), Erastin (10 μM), and DFO (80 μM) treatment for 24 h.

Erastin purchased from MedChemExpress. Usage Cited in: Cell. 2026 Jun 11;189(12):3553-3570.e30. [Abstract]

Levels of total iron in HeLa cells stably expressing the WT TFR1 or TFR1-K53R after treated with Erastin (10 μM) or Erastin (10 μM) and DFO (80 μM) for 24 h.
Cell

SLC7A11 is an unconventional H+ transporter in lysosomes. [Abstract]

2025 Jun 26;188(13):3441-3458.e25. PMID: 40280132

Erastin purchased from MedChemExpress. Usage Cited in: Cell. 2025 Jun 26;188(13):3441-3458.e25. [Abstract]

Effects of Era (Erastin; 10 μM; 2 h) treatment on juxta-lysosomal pH in WT and SLC7A11 KO HT1080 cells. Erastin treatment markedly increased juxta-lysosomal pH in WT but not SLC7A11 KO HT1080 cells.

Erastin purchased from MedChemExpress. Usage Cited in: Cell. 2025 Jun 26;188(13):3441-3458.e25. [Abstract]

Dose-dependent effects of CQ (0.01–10 μM) on cell viability (CCK8 assay) in WT HT1080 cells incubated with Era (Erastin; 10 μM) for 18 h. Era caused a dramatic loss of cell viability.

Erastin purchased from MedChemExpress. Usage Cited in: Cell. 2025 Jun 26;188(13):3441-3458.e25. [Abstract]

Flow cytometric analyses of CQ(1) effects on lipid peroxidation (C11-BODIPY assay) in WT HT1080 cells treated with Era (Erastin; 10 μM) for 16 h. Right panel is summary of gated C11-BODIPY rate.

Erastin purchased from MedChemExpress. Usage Cited in: Cell. 2025 Jun 26;188(13):3441-3458.e25. [Abstract]

Time-dependent Era (Erastin; 10 μM; 0-12 h) effects on GSH/GSSG (reduced GSH vs. oxidized glutathione disulfide) ratios in HT1080 cells co-treated with Fer-1 (2 μM) or NAC (5 mM). Era decreased the GSH/GSSG ratio over time.

Erastin purchased from MedChemExpress. Usage Cited in: Cell. 2025 Jun 26;188(13):3441-3458.e25. [Abstract]

Western blotting analysis of LC3-II levels in WT and SLC7A11 KO HT1080 cells treated with Era (Erastin; 10 μM), Baf-A1 (100 nM), or both for 2 h. Era inhibited Baf-A1-induced LC3 accumulation.
Imeta

2026 Feb 19.
Cell Metab

Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome. [Abstract]

2025 Jan 7;37(1):154-168.e7. PMID: 39561766
Cancer Commun (Lond)

2026 Feb 19:46:0005. PMID: 41727907

Erastin purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2026 Feb 19:46:0005.

Lipid ROS-positive cells were measured by flow cytometry in LN229, LN18, U251, and U87 cells treated with Erastin (20 μmol/L; 24 h), with or without 2 μmol/L Fer-1. U87 and U251 cells showed enhanced resistance to Erastin-induced lipid peroxidation compared with LN229 and LN18 cells.
Cancer Commun (Lond)

Tryptophan 2,3-dioxygenase-positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine-mediated ferroptosis resistance of metastatic cells and T cell dysfunction. [Abstract]

2024 Nov;44(11):1261-1286. PMID: 39221971

Erastin purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2024 Nov;44(11):1261-1286. [Abstract]

Erastin (0.1-5 µM; 48 h) induces cell death (ferroptosis) in both 4T1-LM3 and E0771-LM3 cells.
Nat Immunol

Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response. [Abstract]

2025 Oct;26(10):1660-1672. PMID: 40954252

Erastin purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2025 Oct;26(10):1660-1672. [Abstract]

Erastin (10 μM; 24 h). Cell death assays showing MDA-MB-231 cell responses to SK56.
Nat Aging

Shear stress governs hematopoietic stem cell fate to promote inflammation-induced aging. [Abstract]

2026 Jan 2. PMID: 41482519
Cell Mol Immunol

Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response. [Abstract]

2024 Aug;21(8):856-872. PMID: 38849539
Cell Stem Cell

Mitochondrial serine catabolism safeguards maintenance of the hematopoietic stem cell pool in homeostasis and injury. [Abstract]

2024 Oct 3;31(10):1484-1500.e9. PMID: 39181130

Erastin purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2024 Oct 3;31(10):1484-1500.e9. [Abstract]

Ferroptosis susceptibility analysis of BM HSCs in CD and SGFD mice. HSCs from SGFD mice were more susceptible to Erastin-induced (5 μM; 48 h) ferroptosis.
Nat Cell Biol

PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer. [Abstract]

2025 Apr;27(4):641-653. PMID: 40033101

Erastin purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2025 Apr;27(4):641-653. [Abstract]

HeLa cells were deprived of methionine and restimulated with SAM and SAH. After treatment with Erastin (20 μM) for 6 h, lipid ROS-positive cells were measured.

Erastin purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2025 Apr;27(4):641-653. [Abstract]

Parental HeLa cells and the indicated clones with knock-in expression of GPX4-R152K mutant, were treated with Erastin (20 μM) for 6 h in the absence or presence of pretreated with Fer-1 (2 μM) for 2 h. Relative MDA levels were measured. GPX4-R152K knock-in increased lipid peroxidation-derived MDA under Erastin treatment.

Erastin purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2025 Apr;27(4):641-653. [Abstract]

Parental HeLa cells and the indicated clones with knock-in expression of GPX4-R152K mutant, were treated with Erastin (20 μM) for 24 h, then cultured for 2 weeks. Relative colony number were measured. GPX4-R152K knock-in clones showed greater colony restriction following Erastin treatment than GPX4 wild-type cells.
Nat Cell Biol

Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance. [Abstract]

2022 Feb;24(2):168-180. PMID: 35165418

Erastin purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2022 Feb;24(2):168-180. [Abstract]

Cell survival in MCF10A-RAS cells cultured on stiff or soft Matrigel and treated for 48 h with Erastin (ERA) (10-30 μM).
Cancer Res

ESR1-Activating Mutations Confer Metabolic Vulnerabilities in ER+ Breast Cancer. [Abstract]

2025 Nov 7. PMID: 41201246

Erastin purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Nov 7. [Abstract]

Intracellular ROS levels were measured by DCFDA in MCF7 LTED^Y537C cells treated with Erastin (5 μmol/L; 48 h). Treatment of LTED^Y537C cells with Erastin led to increased ROS levels measured using the DCFDA probe.

Erastin purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Nov 7. [Abstract]

LTED^Y537C cells were treated with 40 μmol/L Erastin for 2 hours and subjected to cytofluorimetric analysis to measure lipid peroxidation using BODIPY581/591-C11. Erastin treatment increased lipid peroxidation levels.

Erastin purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Nov 7. [Abstract]

LTED^Y537C cells were pretreated with 7.5 μmol/L Fer-1 or 7.5 μmol/L DFOM for 4 hours and then exposed for further 48 hours to 5 μmol/L Erastin before cell counting. Cotreatment with the radical-trapping antioxidant ferrostatin-1 (Fer-1) and the iron chelator deferoxamine (DFOM) effectively rescued LTED^Y537C cells from Erastin-induced cell death.
Cancer Res

MEN1 Promotes Ferroptosis by Disrupting CD44 Alternative Splicing to Suppress Lung Cancer. [Abstract]

2025 Sep 24. PMID: 40991294

Erastin purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Sep 24. [Abstract]

Cell viability of WT/KO NCI-H460 cells transfected with siV6 or siNC, followed by 48-hour treatment with Erastin (5-20 μmol/L). siV6 suppressed MEN1 deletion-enhanced proliferation and restored the sensitivity of KO cells to Erastin-induced ferroptosis to a level analogous to siNC-treated WT control cells.

Erastin purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Sep 24. [Abstract]

Lipid peroxidation levels in WT/KO NCI-H460 cells transfected with siV6 or siNC, followed by 24-hour treatment with Erastin (20 μmol/L).

Erastin purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Sep 24. [Abstract]

Transmission electron microscopy images of WT and KO NCI-H460 cells (±Erastin (20 μmol/L; 24 hours)). Transmission electron microscopy observations showed that Erastin-treated cells had impaired mitochondrial integrity.

Erastin purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Sep 24. [Abstract]

Representative lung images from KS and KMS mice treated with Erastin (15 mg/kg; i.p.; three times per week for 3 weeks). Lung weight, tumor number, burden, and size of KS and KMS mice. The lung weight, tumor number, tumor burden, and tumor size were reduced in the Erastin-treated mice compared with Ctrlpep-treated mice.

Erastin purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Sep 24. [Abstract]

Representative images and quantification of Ki67 IHC staining of lung tissue sections from KS and KMS mice. Erastin (15 mg/kg; i.p.; three times per week for 3 weeks) treatment decreased Ki67 expression in the tumor tissues of KS and KMS mice.

Erastin purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Sep 24. [Abstract]

Representative images and quantification for 4HNE fluorescence in lung tissue sections from KS and KMS mice. Erastin (15 mg/kg; i.p.; three times per week for 3 weeks) treatment elevated 4HNE expression in KS and KMS tumors.

Erastin purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Sep 24. [Abstract]

Iron and LPO levels in lungs from KS and KMS mice. Erastin (15 mg/kg; i.p.; three times per week for 3 weeks) treatment increased iron and lipid peroxide levels in KS and KMS tumors.

Erastin purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Sep 24. [Abstract]

qPCR analysis of RPL8, TTC35, IREB2 and ATP5G3 in WT and KO NCI-H460 cells treated with 20 µM Erastin for 24 h. qPCR analysis revealed that MEN1 deficiency significantly inhibited Erastin-induced expression of mitochondrial genes (RPL8, TTC35, IREB2 and ATP5G3).
Cancer Res

PRODH2-Mediated Metabolism in the Bone Microenvironment Promotes Breast Cancer Metastasis. [Abstract]

2025 Aug 1. PMID: 40749014
Cancer Res

ASS1-mediated reductive carboxylation of cytosolic glutamine confers ferroptosis resistance in cancer cells. [Abstract]

2023 May 15;83(10):1646-1665. PMID: 36892426
Adv Funct Mater

2026 May 28;36(50):e76099.
Adv Funct Mater

2023 Apr 28.
Nat Commun

Serine inhibits granulosa cell ferroptosis to maintain ovarian function. [Abstract]

2026 Jan 21;17(1):1738. PMID: 41565641

Erastin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2026 Jan 21;17(1):1738. [Abstract]

Detection of lipid peroxidation levels in GCs after treatment with Erastin (5 μM; 4 h pretreatment followed by 24 h co-incubation with CTX). Erastin enhanced lipid peroxidation in GCs.
Nat Commun

Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes. [Abstract]

2025 Apr 1;16(1):3131. PMID: 40169595
Nat Commun

Intermetallics triggering pyroptosis and disulfidptosis in cancer cells promote anti-tumor immunity. [Abstract]

2024 Oct 8;15(1):8696. PMID: 39379392
Exp Mol Med

Piezo1 activation in endothelial cells aggravates microvascular ischemia-reperfusion injury in limbs by enhancing ferroptosis. [Abstract]

2026 Feb;58(1):143-160. PMID: 41507309
ACS Nano

Long Noncoding RNA URB1-Antisense RNA 1 (AS1) Suppresses Sorafenib-Induced Ferroptosis in Hepatocellular Carcinoma by Driving Ferritin Phase Separation. [Abstract]

2023 Nov 28;17(22):22240-22258. PMID: 37966480

Erastin purchased from MedChemExpress. Usage Cited in: ACS Nano. 2023 Nov 28;17(22):22240-22258. [Abstract]

Percentage of cell viability in HCC samples (paired sorafenib-sensitive and sorafenib-resistant HepG2, PLC/PRF/5, and PDO were included) treated with 3 μM erastin.
J Adv Res

Renal tubular Nfe2l1 protect cisplatin-induced acute kidney injury via suppressing ACSL4-dependent ferroptosis. [Abstract]

2026 May 3:S2090-1232(26)00381-4. PMID: 42086188

Erastin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2026 May 3:S2090-1232(26)00381-4. [Abstract]

The survival rate of HK-2 cells after treatment with Erastin (60 μM; 24 h) was assessed using CCK-8 assays. Nfe2l1 overexpression substantially reduced Erastin-induced ferroptosis.
J Adv Res

DHA ameliorates GDM placental angiogenesis by regulating HAMP-mediated iron imbalance. [Abstract]

2026 Mar 9:S2090-1232(26)00224-9. PMID: 41812706

Erastin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2026 Mar 9:S2090-1232(26)00224-9. [Abstract]

Cell viability of HUVECs under Erastin (10 μM; 24 h) treatment.

Erastin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2026 Mar 9:S2090-1232(26)00224-9. [Abstract]

Migratory ability of HUVECs under Erastin (10 μM; 24 h) treatment, along with representative images of cell migration.

Erastin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2026 Mar 9:S2090-1232(26)00224-9. [Abstract]

Tube formation capacity of HUVECs under Erastin (10 μM; 24 h) treatment, along with representative images of tube formation. Erastin exposure abolished the pro-angiogenic effects of DHA.
J Adv Res

MK8722 alleviates osteoarthritis by activating Sesn2 and transcriptionally upregulating BNIP3 to promote mitophagy and inhibit chondrocyte ferroptosis. [Abstract]

2025 Oct 10:S2090-1232(25)00764-7. PMID: 41077348

Erastin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 10:S2090-1232(25)00764-7. [Abstract]

Representative images and corresponding quantification of Sesn2 protein levels in primary mouse chondrocytes treated with either 10 μm Erastin (24 h) or co-treated with 10 μm Fer-1. Upon stimulation with Erastin, Sesn2 protein expression was significantly reduced in primary chondrocytes.

Erastin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 10:S2090-1232(25)00764-7. [Abstract]

Chondrocyte viability was assessed after treatment of Erastin (10 μM; 24 h) and different concentrations of MK8722. Erastin reduced cell viability.
J Adv Res

SLC7A11 as a therapeutic target to attenuate phthalates-driven testosterone level decline in mice. [Abstract]

2025 May:71:369-381. PMID: 38797476
J Adv Res

Interplay between lipid dysregulation and ferroptosis in chondrocytes and the targeted therapy effect of metformin on osteoarthritis. [Abstract]

2025 Mar:69:515-529. PMID: 38621621
J Adv Res

Quercetin alleviates acute kidney injury by inhibiting ferroptosis. [Abstract]

2020 Jul 22:28:231-243. PMID: 33364059
Cell Discov

Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis. [Abstract]

2022 May 3;8(1):40. PMID: 35504898
Metabolism

Acacetin ameliorates MASLD by inhibiting the Notch1 pathway in hepatocytes and reprogramming macrophage polarization via Keap1-Nrf2-mediated restraint of ferroptosis. [Abstract]

2026 Jun 7:182:156670. PMID: 42259496
Redox Biol

DNMT1-DUOXA1 axis discovers a novel methylation-ferroptosis circuit in bicalutamide-resistant prostate cancer. [Abstract]

2026 Jul:94:104188. PMID: 42097033
Redox Biol

Cathepsin S regulates ferroptosis sensitivity in hepatocellular carcinoma through the KEAP1-NRF2 signaling pathway. [Abstract]

2025 Oct:86:103815. PMID: 40784043
Redox Biol

ATF7IP inhibits Sorafenib-induced ferroptosis in hepatocellular carcinoma cells by inhibiting CYB5R2 transcription and stabilizing PARK7 protein. [Abstract]

2025 Sep:85:103786. PMID: 40716153

Erastin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep:85:103786. [Abstract]

Control or ATF7IP knockdown Huh7 cells were treated with DMSO or Erastin (10 μM) for 48 hours. MTT assay was performed. ATF7IP knockdown enhanced ferroptosis induced by Erastin, as evidenced by decreased cell viability compared to control cells.

Erastin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep:85:103786. [Abstract]

Control or ATF7IP knockdown Huh7 cells were treated with DMSO or Erastin (10 μM) for 48 hours. Cellular lipid ROS was measured. ATF7IP knockdown enhanced ferroptosis induced by Erastin, as evidenced by elevated cellular lipid ROS levels compared to control cells.
Redox Biol

The tryptophan metabolite 3-hydroxyanthranilic acid alleviates hyperoxia-induced bronchopulmonary dysplasia via inhibiting ferroptosis. [Abstract]

2025 May:82:103579. PMID: 40117887

Erastin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 May:82:103579. [Abstract]

Cell viability of the human AECII cells was determined by the CCK-8 assay. Erastin (1-20 μM) were incubated with cells for 24 h with different concentrations under normoxic conditions.
Redox Biol

Histone lactylation drives liver cancer metastasis by facilitating NSF1-mediated ferroptosis resistance after microwave ablation. [Abstract]

2025 Apr:81:103553. PMID: 39970777
Redox Biol

Reactivation of MAPK-SOX2 pathway confers ferroptosis sensitivity in KRASG12C inhibitor resistant tumors. [Abstract]

2024 Dec:78:103419. PMID: 39527862

Erastin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Dec:78:103419. [Abstract]

Cell viability of control NCI–H358 and Calu-1 cells and the corresponding resistant cell lines after 24 h of treatment with Erastin (NCI–H358 series: 1-20 μM, Calu-1 series: 0.1-2 μM). The resistant cells were more sensitive to Erastin than the parental cells.

Erastin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Dec:78:103419. [Abstract]

Representative phase-contrast images of NCI–H358 and its resistant cells and Calu-1 and its resistant cells after treatment with Erastin (NCI–H358 series: 5 μM, Calu-1 series: 1 μM; 18 h). The resistant cells were more sensitive to Erastin than the parental cells.

Erastin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Dec:78:103419. [Abstract]

MDA contents in NCI–H358 and its resistant cells and Calu-1 and its resistant cells after treatment with Erastin (NCI–H358 series: 5 μM, Calu-1 series: 1 μM; 18 h). Erastin produced a greater increase in MDA in the resistant cells than in the parental cells.

Erastin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Dec:78:103419. [Abstract]

Flow cytometry analysis of oxidized BODIPY dye in NCI-H358, NCI-H358AR, and NCI-H358MR cells after treatment with Erastin (5 μM; 18 h), with quantified median fluorescence intensity (MFI). Erastin promoted membrane lipid peroxidation more strongly in the resistant cells than in the parental cells.
Redox Biol

Over-activation of iNKT cells aggravate lung injury in bronchopulmonary dysplasia mice. [Abstract]

2024 Nov:77:103370. PMID: 39342744
Redox Biol

JWA binding to NCOA4 alleviates degeneration in dopaminergic neurons through suppression of ferritinophagy in Parkinson's disease. [Abstract]

2024 Jul:73:103190. PMID: 38744191
Redox Biol

Redistribution of defective mitochondria-mediated dihydroorotate dehydrogenase imparts 5-fluorouracil resistance in colorectal cancer. [Abstract]

2024 Jul:73:103207. PMID: 38805974
Redox Biol

Inhibition of METTL3 ameliorates doxorubicin-induced cardiotoxicity through suppression of TFRC-mediated ferroptosis. [Abstract]

2024 Jun:72:103157. PMID: 38631119
Redox Biol

IL-13 facilitates ferroptotic death in asthmatic epithelial cells via SOCS1-mediated ubiquitinated degradation of SLC7A11. [Abstract]

2024 May:71:103100. PMID: 38484644
Redox Biol

Breast cancer cells have an increased ferroptosis risk induced by system xc- blockade after deliberately downregulating CYTL1 to mediate malignancy. [Abstract]

2024 Apr:70:103034. PMID: 38211443
Redox Biol

Molecular mechanism of interleukin-17A regulating airway epithelial cell ferroptosis based on allergic asthma airway inflammation. [Abstract]

2023 Dec:68:102970. PMID: 38035662
Redox Biol

Cholesterol confers ferroptosis resistance onto myeloid-biased hematopoietic stem cells and prevents irradiation-induced myelosuppression. [Abstract]

2023 Jun:62:102661. PMID: 36906952
Redox Biol

Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes. [Abstract]

2022 Aug;54:102382. PMID: 35767918

Erastin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Aug;54:102382. [Abstract]

After treatment with Ferrostatin-1 (Fer-1, 5 μM) and GW4064 (1 μM) for 2 h, HK2 cells are treated with Erastin (5 μM) for another 24 h. Protein levels of GPX4 are detected by immunoblotting.

Erastin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Aug;54:102382. [Abstract]

After treatment with Ferrostatin-1 (Fer-1, 5 μM) and GW4064 (1 μM) for 2 h, HK2 cells are treated with Erastin (5 μM) for another 24 h. After treatment with Fer-1 and GW4064, the cells are incubated with C11-BODIPY 581/591 (2 μM) and Hoechst 33258 for counterstaining; the images were then immediately visualized by confocal microscopy.
Redox Biol

ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury. [Abstract]

2022 Feb 9;51:102262. PMID: 35180475
Nat Chem Biol

PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation. [Abstract]

2025 Apr 25. PMID: 40281343

Erastin purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2025 Apr 25. [Abstract]

MDA-MB-231 and BT549 cells with reconstituted expression of the indicated proteins were treated with Erastin (20 μM) in the absence or presence of Fer1 (10 μM) for 24 h. 4-HNE level were measured. Type I ferroptosis inducers (Erastin) induced ferroptosis effects, which could be attenuated by CAMK2 activation.

Erastin purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2025 Apr 25. [Abstract]

MDA-MB-231 and BT549 cells with reconstituted expression of the indicated proteins were treated with Erastin (20 μM) in the absence or presence of Fer1 (10 μM) for 24 h. Cell death l were measured. Type I ferroptosis inducers (Erastin) induced ferroptosis effects, which could be attenuated by CAMK2 activation.
Nat Chem Biol

CGI1746 targets σ1R to modulate ferroptosis through mitochondria-associated membranes. [Abstract]

2024 Jun;20(6):699-709. PMID: 38212578
Cardiovasc Diabetol

SREBP1 deficiency aggravates vascular calcification via iASPP-triggered ferroptosis of vascular smooth muscle cells. [Abstract]

2025 Jun 3;24(1):236. PMID: 40462076
J Nanobiotechnology

Sirtuin-3 activation by honokiol attenuated anesthesia/surgery-induced cognitive impairment and neuronal ferroptosis via inhibiting mitochondrial GPX4 acetylation. [Abstract]

2025 Jun 4;23(1):414. PMID: 40462120

Erastin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jun 4;23(1):414. [Abstract]

mRNA expression of ferroptosis-associated genes in PC12 cells after treatment with Erastin (10 μM; 48 h) was detected by qRT-PCR. Erastin upregulated mRNA expression of pro-ferroptosis genes and downregulated anti-ferroptosis genes.

Erastin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jun 4;23(1):414. [Abstract]

Protein levels of NCOA4, GPX4, and SLC7A11 in PC12 cells after treatment with Erastin (10 μM; 48 h) were detected by Western blotting. NCOA4 was upregulated, whereas GPX4 and SLC7A11 were downregulated in the Erastin-treated group.

Erastin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jun 4;23(1):414. [Abstract]

Mitochondrial membrane potential (MMP) in PC12 cells after treatment with Erastin (10 μM; 48 h) was detected by JC-1 staining (scale bar = 20 μm, 400× magnification). Erastin specifically reduced mitochondrial membrane potential in cells.
J Nanobiotechnology

Single-cell multi-omics analysis reveals the mechanism of action of a novel antioxidant polyphenol nanoparticle loaded with STAT3 agonist in mediating cardiomyocyte ferroptosis to ameliorate age-related heart failure. [Abstract]

2025 Mar 29;23(1):258. PMID: 40158134

Erastin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Mar 29;23(1):258. [Abstract]

Expression changes of p-STAT3 protein in CMs cells from different treatment groups detected by Western blot. Compared to the control group, the expression of p-STAT3 protein in CM cells was significantly downregulated in the Erastin-treated (5 μM; 24 h induction followed by 24 h of the indicated treatment) group.

Erastin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Mar 29;23(1):258. [Abstract]

Evaluation of proliferative capacity of CMs in different treatment groups using EDU experiment. EDU staining assays indicated that compared to the control group, the viability and proliferative capacity of CM cells in the Erastin-treated (5 μM; 24 h induction followed by 24 h of the indicated treatment) group significantly decreased.

Erastin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Mar 29;23(1):258. [Abstract]

Assessment of cell migration in different intervention groups of CMs using wound healing assay. Erastin (5 μM; 24 h induction followed by 24 h of the indicated treatment) suppressed the migration ability of CMs.

Erastin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Mar 29;23(1):258. [Abstract]

Detection of apoptosis in CMs from different treatment groups using Annexin V/PI double staining flow cytometry, with bar graph representing the percentage of cells in Q2 and Q3 quadrants indicating apoptotic cells. Erastin (5 μM; 24 h induction followed by 24 h of the indicated treatment) could induce apoptosis in CM cells.

Erastin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Mar 29;23(1):258. [Abstract]

Erastin (5 μM; 24 h induction followed by 24 h of the indicated treatment). Representative confocal images of CMs stained with C11-BODIPY 581/591. Compared to the control group, the model group exhibited elevated the level of intracellular lipid peroxidation in CMs.

Erastin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Mar 29;23(1):258. [Abstract]

Erastin (5 μM; 24 h induction followed by 24 h of the indicated treatment). GSH/GSSG ratio in CMs from different treatment groups. Compared to the control group, the model group exhibited decreased the level of GSH/GSSG ratio in CMs.

Erastin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Mar 29;23(1):258. [Abstract]

Erastin (5 μM; 24 h induction followed by 24 h of the indicated treatment). Transcription levels of ferroptosis-related genes SLC7A11 and GPX4 detected by RT-qPCR. Compared to the control group, the model group exhibited a significant decrease in mRNA expression levels of GPX4 and SLC7A11.
J Nanobiotechnology

Osteoblastic ferroptosis inhibition by small-molecule promoting GPX4 activation for peri-prosthetic osteolysis therapy. [Abstract]

2024 Dec 18;22(1):758. PMID: 39696565
J Nanobiotechnology

Role of PCBP2 in regulating nanovesicles loaded with curcumin to mitigate neuroferroptosis in neural damage caused by heat stroke. [Abstract]

2024 Dec 27;22(1):800. PMID: 39731111

Erastin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Dec 27;22(1):800. [Abstract]

Evaluation of neurological deficit scores in mice of each group. Compared to the NVs-CUR + DMSO group, neuronal damage was exacerbated in the NVs-CUR + Erastin (30 mg/kg; i.v.; once daily for 2 weeks) group of mice.

Erastin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Dec 27;22(1):800. [Abstract]

Histopathological changes in hypothalamic tissues were examined by H&E staining in heat-stroke-induced mice after Erastin (30 mg/kg; i.v.; once daily for 2 weeks) treatment. Neuronal damage was exacerbated in the NVs-CUR + Erastin group compared with the NVs-CUR + DMSO group.

Erastin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Dec 27;22(1):800. [Abstract]

NeuN-labeled neurons in the hypothalamus were examined by immunofluorescence and neuronal numbers were quantified in heat-stroke-induced mice after Erastin (30 mg/kg; i.v.; once daily for 2 weeks) treatment. Neuronal damage was exacerbated in the NVs-CUR + Erastin group compared with the NVs-CUR + DMSO group.

Erastin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Dec 27;22(1):800. [Abstract]

IL-1β, IL-6, and TNF-α levels were measured by ELISA in hypothalamic tissues from heat-stroke-induced mice after treatment with Erastin (30 mg/kg; i.v.; once daily for 2 weeks). IL-1β, IL-6, and TNF-α levels were significantly increased in the NVs-CUR + Erastin group compared with the NVs-CUR + DMSO group.

Erastin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Dec 27;22(1):800. [Abstract]

MDA and GSH levels were assessed using assay kits in hypothalamic tissues from heat-stroke-induced mice after treatment with Erastin (30 mg/kg; i.v.; once daily for 2 weeks). In comparison to the NVs-CUR + DMSO group, the levels of MDA, and GSH significantly increased in the NVs-CUR + Erastin group.
J Nanobiotechnology

Extracellular vesicle-derived silk fibroin nanoparticles loaded with MFGE8 accelerate skin ulcer healing by targeting the vascular endothelial cells. [Abstract]

2023 Nov 29;21(1):455. PMID: 38017428
J Nanobiotechnology

miR-124-3p delivered by exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells inhibits ferroptosis to attenuate ischemia-reperfusion injury in steatotic grafts. [Abstract]

2022 Apr 22;20(1):196. PMID: 35459211
Theranostics

Nanotuner targeting mitochondrial redox and iron homeostasis imbalance for the treatment of acute liver injury. [Abstract]

2025 Aug 16;15(17):9131-9158. PMID: 40963901
Theranostics

Designer exosomes for targeted and efficient ferroptosis induction in cancer via chemo-photodynamic therapy. [Abstract]

2021 Jul 13;11(17):8185-8196. PMID: 34373736
Genes Dis

2026 Mar 19.
Acta Pharm Sin B

2025 Oct 28.
Biomark Res

ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2. [Abstract]

2025 Jan 23;13(1):17. PMID: 39849645
Acta Pharm Sin B

The suppression of cervical cancer ferroptosis by macrophages: The attenuation of ALOX15 in cancer cells by macrophages-derived exosomes. [Abstract]

2023 Jun;13(6):2645-2662. PMID: 37425043
J Biomed Sci

N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis. [Abstract]

2025 Jan 13;32(1):8. PMID: 39800682
J Exp Clin Cancer Res

TCF3 activates super-enhancer-driven TRIB2 overexpression to suppress ferroptosis and promote hepatoblastoma proliferation. [Abstract]

2025 Dec 29;44(1):329. PMID: 41462308
J Exp Clin Cancer Res

Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis. [Abstract]

2024 May 3;43(1):133. PMID: 38698462
J Exp Clin Cancer Res

Augmented ERO1α upon mTORC1 activation induces ferroptosis resistance and tumor progression via upregulation of SLC7A11. [Abstract]

2024 Apr 13;43(1):112. PMID: 38610018
J Clin Invest

ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2. [Abstract]

2024 Jan 23;134(6):e171166. PMID: 38488001
J Exp Clin Cancer Res

Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer. [Abstract]

2023 Jun 6;42(1):142. PMID: 37277863
J Exp Clin Cancer Res

Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m6A-dependent recognition of Nrf2 mRNA mediated by SND1. [Abstract]

2023 May 19;42(1):127. PMID: 37202791
J Exp Clin Cancer Res

Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy. [Abstract]

2023 Apr 19;42(1):92. PMID: 37072838
J Exp Clin Cancer Res

Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer. [Abstract]

2021 Jun 23;40(1):206. PMID: 34162423
Adv Sci (Weinh)

2026 Jul 13:e76586. PMID: 42439361
Adv Sci (Weinh)

Inhibition of Focal Adhesion Restricts Chemoresistance in Pancreatic Cancer by Targeting SLC7A11 Mediated Ferroptosis. [Abstract]

2026 Jul;13(37):e75216. PMID: 42003743
Adv Sci (Weinh)

Inhibition of Calcium-Dependent Lipid Droplets Relocation of ACSL4-PKCβ-ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis. [Abstract]

2026 Apr;13(19):e15768. PMID: 41589658
Adv Sci (Weinh)

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress-Induced Depression in Male Mice. [Abstract]

2025 Dec 12:e13438. PMID: 41387185
Adv Sci (Weinh)

Novel Cyano-Artemisinin Dimer ZQJ29 Targets PARP1 to Induce Ferroptosis in Pancreatic Cancer Treatment. [Abstract]

2025 Aug;12(29):e01935. PMID: 40387570
Adv Sci (Weinh)

PHOSPHO1 Suppresses Ferroptosis in Retinal Pigment Epithelial Cells by Reducing the Levels of Phosphatidylethanolamine Molecular Species. [Abstract]

2025 Jul;12(28):e2505359. PMID: 40396905

Erastin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul;12(28):e2505359. [Abstract]

Intracellular ROS was assessed using the DCFH-DA probe after being treated with 30 µM erastin or 500 µM FAC (Ammonium iron(III) citrate) for 4 h.

Erastin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul;12(28):e2505359. [Abstract]

Intracellular Fe2+ levels under 30 µM erastin or 500 µM FAC (Ammonium iron(III) citrate) treatment for 4 h were detected with the RhoNox-1(1μM; 1 h) fluorescent probe.

Erastin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul;12(28):e2505359. [Abstract]

Representative images of ferroptotic cells among iPSC-RPE cells, De-iPSC-RPE cells, and iRPE cells treated with 30 µM erastin or 500 µM FAC (Ammonium iron(III) citrate) for 2 days.
Adv Sci (Weinh)

Functionalized Biomimetic Nanoparticles Targeting the IL-10/IL-10Rα/Glycolytic Axis in Synovial Macrophages Alleviate Cartilage Degeneration in Osteoarthritis. [Abstract]

2025 Jul;12(27):e2504768. PMID: 40317692
Adv Sci (Weinh)

3-D Sustained-Release Culture Carrier Alleviates Rat Intervertebral Disc Degeneration by Targeting STING in Transplanted Skeletal Stem Cells. [Abstract]

2025 Apr;12(15):e2410151. PMID: 39985222
Adv Sci (Weinh)

NGR-Modified CAF-Derived exos Targeting Tumor Vasculature to Induce Ferroptosis and Overcome Chemoresistance in Osteosarcoma. [Abstract]

2025 Mar;12(12):e2410918. PMID: 39889249
Adv Sci (Weinh)

Lactylation of HDAC1 Confers Resistance to Ferroptosis in Colorectal Cancer. [Abstract]

2025 Mar;12(12):e2408845. PMID: 39888307
Adv Sci (Weinh)

A Membrane-Targeting Aggregation-Induced Emission Probe for Monitoring Lipid Droplet Dynamics in Ischemia/Reperfusion-Induced Cardiomyocyte Ferroptosis. [Abstract]

2024 Jul;11(26):e2309907. PMID: 38696589
Adv Sci (Weinh)

Apoptotic Bodies Derived from Fibroblast-Like Cells in Subcutaneous Connective Tissue Inhibit Ferroptosis in Ischaemic Flaps via the miR-339-5p/KEAP1/Nrf2 Axis. [Abstract]

2024 Jun;11(24):e2307238. PMID: 38639443
Adv Sci (Weinh)

Inhibition of CARM1-Mediated Methylation of ACSL4 Promotes Ferroptosis in Colorectal Cancer. [Abstract]

2023 Dec;10(36):e2303484. PMID: 37946697
Adv Sci (Weinh)

ANO1-Mediated Inhibition of Cancer Ferroptosis Confers Immunotherapeutic Resistance through Recruiting Cancer-Associated Fibroblasts. [Abstract]

2023 Aug;10(24):e2300881. PMID: 37341301
Adv Sci (Weinh)

Bidirectionally Regulating Viral and Cellular Ferroptosis with Metastable Iron Sulfide Against Influenza Virus. [Abstract]

2023 Jun;10(17):e2206869. PMID: 37092591
Cell Rep Med

Enalaprilat reverses neutrophil polarization imbalance via targeting taurine-STING axis for treatment of diabetic wounds. [Abstract]

2026 Apr 21;7(4):102714. PMID: 41916295
Cell Rep Med

Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation. [Abstract]

2024 Sep 17;5(9):101711. PMID: 39232498
Sci Adv

Therapeutic implications of mitochondrial stress-induced proteasome inhibitor resistance in multiple myeloma. [Abstract]

2022 Sep 30;8(39):eabq5575. PMID: 36170375
Cell Death Differ

Cell death-induced release of the pro-aging protein acyl CoA binding protein (ACBP) into the circulation. [Abstract]

2026 Jun 3. PMID: 42236908
Cell Death Differ

Deltex E3 ubiquitin ligase 2 prevents sepsis-induced myocardial injury through degrading TfR1 via promoting K27-linked ubiquitination. [Abstract]

2026 Mar 2. PMID: 41772062
Biomaterials

Reverse magnetic resonance tuning nanoplatform with heightened sensitivity for non-invasively multiscale visualizing ferroptosis-based tumor sensitization therapy. [Abstract]

2025 Apr:315:122935. PMID: 39489017
Cell Death Differ

The AKR1C1-CYP1B1-cAMP signaling axis controls tumorigenicity and ferroptosis susceptibility of extrahepatic cholangiocarcinoma. [Abstract]

2025 Mar;32(3):506-520. PMID: 39478199
Cell Death Differ

Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells. [Abstract]

2021 Apr;28(4):1222-1236. PMID: 33097833

Erastin purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2021 Apr;28(4):1222-1236. [Abstract]

Western blot analysis of the protein expression levels of BCAT2, AMPK, and pAMPK(T172) in Aspc-1, and HepG2 cells treated with Erastin (20 or 10 μM) Vin the absence or presence of AICAR (AMPK activator, 2 mmol/L) and Compound C (AMPK inhibitor, 1 μmol/L).
Cell Death Differ

Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury. [Abstract]

2020 Sep;27(9):2635-2650. PMID: 32203170

Erastin purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2020 Sep;27(9):2635-2650. [Abstract]

Erastin (10 μM; tail-injected intravenously; for 20 days) treatment of I/R mice significantly increases the protein/mRNA levels of TF and significantly decreased the percentage GSH and protein/mRNA levels of FTH1 and GPX4, but these effects are reversed by Liproxstatin-1 treatment.

Erastin purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2020 Sep;27(9):2635-2650. [Abstract]

H&E and Masson’s staining of lung tissues show that Erastin (10 μM; tail-injected intravenously; for 20 days) aggravated edema, atelectasis, necrosis, alveolar and interstitial inflammation, and pulmonary fibrosis in I/R mice compared with sham mice, but these effects are reversed in I/R + erastin mice treated with Liproxstatin-1.
Carbohydr Polym

A sulfated pectin polysaccharide from Chrysanthemum morifolium induces ferroptosis in pancreatic cancer by stabilizing TFRC. [Abstract]

2026 Jun 1:381:125224. PMID: 41943328
Research (Wash D C)

Extracellular Vesicle-Mediated Delivery of Mitochondrial Circular RNA MTCO2 Protects against Cerebral Ischemia by Modulating mPTP-Dependent Ferroptosis. [Abstract]

2026 Apr 14:9:1232. PMID: 41988019
Research (Wash D C)

Piezo1-Mediated Ferroptosis Delays Wound Healing in Aging Mice by Regulating the Transcriptional Activity of SLC7A11 through Activating Transcription Factor 3. [Abstract]

2025 Jun 3:8:0718. PMID: 40463502
Research (Wash D C)

Combinational Analysis of Metabolomic and O-GlcNAcylation Omics Reveals the HBP Metabolic Regulation of Chemoresistance via GFPT1/NR3C1 O-GlcNAcylation/GPX4 Axis. [Abstract]

2025 Jul 30:8:0809. PMID: 40740652
Research (Wash D C)

Targeting the Exonic Circular OGT RNA/O-GlcNAc Transferase/Forkhead Box C1 Axis Inhibits Asparagine- and Alanine-Mediated Ferroptosis Repression in Neuroblastoma Progression. [Abstract]

2025 May 23:8:0703. PMID: 40416363
Asian J Pharm Sci

Implantation of hydrogel-liposome nanoplatform inhibits glioblastoma relapse by inducing ferroptosis. [Abstract]

2023 May;18(3):100800. PMID: 37274924
Chem Eng J

2026 Apr 30;538:176852.
Chem Eng J

2025 Sep 1.
Chem Eng J

2024 Nov 15.
Chem Eng J

2023 May 22, 143685.
Chem Eng J

2023 Jun 15, 466, 143104.
J Control Release

Apoptotic neutrophil membrane-modified nanoparticles promote wound healing by enhancing efferocytotic capacity of dendritic cells. [Abstract]

2025 Oct 10:386:114127. PMID: 40816639
J Control Release

Pitavastatin and resveratrol bio-nanocomplexes against hyperhomocysteinemia-induced atherosclerosis via blocking ferroptosis-related lipid deposition. [Abstract]

2025 May 10:381:113598. PMID: 40043912
J Control Release

Laser-responsive erastin-loaded chondroitin sulfate nanomedicine targeting CD44 and system xc- in liver cancer: A non-ferroptotic approach. [Abstract]

2024 Nov:375:574-588. PMID: 39293529
Cell Death Dis

2026 Jul 1. PMID: 42380121
Pharmacol Res

AXL prevents amyloid-β-induced microglial ferroptosis by sustaining SLC2A3-mediated mitochondrial respiration. [Abstract]

2026 Jun:228:108203. PMID: 42025825
Environ Sci Technol

Environmental PFOS and 6:2 Cl-PFESA Reshape Ferroptosis Vulnerability in Liver Cancer. [Abstract]

2026 Mar 3;60(8):6096-6110. PMID: 41700700
Cell Death Dis

Targeting the SMAD3/CISD2 axis suppresses bladder cancer progression by promoting ferroptosis in mesenchymal-like bladder cancer cells. [Abstract]

2025 Dec 18. PMID: 41413023
Cell Death Dis

DCAF7 recruits USP2 to facilitate hepatocellular carcinoma progression by suppressing clockophagy-induced ferroptosis. [Abstract]

2025 Aug 28;16(1):654. PMID: 40877242
Cell Death Dis

ILF3 promotes colorectal cancer cell resistance to ferroptosis by enhancing cysteine uptake and GSH synthesis via stabilizing SLC3A2 mRNA. [Abstract]

2025 Jul 23;16(1):549. PMID: 40695795
Cell Death Dis

Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis. [Abstract]

2025 Apr 6;16(1):257. PMID: 40189563
Cell Death Dis

TMEM160 inhibits KEAP1 to suppress ferroptosis and induce chemoresistance in gastric cancer. [Abstract]

2025 Apr 13;16(1):287. PMID: 40223081
Cell Death Dis

Trifluridine/tipiracil induces ferroptosis by targeting p53 via the p53-SLC7A11 axis in colorectal cancer 3D organoids. [Abstract]

2025 Apr 5;16(1):255. PMID: 40188162
Cell Death Dis

Histone lactylation enhances GCLC expression and thus promotes chemoresistance of colorectal cancer stem cells through inhibiting ferroptosis. [Abstract]

2025 Mar 20;16(1):193. PMID: 40113760
Cell Death Dis

Overexpression of ELF3 in the PTEN-deficient lung epithelium promotes lung cancer development by inhibiting ferroptosis. [Abstract]

2024 Dec 18;15(12):897. PMID: 39695109
Cell Death Dis

FXR deficiency induced ferroptosis via modulation of the CBP-dependent p53 acetylation to suppress breast cancer growth and metastasis. [Abstract]

2024 Nov 14;15(11):826. PMID: 39543094
Cell Death Dis

Phosphatase LHPP confers prostate cancer ferroptosis activation by modulating the AKT-SKP2-ACSL4 pathway. [Abstract]

2024 Sep 11;15(9):665. PMID: 39261475
Cell Mol Biol Lett

α-Ketoglutarate alleviates osteoarthritis by inhibiting ferroptosis via the ETV4/SLC7A11/GPX4 signaling pathway. [Abstract]

2024 Jun 14;29(1):88. PMID: 38877424
Pharmacol Res

Vanillic acid restores homeostasis of intestinal epithelium in colitis through inhibiting CA9/STIM1-mediated ferroptosis. [Abstract]

2024 Apr:202:107128. PMID: 38438089
Cell Mol Biol Lett

High-content image screening to identify chemical modulators for peroxisome and ferroptosis. [Abstract]

2024 Feb 17;29(1):26. PMID: 38368371
Cell Death Dis

LINC01133 can induce acquired ferroptosis resistance by enhancing the FSP1 mRNA stability through forming the LINC01133-FUS-FSP1 complex. [Abstract]

2023 Nov 25;14(11):767. PMID: 38007473
Cell Death Dis

Ferroptosis sensitization in glioma: exploring the regulatory mechanism of SOAT1 and its therapeutic implications. [Abstract]

2023 Nov 18;14(11):754. PMID: 37980334
Cell Death Dis

Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis. [Abstract]

2023 Oct 11;14(10):668. PMID: 37816731
Pharmacol Res

PIAS3 promotes ferroptosis by regulating TXNIP via TGF-β signaling pathway in hepatocellular carcinoma. [Abstract]

2023 Oct:196:106915. PMID: 37689128
Cell Death Dis

Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC. [Abstract]

2023 Aug 21;14(8):539. PMID: 37604811
Cell Death Dis

Downregulation of N6-methyladenosine-modified LINC00641 promotes EMT, but provides a ferroptotic vulnerability in lung cancer. [Abstract]

2023 Jun 13;14(6):359. PMID: 37311754
Cell Death Dis

Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats. [Abstract]

2023 May 13;14(5):325. PMID: 37179386
Cell Death Dis

PDIA4 confers resistance to ferroptosis via induction of ATF4/SLC7A11 in renal cell carcinoma. [Abstract]

2023 Mar 11;14(3):193. PMID: 36906674
Cell Death Dis

3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) induces cell death through ferroptosis and acts as a trigger of apoptosis in kidney cells. [Abstract]

2023 Feb 2;14(2):78. PMID: 36732325
Cell Death Dis

SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4. [Abstract]

2023 Jan 31;14(1):74. PMID: 36720852
Cell Death Dis

SLC27A5 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by downregulating glutathione reductase. [Abstract]

2023 Jan 12;14(1):22. PMID: 36635256
Cell Death Dis

Long noncoding RNA LINC00239 inhibits ferroptosis in colorectal cancer by binding to Keap1 to stabilize Nrf2. [Abstract]

2022 Aug 29;13(8):742. PMID: 36038548
Cell Death Dis

Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury. [Abstract]

2022 May 30;13(5):507. PMID: 35637215
Cell Death Dis

HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis. [Abstract]

2022 Apr 8;13(4):319. PMID: 35395830
Cell Death Dis

Adenine overload induces ferroptosis in human primary proximal tubular epithelial cells. [Abstract]

2022 Feb 2;13(2):104. PMID: 35110539
Cell Death Dis

RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m6A-dependent manner. [Abstract]

2022 Jan 21;13(1):73. PMID: 35064112
Cell Death Dis

Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation. [Abstract]

2021 Oct 27;12(11):1009. PMID: 34707088
Cell Death Dis

MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma. [Abstract]

2021 May 19;12(6):511. PMID: 34011924
Cell Death Dis

GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. [Abstract]

2021 Apr 30;12(5):426. PMID: 33931597
Cell Death Dis

Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI. [Abstract]

2021 Jan 11;12(1):65. PMID: 33431801
Cell Death Dis

Discovery of a novel ferroptosis inducer-talaroconvolutin A-killing colorectal cancer cells in vitro and in vivo. [Abstract]

2020 Nov 17;11(11):988. PMID: 33203867
Cell Death Dis

The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis. [Abstract]

2019 Oct 7;10(10):755. PMID: 31591388
Cell Death Dis

Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells. [Abstract]

2019 Apr 15;10(5):331. PMID: 30988278
Cancer Lett

The Zeb1/system Xc- axis safeguards iron-loaded cancer-associated fibroblasts against ferroptosis and promotes immunosuppression in prostate cancer. [Abstract]

2026 Feb 28:639:218243. PMID: 41485685
Cancer Lett

SIK1 promotes ferroptosis resistance in pancreatic cancer via HDAC5-STAT6-SLC7A11 axis. [Abstract]

2025 Jul 28:623:217726. PMID: 40250791
Cancer Lett

A novel protein encoded by circFOXP1 enhances ferroptosis and inhibits tumor recurrence in intrahepatic cholangiocarcinoma. [Abstract]

2024 Aug 28:598:217092. PMID: 38945202
Cancer Lett

Preoperative neoadjuvant targeted therapy remodels intra-tumoral heterogeneity of clear-cell renal cell carcinoma and ferroptosis inhibition induces resistance progression. [Abstract]

2024 Jul 1:593:216963. PMID: 38768682
Cancer Lett

Super-enhancer mediated upregulation of MYEOV suppresses ferroptosis in lung adenocarcinoma. [Abstract]

2024 May 1:589:216811. PMID: 38490328
Cancer Lett

SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition. [Abstract]

2021 Jul 10:510:93-104. PMID: 33872694
Cancer Lett

Mitochondrial pyruvate carrier 1 regulates ferroptosis in drug-tolerant persister head and neck cancer cells via epithelial-mesenchymal transition. [Abstract]

2021 Jun 1:507:40-54. PMID: 33741422
J Immunother Cancer

C5a/C5aR pathway blocking promoted CuS-mediated cancer therapy effect by inhibiting cuproptosis resistance. [Abstract]

2025 Jun 8;13(6):e011472. PMID: 40484643
Int J Biol Sci

Neferine Ameliorates Severe Acute Pancreatitis-Associated Intestinal Injury by Promoting NRF2-mediated Ferroptosis. [Abstract]

2025 Apr 28;21(7):3247-3261. PMID: 40384872
Int J Biol Sci

METTL16 suppresses ferroptosis in cholangiocarcinoma by promoting ATF4 via m6A modification. [Abstract]

2025 Jan 1;21(1):189-203. PMID: 39744432
Int J Biol Sci

Aberrant Expression of SLC7A11 Impairs the Antimicrobial Activities of Macrophages in Staphylococcus Aureus Osteomyelitis in Mice. [Abstract]

2024 Apr 22;20(7):2555-2575. PMID: 38725861
Int J Biol Sci

Novel LncRNA LINC02936 Suppresses Ferroptosis and Promotes Tumor Progression by Interacting with SIX1/CP Axis in Endometrial Cancer. [Abstract]

2024 Jan 27;20(4):1356-1374. PMID: 38385087
Int J Biol Sci

microRNA-130b-3p Attenuates Septic Cardiomyopathy by Regulating the AMPK/mTOR Signaling Pathways and Directly Targeting ACSL4 against Ferroptosis. [Abstract]

2023 Aug 15;19(13):4223-4241. PMID: 37705752
Int J Biol Sci

Downregulation of PPARα mediates FABP1 expression, contributing to IgA nephropathy by stimulating ferroptosis in human mesangial cells. [Abstract]

2022 Aug 29;18(14):5438-5458. PMID: 36147466
Int J Biol Sci

PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer. [Abstract]

2022 Aug 29;18(14):5459-5474. PMID: 36147463
Int J Biol Sci

O-GlcNAcylation of ZEB1 facilitated mesenchymal pancreatic cancer cell ferroptosis. [Abstract]

2022 Jun 21;18(10):4135-4150. PMID: 35844792
Int J Biol Sci

Forsythoside A Mitigates Alzheimer's-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2/GPX4 Axis Activation. [Abstract]

2022 Feb 28;18(5):2075-2090. PMID: 35342364
Cell Commun Signal

PRPF19 mediates the proteasomal degradation of VDR to exacerbate ferroptosis in diabetic nephropathy. [Abstract]

2025 May 25;23(1):242. PMID: 40414879
Cell Commun Signal

Megakaryocytic IGF1 coordinates activation and ferroptosis to safeguard hematopoietic stem cell regeneration after radiation injury. [Abstract]

2024 May 27;22(1):292. PMID: 38802843
Cell Commun Signal

Mitochondria-mediated ferroptosis induced by CARD9 ablation prevents MDSCs-dependent antifungal immunity. [Abstract]

2024 Apr 2;22(1):210. PMID: 38566195
Cell Commun Signal

The ferroptosis and iron-metabolism signature robustly predicts clinical diagnosis, prognosis and immune microenvironment for hepatocellular carcinoma. [Abstract]

2020 Oct 28;18(1):174. PMID: 33115468
Phytomedicine

Huaier induces lipophagy to promote ferroptosis and chemosensitivity via de-acetylation of PLIN3 in triple-negative breast cancer. [Abstract]

2026 Sep:159:158559. PMID: 42470956
Phytomedicine

2026 Sep:159:158518. PMID: 42391816
Phytomedicine

2026 Sep:159:158563. PMID: 42470954
Phytomedicine

Patchouli oil and its main component patchouli alcohol inhibit colorectal cancer by activating ectopic olfactory receptor. [Abstract]

2026 Aug:158:158408. PMID: 42287815
Phytomedicine

Rhoifolin inhibits ferroptosis and alleviates pulmonary arterial hypertension via the TNF-α/TNF-R1/CASP8/CASP3 pathway. [Abstract]

2026 Jun:155:158095. PMID: 41895094
Phytomedicine

Delphinidin targets voltage-dependent anion channel 1 to inhibit ferroptosis and protect against retinal photochemical damage. [Abstract]

2026 Jun 17:159:158455. PMID: 42335641
Phytomedicine

Oxymatrine alleviates cerebral ischemia-reperfusion injury by inhibiting microglia ferroptosis via NRF2 pathway activation. [Abstract]

2026 Jun 17:159:158450. PMID: 42322761
Phytomedicine

Novel BLT1 inhibitor baeckein E ameliorates LPS-induced acute lung injury through ferroptosis inhibition. [Abstract]

2026 Jun:155:158147. PMID: 41966024
Phytomedicine

Hydroalcoholic gel of Angelica sinensis polysaccharides promotes wound healing by suppressing ferroptosis through PI3K/AKT/Nrf2 signaling pathway. [Abstract]

2026 Apr:153:157962. PMID: 41724102
Phytomedicine

Concentrated Angelica sinensis pills ameliorate ovarian insufficiency by promoting vascular remodeling via inhibiting CYP1B1/ACSL4-mediated ferroptosis. [Abstract]

2026 May:154:158024. PMID: 41795290
Phytomedicine

Molecular mechanisms of shenhong tongluo formula against myocardial ischemia-reperfusion injury: Insights from RNA sequencing, bioinformatics, reverse network pharmacology, molecular docking, and molecular dynamics simulations combined with experimental studies. [Abstract]

2026 Jun:155:157896. PMID: 41921237
Phytomedicine

Gastrodin promotes Alkbh5 nuclear localization and Gclm m6A demethylation to alleviate ferroptosis in ischemic stroke. [Abstract]

2025 Nov:147:157177. PMID: 40839993
Phytomedicine

Guilu Erxian glue mitigates spermatogenesis dysfunction through HIF-1α/SLC7A11-mediated ferroptosis inhibition: An integrated metabolomics and network pharmacology study. [Abstract]

2025 Nov 25:148:157321. PMID: 41092579
Phytomedicine

Andrographolide induces ferroptosis in colorectal cancer via P53-mediated downregulation of the SLC7A11/GPX4 signaling pathway. [Abstract]

2025 Nov 25:148:157470. PMID: 41187650
Phytomedicine

Psoraleae Fructus combined with Walnut kernels improves postmenopausal osteoporosis by inhibiting ferroptosis through the Nrf2/GPX4/SLC7A11 pathway. [Abstract]

2025 Sep 23:148:157319. PMID: 41016294
Phytomedicine

Ginsenoside Rg5 ameliorates lipopolysaccharide (LPS)-induced acute liver injury via interfering Autophagy/Nrf2/Ferroptosis signal axis. [Abstract]

2025 Aug:144:156941. PMID: 40516288
Phytomedicine

Ponicidin triggered ferroptosis in esophageal squamous cell carcinoma by suppressing the SLC7A11/Glutathione/GPX4 signalling axis. [Abstract]

2025 Jul 25:143:156925. PMID: 40456202
Phytomedicine

α-Hederin causes ferroptosis in triple-negative breast cancer through modulating IRF1 to suppress GPX4. [Abstract]

2025 Jun:141:156611. PMID: 40153970
Phytomedicine

Scutellaria baicalensis Extracts Restrict Intestinal Epithelial Cell Ferroptosis by Regulating Lipid Peroxidation and GPX4/ACSL4 in Colitis. [Abstract]

2025 Jun:141:156708. PMID: 40220415
Phytomedicine

Diosmin attenuates UUO-induced renal ferroptosis and fibrosis by inhibiting the HIF-1α/FABP4 signaling axis. [Abstract]

2025 Jun:141:156738. PMID: 40233506
Phytomedicine

Biochanin A mitigates colitis by inhibiting ferroptosis-mediated intestinal barrier dysfunction, oxidative stress, and inflammation via the JAK2/STAT3 signaling pathway. [Abstract]

2025 Jun:141:156699. PMID: 40215818
Phytomedicine

Vinpocetine protects against osteoarthritis by inhibiting ferroptosis and extracellular matrix degradation via activation of the Nrf2/GPX4 pathway. [Abstract]

2024 Dec:135:156115. PMID: 39368343
Phytomedicine

Penthorum chinense Pursh inhibits ferroptosis in cellular and Caenorhabditis elegans models of Alzheimer's disease. [Abstract]

2024 May:127:155463. PMID: 38452694
Phytomedicine

Poliumoside protects against type 2 diabetes-related osteoporosis by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway. [Abstract]

2024 Mar:125:155342. PMID: 38295665
Phytomedicine

Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells. [Abstract]

2021 May:85:153551. PMID: 33827043
J Pharm Anal

2026 Apr 13.
J Pharm Anal

2025 Dec 15.
EBioMedicine

2025 Dec 8;123:106058.
J Pharm Anal

Metformin alleviates renal tubular injury in diabetic kidney disease by activating mitophagy and inhibiting ferroptosis via HIF-1α/MIOX axis. [Abstract]

2025 Oct;15(10):101284. PMID: 41127648
J Pharm Anal

Screen of FDA-approved drug library identifies vitamin K as anti-ferroptotic drug for osteoarthritis therapy through Gas6. [Abstract]

2025 May;15(5):101092. PMID: 40496065

Erastin purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 May;15(5):101092. [Abstract]

The protein levels of MMP13, ADAMTS4, COL II and Aggrecan in chondrocytes treated with ferroptosis inducers erastin (10 μM), vitamin K1 (VK1;10 μM) and ferroptosis inhibitor Ferrostatin-1 (Fer-1; 1 μM) for 24 h were determined by Western blotting assay

Erastin purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 May;15(5):101092. [Abstract]

The mRNA levels of catabolic enzymes (Mmp13 and Adamts4) and matrix components (Col2a1 and Acan) in chondrocytes treated with ferroptosis inducers erastin (10 μM), vitamin K1 (VK1; 10 μM) and ferroptosis inhibitor Ferrostatin-1 (Fer-1; 1 μM) for 24 h were determined by RT-qPCR.

Erastin purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 May;15(5):101092. [Abstract]

Immunofluorescence of MMP13, ADAMTS4, COL II and Aggrecan in chondrocytes treated with ferroptosis inducers erastin (10 μM), vitamin K1 (VK1; 10 μM) and ferroptosis inhibitor Ferrostatin-1 (Fer-1; 1 μM) for 24 h.
J Pharm Anal

Ursodeoxycholic acid inhibits the uptake of cystine through SLC7A11 and impairs de novo synthesis of glutathione. [Abstract]

2025 Jan;15(1):101068. PMID: 39902457
Mater Today Bio

Application of a novel myristoylproteomics approach identifies GLIPR2 as a key pro-ferroptotic substrate in non-small cell lung cancer. [Abstract]

2026 Feb 18:37:102945. PMID: 41782991
Mater Today Bio

Umbilical cord mesenchymal stem cells and their extracellular vesicles attenuate cryopreservation-induced ovarian injury via the suppression of ferroptosis in an in vitro culture system. [Abstract]

2026 Feb 23:37:102965. PMID: 41800454
Mater Today Bio

IGF2BP3 is an essential N6-methyladenosine biotarget for suppressing ferroptosis in lung adenocarcinoma cells. [Abstract]

2022 Nov 24:17:100503. PMID: 36457846
J Hazard Mater

HFPO-TA inhibits testosterone synthesis by triggering FTO-mediated m6A modification to drive NCOA4-associated ferroptosis. [Abstract]

2026 Jun 16:514:142733. PMID: 42314315
J Hazard Mater

Copper mediated follicular atresia: Implications for granulosa cell death. [Abstract]

2024 Sep 15:477:135391. PMID: 39106724
Cell Death Discov

NT5DC2 inhibits ferroptosis by stabilizing ACSL3 in bladder cancer. [Abstract]

2026 Apr 14;12(1):235. PMID: 41974665
Cell Death Discov

PDHA1 enhances resistance to ferroptosis in anoikis-resistant prostate cancer by upregulating AIFM2. [Abstract]

2026 Feb 23;12(1):105. PMID: 41724793
Cell Death Discov

FDX1-mediated cuproptosis promotes cholestatic liver injury exacerbated by taurocholic acid-enhanced copper accumulation. [Abstract]

2026 Jan 9;12(1):12. PMID: 41513631
Cell Death Discov

NRG1/PDGFC loop between fibroblasts and cancer cells drives paclitaxel resistance via ferroptosis suppression in breast cancer. [Abstract]

2025 Nov 10;11(1):520. PMID: 41213930
Cell Death Discov

Metabolic interplay between exogenous cystine and glutamine dependence in triple-negative breast cancer. [Abstract]

2025 Oct 6;11(1):430. PMID: 41053011
Cell Death Discov

Exploiting dysregulated iron homeostasis to eradicate persistent high-grade serous ovarian cancer. [Abstract]

2025 Sep 25;11(1):423. PMID: 40998801
Cell Death Discov

ERBB3 influences the ferroptosis pathway via modulation of lipid peroxidation and GSH synthesis in gastric cancer. [Abstract]

2025 Aug 22;11(1):398. PMID: 40846695
Cell Death Discov

Decreased miR-128-3p in serum exosomes from polycystic ovary syndrome induces ferroptosis in granulosa cells via the p38/JNK/SLC7A11 axis through targeting CSF1. [Abstract]

2025 Feb 18;11(1):64. PMID: 39966422
Cell Death Discov

MDH2 regulates the sensitivity of clear cell renal cell carcinoma to ferroptosis through its interaction with FSP1. [Abstract]

2024 Aug 13;10(1):363. PMID: 39138167
Acta Pharmacol Sin

Cpd-A1 alleviates acute kidney injury by inhibiting ferroptosis. [Abstract]

2024 Aug;45(8):1673-1685. PMID: 38641746
Cell Death Discov

Epirubicin induces cardiotoxicity through disrupting ATP6V0A2-dependent lysosomal acidification and triggering ferroptosis in cardiomyocytes. [Abstract]

2024 Jul 24;10(1):337. PMID: 39048556
Cell Death Discov

Coculture with macrophages alters ferroptosis susceptibility of triple-negative cancer cells. [Abstract]

2024 Mar 1;10(1):108. PMID: 38429255
Cell Death Discov

NMDARs activation regulates endothelial ferroptosis via the PP2A-AMPK-HMGB1 axis. [Abstract]

2024 Jan 17;10(1):34. PMID: 38233385
Cell Death Discov

NeuroD4 converts glioblastoma cells into neuron-like cells through the SLC7A11-GSH-GPX4 antioxidant axis. [Abstract]

2023 Aug 15;9(1):297. PMID: 37582760
Cell Death Discov

Regulating Nrf2-GPx4 axis by bicyclol can prevent ferroptosis in carbon tetrachloride-induced acute liver injury in mice. [Abstract]

2022 Sep 7;8(1):380. PMID: 36071041
Cell Death Discov

The NSUN5-FTH1/FTL pathway mediates ferroptosis in bone marrow-derived mesenchymal stem cells. [Abstract]

2022 Mar 5;8(1):99. PMID: 35249107
Cell Death Discov

TRIB2 desensitizes ferroptosis via βTrCP-mediated TFRC ubiquitiantion in liver cancer cells. [Abstract]

2021 Jul 27;7(1):196. PMID: 34315867
Acta Pharmacol Sin

ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma. [Abstract]

2021 Jan;42(1):160-170. PMID: 32541921
Environ Int

Integrated network toxicology and molecular docking are used to elucidate the mechanism by which chlorpyrifos induces hepatotoxicity (Cyprinus carpio). [Abstract]

2025 Dec 30:207:110032. PMID: 41496238
NPJ Precis Oncol

SPOCK1 acts as a negative regulator of ferroptosis in non-small cell lung cancer. [Abstract]

2026 May 14. PMID: 42135411
J Orthop Translat

2025 Aug 1.
J Transl Med

Cold atmospheric plasma drives USP49/HDAC3 axis mediated ferroptosis as a novel therapeutic strategy in endometrial cancer via reinforcing lactylation dependent p53 expression. [Abstract]

2025 Apr 15;23(1):442. PMID: 40234906
J Transl Med

Metformin enhances endogenous neural stem cells proliferation, neuronal differentiation, and inhibits ferroptosis through activating AMPK pathway after spinal cord injury. [Abstract]

2024 Aug 5;22(1):723. PMID: 39103875
Nano Res

2023 Apr 18.
Dev Cell

GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development. [Abstract]

2024 Oct 7;59(19):2643-2658.e7. PMID: 38981469
Dev Cell

A single fluorescent probe to examine the dynamics of mitochondria-lysosome interplay and extracellular vesicle role in ferroptosis. [Abstract]

2024 Feb 26;59(4):517-528.e3. PMID: 38272028
Oncogene

2026 Aug;45(32):3327-3341. PMID: 42414656
Oncogene

2026 Jul 4. PMID: 42401760
Oncogene

LINC-AC092535.5 regulates MICAL2 mRNA level to inhibit p53-mediated ferroptosis in nasopharyngeal carcinoma. [Abstract]

2026 Apr;45(14):1260-1274. PMID: 41832266
Apoptosis

2026 Jul 22;31(8):195. PMID: 42487045
Apoptosis

Artesunate overcomes oxaliplatin resistance in colorectal cancer by inducing ferroptosis through inhibition of the CDK5/Nrf2/GPX4 pathway. [Abstract]

2026 May 24;31(6):156. PMID: 42178429
Apoptosis

QD394 induces ferroptosis and suppresses the proliferation of colorectal cancer via the SP1/JNK pathway. [Abstract]

2026 May 6;31(5):133. PMID: 42090009
Int J Nanomedicine

Polydopamine Modified with Brain Targeting Peptide Rabies Virus Glycoprotein for Treatment of Alzheimer's Disease by Inhibiting Oxidative Stress and Inflammatory Response. [Abstract]

2026 Feb 5:21:564013. PMID: 41884282
Int J Biol Macromol

USP38 regulates autophagy-dependent ferroptosis by deubiquitinating CTNNB1 in melanoma. [Abstract]

2025 Dec 15:149611. PMID: 41407221
Int J Biol Macromol

Suppression of dual-specificity phosphatase 6 protects against liver fibrosis via targeting CYP2E1-mediated ferroptosis. [Abstract]

2025 Dec 27;339(Pt 1):149856. PMID: 41461229
Int J Biol Macromol

SPINT2 inhibits NEDD4L-mediated ACSL4 ubiquitination to promote ferroptosis and suppress gallbladder cancer progression. [Abstract]

2025 Oct 9;330(Pt 3):148141. PMID: 41067336
Int J Biol Macromol

TF and TFRC regulate ferroptosis in swine testicular cells through the JNK signaling pathway. [Abstract]

2025 Mar 20;307(Pt 4):142369. PMID: 40120870
Int J Biol Macromol

Tremella aurantialba polysaccharides alleviate ulcerative colitis in mice by improving intestinal barrier via modulating gut microbiota and inhibiting ferroptosis. [Abstract]

2024 Nov;281(Pt 4):135835. PMID: 39306158
Int J Nanomedicine

Curcumin Nanoparticles Inhibiting Ferroptosis for the Enhanced Treatment of Intracerebral Hemorrhage. [Abstract]

2021 Dec 14;16:8049-8065. PMID: 34938072
Int J Nanomedicine

p53 Promoted Ferroptosis in Ovarian Cancer Cells Treated with Human Serum Incubated-Superparamagnetic Iron Oxides. [Abstract]

2021 Jan 12:16:283-296. PMID: 33469287
Int J Mol Med

HELLS inhibits autophagy‑dependent ferroptosis in nasopharyngeal carcinoma by modulating the Nrf2/HO‑1/GPX4 pathway. [Abstract]

2026 May;57(5):117. PMID: 41823538
Neural Regen Res

TP53 drives neuronal ferroptosis by promoting KLHL4-mediated SLC7A11 ubiquitination after spinal cord injury. [Abstract]

2025 Sep 3. PMID: 40903977
Neural Regen Res

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation. [Abstract]

2025 Jul 1;20(7):2038-2052. PMID: 38993139
Int J Mol Med

Curcumin pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis, autophagy and apoptosis via HES1. [Abstract]

2024 Dec;54(6):110. PMID: 39364745
Int J Mol Med

Unveiling the role of RhoA and ferroptosis in vascular permeability: Implications for osteoarthritis. [Abstract]

2024 Oct;54(4):86. PMID: 39129277
Int J Mol Med

Tanshinone IIA confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis and apoptosis via VDAC1. [Abstract]

2023 Nov;52(5):109. PMID: 37800609
Neural Regen Res

Eph receptor A4 regulates motor neuron ferroptosis in spinal cord ischemia/reperfusion injury in rats. [Abstract]

2023 Oct;18(10):2219-2228. PMID: 37056141
Int J Mol Med

Metabolic heterogeneity protects metastatic mucosal melanomas cells from ferroptosis. [Abstract]

2022 Oct;50(4):124. PMID: 36004461
Int J Mol Med

miR‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in in vivo and in vitro models of Parkinson's disease. [Abstract]

2021 Apr;47(4):61. PMID: 33649797
Nephrol Dial Transplant

Klotho suppresses cyst growth in ADPKD through the regulation of ferroptosis and reversing DNA methylation. [Abstract]

2026 Jun 18:gfag141. PMID: 42314074
Mol Med

Caffeic acid phenethyl ester protects renal tubular epithelial cells against ferroptosis in diabetic kidney disease via restoring PINK1-mediated mitophagy. [Abstract]

2025 Jul 24;31(1):264. PMID: 40702453
Mol Med

CKS2 induces autophagy-mediated glutathione metabolic reprogramming to facilitate ferroptosis resistance in colon cancer. [Abstract]

2024 Nov 15;30(1):219. PMID: 39548421
Mol Med

MGST1 facilitates novel KRASG12D inhibitor resistance in KRASG12D-mutated pancreatic ductal adenocarcinoma by inhibiting ferroptosis. [Abstract]

2024 Nov 5;30(1):199. PMID: 39501138
Sens Actuators B Chem

2024 Nov 1.
Mol Med

G protein-coupled estrogen receptor activates PI3K/AKT/mTOR signaling to suppress ferroptosis via SREBP1/SCD1-mediated lipogenesis. [Abstract]

2024 Feb 21;30(1):28. PMID: 38383297
Sens Actuators B Chem

2024 Jan 15, 399, 134872.
Mol Med

Vitexin attenuates chronic kidney disease by inhibiting renal tubular epithelial cell ferroptosis via NRF2 activation. [Abstract]

2023 Oct 27;29(1):147. PMID: 37891461
Sens Actuators B Chem

15 December 2022, 132707.
Arch Pharm Res

JAK2/STAT3-dependent regulation of MDM4/MDM2-p53 signaling in methotrexate-induced ferroptosis and nephrotoxicity. [Abstract]

2026 Feb;49(2):223-241. PMID: 41723769
Antioxidants (Basel)

Pterostilbene Promotes Spinal Cord Injury Recovery by Inhibiting Ferroptosis via Keap1/Nrf2/SLC7A11/GPX4 Axis Activation. [Abstract]

2026 Feb 2;15(2):188. PMID: 41750570
Antioxidants (Basel)

5-Aminolevulinic Acid-Mediated Photodynamic Therapy Induces Ferroptosis in Oral Leukoplakia and Oral Squamous Cell Carcinoma. [Abstract]

2026 Jan 26;15(2):167. PMID: 41750549
Antioxidants (Basel)

miR-26a-Targeting SLC7A11 Regulates Erastin-Induced Granulosa Cell Ferroptosis. [Abstract]

2025 Oct 26;14(11):1283. PMID: 41300440
Antioxidants

Serine-Driven Metabolic Plasticity Drives Adaptive Resilience in Pancreatic Cancer Cells. [Abstract]

2025 Jul 7;14(7):833. PMID: 40722937
Antioxidants

Taurine Attenuates Disuse Muscle Atrophy Through Modulation of the xCT-GSH-GPX4 and AMPK-ACC-ACSL4 Pathways. [Abstract]

2025 Jul 10;14(7):847. PMID: 40722950
Antioxidants (Basel)

Effect of Media Composition and Oxygen Tension on Cellular Stress Response and Nrf2 Activation in HepG2ARE Cells. [Abstract]

2025 Jan 24;14(2):137. PMID: 40002325
Antioxidants (Basel)

PTC596-Induced BMI-1 Inhibition Fights Neuroblastoma Multidrug Resistance by Inducing Ferroptosis. [Abstract]

2023 Dec 19;13(1):3. PMID: 38275623
Antioxidants (Basel)

Comparative Proteomics Unveils LRRFIP1 as a New Player in the DAPK1 Interactome of Neurons Exposed to Oxygen and Glucose Deprivation. [Abstract]

2020 Nov 30;9(12):1202. PMID: 33265962
Phytother Res

Vitexin Alleviates Osteoarthritis Progression Through Sirtuin 3-Mediated Inhibition of Chondrocyte Ferroptosis and Mitochondrial Dysfunction. [Abstract]

2026 Jun 22. PMID: 42333683
Phytother Res

Epigallocatechin-3-Gallate (EGCG) Mitigates Deep Vein Thrombosis Through Antioxidant and Anti-Ferroptotic Actions via the NRF2-NEDD4 Pathway. [Abstract]

2026 Jun;40(6):3668-3687. PMID: 41947351
Phytother Res

Quercetin Overcomes Cisplatin Resistance by Inducing Ferroptosis via the DDB2-AS1/miR-4728-5p/p53 Axis. [Abstract]

2026 Mar;40(3):1230-1251. PMID: 41562315
Phytother Res

Sepsis-Induced Liver Injury Mitigated by Isoferulic Acid Through Inhibition of Hepatic Ferroptosis via the SIRT1 Signaling Pathway. [Abstract]

2025 Sep 18. PMID: 40968354
Phytother Res

Crocin Attenuates Nrf2/GPX4 Mediated Ferroptosis in Obstructive Nephropathy by Selectively Targeting MKK4. [Abstract]

2025 Sep 17. PMID: 40958746
Phytother Res

l-Theanine Improves Learning and Memory Through Attenuation of NOX4-Mediated Ferroptosis in Hippocampal Neurons of Sleep-Deprived Mice. [Abstract]

2025 Jul 19. PMID: 40682446
Phytother Res

Procyanidin B1 Promotes PSMC3-NRF2 Ubiquitination to Induce Ferroptosis in Glioblastoma. [Abstract]

2024 Dec;38(12):5583-5597. PMID: 39293861
Phytother Res

Delay the progression of glucocorticoid-induced osteoporosis: Fraxin targets ferroptosis via the Nrf2/GPX4 pathway. [Abstract]

2024 Nov;38(11):5203-5224. PMID: 39192711
Phytother Res

Curcumin suppresses colorectal cancer by induction of ferroptosis via regulation of p53 and solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 signaling axis. [Abstract]

2024 Aug;38(8):3954-3972. PMID: 38837315
Free Radic Biol Med

DLAT sustains redox homeostasis and prevent colorectal cancer from ferroptosis by regulating SLC25A39-mediated mitochondrial glutathione transport. [Abstract]

2026 Aug 1:251:229-242. PMID: 42009144
Free Radic Biol Med

Mitochondrial-derived peptide MOTS-c targets SLC7A11 to preserve spermatogenesis by suppressing ferroptosis. [Abstract]

2026 Jul:250:284-297. PMID: 41933740
Free Radic Biol Med

Repurposing the hERG activator NS-1643 as a ferroptosis-targeting therapeutic against doxorubicin cardiotoxicity. [Abstract]

2026 Jun:249:14-26. PMID: 41794151
Free Radic Biol Med

Ginsenoside Rk1 suppresses osteosarcoma progression by coordinately activating ferritinophagy and disrupting antioxidant defense to induce ferroptosis. [Abstract]

2026 Jun 27:S0891-5849(26)00907-X. PMID: 42364854
Free Radic Biol Med

Troxerutin mitigates ferroptosis-related neuroinflammation by regulating the microglial NOX4/Nrf2 axis in Parkinson's disease. [Abstract]

2026 Jun 6:254:46-61. PMID: 42252064
Free Radic Biol Med

Radiotherapy disrupts ferroptosis tolerance by reducing DNMT1 levels and uncouples STING silencing in LKB1-deficient lung tumors. [Abstract]

2026 May:248:150-161. PMID: 41722660
Free Radic Biol Med

The autophagy receptor NDP52 recruits the E3 ligase ASB2 to mediate NOX4 degradation, suppressing cardiomyocyte ferroptosis and ameliorating heart failure. [Abstract]

2026 Apr:247:378-392. PMID: 41662915
Free Radic Biol Med

Inhibiting Arachidonate-5-lipoxygenase expression ameliorates osteoarthritis progression by suppressing ferroptosis via the JAK2/STAT3 signaling pathway. [Abstract]

2026 Mar 16:246:334-349. PMID: 41581577
Free Radic Biol Med

The MafG/Bach1-Lcn2 transcriptional axis drives ferroptosis in sepsis-induced acute lung injury via disrupting redox homeostasis. [Abstract]

2025 Dec 29:245:250-268. PMID: 41475687
Free Radic Biol Med

N6-methyladenosine regulated FZD7 inhibits ferroptosis in endometriosis via β-catenin/SLC7A11 pathway. [Abstract]

2025 Nov 13:243:54-66. PMID: 41241001
Free Radic Biol Med

Exosomal CagA induces macrophage polarization and ferroptosis by JAK1-2/STAT1 signaling pathway in Helicobacter pylori-associated gastritis. [Abstract]

2025 Nov:239:91-103. PMID: 40706822
Free Radic Biol Med

Cadmium induces ferroptosis in B cells via ATP6V0A1-upregulated lysosomal ferritinophagy: insights from murine transcriptomics and human cellular models. [Abstract]

2025 Oct 27:S0891-5849(25)01318-8. PMID: 41161393
Free Radic Biol Med

Rosmarinic Acid suppresses ferroptosis and confers neuroprotection in cerebral ischemia-reperfusion via direct KEAP1 inhibition and NRF2 activation. [Abstract]

2025 Oct 28:S0891-5849(25)01322-X. PMID: 41167534
Free Radic Biol Med

Reticulon 3 deficiency induces ferroptosis via chaperone-mediated autophagy in ischemia-reperfusion induced acute kidney injury. [Abstract]

2025 Oct 10:242:9-20. PMID: 41077100
Free Radic Biol Med

Low-dose valproic acid ameliorates osteoporosis by restoring redox homeostasis and suppressing ferritinophagy-dependent ferroptosis via EZH2/H3K27me3 signaling. [Abstract]

2025 Sep 12:S0891-5849(25)00980-3. PMID: 40947036
Free Radic Biol Med

Resveratrol induces ferroptosis in triple-negative breast cancer through NEDD4L-mediated GPX4 ubiquitination and degradation. [Abstract]

2025 Aug 1:235:231-247. PMID: 40316059
Free Radic Biol Med

Exercise training ameliorates high-fat diet-induced skeletal muscle atrophy and ferroptosis via downregulation of STING. [Abstract]

2025 Aug 20:240:373-383. PMID: 40846100
Free Radic Biol Med

Baicalein attenuates metabolic dysfunction-associated steatohepatitis by regulating macrophage ferroptosis through nuclear factor (erythroid-derived 2)-like 2 pathway. [Abstract]

2025 Aug 11:240:238-252. PMID: 40803417
Free Radic Biol Med

Neutrophil extracellular traps induce fibroblast ferroptosis via IRE1α/XBP1-mediated ER stress to impair diabetic wound healing. [Abstract]

2025 Aug 16:236:17-27. PMID: 40379156
Free Radic Biol Med

YAP-mediated DDX3X confers resistance to ferroptosis in breast cancer cells by reducing lipid peroxidation. [Abstract]

2025 May:232:330-339. PMID: 40089076
Free Radic Biol Med

Crucial roles of asprosin in cisplatin-induced ferroptosis and acute kidney injury. [Abstract]

2024 Dec 9:227:296-311. PMID: 39653130
Free Radic Biol Med

LRRC45 accelerates bladder cancer development and ferroptosis inhibition via stabilizing NRF2 by competitively KEAP1 interaction. [Abstract]

2024 Nov 8:226:29-42. PMID: 39522565
Free Radic Biol Med

Epithelial Piezo1 deletion ameliorates intestinal barrier damage by regulating ferroptosis in ulcerative colitis. [Abstract]

2024 Nov 1:224:272-286. PMID: 39216559
Free Radic Biol Med

LATS1 inhibitor and zinc supplement synergistically ameliorates contrast-induced acute kidney injury: Induction of Metallothionein-1 and suppression of tubular ferroptosis. [Abstract]

2024 Oct:223:42-52. PMID: 39033829
Free Radic Biol Med

Cryptochrome 1 regulates ovarian granulosa cell senescence through NCOA4-mediated ferritinophagy. [Abstract]

2024 May 1:217:1-14. PMID: 38522484
Free Radic Biol Med

Zinc deficiency drives ferroptosis resistance by lactate production in esophageal squamous cell carcinoma. [Abstract]

2024 Mar:213:512-522. PMID: 38301975
Free Radic Biol Med

DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis. [Abstract]

2023 Oct:207:32-44. PMID: 37419216
Free Radic Biol Med

Luteolin exhibits synergistic therapeutic efficacy with erastin to induce ferroptosis in colon cancer cells through the HIC1-mediated inhibition of GPX4 expression. [Abstract]

2023 Nov 1:208:530-544. PMID: 37717793
Free Radic Biol Med

Trastuzumab-induced cardiomyopathy via ferroptosis-mediated mitochondrial dysfunction. [Abstract]

2023 Sep:206:143-161. PMID: 37392951
Free Radic Biol Med

Overexpression of GPX4 attenuates cognitive dysfunction through inhibiting hippocampus ferroptosis and neuroinflammation after traumatic brain injury. [Abstract]

2023 Aug 1:204:68-81. PMID: 37105419
Free Radic Biol Med

Neurotoxic A1 astrocytes promote neuronal ferroptosis via CXCL10/CXCR3 axis in epilepsy. [Abstract]

2023 Feb 1:195:329-342. PMID: 36610561
Free Radic Biol Med

Empagliflozin attenuates the renal tubular ferroptosis in diabetic kidney disease through AMPK/NRF2 pathway. [Abstract]

2023 Feb 1:195:89-102. PMID: 36581059
Free Radic Biol Med

Irisin protects against sepsis-associated encephalopathy by suppressing ferroptosis via activation of the Nrf2/GPX4 signal axis. [Abstract]

2022 Jul:187:171-184. PMID: 35660523
Free Radic Biol Med

Sodium molybdate inhibits the growth of ovarian cancer cells via inducing both ferroptosis and apoptosis. [Abstract]

2022 Mar:182:79-92. PMID: 35219846
Free Radic Biol Med

Bim- and Bax-mediated mitochondrial pathway dominates abivertinib-induced apoptosis and ferroptosis. [Abstract]

2022 Feb 20:180:198-209. PMID: 35063650
Free Radic Biol Med

Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis. [Abstract]

2021 Sep:173:29-40. PMID: 34246777
Free Radic Biol Med

Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell. [Abstract]

2020 Nov 20:160:92-102. PMID: 32768568
Free Radic Biol Med

Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury. [Abstract]

2020 Nov 20:160:303-318. PMID: 32846217
Free Radic Biol Med

Ferroptosis was more initial in cell death caused by iron overload and its underlying mechanism in Parkinson's disease. [Abstract]

2020 May 20:152:227-234. PMID: 32217194
Clin Transl Med

USP43-mediated deubiquitination of SLC7A11 protects against LPS-induced acute lung injury by inhibiting ferroptosis. [Abstract]

2026 Jul;16(7):e70718. PMID: 42381269
Clin Transl Med

USP22 promotes the proliferation and Sorafenib resistance of hepatocellular carcinoma cells via its deubiquitinase activity. [Abstract]

2025 May;15(5):e70324. PMID: 40341781
Clin Transl Med

LINC01088 prevents ferroptosis in glioblastoma by enhancing SLC7A11 via HLTF/USP7 axis. [Abstract]

2025 Mar;15(3):e70257. PMID: 40000422
J Anim Sci Biotechnol

Bovine milk-derived extracellular vesicles reduce oxidative stress and ferroptosis induced by Klebsiella pneumoniae in bovine mammary epithelial cells. [Abstract]

2025 Feb 14;16(1):24. PMID: 39953606
J Anim Sci Biotechnol

Quercetin mitigates iron-induced cell death in chicken granulosa cell. [Abstract]

2024 Dec 8;15(1):168. PMID: 39645563
EMBO Mol Med

FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer. [Abstract]

2024 Jul;16(7):1533-1559. PMID: 38926633
Clin Transl Med

Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de-palmitoylation. [Abstract]

2023 Jun;13(6):e1300. PMID: 37337470
Clin Transl Med

Long noncoding RNA LINC01606 protects colon cancer cells from ferroptotic cell death and promotes stemness by SCD1-Wnt/β-catenin-TFE3 feedback loop signalling. [Abstract]

2022 Apr;12(4):e752. PMID: 35485210

Erastin purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2022 Apr;12(4):e752. [Abstract]

Representative images of intracellular mitochondrial superoxide level in SW480 and HT29 cells subjected to the stable knockdown of LINC001606 or stably overexpressing LINC001606 after treatment of DMSO, Erastin (10 μM) and RSL3 (2 μM) for 48 h.
Am J Chin Med

Quercetin Alleviates Endothelial Dysfunction in Atherosclerosis by Inhibiting Ferroptosis Through PACS2/HMOX-1 Pathway. [Abstract]

2026;54(2):603-625. PMID: 41692703
Am J Chin Med

Astragaloside IV Improves Pulmonary Vascular Endothelial Dysfunction in Pulmonary Arterial Hypertension by Inhibiting Ferroptosis through Modulation of the Calpain-1/TGF-β/TFRC Pathway. [Abstract]

2025;53(4):1181-1206. PMID: 40582717
Stem Cell Res Ther

Human spindle-shaped urine-derived stem cell exosomes alleviate severe fatty liver ischemia-reperfusion injury by inhibiting ferroptosis via GPX4. [Abstract]

2025 Feb 21;16(1):81. PMID: 39985001
Stem Cell Res Ther

FAM96B negatively regulates FOSL1 to modulate the osteogenic differentiation and regeneration of periodontal ligament stem cells via ferroptosis. [Abstract]

2024 Dec 18;15(1):471. PMID: 39696611
Am J Chin Med

Liquiritigenin, an Active Ingredient of Liquorice, Alleviates Acute Kidney Injury by VKORC1-Mediated Ferroptosis Inhibition. [Abstract]

2024;52(5):1507-1526. PMID: 39192677
Stem Cell Res Ther

MSCs promote the efferocytosis of large peritoneal macrophages to eliminate ferroptotic monocytes/macrophages in the injured endometria. [Abstract]

2024 May 1;15(1):127. PMID: 38693589
Am J Chin Med

Panax notoginseng Saponins Activate Nuclear Factor Erythroid 2-Related Factor 2 to Inhibit Ferroptosis and Attenuate Inflammatory Injury in Cerebral Ischemia-Reperfusion. [Abstract]

2024;52(3):821-839. PMID: 38699996
ACS Appl Mater Interfaces

Targeting Ferroptosis by Polydopamine Nanoparticles Protects Heart against Ischemia/Reperfusion Injury. [Abstract]

2021 Nov 17;13(45):53671-53682. PMID: 34730938
Cell Rep

IL4i1 activity generates oncometabolites that rescue neuroblastoma cells from oxidative death. [Abstract]

2026 Jun 23;45(6):117441. PMID: 42176266
Cell Rep

The xCT/CD98 complex suppresses ferroptosis in pan-cancer via a non-canonical RACK1-mediated iron homeostasis pathway. [Abstract]

2025 Nov 25;44(11):116563. PMID: 41252251
Cell Rep

Cancer-associated fibroblast-derived fibulin-5 promotes radioresistance in non-small-cell lung cancer. [Abstract]

2025 Jul 23;44(8):116018. PMID: 40711881
Cell Rep

OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression. [Abstract]

2025 May 6;44(5):115681. PMID: 40338740
Cell Rep

Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer's disease. [Abstract]

2024 Nov 28;43(12):114982. PMID: 39612244
Cell Rep

STUB1-mediated ubiquitination and degradation of NSUN2 promotes hepatocyte ferroptosis by decreasing m5C methylation of Gpx4 mRNA. [Abstract]

2024 Oct 24;43(11):114885. PMID: 39453812
Cell Rep

CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism. [Abstract]

2024 Aug 22;43(9):114662. PMID: 39178116
Cell Prolif

Tryptophan Metabolic Enzyme IL4I1 Inhibits Ferroptosis by Decreasing Ubiquitination of Nrf2 via I3P in Glioblastoma. [Abstract]

2025 Jun;58(6):e13816. PMID: 40071723
Cell Prolif

D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2α-dependent manner. [Abstract]

2021 Nov;54(11):e13134. PMID: 34561933
Br J Pharmacol

Quercetin alleviates postmenopausal atherosclerosis by suppressing endothelial cell ferroptosis via regulating the KEAP1/NRF2/GPX4 signalling pathway. [Abstract]

2025 Oct 8. PMID: 41063334
Br J Pharmacol

Spexin inhibits excessive autophagy-induced ferroptosis to alleviate doxorubicin-induced cardiotoxicity by upregulating Beclin 1. [Abstract]

2024 Nov;181(21):4195-4213. PMID: 38961632
J Ginseng Res

Ginsenoside Rg5 promotes wound healing in diabetes by reducing the negative regulation of SLC7A11 on the efferocytosis of dendritic cells. [Abstract]

2023 Nov;47(6):784-794. PMID: 38107390
Br J Pharmacol

Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signalling pathway. [Abstract]

2022 Aug;179(15):3991-4009. PMID: 35303762
Chin Med

Electroacupuncture ameliorates ulcerative colitis by suppressing ferroptosis via the JAK2/STAT3 signaling pathway. [Abstract]

2026 Jan 28;21(1):56. PMID: 41606666
Neurotherapeutics

FTH1 Inhibits Ferroptosis Through Ferritinophagy in the 6-OHDA Model of Parkinson's Disease. [Abstract]

2020 Oct;17(4):1796-1812. PMID: 32959272

Erastin purchased from MedChemExpress. Usage Cited in: Neurotherapeutics. 2020 Oct;17(4):1796-1812. [Abstract]

The effect of an inducer or inhibitor of ferroptosis on PC-12 cells. PC-12 cells are treated with 40 μM 6-OHDA in combination with an inducer (1 μM Erastin) of ferroptosis for 24 h. The expression of GPX4, TH, and FTH1 is significantly reduced in cells treated with the combination of erastin and 6-OHDA compared with those treated with 6-OHDA alone.
J Med Chem

2026 Jul 23;69(14):17171-17188. PMID: 42402137
Anal Chem

Systematic and Quantitative Investigation of Newly Synthesized Proteins Reveals Distinct Ion Homeostasis and Mitochondrial Changes between Cuproptosis and Ferroptosis in Human Cells. [Abstract]

2026 Mar 10. PMID: 41804563
Anal Chem

Ferroptosis Pathway Discrimination and Anticancer Therapeutic Screening Enabled by Cascade-Activated Fluorescence Reporting of Cysteine-Viscosity Dynamics. [Abstract]

2025 Nov 18;97(45):25056-25066. PMID: 41191406
J Med Chem

Discovery of a Novel Benzimidazole Derivative Targeting Histone Deacetylase to Induce Ferroptosis and Trigger Immunogenic Cell Death. [Abstract]

2024 Sep 12;67(17):15098-15117. PMID: 39145486
Food Sci Hum Wellness

2023 Sep.
Anal Chem

In Situ and Quantitatively Monitoring the Dynamic Process of Ferroptosis in Single Cancer Cells by Scanning Electrochemical Microscopy. [Abstract]

2023 Jan 6. PMID: 36608044
Int J Oncol

A novel ferroptosis‑related gene signature for overall survival prediction and immune infiltration in patients with breast cancer. [Abstract]

2022 Dec;61(6):148. PMID: 36222299
Brief Bioinform

Ferroptosis-related lncRNA pairs to predict the clinical outcome and molecular characteristics of pancreatic ductal adenocarcinoma. [Abstract]

2022 Jan 17;23(1):bbab388. PMID: 34553745
Environ Pollut

Silica nanoparticles induce liver lipid metabolism disorder via ACSL4-mediated ferroptosis. [Abstract]

2024 Oct 15:359:124590. PMID: 39043312
Cancer Cell Int

Polysaccharides from Huaier induce autophagy-dependent ferroptosis to inhibit breast cancer stem cells in triple-negative breast cancer. [Abstract]

2025 Dec 10. PMID: 41372887
EPMA J

Ferroptosis in acinar cells of traumatic pancreatitis: implications for predictive, preventive, and personalized approaches in intra-abdominal infection management. [Abstract]

2025 Sep 3;16(3):689-707. PMID: 40948981
Cancer Cell Int

Heme oxygenase-1 leads to cisplatin resistance in nasopharyngeal carcinoma by reducing oxidative stress and ferroptosis. [Abstract]

2025 Aug 11;25(1):302. PMID: 40790738
Cancer Cell Int

Comprehensive network pharmacology and experimental study to investigate the effect and mechanism of solasonine on breast carcinoma treatment. [Abstract]

2025 Feb 17;25(1):49. PMID: 39962568
J Invest Dermatol

CAMKK2 Defines Ferroptosis Sensitivity of Melanoma Cells by Regulating AMPK‒NRF2 Pathway. [Abstract]

2022 Jan;142(1):189-200.e8. PMID: 34242660
Redox Rep

Kaempferol protects against doxorubicin-induced myocardial damage by inhibiting mitochondrial ROS-dependent ferroptosis. [Abstract]

2025 Dec;30(1):2503130. PMID: 40361284
Pharmaceutics

Induction of Non-Canonical Ferroptosis by Targeting Clusters Suppresses Glioblastoma. [Abstract]

2024 Sep 13;16(9):1205. PMID: 39339241
Lipids Health Dis

Heme oxygenase 1 alleviates nonalcoholic steatohepatitis by suppressing hepatic ferroptosis. [Abstract]

2023 Jul 8;22(1):99. PMID: 37422643
J Ethnopharmacol

Chaihu Guizhi Ganjiang decoction attenuates chronic pancreatitis by suppressing acinar cell ferroptosis via regulating p53/SLC7A11/GPX4 pathway. [Abstract]

2026 Mar 1:358:121001. PMID: 41354015
J Ethnopharmacol

Integration of network pharmacology and transcriptomics to reveal the mechanism of Paeoniae Radix Alba Polysaccharide in alleviating hepatic fibrosis. [Abstract]

2025 Aug 5;353(Pt A):120357. PMID: 40759297
J Ethnopharmacol

Hu Gan Tang ameliorates metabolic-associated fatty liver disease by inhibiting ferroptosis through the Nrf2/GPX4 pathway. [Abstract]

2025 Jul 31;353(Pt A):120342. PMID: 40752599
Antioxid Redox Signal

Exosomal miR-196a-5p Secreted by Bone Marrow Mesenchymal Stem Cells Inhibits Ferroptosis and Promotes Drug Resistance of Acute Myeloid Leukemia. [Abstract]

2025 Jun;42(16-18):933-953. PMID: 40388337
J Ethnopharmacol

Total Sanghuangporus vaninii extract inhibits hepatocyte ferroptosis and intestinal microbiota disturbance to attenuate liver fibrosis in mice. [Abstract]

2025 Apr 9:345:119571. PMID: 40023344
J Ethnopharmacol

Proteomic and lipidomic analysis of the mechanism underlying astragaloside IV in mitigating ferroptosis through hypoxia-inducible factor 1α/heme oxygenase 1 pathway in renal tubular epithelial cells in diabetic kidney disease. [Abstract]

2024 Nov 15:334:118517. PMID: 38972525
J Ethnopharmacol

Salvia miltiorrhiza suppresses cardiomyocyte ferroptosis after myocardial infarction by activating Nrf2 signaling. [Abstract]

2024 Aug 10:330:118214. PMID: 38641076
J Ethnopharmacol

Chinese traditional formula Kaixin San suppressed ferroptosis of hippocampal neurons and cardiomyocytes in mice with paradoxical sleep deprivation. [Abstract]

2023 Mar 25:304:116034. PMID: 36529245
Hum Reprod

Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis. [Abstract]

2021 Mar 18;36(4):951-964. PMID: 33378529
J Agric Food Chem

2026 Jul 15;74(27):21141-21158. PMID: 42385689
J Agric Food Chem

Nonesterified Fatty Acids Cause Hepatic Ferroptosis in Dairy Cows via SIRT3-JNK Signaling. [Abstract]

2026 Mar 11;74(9):7553-7565. PMID: 41742716
J Agric Food Chem

Ginsenoside RK1 Promotes Hepatic Stellate Cell Glycolysis-Mediated Ferroptosis by Activating the HK2/ACSL4/LPCAT3/ALOX5 Signaling Pathway. [Abstract]

2025 Jul 9;73(27):17205-17218. PMID: 40570179
J Agric Food Chem

Astaxanthin Prevents Glucocorticoid-Induced Femoral Head Osteonecrosis by Targeting Ferroptosis through the JAK2/STAT3 Signaling Pathway. [Abstract]

2025 Feb 19;73(7):4270-4287. PMID: 39903514
J Agric Food Chem

Nuciferine Alleviates High-Fat Diet- and ApoE-/--Induced Hepatic Steatosis and Ferroptosis in NAFLD Mice via the PPARα Signaling Pathway. [Abstract]

2024 Nov 6;72(44):24417-24431. PMID: 39445611
J Agric Food Chem

Quercetin Inhibits Neuronal Pyroptosis and Ferroptosis by Modulating Microglial M1/M2 Polarization in Atherosclerosis. [Abstract]

2024 May 29;72(21):12156-12170. PMID: 38755521
J Agric Food Chem

Quercetin Alleviates Acrylamide-Induced Liver Injury by Inhibiting Autophagy-Dependent Ferroptosis. [Abstract]

2023 May 17;71(19):7427-7439. PMID: 37134181
Ecotoxicol Environ Saf

Chrysin reshapes ferroptosis sensitivity to reverse nickel refining fumes-induced lung injury via the miR-210/ANGPTL4 signaling axis mediated by the PHD1/HIF-1α pathway. [Abstract]

2026 May 13:318:120239. PMID: 42127541
Ecotoxicol Environ Saf

LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling. [Abstract]

2021 Sep 1:220:112376. PMID: 34051661
Biochem Pharmacol

2026 Oct:252:118224. PMID: 42409323
Biochem Pharmacol

Propyl gallate mitigates diabetic liver injury via suppressing SLC7A11/GPX4-mediated hepatic ferroptosis and modulating gut-liver axis. [Abstract]

2026 Jul:249:117926. PMID: 41876017
Biochem Pharmacol

5-Methoxyseselin inhibits neuronal ferroptosis and β-amyloid production in female APP/PS1 transgenic mice. [Abstract]

2026 Jun 25;251(Pt 2):118188. PMID: 42349617
Cell Biosci

Poly-GR promotes ferroptosis-associated vulnerability in C9orf72-ALS. [Abstract]

2026 Apr 26. PMID: 42036719
Biochem Pharmacol

Wedelolide A induces ferroptosis and apoptosis in gastric cancer via keap1/Nrf2 modulation and ROS generation. [Abstract]

2026 Jan;243(Pt 1):117519. PMID: 41192684
Biochem Pharmacol

PFKFB4-Mediated HSPB1 phosphorylation suppresses ferroptosis to Promote gastric cancer progression. [Abstract]

2026 Apr:246:117714. PMID: 41577048
Biochem Pharmacol

KDM2B promotes chemoresistance in glioma cells by inhibiting ferroptosis via the LINC01018/miR-182-5p axis. [Abstract]

2025 Dec;242(Pt 4):117416. PMID: 41077157
Biochem Pharmacol

Tetramethylpyrazine ameliorates sepsis-induced liver injury via inhibiting ferroptosis. [Abstract]

2025 Nov:241:117193. PMID: 40721008
Cell Mol Life Sci

Synergetic contributions of Seneca Valley virus 3 C and 3D proteins to induction of ferroptosis for viral replication. [Abstract]

2025 Nov 14;82(1):406. PMID: 41236547
Biochem Pharmacol

SLC1A5 mediates myocardial damage after myocardial infarction by triggering cardiomyocyte ferroptosis. [Abstract]

2025 Sep:239:117047. PMID: 40490039
Biochem Pharmacol

HDAC inhibitors activate lipid peroxidation and ferroptosis in gastric cancer. [Abstract]

2024 Jul:225:116257. PMID: 38705532
Cell Biosci

NOX4-mediated astrocyte ferroptosis in Alzheimer's disease. [Abstract]

2024 Jul 2;14(1):88. PMID: 38956702
Biochem Pharmacol

G-4 inhibits triple negative breast cancer by inducing cell apoptosis and promoting LCN2-dependent ferroptosis. [Abstract]

2024 Apr:222:116077. PMID: 38395264
Biochem Pharmacol

ALOX5 Promotes Autophagy-dependent Ferroptosis by Activating the AMPK/mTOR Pathway in Melanoma. [Abstract]

2023 Jun:212:115554. PMID: 37080437
Cancer Gene Ther

GOT1 promotes endometrial cancer progression by regulating ferroptosis through the STAT3-GPX4 axis and attenuating medroxyprogesterone acetate sensitivity. [Abstract]

2026 Jun 2. PMID: 42230821
Life Sci

TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury. [Abstract]

2023 May 15:321:121608. PMID: 36958437
Food Funct

Dietary hispidulin ameliorated chemically-induced colitis by inhibiting epithelial cell ferroptosis via the ACAT2-GPX4 axis and remodeling the gut microbiota. [Abstract]

2025 Aug 26. PMID: 40856206
Food Funct

Fucoxanthin alleviated myocardial ischemia and reperfusion injury through inhibition of ferroptosis via the NRF2 signaling pathway. [Abstract]

2023 Nov 13;14(22):10052-10068. PMID: 37861458
Inflamm Res

MLK3 promotes atherosclerosis by regulating ferroptosis in macrophages. [Abstract]

2026 Jun 20;75(1):142. PMID: 42323431
Inflamm Res

Methylmalonic acid as a ferroptosis-derived danger signal: activation of the PI3K-NF-κB pathway drives M1 macrophage polarization in renal ischemia-reperfusion injury. [Abstract]

2026 Jun 22;75(1):153. PMID: 42329408
Food Biosci

2026 May 8;80:109051.
Liver Int

Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity. [Abstract]

2020 Jun;40(6):1378-1394. PMID: 32145145
RSC Adv

2026 Jul 23;16(38):42679-42696. PMID: 42495555
Drug Des Devel Ther

Exploratory Study on the Role of Emodin in Alleviating MPTP-Induced Neurotoxicity: A Focus on p53-Ferroptosis Signaling. [Abstract]

2025 Dec 1:19:10645-10660. PMID: 41356603
Gastric Cancer

Nuclear export of transmembrane protein PROM2 is specially regulated by CRM1 and affects the sensitivity of ferroptosis in gastric cancer. [Abstract]

2025 Sep;28(5):837-851. PMID: 40679705
Gastric Cancer

The alkylglycerone phosphate synthase sustains the resistance of gastric cancer cells to ferroptosis induced by Apatinib. [Abstract]

2025 Apr 5. PMID: 40186794
Drug Des Devel Ther

Network Pharmacology and Metabolomics Reveal Anti-Ferroptotic Effects of Curcumin in Acute Kidney Injury. [Abstract]

2024 Dec 21:18:6223-6241. PMID: 39722679
Transl Res

GPX4 transcriptionally promotes liver cancer metastasis via GRHL3/PTEN/PI3K/AKT axis. [Abstract]

2024 Sep:271:79-92. PMID: 38797432
RSC Adv

Bioactive peptides derived from Radix Angelicae sinensis inhibit ferroptosis in HT22 cells through direct Keap1-Nrf2 PPI inhibition. [Abstract]

2023 Jul 24;13(32):22148-22157. PMID: 37492506
RSC Adv

Structure-activity relationship and mechanism of four monostilbenes with respect to ferroptosis inhibition. [Abstract]

2020 Aug 21;10(52):31171-31179. PMID: 35520676
Biomater Sci

Nanoparticle ferritin-bound erastin and rapamycin: a nanodrug combining autophagy and ferroptosis for anticancer therapy. [Abstract]

2019 Aug 20;7(9):3779-3787. PMID: 31211307
Biomater Sci

Assessment of zero-valent iron-based nanotherapeutics for ferroptosis induction and resensitization strategy in cancer cells. [Abstract]

2019 Mar 26;7(4):1311-1322. PMID: 30734774
Pharm Biol

Sauchinone attenuates UVB-induced photoaging by suppressing oxidative stress and ferroptosis through activation of the Keap1-Nrf2 pathway in dermal fibroblasts. [Abstract]

2026 Dec;64(1):764-782. PMID: 42165632
Foods

Effect of Selenium-Enriched Donkey Milk on Lipid Metabolism Disorders Induced by a High-Fat Diet. [Abstract]

2026 May 8;15(10):1640. PMID: 42195843
ACS Biomater Sci Eng

PF-PEG@ASIV-EXO Hydrogel Accelerates Diabetic Wound Healing by Ferroptosis Resistance and Promoting Angiogenesis. [Abstract]

2024 Oct 14;10(10):6263-6285. PMID: 39311841
Cells

TMEM43 Protects against Sepsis-Induced Cardiac Injury via Inhibiting Ferroptosis in Mice. [Abstract]

2022 Sep 26;11(19):2992. PMID: 36230956
Cells

Maresin1 Suppresses High-Glucose-Induced Ferroptosis in Osteoblasts via NRF2 Activation in Type 2 Diabetic Osteoporosis. [Abstract]

2022 Aug 17;11(16):2560. PMID: 36010637
Commun Biol

Therapeutic targeting SPI1 in combination with erastin promotes ferroptosis in ccRCC. [Abstract]

2025 Dec 10;8(1):1772. PMID: 41372608
Commun Biol

Chemerin attenuates acute kidney injury by inhibiting ferroptosis via the AMPK/NRF2/SLC7A11 axis. [Abstract]

2024 Dec 19;7(1):1679. PMID: 39702678
Commun Biol

USP24 promotes autophagy-dependent ferroptosis in hepatocellular carcinoma by reducing the K48-linked ubiquitination of Beclin1. [Abstract]

2024 Oct 8;7(1):1279. PMID: 39379617
Commun Biol

PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis. [Abstract]

2024 Apr 9;7(1):429. PMID: 38594496
Commun Biol

Elevated glutamate impedes anti-HIV-1 CD8 + T cell responses in HIV-1-infected individuals on antiretroviral therapy. [Abstract]

2023 Jul 7;6(1):696. PMID: 37419968
Commun Biol

Golgi stress mediates redox imbalance and ferroptosis in human cells. [Abstract]

2018 Nov 28:1:210. PMID: 30511023
Mitochondrion

Sensitivity of primary mitochondrial disease fibroblasts to ferroptosis: The role of intracellular iron. [Abstract]

2026 Mar:87:102112. PMID: 41581630
J Endocrinol

Leonurine alleviates lung ischemia-reperfusion injury through suppression of ferroptosis via RORα in male mice. [Abstract]

2026 Jan 19;268(1):e250298. PMID: 41498500
Cancer Biol Ther

FASN contributes to ADM resistance of diffuse large B-cell lymphoma by inhibiting ferroptosis via nf-κB/STAT3/GPX4 axis. [Abstract]

2024 Dec 31;25(1):2403197. PMID: 39345091
Eur J Pharmacol

Huperzine A protected against ferroptosis via activating PI3K/Akt signaling in lipopolysaccharide induced acute lung injury. [Abstract]

2024 Nov 15:983:177004. PMID: 39278310
Cell Biol Toxicol

Protocatechuic acid relieves ferroptosis in hepatic lipotoxicity and steatosis via regulating NRF2 signaling pathway. [Abstract]

2024 Nov 26;40(1):104. PMID: 39589556
Eur J Pharmacol

ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway. [Abstract]

2024 Apr 15:969:176303. PMID: 38211715
Eur J Pharmacol

Metformin improves nonalcoholic fatty liver disease in db/db mice by inhibiting ferroptosis. [Abstract]

2024 Mar 5:966:176341. PMID: 38244761
Eur J Pharmacol

Quercetin attenuates cerebral ischemic injury by inhibiting ferroptosis via Nrf2/HO-1 signaling pathway. [Abstract]

2024 Jan 15:963:176264. PMID: 38123006
Cell Biol Toxicol

METTL14 promotes doxorubicin-induced cardiomyocyte ferroptosis by regulating the KCNQ1OT1-miR-7-5p-TFRC axis. [Abstract]

2023 Jun;39(3):1015-1035. PMID: 34648132
Eur J Pharmacol

Astragaloside IV mitigates cerebral ischaemia-reperfusion injury via inhibition of P62/Keap1/Nrf2 pathway-mediated ferroptosis. [Abstract]

2023 Apr 5:944:175516. PMID: 36758783
Cell Biol Toxicol

The mtDNA-STING pathway plays an important role in both navitoclax- and S63845-induced autophagy and enhances cell death. [Abstract]

2023 Dec;39(6):2821-2839. PMID: 37002446
Eur J Pharmacol

The mechanism of the imbalance between proliferation and ferroptosis in pulmonary artery smooth muscle cells based on the activation of SLC7A11. [Abstract]

2022 Aug 5:928:175093. PMID: 35700835
Eur J Pharmacol

Ferroptosis involves in renal tubular cell death in diabetic nephropathy. [Abstract]

2020 Dec 5:888:173574. PMID: 32976829

Erastin purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2020 Dec 5:888:173574. [Abstract]

With the various dosage of ferroptosis inducer Erastin treatment for 24 h, the cell viability is determined by SRB method.
Int Immunopharmacol

2026 Jul 28:187:117174. PMID: 42520681
Int J Mol Sci

2026 Jul 18;27(14):6391. PMID: 42511738
Int Immunopharmacol

Kaempferide alleviates glucocorticoid-induced osteoporosis by targeting ferroptosis through the GSK3β/Nrf-2/GPX4 pathway. [Abstract]

2026 Jun 15:179:116601. PMID: 41962468
Int Immunopharmacol

MCL inhibits macrophage ferroptosis through the NRF2/HO-1/GPX4 axis to attenuate carotid atherosclerotic plaque formation. [Abstract]

2026 Jun 22:185:117056. PMID: 42330582
Cell Oncol (Dordr)

Tasimelteon inhibits glioma proliferation by inducing ferroptosis via the SP1/ACSL4 pathway. [Abstract]

2026 Jun 23. PMID: 42334777
Int Immunopharmacol

Se-methylselenocysteine alleviates sepsis-associated inflammation by upregulating GPX4 to inhibit macrophage ferroptosis. [Abstract]

2026 May 14:182:116851. PMID: 42134291
Int J Mol Sci

SLC25A28 Ameliorates Hyperoxic Lung Injury by Improving Mitochondrial Oxidative Phosphorylation in Alveolar Epithelial Cells. [Abstract]

2026 Apr 8;27(8):3357. PMID: 42074001
Int J Mol Sci

2026 Jan;27(11):4747.
Int J Mol Sci

MED12 Dictates Epithelial Ovarian Cancer Cell Ferroptosis Sensitivity via YAP-TEAD1 Signaling. [Abstract]

2026 Jan 20;27(2):1020. PMID: 41596664
Int Immunopharmacol

RICTOR-mediated GPX4 downregulation regulates chondrocyte ferroptosis in osteoarthritis progression. [Abstract]

2026 Mar 15:173:116274. PMID: 41605054
Int J Mol Sci

Cadmium Inhibits Proliferation of Human Bronchial Epithelial BEAS-2B Cells Through Inducing Ferroptosis via Targeted Regulation of the Nrf2/SLC7A11/GPX4 Pathway. [Abstract]

2025 Jul 25;26(15):7204. PMID: 40806353
Int Immunopharmacol

Dracorhodin perochlorate sensitizes colorectal cancer to ferroptosis by activating HMOX1 and inhibiting the SLC7A11/GPX4 axis. [Abstract]

2025 Jun 17:158:114827. PMID: 40359890
Int Immunopharmacol

Inhibition of LPL suppresses the osteoclast differentiation of bone-marrow-derived macrophages by promoting the ACSL4 ubiquitination. [Abstract]

2025 May 27:156:114694. PMID: 40273672
Int Immunopharmacol

Unraveling the crucial role of SDF-1 in osteoarthritis progression: IL6/HIF-1α positive feedback and chondrocyte ferroptosis. [Abstract]

2025 Apr 16:152:114400. PMID: 40058106
Int Immunopharmacol

Puerarin triggers sensitivity to ferroptosis in glioblastoma cells by activating SIRT3/NCOA4-dependent autophagy. [Abstract]

2025 Mar 6:149:114246. PMID: 39929095
Int J Mol Sci

Smilax glabra Flavonoids Inhibit AMPK Activation and Induce Ferroptosis in Obesity-Associated Colorectal Cancer. [Abstract]

2025 Mar 10;26(6):2476. PMID: 40141120
Int J Mol Sci

JAG1/Notch Pathway Inhibition Induces Ferroptosis and Promotes Cataractogenesis. [Abstract]

2025 Jan 1;26(1):307. PMID: 39796164
Int Immunopharmacol

CTRP13 attenuates atherosclerosis by inhibiting endothelial cell ferroptosis via activating GCH1. [Abstract]

2024 Nov 13;143(Pt 3):113617. PMID: 39541845
Int Immunopharmacol

The VDR/FFAR2 axis mitigates sepsis-induced lung injury by suppressing macrophage lipid peroxidation. [Abstract]

2024 Oct 16;143(Pt 2):113328. PMID: 39418731
Int Immunopharmacol

PKCδ modulates SP1 mediated mitochondrial autophagy to exacerbate diacetylmorphine-induced ferroptosis in neurons. [Abstract]

2024 Oct 25;143(Pt 2):113468. PMID: 39490143
Int Immunopharmacol

Stachyose ameliorates myocardial ischemia-reperfusion injury by inhibiting cardiomyocyte ferroptosis and macrophage pyroptosis. [Abstract]

2024 Oct 8;143(Pt 1):113334. PMID: 39383784
Int J Mol Sci

PTEN Deficiency Induced by Extracellular Vesicle miRNAs from Clonorchis sinensis Potentiates Cholangiocarcinoma Development by Inhibiting Ferroptosis. [Abstract]

2024 Sep 26;25(19):10350. PMID: 39408679
Int Immunopharmacol

Berberine attenuates neuronal ferroptosis via the AMPK-NRF2-HO-1-signaling pathway in spinal cord-injured rats. [Abstract]

2024 Sep 24;142(Pt B):113227. PMID: 39321704
Int Immunopharmacol

Asiaticoside promoted ferroptosis and suppressed immune escape in gastric cancer cells by downregulating the Wnt/β-catenin pathway. [Abstract]

2024 Jun 15:134:112175. PMID: 38733821
Int J Mol Sci

TRIM21 Promotes Oxidative Stress and Ferroptosis through the SQSTM1-NRF2-KEAP1 Axis to Increase the Titers of H5N1 Highly Pathogenic Avian Influenza Virus. [Abstract]

2024 Mar 14;25(6):3315. PMID: 38542289
Int J Mol Sci

Cadmium Induces Kidney Iron Deficiency and Chronic Kidney Injury by Interfering with the Iron Metabolism in Rats. [Abstract]

2024 Jan 7;25(2):763. PMID: 38255838
Int Immunopharmacol

TMEM16A deficiency in alveolar type 2 epithelial cells protected against endoplasmic reticulum stress-induced ferroptosis during acute lung injury. [Abstract]

2023 Nov 15;125(Pt B):111208. PMID: 37976603
Int J Mol Sci

Three-Dimensional Gene Regulation Network in Glioblastoma Ferroptosis. [Abstract]

2023 Oct 6;24(19):14945. PMID: 37834393
Int J Mol Sci

Krüppel-like Factor 15 Suppresses Ferroptosis by Activating an NRF2/GPX4 Signal to Protect against Folic Acid-Induced Acute Kidney Injury. [Abstract]

2023 Sep 26;24(19):14530. PMID: 37833977
Int Immunopharmacol

Sennoside A restrains TRAF6 level to modulate ferroptosis, inflammation and cognitive impairment in aging mice with Alzheimer's Disease. [Abstract]

2023 Jul:120:110290. PMID: 37216800
Int Immunopharmacol

Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro. [Abstract]

2023 Apr:117:110042. PMID: 36940552
Int Immunopharmacol

FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3. [Abstract]

2023 Mar:116:109762. PMID: 36702076
Int Immunopharmacol

Astragaloside IV regulates the ferroptosis signaling pathway via the Nrf2/SLC7A11/GPX4 axis to inhibit PM2.5-mediated lung injury in mice. [Abstract]

2022 Nov:112:109186. PMID: 36115280
Int J Mol Sci

The Possible Connection of Two Dual Function Processes: The Relationship of Ferroptosis and the JNK Pathway. [Abstract]

2022 Sep 20;23(19):11004. PMID: 36232313
Biol Direct

NSDHL as a regulator of lipid peroxidation and ER stress-mediated apoptosis in ovarian cancer. [Abstract]

2026 Apr 8;21(1):68. PMID: 41952197
Mol Neurobiol

3-n-Butylphthalide Protects SH-SY5Y Cells from Ferroptosis by Inhibiting ACSL4-Mediated Lipid Peroxidation. [Abstract]

2026 Jan 16;63(1):369. PMID: 41545774
Mol Neurobiol

Deciphering Ferroptosis-Related Astrocyte Subpopulations and Diagnostic Biomarkers in Parkinson's Disease through RNA Transcriptomics. [Abstract]

2025 Dec 1;63(1):221. PMID: 41324729
Biol Direct

MINPP1 promotes ferroptosis in HBV-related hepatocellular carcinoma by regulating CTSB K33-linked deubiquitination via ZRANB1. [Abstract]

2025 Oct 1;20(1):100. PMID: 41035046
Mol Neurobiol

Cholesterol and 24S-OHC Induce Neuronal Apoptosis and Necroptosis, but Not Ferroptosis Despite Elevated Iron Levels. [Abstract]

2025 Sep 18. PMID: 40968333
Biol Direct

MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis. [Abstract]

2024 Dec 22;19(1):133. PMID: 39709463
Biol Direct

Neuregulin-4 protects cardiomyocytes against high-glucose-induced ferroptosis via the AMPK/NRF2 signalling pathway. [Abstract]

2024 Aug 2;19(1):62. PMID: 39095871
Front Pharmacol

Pomolic acid induces ferroptosis-mediated cell death in non-small cell lung cancer. [Abstract]

2025 Jun 4:16:1567942. PMID: 40535769
Inflammation

FBXW7-Mediated Downregulation of GPX4 Aggravates Acute Kidney Injury Following Ischemia‒Reperfusion. [Abstract]

2025 Jun;48(3):1484-1498. PMID: 39207602
mBio

The long noncoding RNA APR attenuates PPRV infection-induced accumulation of intracellular iron to inhibit membrane lipid peroxidation and viral replication. [Abstract]

2025 Apr 9;16(4):e0012725. PMID: 40126010
Inflammation

4-Octyl Itaconate Attenuates Postmenopausal Osteoporosis by Inhibiting Ferroptosis and Enhancing Osteogenesis via the Nrf2 Pathway. [Abstract]

2025 Feb 22. PMID: 39984770
Inflammation

4-octyl Itaconate Attenuates Acute Pancreatitis and Associated Lung Injury by Suppressing Ferroptosis in Mice. [Abstract]

2025 Feb 7. PMID: 39920558
Inflammation

Targeting Lcn2 to Inhibit Myocardial Cell Ferroptosis is a Potential Therapy for Alleviating Septic Cardiomyopathy. [Abstract]

2025 Feb 3. PMID: 39899131
COLLOID SURFACE A

2023 Apr 13, 131458.
Front Pharmacol

Identification of the key ferroptosis-related genes involved in sepsis progression and experimental validation in vivo. [Abstract]

2022 Aug 11;13:940261 PMID: 36188533
Front Pharmacol

Polyphyllin Ⅲ-Induced Ferroptosis in MDA-MB-231 Triple-Negative Breast Cancer Cells can Be Protected Against by KLF4-Mediated Upregulation of xCT. [Abstract]

2021 May 10:12:670224. PMID: 34040532
Front Pharmacol

Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage. [Abstract]

2021 Mar 19:12:629379. PMID: 33815110
Front Cell Dev Biol

Blockade of GCH1/BH4 Axis Activates Ferritinophagy to Mitigate the Resistance of Colorectal Cancer to Erastin-Induced Ferroptosis. [Abstract]

2022 Feb 10:10:810327. PMID: 35223839
Toxicology

2026 Nov:526:154543. PMID: 42476445
J Nutr Biochem

Ferroptosis inhibition by spermidine via the NCOA4/Ferritin axis and polyamine-microbiota dysbiosis in ulcerative colitis. [Abstract]

2026 Apr:150:110222. PMID: 41352542
J Nutr Biochem

Plant sterol ester of α-linolenic acid protects against ferroptosis in metabolic dysfunction-associated fatty liver disease via activating the Nrf2 signaling pathway. [Abstract]

2026 Jan:147:110098. PMID: 40915508
J Nutr Biochem

P-coumaric-acid ameliorates acute kidney injury induced by ischemia-reperfusion injury via suppressing ferroptosis. [Abstract]

2025 Nov 7:149:110175. PMID: 41207539
ACS Omega

Elucidating the Neuroprotective Mechanism of Geissoschizine Methyl Ether against Parkinson's Disease: Inhibition of Ferroptosis Pathway via Network Pharmacology and In Vitro Validation. [Abstract]

2025 Sep 16;10(38):44447-44460. PMID: 41048757
Microchem J

2025 Sep 9;218:115245.
Toxicology

NNMT is involved in deoxynivalenol-induced hepatocyte toxicity via promoting ferroptosis. [Abstract]

2025 May:513:154084. PMID: 39983889
Microchem J

2024 Dec.
Chem Biol Interact

Targeting PKD2 aggravates ferritinophagy-mediated ferroptosis via promoting autophagosome-lysosome fusion and enhances efficacy of carboplatin in lung adenocarcinoma. [Abstract]

2024 Jan 5:387:110794. PMID: 37951334
Chem Biol Interact

Astaxanthin ameliorates oxidative stress in lens epithelial cells by regulating GPX4 and ferroptosis. [Abstract]

2023 Sep 25:383:110684. PMID: 37648051
Chem Biol Interact

Gambogenic acid induces cell death in human osteosarcoma through altering iron metabolism, disturbing the redox balance, and activating the P53 signaling pathway. [Abstract]

2023 Sep 1:382:110602. PMID: 37302459
Toxicology

Resveratrol protects against deoxynivalenol-induced ferroptosis in HepG2 cells. [Abstract]

2023 Aug 1:494:153589. PMID: 37419272
Toxicology

Wnt5a/Ca2+ signaling regulates silica-induced ferroptosis in mouse macrophages by altering ER stress-mediated redox balance. [Abstract]

2023 May 15:490:153514. PMID: 37075931
Toxicology

Inhibition of ferroptosis reduces susceptibility to frequent excessive alcohol consumption-induced atrial fibrillation. [Abstract]

2022 Jan 15:465:153055. PMID: 34864093
Nanoscale

Nanoparticles improved resveratrol brain delivery and its therapeutic efficacy against intracerebral hemorrhage. [Abstract]

2021 Feb 14;13(6):3827-3840. PMID: 33565555
Toxicology

Oxidative stress-dependent frataxin inhibition mediated alcoholic hepatocytotoxicity through ferroptosis. [Abstract]

2020 Dec 1:445:152584. PMID: 33017621
Bioorg Chem

A mitochondria-targeting glutathione fluorescent probe reveals distinct mitochondria-endoplasmic reticulum contact between disulfidptosis and ferroptosis. [Abstract]

2026 Feb:169:109437. PMID: 41453306
Exp Gerontol

Idebenone protects against doxorubicin-induced cardiac injury by inhibiting ferroptosis in cardiomyocytes. [Abstract]

2026 Feb:214:113039. PMID: 41547496
Spine J

Beyond a ferroptosis inducer: erastin can suppress nutrient deprivation induced cell death in the intervertebral disc. [Abstract]

2025 Mar;25(3):597-608. PMID: 39522771
Eur J Pharm Sci

Pharmacodynamic insights into maresin 1: Enhancing flap viability via the keap1/Nrf2 axis to control ROS-driven apoptosis and ferroptosis. [Abstract]

2024 Dec 1:203:106923. PMID: 39368783
Molecules

Methylophiopogonanone A Inhibits Ferroptosis in H9c2 Cells: An Experimental and Molecular Simulation Study. [Abstract]

2024 Dec 6;29(23):5764. PMID: 39683922
Exp Gerontol

Elucidating the molecular mechanisms behind the therapeutic impact of median nerve stimulation on cognitive dysfunction post-traumatic brain injury. [Abstract]

2024 Sep:194:112500. PMID: 38901771
Molecules

Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway. [Abstract]

2022 Sep 24;27(19):6311. PMID: 36234847
Molecules

Simultaneous Study of Anti-Ferroptosis and Antioxidant Mechanisms of Butein and ( S)-Butin. [Abstract]

2020 Feb 5;25(3):674. PMID: 32033283
Food Sci Nutr

From Wild Vegetable to Renal Protector: The Therapeutic Potential of Aralia elata (Miq.) Seem. [Abstract]

2025 Nov 17;13(11):e71212. PMID: 41256226
J Mol Med (Berl)

Increased ZNF83 is a potential prognostic biomarker and regulates oxidative stress-induced ferroptosis in clear cell renal cell carcinoma. [Abstract]

2025 Apr 12. PMID: 40220129
Mol Med Rep

Quercetin attenuates the symptoms of osteoarthritis in vitro and in vivo by suppressing ferroptosis via activation of AMPK/Nrf2/Gpx4 signaling. [Abstract]

2025 Mar;31(3):60. PMID: 39717946
Mol Med Rep

Cytoglobin attenuates melanoma malignancy but protects melanoma cells from ferroptosis. [Abstract]

2024 Dec;30(6):219. PMID: 39370785
Biochim Biophys Acta Mol Basis Dis

Botulinum toxin A attenuates osteoarthritis development via inhibiting chondrocyte ferroptosis through SLC7Al1/GPX4 axis. [Abstract]

2024 Jun;1870(5):167215. PMID: 38714267
Mol Med Rep

Food therapy of scutellarein ameliorates pirarubicin‑induced cardiotoxicity in rats by inhibiting apoptosis and ferroptosis through regulation of NOX2‑induced oxidative stress. [Abstract]

2024 May;29(5):84. PMID: 38516760
Mol Med Rep

Triptolide promotes ferroptosis by suppressing Nrf2 to overcome leukemia cell resistance to doxorubicin. [Abstract]

2023 Jan;27(1):17. PMID: 36453238
Ann Med

Overexpression of SLC44A4 suppresses ferroptosis and reduces lipid peroxidation via noncanonical NF-κB signaling in a NIK-dependent manner. [Abstract]

2026 Dec;58(1):2677931. PMID: 42186342
Cancer Sci

2026 Jul 23:10.1111/cas.70479. PMID: 42492013
Mediators Inflamm

Qingxin Lianzi Yin Improves Chronic Kidney Disease by Targeting Ferroptosis via the TLR4/HIF-1α Pathway. [Abstract]

2026;2026(1):e7440641. PMID: 42244400
Sci Rep

Small-molecule FTO inhibitor MO-I-500 protects C8-B4 microglial cells from erastin-induced ferroptosis. [Abstract]

2026 Apr 18;16(1):18062. PMID: 42000801
Sci Rep

Ferroptosis inhibits biological behaviors of glioma cells by downregulating Galectin-9 transcriptional level via extracellular Acetyl-HMGB1. [Abstract]

2026 Mar 29;16(1):10681. PMID: 41905987
Sci Rep

Quercetin-4'-O-β-D-glucopyranoside inhibits ferroptosis though SIRT5-mediated desuccinylation of TFR1 in diabetic nephropathy. [Abstract]

2026 Mar 6;16(1):12384. PMID: 41792305
Sci Rep

IRX4204 sensitizes multiple myeloma to ferroptosis and improves lenalidomide efficacy through the HMOX1-GPX4 axis. [Abstract]

2026 Mar 17. PMID: 41844739
PLoS Pathog

EnP1 exploits H2Aub-dependent epigenetic reprogramming to promote microsporidia proliferation in host cells. [Abstract]

2026 Jan 7;22(1):e1013853. PMID: 41499632
Transl Oncol

The CHPT-pSTAT3-SLC7A11 signaling axis controls progression and ferroptosis susceptibility of pancreatic cancer. [Abstract]

2026 Jan:63:102624. PMID: 41337814
J Mol Cell Cardiol

DPP4-regulated endothelial cell ferroptosis modulates atherosclerosis progression by ferritinophagy. [Abstract]

2026 Jan 19:213:14-30. PMID: 41565199
Mediators Inflamm

LncRNA NEAT1 Knockdown Alleviates Macrophage Ferroptosis and Atherosclerosis by Suppressing STAT3 Activation. [Abstract]

2025 Nov 12:2025:8862449. PMID: 41268533
J Mol Cell Cardiol

ZIP14 upregulation leads to ferroptosis and lysosomal dysfunction through intracellular iron overload and induces myocardial ischemia/reperfusion injury in mouse hearts. [Abstract]

2025 Nov 27:211:78-91. PMID: 41317841
Transl Oncol

USP11 is involved in the sensitivity of liver cancer cells to ferroptosis and taxanes through the regulation of NRF2 ubiquitin-mediated degradation. [Abstract]

2025 Sep 30:62:102553. PMID: 41033073
Sci Rep

Leveraging diverse cell death patterns in osteosarcoma patients and identification of the function of FADS2 in osteosarcoma cells. [Abstract]

2025 Jul 1;15(1):20831. PMID: 40593006
Sci Rep

TNF-α inhibits Epstein Barr virus reactivation through the GPX4 mediated glutathione pathway. [Abstract]

2025 May 12;15(1):16448. PMID: 40355596
Sci Rep

Gastrodia protects HT22 cells from damage caused by oxygen glucose deprivation and reperfusion through inhibiting ferroptosis. [Abstract]

2025 May 27;15(1):18470. PMID: 40425648
Sci Rep

Helium cold atmospheric pressure plasma reduces erastin induced inflammation and ferroptosis in human gingival fibroblasts. [Abstract]

2025 Mar 3;15(1):7440. PMID: 40032893
Biosci Trends

FNDC5/Irisin mitigates high glucose-induced neurotoxicity in HT22 cell via ferroptosis. [Abstract]

2024 Nov 15;18(5):465-475. PMID: 39414463
Transl Oncol

Cytochrome P450 F3 promotes colorectal cancer via inhibiting NRF2-mediated ferroptosis. [Abstract]

2024 Oct:48:102077. PMID: 39106550
Toxics

Effects on Iron Metabolism and System Xc- /GPX4 Pathway from Hydroquinone Suggest Ferroptosis of Jurkat Cells. [Abstract]

2024 Aug 31;12(9):644. PMID: 39330572
Sci Rep

Myricetin mitigates motor disturbance and decreases neuronal ferroptosis in a rat model of Parkinson's disease. [Abstract]

2024 Jul 2;14(1):15107. PMID: 38956066
Am J Pathol

Cryptochrome 2 suppresses epithelial-mesenchymal transition by promoting trophoblastic ferroptosis in unexplained recurrent spontaneous abortion. [Abstract]

2024 Jul;194(7):1197-1217. PMID: 38537935
Sci Rep

Salvianolic acid A inhibits ferroptosis and protects against intracerebral hemorrhage. [Abstract]

2024 May 30;14(1):12427. PMID: 38816543
Sci Rep

Characterization of a fluorescence imaging probe that exploits metabolic dependency of ovarian clear cell carcinoma. [Abstract]

2023 Nov 20;13(1):20292. PMID: 37985723
Mediators Inflamm

lnc-MRGPRF-6:1 Promotes ox-LDL-Induced Macrophage Ferroptosis via Suppressing GPX4. [Abstract]

2023 Aug 16:2023:5513245. PMID: 37621767
Sci Rep

LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells. [Abstract]

2019 Nov 7;9(1):16185. PMID: 31700067
Cancer Sci

Targeted exosome-encapsulated erastin induced ferroptosis in triple negative breast cancer cells. [Abstract]

2019 Oct;110(10):3173-3182. PMID: 31464035
Eur J Med Res

Long non-coding RNA NORAD serves as a promoter of oncogenesis and inhibits ferroptosis via miR-144-3p-mTOR-ferritinophagy axis in cancer. [Abstract]

2025 Aug 4;30(1):704. PMID: 40760677
Eur J Med Res

TCF7L2 regulates GPX4 to resist ferroptosis and enhance osteogenesis in mouse mesenchymal stem cells. [Abstract]

2025 Aug 5;30(1):713. PMID: 40764595
Eur J Med Res

Low doses of ozone alleviate cardiomyocyte ferroptosis induced by hypoxia-reoxygenation injury via the AMPK-mTOR pathway. [Abstract]

2025 Jul 2;30(1):558. PMID: 40604957
Stem Cells

Amphiregulin secreted by umbilical cord Multipotent Stromal Cells protects against ferroptosis of macrophages via the Activating Transcription Factor 3-CD36 axis to alleviate endometrial fibrosis. [Abstract]

2024 Aug 1;42(8):763-776. PMID: 38733123
Eur J Med Res

Quercetin inhibits the progression of endometrial HEC-1-A cells by regulating ferroptosis-a preliminary study. [Abstract]

2022 Dec 15;27(1):292. PMID: 36522794
Cell Signal

2026 Jul 4:112722. PMID: 42401358
J Cell Mol Med

Anti-HMGB1 Antibody Therapy Ameliorates Depression Following Spinal Cord Injury in Rats by Inhibiting Ferroptosis. [Abstract]

2026 Jun;30(12):e71255. PMID: 42337999
Cell Signal

SHC4 suppresses ferroptosis and promotes sorafenib resistance in hepatocellular carcinoma by disrupting the interaction between NCOA4 and FTH1. [Abstract]

2026 Jun 27:146:112699. PMID: 42364863
Mol Cell Biochem

2026 Jan 20;481(3):1453-1468.
Mol Cell Biochem

METTL5 promotes tumor progression and ferroptosis resistance via MGST1 in HCC. [Abstract]

2026 Jan 20. PMID: 41557129
Cell Signal

Natural exosome-like nanovesicles from Salvia chinensis Benth induce ferroptosis to suppress hepatocellular carcinoma progression via AMPK/Nrf2/xCT axis. [Abstract]

2025 Oct:134:111928. PMID: 40484104
Mol Cell Biochem

CIITA was involved in regulating ACSL4-dependent ferroptosis in gastric cancer cells. [Abstract]

2025 Oct 20. PMID: 41114762
Oncol Rep

HOTTIP suppresses ferroptosis via mediating DGCR8/miR‑214‑3p/GPX4 regulatory axis in osteosarcoma. [Abstract]

2025 Aug;54(2):94. PMID: 40539448
J Cell Mol Med

Identification of FADS2 as a Contributor of Ferroptosis Escape in Bladder Cancer. [Abstract]

2025 Jul;29(14):e70710. PMID: 40682485
J Cell Mol Med

Modified Qianghuo Shengshi Decoction Ameliorates Osteoarthritis via Inhibiting PI3K/Akt Pathway-Related Ferroptosis. [Abstract]

2025 Jul;29(13):e70691. PMID: 40586853
Mol Cell Biochem

Cytoglobin augments ferroptosis through autophagic degradation of ferritin in colorectal cancer cells. [Abstract]

2025 May;480(5):2881-2892. PMID: 39503803
Mol Cell Biochem

Senescence of endothelial cells promotes phenotypic changes in adventitial fibroblasts: possible implications for vascular aging. [Abstract]

2025 Feb;480(2):1027-1043. PMID: 38743322
J Cell Mol Med

Loss of FTH1 Induces Ferritinophagy-Mediated Ferroptosis in Anaemia of Myelodysplastic Syndromes. [Abstract]

2025 Jan;29(1):e70350. PMID: 39804099
J Cell Mol Med

Aucubin Promotes BMSCs Proliferation and Differentiation of Postmenopausal Osteoporosis Patients by Regulating Ferroptosis and BMP2 Signalling. [Abstract]

2025 Jan;29(2):e70288. PMID: 39823248
J Dairy Sci

Role of hypoxia-inducible-factor-1α (HIF-1α) in ferroptosis of adipose tissue during ketosis. [Abstract]

2024 Dec;107(12):10611-10627. PMID: 39067746
J Cell Mol Med

Dihydroartemisinin induces ferroptosis of hepatocellular carcinoma via inhibiting ATF4-xCT pathway. [Abstract]

2024 Apr;28(8):e18335. PMID: 38652216
J Cell Mol Med

SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxidation. [Abstract]

2024 Apr;28(7):e18212. PMID: 38516826
Oncol Rep

SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1. [Abstract]

2024 Feb;51(2):34. PMID: 38186303
Cell Signal

PKD knockdown mitigates Ang II-induced cardiac hypertrophy and ferroptosis via the JNK/P53 signaling pathway. [Abstract]

2024 Jan:113:110974. PMID: 37972803
Med Oncol

Zoledronic acid induces ferroptosis by upregulating POR in osteosarcoma. [Abstract]

2023 Apr 10;40(5):141. PMID: 37036615
Cell Signal

Artesunate induces apoptosis, autophagy and ferroptosis in diffuse large B cell lymphoma cells by impairing STAT3 signaling. [Abstract]

2021 Dec:88:110167. PMID: 34628002
J Cell Mol Med

Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon cancer cells. [Abstract]

2021 Apr;25(7):3300-3311. PMID: 33611811
Cell Signal

O-GlcNAcylated c-Jun antagonizes ferroptosis via inhibiting GSH synthesis in liver cancer. [Abstract]

2019 Nov:63:109384. PMID: 31394193
Oncol Res

SLC16A1 Activates the STAT3/SLC7A11 Pathway to Mediate Ferroptosis Resistance and Tumor Progression in Head and Neck Squamous Cell Carcinoma. [Abstract]

2026 Apr 22;34(5):34. PMID: 42065048
J Inflamm Res

Ferroptosis-Related Gene CRYAB in Asthma: Bioinformatics Identification and Experimental Validation. [Abstract]

2025 Oct 26:18:14721-14735. PMID: 41181358
J Inflamm Res

Astragaloside IV Attenuates Chronic Prostatitis by Activating Keap1/Nrf2/HO-1 Pathway: Suppressing Ferroptosis and Enhancing Antioxidant Defense. [Abstract]

2025 Jul 29:18:10061-10079. PMID: 40761383
J Inflamm Res

Cell Death-Related Genesets Activity Improved Clinical Concordance and Intrinsically Associated with Alterations in Ulcerative Colitis: Mucosal Healing at Molecular Depth. [Abstract]

2025 Jul 19:18:9587-9608. PMID: 40708727
J Inflamm Res

Menaquinone-4 Alleviates Sepsis-Associated Acute Lung Injury via Activating SIRT3-p53/SLC7A11 Pathway. [Abstract]

2024 Oct 24:17:7675-7685. PMID: 39469061
J Inflamm Res

Protective Effects of Dexmedetomidine on Sepsis-Induced Vascular Leakage by Alleviating Ferroptosis via Regulating Metabolic Reprogramming. [Abstract]

2021 Dec 10;14:6765-6782. PMID: 34916824
Brain Res Bull

2026 Oct 1:244:112037. PMID: 42437603
Brain Res Bull

2026 Oct 1:244:112053. PMID: 42492895
ACS Chem Neurosci

Destabilized Soluble SOD1 Species as Potential Determinants of Disease Severity in Familial Amyotrophic Lateral Sclerosis. [Abstract]

2026 Mar 27. PMID: 41894255
Brain Res Bull

Morin alleviates sepsis-associated encephalopathy through inhibiting ferroptosis via SIRT1. [Abstract]

2025 Dec:233:111638. PMID: 41241125
Biosci Rep

Identification and Functional Validation of ACSL1 as a Biomarker Regulating Ferroptosis in Nucleus Pulposus Cell. [Abstract]

2025 Apr 2;45(4):215-231. PMID: 40042449
Brain Res Bull

Electroacupuncture regulates ferroptosis to improve postoperative cognitive dysfunction in mice through mediating GRX1/GSK-3β/Nrf2 axis. [Abstract]

2025 Mar:222:111234. PMID: 39889835
Neurochem Res

Propofol Mitigates Sepsis-Induced Brain Injury by Inhibiting Ferroptosis Via Activation of the Nrf2/HO-1axis. [Abstract]

2024 Aug;49(8):2131-2147. PMID: 38822984
Mol Nutr Food Res

Ethanol-Induced Hepatic Ferroptosis Is Mediated by PERK-Dependent MAMs Formation: Preventive Role of Quercetin. [Abstract]

2024 Apr;68(7):e2300343. PMID: 38501770
iScience

USP7 upregulated by TGF-β1 promotes ferroptosis via inhibiting LATS1-YAP axis in sepsis-induced acute lung injury. [Abstract]

2024 Apr 5;27(6):109667. PMID: 38966570
iScience

A mechanism linking ferroptosis and ferritinophagy in melatonin-related improvement of diabetic brain injury. [Abstract]

2024 Mar 15;27(4):109511. PMID: 38571759
iScience

OGT/HIF-2α axis promotes the progression of clear cell renal cell carcinoma and regulates its sensitivity to ferroptosis. [Abstract]

2023 Oct 5;26(11):108148. PMID: 37915611
Brain Res Bull

YT521-B homology domain containing 1 ameliorates mitochondrial damage and ferroptosis in sleep deprivation by activating the sirtuin 1/nuclear factor erythroid-derived 2-like 2/heme oxygenase 1 pathway. [Abstract]

2023 Jun 1:197:1-12. PMID: 36935054
ACS Chem Neurosci

Antiferroptotic Activities of Oxindole GIF-0726-r Derivatives: Involvement of Ferrous Iron Coordination and Free-Radical Scavenging Capacities. [Abstract]

2023 May 17;14(10):1826-1833. PMID: 37104649
Acta Biochim Biophys Sin (Shanghai)

Glutamine deprivation induces ferroptosis in pancreatic cancer cells. [Abstract]

2023 Mar 20;55(8):1288-1300. PMID: 36942991
Mol Oncol

Loss of GABARAPL1 confers ferroptosis resistance to cancer stem-like cells in hepatocellular carcinoma. [Abstract]

2022 Oct;16(20):3703-3719. PMID: 36062307
Acta Biochim Biophys Sin (Shanghai)

Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer. [Abstract]

2021 Mar 2;53(3):333-341. PMID: 33522578
ACS Chem Neurosci

Liproxstatin-1 Attenuates Morphine Tolerance through Inhibiting Spinal Ferroptosis-like Cell Death. [Abstract]

2019 Dec 18;10(12):4824-4833. PMID: 31682397
BMC Complement Med Ther

Potential mechanism underlying HXSJ decoction in the treatment of venous leg ulcers: based on the association between venous leg ulcers and ferroptosis. [Abstract]

2025 Dec 30;25(1):451. PMID: 41469646
J Pharmacol Exp Ther

2026 Jun 17;393(8):104968. PMID: 42442018
FASEB J

3,4-Dimethoxychalcone Protects Against Steroid Induced Femoral Head Necrosis by Suppressing Ferroptosis via Activation of STAT3-Nrf2 Signaling Pathway. [Abstract]

2026 Jun 30;40(12):e72021. PMID: 42268673
FASEB J

CAF-Secreted Exosomes Deliver BMP4 to Confer Radiotherapy Resistance in Cervical Cancer Through a Novel Mechanism Linking Nrf2 Activation to Cuproptosis Inhibition. [Abstract]

2026 May 15;40(9):e71838. PMID: 42081167
Lung

USP10 from Human Umbilical Cord Mesenchymal Stem Cells-Derived Extracellular Vesicles Mediates SCL7A11 Deubiquitination in Epithelial Cells: A Key to Anti-ferroptosis and Anti-fibrosis in Pulmonary Fibrosis. [Abstract]

2026 Apr 29;204(1):26. PMID: 42053831
Autoimmunity

High glucose promotes O-GlcNAcylation of ACSL4 to induce ferroptosis of renal tubular epithelial cell. [Abstract]

2025 Dec;58(1):2576881. PMID: 41133730
FASEB J

LEF1 Suppresses Ferroptosis in Colorectal Cancer Cells by Targeted Promotion of SLC7A11 Transcription. [Abstract]

2025 Nov 30;39(22):e71231. PMID: 41258989
FASEB J

Glutathione S-transferase-Pi 1 protects cells from irradiation-induced death by inhibiting ferroptosis in pancreatic cancer. [Abstract]

2024 Sep;38(17):e70033. PMID: 39258853
FASEB J

Melatonin suppresses atherosclerosis by ferroptosis inhibition via activating NRF2 pathway. [Abstract]

2024 May 31;38(10):e23678. PMID: 38780199
FASEB J

Estrogen deficiency accelerates postmenopausal atherosclerosis by inducing endothelial cell ferroptosis through inhibiting NRF2/GPX4 pathway. [Abstract]

2023 Jun;37(6):e22992. PMID: 37219513
Fish Shellfish Immunol

Hemocyanin modulates ferroptosis through a HSP90-dependent antioxidant function in shrimp. [Abstract]

2026 Sep:176:111501. PMID: 42296727
FEBS J

Pentraxin-related protein PTX3 alleviates blast-induced acute lung injury by promoting efferocytosis to eliminate ferroptotic alveolar epithelial cells in vitro. [Abstract]

2025 Dec 3. PMID: 41340229
Drug Dev Res

Curcumin Alleviates Sepsis-Associated Acute Kidney Injury Potentially by Inhibiting Ferroptosis Through the ACSL4/GPX4 Signaling Pathway. [Abstract]

2025 Nov;86(7):e70181. PMID: 41140036
Fish Shellfish Immunol

Perfluorooctanoic acid (PFOA) exposure induced ferroptosis through the PPARα/FABP7 signaling pathway in the liver of spotted sea bass (Lateolabrax maculatus). [Abstract]

2025 Oct 8:168:110908. PMID: 41067592
Fish Shellfish Immunol

Scale drop disease virus (SDDV) triggers ferroptosis both in mandarin fish (Siniperca chuatsi) and MFF-1 cells to facilitate virus infection via linking to transferrin receptor 1 (TfR1). [Abstract]

2025 Aug:163:110416. PMID: 40373888
Antimicrob Agents Chemother

Synergistic activity of RSL3 and Pyrimethamine to inhibit the proliferation of Plasmodium falciparum. [Abstract]

2025 Aug 18:e0047125. PMID: 40823867
Int J Dermatol

Unbiased Drug Target Prediction Reveals Sensitivity to Ferroptosis Inducers, HDAC and RTK Inhibitors in Melanoma Subtypes. [Abstract]

2025 May;64(5):870-881. PMID: 39722169
Cancer Res Treat

Elevated SLC3A2 Expression Promotes the Progression of Gliomas and Enhances Ferroptosis Resistance through the AKT/NRF2/GPX4 Axis. [Abstract]

2025 Mar 10. PMID: 40083086
Drug Dev Res

Epigenetic mechanism of EZH2-mediated histone methylation modification in regulating ferroptosis of alveolar epithelial cells in sepsis-induced acute lung injury. [Abstract]

2024 Nov;85(7):e22263. PMID: 39344139
Fish Shellfish Immunol

Vitamin D ameliorates Aeromonas hydrophila-induced iron-dependent oxidative damage of grass carp splenic macrophages by manipulating Nrf2-mediated antioxidant pathway. [Abstract]

2023 Nov:142:109145. PMID: 37805110
FEBS J

Interferon-γ induces retinal pigment epithelial cell Ferroptosis by a JAK1-2/STAT1/SLC7A11 signaling pathway in Age-related Macular Degeneration. [Abstract]

2022 Apr;289(7):1968-1983. PMID: 34741776
J Biol Chem

CEP55 promotes prostate cancer progression via TPX2-dependent activation of AURKA-PI3K-AKT signaling and inhibition of ferroptosis. [Abstract]

2026 Mar;302(3):111218. PMID: 41617029
BMC Cancer

NDRG1 alleviates Erastin-induced ferroptosis of hepatocellular carcinoma. [Abstract]

2025 Mar 21;25(1):522. PMID: 40119318
J Biol Chem

LncRNA FAM83H-AS1 inhibits ferroptosis of endometrial cancer by promoting DNMT1-mediated CDO1 promoter hypermethylation. [Abstract]

2024 Sep;300(9):107680. PMID: 39159808
J Biol Chem

SET7 methylates the deubiquitinase OTUB1 at Lys 122 to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis. [Abstract]

2023 Apr;299(4):103054. PMID: 36822329
Lab Invest

CircRNA-ST6GALNAC6 increases the sensitivity of bladder cancer cells to erastin-induced ferroptosis by regulating the HSPB1/P38 axis. [Abstract]

2022 Dec;102(12):1323-1334. PMID: 35945269
Cell Stress Chaperones

ALDH3B1 protects interfollicular epidermal cells against lipid peroxidation via the NRF2 pathway. [Abstract]

2022 Nov;27(6):703-715. PMID: 36327089
ACS Pharmacol Transl Sci

Dapagliflozin Protects Cardiomyocytes against Doxorubicin-Induced Toxicity by Modulating Sirtuin 1/Sirtuin 3 and Ferroptosis Pathway. [Abstract]

2026 Apr 3;9(5):1134-1152. PMID: 42130718
Naunyn Schmiedebergs Arch Pharmacol

Gastrodin improves learning and memory in sleep-deprived mice through suppression of ferroptosis in hippocampal neurons via Nrf2. [Abstract]

2025 Aug 4. PMID: 40760051
Naunyn Schmiedebergs Arch Pharmacol

L-theanine prevents myocardial injury in sleep‑deprived mice by suppressing ferroptosis through SIRT1. [Abstract]

2025 May 6. PMID: 40328913
Naunyn Schmiedebergs Arch Pharmacol

Gastrodin prevents myocardial injury in sleep-deprived mice by suppressing ferroptosis through SIRT6. [Abstract]

2024 Nov;397(11):9111-9121. PMID: 38896272
Neurobiol Aging

Downregulation of KCNMA1 in mice accelerates auditory hair cells senescence via ferroptosis. [Abstract]

2024 Feb:134:115-125. PMID: 38056217
ACS Pharmacol Transl Sci

Inhibition of Protein Disulfide Isomerase (PDIA1) Leads to Proteasome-Mediated Degradation of Ubiquitin-like PHD and RING Finger Domain-Containing Protein 1 (UHRF1) and Increased Sensitivity of Glioblastoma Cells to Topoisomerase II Inhibitors. [Abstract]

2022 Dec 7;6(1):100-114. PMID: 36654750
J Cell Physiol

Effects of various calcium transporters on mitochondrial Ca2+ changes and oocyte maturation. [Abstract]

2021 Sep;236(9):6548-6558. PMID: 33704771
J Cell Physiol

MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells. [Abstract]

2020 Jul;235(7-8):5637-5648. PMID: 31960438
J Cell Physiol

Acetaminophen sensitizing erastin-induced ferroptosis via modulation of Nrf2/heme oxygenase-1 signaling pathway in non-small-cell lung cancer. [Abstract]

2020 Apr;235(4):3329-3339. PMID: 31541463
Bone

Lif-deficiency promote systemic Iron metabolism disorders and increases the susceptibility of osteoblasts to ferroptosis. [Abstract]

2024 Dec:189:117266. PMID: 39341481
Ren Fail

ADAMTS13 ameliorates diabetic nephropathy by Nrf2/GPX4/eNOS signaling pathway. [Abstract]

2026 Dec;48(1):2646089. PMID: 41912450
Carcinogenesis

USP49 promotes adenocarcinoma of the esophagogastric junction malignant progression via activating SHCBP1-β-catenin-GPX4 axis. [Abstract]

2025 Jan 20;46(1):bgae060. PMID: 39234990
J Proteome Res

Taurine Alleviates Ferroptosis-Induced Metabolic Impairments in C2C12 Myoblasts by Stabilizing the Labile Iron Pool and Improving Redox Homeostasis. [Abstract]

2024 Aug 2;23(8):3444-3459. PMID: 39024330
Carcinogenesis

SOCS1 acts as a ferroptosis driver to inhibit the progression and chemotherapy resistance of triple-negative breast cancer. [Abstract]

2023 Dec 2;44(8-9):708-715. PMID: 37665951
Pathogens

Brucella abortus Rough-Type Mutant Induces Ferroptosis and More Oxidative Stress in Infected Macrophages. [Abstract]

2023 Sep 23;12(10):1189. PMID: 37887705
J Orthop Surg Res

Circ-STC2 promotes the ferroptosis of nucleus pulposus cells via targeting miR-486-3p/TFR2 axis. [Abstract]

2023 Jul 21;18(1):518. PMID: 37480032
Mol Immunol

Transcription factor STAT1 upregulates IL-36γ to mediate the sensitivity of human nasal epithelial cells to ferroptosis and promote inflammatory progression in chronic rhinosinusitis. [Abstract]

2026 Aug:196:11-23. PMID: 42247985
Pathol Res Pract

Serine/arginine-rich splicing factor 1 inhibits ferroptosis and promotes glycolysis in endometrial cancer via activating mTOR and β-catenin. [Abstract]

2026 Mar:279:156364. PMID: 41564687
J Pharm Pharmacol

Taoren Honghua Jian improves ferroptosis-mediated myocardial damage following myocardial infarction via Nrf2-dependent enhancement of GPX4/FSP1. [Abstract]

2025 Oct 17:rgaf075. PMID: 41105727
Parasit Vectors

csi-miR-96-5p delivered by Clonorchis sinensis extracellular vesicles promotes intrahepatic cholangiocarcinoma proliferation and migration via the ferroptosis-related PTEN/SLC7A11/GPX4 axis. [Abstract]

2023 Dec 20;16(1):465. PMID: 38124152
J Pharm Pharmacol

Ferrostatin-1 suppresses cardiomyocyte ferroptosis after myocardial infarction by activating Nrf2 signaling. [Abstract]

2023 Nov 23;75(11):1467-1477. PMID: 37738327
Cytokine

IL-35 alleviates ferroptosis in macrophage by activating the NRF2/GPX4 pathway to improve sepsis-induced ARDS. [Abstract]

2026 Feb:198:157086. PMID: 41370997
J Biochem Mol Toxicol

N7-Methylguanine Modification of SHMT2 Mediated by GEMIN5 Inhibits Cell Ferroptosis of Colorectal Cancer Cells. [Abstract]

2025 Dec;39(12):e70647. PMID: 41416630
J Biochem Mol Toxicol

The Nrf2-GPX4 Pathway Provides Protection Against Rheumatoid Arthritis via Inhibition of Macrophage Ferroptosis-Mediated Inflammation and Synovial Fibroblast Proliferation. [Abstract]

2025 Nov;39(11):e70539. PMID: 41147649
Toxicol Appl Pharmacol

CDKN3 promoted triple-negative breast cancer by inhibiting ferroptosis through the upregulation of HSP90. [Abstract]

2026 Jan:506:117629. PMID: 41207514
J Biochem Mol Toxicol

Kaempferide Inhibits the Proliferation and Invasion and Induces Ferroptosis in Melanoma by Inactivating Wnt/β-Catenin Pathway. [Abstract]

2025 Oct;39(10):e70535. PMID: 41046540
J Biochem Mol Toxicol

Brucine Inhibits Gastric Cancer via Activation of Ferroptosis Through Regulating the NF-κB Signaling Pathway. [Abstract]

2025 Sep;39(9):e70479. PMID: 40919637
J Biochem Mol Toxicol

Falcarindiol Suppresses Malignant Progression and Induces Ferroptosis in Non-Small Cell Lung Cancer by Regulating JAK/STAT3 Axis. [Abstract]

2025 Sep;39(9):e70486. PMID: 40901755
J Biochem Mol Toxicol

Blockade of Interferon-Induced Protein 35 Alleviates Cisplatin-Induced Ferroptosis in Acute Kidney Injury Through Activation of the NRF2. [Abstract]

2025 Jul;39(7):e70383. PMID: 40654249
PLoS Negl Trop Dis

Hepatic ferroptosis induced by Clonorchis sinensis exacerbates liver fibrosis. [Abstract]

2025 Jun 2;19(6):e0013164. PMID: 40455823
Toxicol Appl Pharmacol

Lonicerin protects pancreatic acinar cells from caerulein-induced apoptosis, inflammation, and ferroptosis by activating the SIRT1/GPX4 signaling pathway. [Abstract]

2024 Nov:492:117136. PMID: 39476876
Anim Cells Syst

Blocking SLC7A11 attenuates the proliferation of esophageal squamous cell carcinoma cells. [Abstract]

2024 May 11;28(1):237-250. PMID: 38741950
Cytokine

Calcipotriol suppresses GPX4-mediated ferroptosis in OA chondrocytes by blocking the TGF-β1 pathway. [Abstract]

2023 Nov:171:156382. PMID: 37782985
Stem Cells Int

Endometrial Regenerative Cell-Derived Exosomes Attenuate Experimental Colitis through Downregulation of Intestine Ferroptosis. [Abstract]

2022 Aug 22:2022:3014123. PMID: 36045952
Stem Cells Int

Hypoxia Enhances HIF1 α Transcription Activity by Upregulating KDM4A and Mediating H3K9me3, Thus Inducing Ferroptosis Resistance in Cervical Cancer Cells. [Abstract]

2022 Mar 5:2022:1608806. PMID: 35287356
Arch Biochem Biophys

Tetrandrine attenuates diabetic neuropathic pain by suppressing ferroptosis and inflammation via Alox15 modulation. [Abstract]

2026 Sep:783:110903. PMID: 42303102
Int J Parasitol Drugs Drug Resist

2026 Aug:31:100661. PMID: 42476011
Appl Biochem Biotechnol

Paris Saponin VII Inhibits Ferroptosis through USP7/SLC7A11 to Alleviate Metabolic-associated Fatty Liver Disease in Rats. [Abstract]

2026 Jul;198(7):5045-5066. PMID: 41941048
Cancer Med

FKBP9 Enhances Colon Cancer Cell Proliferation by Inhibiting GPX4-Mediated Ferroptosis. [Abstract]

2026 Jun;15(6):e71772. PMID: 42204437
Mol Carcinog

2026 Jun 30. PMID: 42378631
Exp Cell Res

Role of CIRP in glioma Progression: Inhibition of ferroptosis via UBR5-Mediated ACSL4 degradation. [Abstract]

2026 Apr 15;457(2):114942. PMID: 41687914
Exp Cell Res

MiR-181c-5p-SIRT1 axis-driven Pink1/Parkin-mediated mitophagy prevents ferroptosis and vascular calcification in chronic kidney disease. [Abstract]

2026 Mar 1;456(1):114875. PMID: 41512994
Appl Biochem Biotechnol

Mechanistic Study of S100A8-mediated Ferroptosis in Vascular Dementia Through the JAK2/STAT3 Pathway. [Abstract]

2026 Jan 15. PMID: 41538098
Appl Biochem Biotechnol

OGT Silencing Protects against Trophoblast Ferroptosis in Gestational Diabetes Mellitus Via ELP3 O-GlcNAcylation Suppression. [Abstract]

2026 Jan 8. PMID: 41504842
Int J Biochem Cell Biol

Chromobox protein homolog 7 (CBX7) deficiency inhibits osteoblast ferroptosis by activating the Nrf2 function in type 2 diabetic osteoporosis. [Abstract]

2025 Dec:189:106866. PMID: 40998236
Exp Cell Res

PERK suppression induces susceptibility to ferroptosis in lupus nephritis. [Abstract]

2025 Aug 25;452(1):114725. PMID: 40865630
Mol Carcinog

M2 macrophage exosome-derived Apoc1 promotes ferroptosis resistance in osteosarcoma by inhibiting ACSF2 deubiquitination. [Abstract]

2024 Nov;63(11):2103-2118. PMID: 39041949
Cell Biol Int

METTL3 mediated ferroptosis in chondrocytes and promoted pain in KOA via HMGB1 m6A modification. [Abstract]

2024 Nov;48(11):1755-1765. PMID: 39129231
Cell Biol Int

Golgi protein ACBD3 downregulation sensitizes cells to ferroptosis. [Abstract]

2024 Oct;48(10):1559-1572. PMID: 38953242
Cancer Med

TRIM8 promotes ovarian cancer proliferation and migration by targeting VDAC2 for ubiquitination and degradation. [Abstract]

2024 Jun;13(11):e7396. PMID: 38881325
Int J Biochem Cell Biol

Protocadherin 20 promotes ferroptosis by suppressing the expression of Sirtuin 1 and promoting the acetylation of nuclear factor erythroid 2-related factor 2 in hepatocellular carcinoma. [Abstract]

2023 Mar:156:106363. PMID: 36641129
Cell Biol Int

Protective effect of rutin on ferroptosis-induced oxidative stress in aging laying hens through Nrf2/HO-1 signaling. [Abstract]

2023 Mar;47(3):598-611. PMID: 36378583
Arch Biochem Biophys

FAM98A promotes resistance to 5-fluorouracil in colorectal cancer by suppressing ferroptosis. [Abstract]

2022 Jun 15;722:109216. PMID: 35421356
Mol Cell Endocrinol

EGR1 promotes ferroptosis in endometriosis through transcriptional activation of HMOX1. [Abstract]

2026 Mar:613:112721. PMID: 41422938
J Cancer

SREBP1-SCD1 enhanced MUFAs Biosynthesis drives Nutrient Deprived Pancreatic cancer cell Ferroptosis Resistance. [Abstract]

2025 Sep 8;16(13):3960-3971. PMID: 41049011
Reproduction

METTL3-mediated m6A modification promotes ferroptosis in adenomyosis through GPX4 in a YTHDF1-dependent manner. [Abstract]

2025 Sep 19;170(4):e250251. PMID: 40911580
J Cancer

QiLing Decoction promotes ferroptosis of castration-resistant prostate cancer cells by inhibiting FSP1 in vitro and in vivo. [Abstract]

2023 Jul 16;14(12):2236-2245. PMID: 37576395
J Cancer

PERK/ATF3-Reduced ER Stress on high potassium environment in the suppression of tumor ferroptosis. [Abstract]

2023 May 15;14(8):1336-1349. PMID: 37283787
Front Oncol

Solasonine Causes Redox Imbalance and Mitochondrial Oxidative Stress of Ferroptosis in Lung Adenocarcinoma. [Abstract]

2022 May 18:12:874900. PMID: 35664792
Neuroscience

The protective effect of biochanin A on LPS/TNF-α-induced PD models is exerted by regulating ferroptosis through the Sirt1/Nrf2/GPX4 signaling pathway. [Abstract]

2026 Jun 22:605:91-107. PMID: 41999934
Animal Model Exp Med

IRF-1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α. [Abstract]

2026 Jun 16. PMID: 42299064
Chem Biol Drug Des

Dexmedetomidine Inhibits Ferroptosis by Regulating the SRY-Box Transcription Factor 9/Divalent Metal Transporter-1 Axis to Alleviate Cerebral Ischemia/Reperfusion Injury. [Abstract]

2025 Jan;105(1):e70022. PMID: 39757387
Mol Biol Rep

2026 Jul 10;53(1):1131. PMID: 42429998
Brain Res

MICU1 promotes Ca2+ homeostasis and curbs ferroptosis to attenuate brain tissue damage in rats with postoperative cognitive dysfunction. [Abstract]

2026 Feb 1:1872:150087. PMID: 41349812
Brain Res

Silencing of METTL14 attenuates experimental intracerebral hemorrhage by suppressing TFRC-mediated ferroptosis. [Abstract]

2025 Nov 1:1866:149927. PMID: 40907591
Food Chem Toxicol

Osthole inhibits proliferation and induces autophagy-dependent ferroptosis of cervical cancer cells through induction of TFR1. [Abstract]

2025 Sep:203:115577. PMID: 40446951
Adv Biol (Weinh)

Oncogenic miR-182-5p Targets NCOA4 to Disrupt the NCOA4-FTH1 Axis-Mediated Ferroptosis in Head and Neck Squamous Cell Carcinoma. [Abstract]

2025 Sep;9(9):e70000. PMID: 40464217
Animals (Basel)

Transcriptome and Proteome Analyses Revealed Differences in JEV-Infected PK-15 Cells in Response to Ferroptosis Agonists and Antagonists. [Abstract]

2024 Dec 5;14(23):3516. PMID: 39682481
Food Chem Toxicol

Ferroptosis is involved in quercetin-mediated alleviation of Ochratoxin A-induced kidney damage. [Abstract]

2024 Sep:191:114877. PMID: 39053875
Mol Cell Probes

A dual-labeling molecule for efficient drug discovery of mitochondrial-lysosomal interactions. [Abstract]

2024 Aug:76:101968. PMID: 38960210
Food Chem Toxicol

Fluorene-9-bisphenol exposure damages the testis in mice through a novel mechanism of ferroptosis. [Abstract]

2024 Feb:184:114385. PMID: 38123054
IUBMB Life

CPEB1 enhances erastin-induced ferroptosis in gastric cancer cells by suppressing twist1 expression. [Abstract]

2021 Sep;73(9):1180-1190. PMID: 34184391
Tissue Cell

2026 Jul 6;104(Pt 1):103757. PMID: 42456389
Immunopharmacol Immunotoxicol

2026 Jul 8:1-17. PMID: 42421290
Kaohsiung J Med Sci

Valproic Acid Inhibits Ferroptosis and Improves Bone Integration in OVX Rats Through the AMPK/SIRT1 Pathway. [Abstract]

2026 Feb 4:e70175. PMID: 41636120
Tissue Cell

USP7 represses ferroptosis in trophoblasts in pre-eclampsia by mediating the xCT/GPX4 axis via deubiquitination of NRF2. [Abstract]

2025 Dec:97:103050. PMID: 40774093
Placenta

HIF-2α / HILPDA promotes ferroptosis sensitivity in placenta trophoblast cells of early-onset preeclampsia. [Abstract]

2025 Dec 15:174:126-137. PMID: 41422655
Tissue Cell

Tempol suppresses ferroptosis and relieves chronic intermittent hypoxia-induced lung injury through the inhibition of TLR4 and activation of the Nrf2/GSH axis. [Abstract]

2026 Feb:98:103225. PMID: 41232311
Tissue Cell

Formononetin enhances angiogenesis in diabetic wounds by inhibiting ferroptosis through suppression of mtROS-mediated xCT/GPX4 upregulation. [Abstract]

2025 Sep 18:98:103141. PMID: 40992258
Tissue Cell

The interplay of sleep deprivation, ferroptosis, and BACH1 in cardiovascular disease pathogenesis. [Abstract]

2025 Aug:95:102848. PMID: 40081254
Free Radic Res

Apelin deficiency exacerbates cardiac injury following infarction by accelerating cardiomyocyte ferroptosis. [Abstract]

2024 Dec;58(12):854-867. PMID: 39731709
Epigenomics

LINC01232 promotes ARNTL2 transcriptional activation and inhibits ferroptosis of CRC cells through p300/H3K27ac. [Abstract]

2024;16(15-16):1097-1115. PMID: 39268727
Exp Eye Res

Effects of amygdalin on ferroptosis and oxidative stress in diabetic retinopathy progression via the NRF2/ARE signaling pathway. [Abstract]

2023 Sep:234:109569. PMID: 37422064
Am J Cancer Res

SIRT6 drives sensitivity to ferroptosis in anaplastic thyroid cancer through NCOA4-dependent autophagy. [Abstract]

2023 Feb 15;13(2):464-474. PMID: 36895980
Life Sci Alliance

Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis. [Abstract]

2022 Nov 1;6(1):e202201667. PMID: 36319062
Am J Cancer Res

Abrogation of ARF6 promotes RSL3-induced ferroptosis and mitigates gemcitabine resistance in pancreatic cancer cells. [Abstract]

2020 Apr 1;10(4):1182-1193. PMID: 32368394
Haemophilia

Inhibition of CIRBP as a Novel Strategy to Alleviate Chondrocyte Ferroptosis in Haemophilic Arthropathy. [Abstract]

2025 Dec 22. PMID: 41427808
J Cell Biochem

SPI1 Regulates Autophagy by Promoting ATG7 Transcription to Enhance Ferroptosis in Myocardial Ischemia/Reperfusion Injury. [Abstract]

2025 Dec;126(12):e70078. PMID: 41363097
Cell Biochem Biophys

T-Box Transcription Factor 2 Mediates Chemoresistance of Endometrial Cancer via Regulating FSP1-involved Ferroptosis. [Abstract]

2025 Mar;83(1):1313-1320. PMID: 39325362
Front Cardiovasc Med

miR-135b-3p Promotes Cardiomyocyte Ferroptosis by Targeting GPX4 and Aggravates Myocardial Ischemia/Reperfusion Injury. [Abstract]

2021 Aug 13;8:663832. PMID: 34485394
Theriogenology

Regulation of autophagy-Ferroptosis crosstalk by the SLC7A11-GPX4 axis during sperm capacitation. [Abstract]

2026 Apr 1:254:117795. PMID: 41483535
Chem Biodivers

Rhein-Emodin Combination Activates UQCRC1 to Attenuate MPP+-Induced Ferroptosis in Dopaminergic Neurons. [Abstract]

2026 Mar;23(3):e02053. PMID: 41838561
Biochim Biophys Acta Gen Subj

IRF1 transcriptionally activates ALOX15B to enhance ferroptosis sensitivity in triple-negative breast cancer. [Abstract]

2025 Sep;1869(10):130846. PMID: 40749811
Biomed Res Int

Pyridoxal Isonicotinoyl Hydrazone Improves Neurological Recovery by Attenuating Ferroptosis and Inflammation in Cerebral Hemorrhagic Mice. [Abstract]

2021 Sep 8;2021:9916328. PMID: 34541001
Int J Immunopathol Pharmacol

Shikonin improves intestinal barrier function through modulation of GPX4 expression in intestinal epithelial cells. [Abstract]

2026 Jan-Dec:40:3946320261427239. PMID: 41747744
Reprod Sci

SPI1 Transcriptional Activates TXNRD1 to Protect Trophoblast Cell from Ferroptosis. [Abstract]

2025 Aug 18. PMID: 40826214
Discov Oncol

The role of RAB GTPases in predicting prognosis and therapy response in pancreatic cancer. [Abstract]

2025 Jul 21;16(1):1383. PMID: 40690079
Toxicon

18beta-glycyrrhetinic acid alleviates deoxynivalenol-induced hepatotoxicity by inhibiting GPX4-dependent ferroptosis. [Abstract]

2025 Feb:255:108228. PMID: 39798898
Vet Microbiol

Brucella rough RB51 infection activates P53-Slc7a11-Gpx4/GSH pathway to induce ferroptosis to attenuate the intracellular survival on macrophages. [Abstract]

2024 Nov:298:110224. PMID: 39153287
Discov Oncol

TMSB4X is a regulator of inflammation-associated ferroptosis, and promotes the proliferation, migration and invasion of hepatocellular carcinoma cells. [Abstract]

2024 Nov 18;15(1):671. PMID: 39556271
PLoS One

Curcumin suppresses tumorigenesis by ferroptosis in breast cancer. [Abstract]

2022 Jan 18;17(1):e0261370. PMID: 35041678
Gene

Menaquinone-4 ameliorates abdominal aortic aneurysm by suppressing ferroptosis through NRF2/GCLM axis. [Abstract]

2025 Oct 20:970:149785. PMID: 40992546
Fundam Clin Pharmacol

Knockdown of RFC3 enhances the sensitivity of colon cancer cells to oxaliplatin by inducing ferroptosis. [Abstract]

2025 Feb;39(1):e13044. PMID: 39749364
Gene

Enhancing vulnerability of Afatinib using Erastin via xCT-mediated ROS/P38MAPK signaling feedback loop in gastric cancer cells. [Abstract]

2023 Jul 15:873:147468. PMID: 37169154

Erastin purchased from MedChemExpress. Usage Cited in: Gene. 2023 Jul 15:873:147468. [Abstract]

Erastin (8 μM; 48 h) greatly induces apoptosis and cell death in AGS and BGC-823 cells.

Erastin purchased from MedChemExpress. Usage Cited in: Gene. 2023 Jul 15:873:147468. [Abstract]

Erastin (8, 16 μM; 48 h) reduces the expression of xCT in AGS and BGC-823 cells.
Photodiagnosis Photodyn Ther

5-ALA-PDT induced ferroptosis in keloid fibroblasts via ROS, accompanied by downregulation of xCT, GPX4. [Abstract]

2023 Jun:42:103612. PMID: 37220842
Photodiagnosis Photodyn Ther

YAP knockdown in combination with ferroptosis induction increases the sensitivity of HOS human osteosarcoma cells to pyropheophorbide-α methyl ester-mediated photodynamic therapy. [Abstract]

2022 Sep:39:102964. PMID: 35705143
Shock

Etomidate Attenuates the Ferroptosis in Myocardial Ischemia/Reperfusion Rat Model via Nrf2/HO-1 Pathway. [Abstract]

2021 Sep 1;56(3):440-449. PMID: 34091586
J Mol Histol

APMAP regulated by YY1 transcription mediates ferroptosis and metastasis in non-small cell lung cancer through the PI3K/AKT/mTOR pathway. [Abstract]

2026 Jan 7;57(1):27. PMID: 41495322
Hereditas

The synergistic antitumor effects of psoralidin and cisplatin in gastric cancer by inducing ACSL4-mediated ferroptosis. [Abstract]

2025 Nov 4;162(1):223. PMID: 41188993
Hereditas

Inhibition of ferroptosis-related NCF2 blocks the progression of lupus nephritis by activating PPARα pathway. [Abstract]

2025 Oct 1;162(1):201. PMID: 41035016
J Mol Histol

The effect of USP17 knockdown on autophagic ferroptosis in gastric cancer by regulating the BNIP3-NCOA4-FTH1 axis. [Abstract]

2025 Jul 31;56(4):245. PMID: 40742478
J Mol Histol

Decoding phillygenin's dual attack on breast cancer: ferroptosis induction and immune evasion suppression. [Abstract]

2025 Jul 22;56(4):234. PMID: 40694249
Ital J Anim Sci

2024 Dec 27.
J Chem Neuroanat

Ozone-Mediated Cerebral Protection: Unraveling the Mechanism through Ferroptosis and the NRF2/SLC7A11/GPX4 Signaling Pathway. [Abstract]

2024 Mar:136:102387. PMID: 38182039
DNA Cell Biol

Effect of the Mitogen-Activated Protein Kinase Pathway on the Erastin-Induced Ferroptosis of Molt-4 Cells. [Abstract]

2023 Jun;42(6):348-356. PMID: 37140570
DNA Cell Biol

ZNF8-miR-552-5p Axis Modulates ACSL4-Mediated Ferroptosis in Hepatocellular Carcinoma. [Abstract]

2023 Jun;42(6):336-347. PMID: 37126948
Biochem Biophys Res Commun

Natural exosome-like nanovesicles from Smilax China rhizome induce mitophagy-dependent ferroptosis in hepatocellular carcinoma via GPX4/ACSL4 axis. [Abstract]

2026 Feb 12:800:153270. PMID: 41529459
Biochem Biophys Res Commun

YBX1 contributes to lung adenocarcinoma progression and is associated with ferroptosis-related changes via the PI3K/AKT/mTOR pathway. [Abstract]

2026 Jan 8:795:153109. PMID: 41389617
J Physiol Pharmacol

Etomidate ameliorates ferroptosis and mitochondrial damage in myocardial ischemia/reperfusion injury. [Abstract]

2025 Feb;76(1). PMID: 40137844
Biochem Biophys Res Commun

Network pharmacology, molecular docking and experimental study on the mechanism of Curcumin's anti-ferroptosis in melanocytes. [Abstract]

2024 Dec 3:736:150871. PMID: 39461013
Korean J Physiol Pharmacol

Salidroside attenuates sepsis-induced acute lung injury by inhibiting ferroptosis-dependent pathway. [Abstract]

2024 Nov 1;28(6):549-558. PMID: 39467718
Biochem Biophys Res Commun

Icariin alleviates cellular injury induced by cardiac ischemia-reperfusion injury by inhibiting IRE1/JNK-induced ferroptosis. [Abstract]

2024 Nov 12:733:150716. PMID: 39321486
Cancer Chemother Pharmacol

A polo-like kinase 1 inhibitor enhances erastin sensitivity in head and neck squamous cell carcinoma cells in vitro. [Abstract]

2024 Aug;94(2):183-195. PMID: 38536443
Biochem Biophys Res Commun

The anti-atherosclerotic effect of Paeonol against the lipid accumulation in macrophage-derived foam cells by inhibiting ferroptosis via the SIRT1/NRF2/GPX4 signaling pathway. [Abstract]

2024 May 14:708:149788. PMID: 38518720
Biochem Biophys Res Commun

Non-cytotoxic nanomolar concentration of arctigenin protects neuronal cells from chemotherapy-induced ferroptosis by regulating SLC7A11-cystine-cysteine axis. [Abstract]

2024 May 28:710:149895. PMID: 38593620
Biochem Biophys Res Commun

Puerarin reduces cell damage from cerebral ischemia-reperfusion by inhibiting ferroptosis. [Abstract]

2024 Jan 22:693:149324. PMID: 38101001
Clin Cosmet Investig Dermatol

Variation of Ferroptosis-Related Markers in HaCaT Cell Photoaging Models Induced by UVB. [Abstract]

2023 Nov 1:16:3147-3155. PMID: 37937317
Biochem Biophys Res Commun

2, 2-dimethylthiazolidine hydrochloride protects against experimental contrast-induced acute kidney injury via inhibition of tubular ferroptosis. [Abstract]

2023 Oct 30:679:15-22. PMID: 37659274
Biochem Biophys Res Commun

miR-491-5p regulates the susceptibility of glioblastoma to ferroptosis through TP53. [Abstract]

2023 Sep 3:671:309-317. PMID: 37327702
Mol Imaging Biol

The Detection of Divalent Iron and Reactive Oxygen Species During Ferroptosis with the Use of a Dual-Reaction Turn-On Fluorescent Probe. [Abstract]

2023 Apr;25(2):423-434. PMID: 36195741
Biochem Biophys Res Commun

ACSL4 is overexpressed in psoriasis and enhances inflammatory responses by activating ferroptosis. [Abstract]

2022 Oct 1:623:1-8. PMID: 35868067
Biochem Biophys Res Commun

Targeting FAM134B-mediated reticulophagy activates sorafenib-induced ferroptosis in hepatocellular carcinoma. [Abstract]

2022 Jan 22:589:247-253. PMID: 34929448
Biochem Biophys Res Commun

Atorvastatin treatment ameliorates cardiac function and remodeling induced by isoproterenol attack through mitigation of ferroptosis. [Abstract]

2021 Oct 15:574:39-47. PMID: 34438345
Biochem Biophys Res Commun

Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt's Lymphoma. [Abstract]

2019 Nov 12;519(3):533-539. PMID: 31537387
Onco Targets Ther

Icariin Inhibits Lung Adenocarcinoma Progression Through TP53-Mediated Ferroptosis. [Abstract]

2025 Nov 15:18:1281-1298. PMID: 41268535
Int J Gen Med

2026 Jul 10:19:612496. PMID: 42445556
Int J Gen Med

Phosphoglycerate Dehydrogenase Overexpression Inhibits Ferroptosis to Repress Calcification of Human Coronary Artery Vascular Smooth Muscle Cells via the P53/SLC7A11 Pathway. [Abstract]

2024 Aug 24:17:3673-3687. PMID: 39206267
Ann Hematol

Ferroptosis: a new target for iron overload-induced hemophilic arthropathy synovitis. [Abstract]

2023 May;102(5):1229-1237. PMID: 36951967
Cytotechnology

Liquid-liquid phase separation of TRIM21 regulates EZH2-mediated ferroptosis to facilitate hepatocellular carcinoma progression. [Abstract]

2026 Jun;78(3):100. PMID: 42079301
Mol Genet Genomics

PTK6 suppresses NSCLC ferroptosis by promoting m6A-YTHDF2-dependent FOXO3 mRNA degradation through phosphorylation. [Abstract]

2026 Apr 24;301(1):101. PMID: 42029771
Exp Ther Med

Ginsenoside Re attenuates homocysteine-induced endothelial cell ferroptosis through upregulation of GPX4/xCT signaling. [Abstract]

2025 Nov 21;31(1):27. PMID: 41356750
Cytotechnology

Naringin regulates the cGAS-STING pathway to improve mitochondrial dysfunction and ferroptosis after myocardial ischemia-reperfusion injury. [Abstract]

2025 Jun;77(3):103. PMID: 40384845
Head Neck

iPLA2β regulates the dual effects of arachidonic acid in thyroid cancer. [Abstract]

2025 Feb;47(2):504-516. PMID: 39290130
Neurosci Lett

Effects of ligustrazine on energy metabolism in migraine rats based on mitochondria-inflammation pathway. [Abstract]

2025 Jan 1:844:138035. PMID: 39505199
Biochem Cell Biol

NDUFA4 promotes the progression of head and neck paraganglioma by inhibiting ferroptosis. [Abstract]

2023 Dec 1;101(6):523-530. PMID: 37602474
Exp Ther Med

Xanthohumol attenuates renal ischemia/reperfusion injury by inhibiting ferroptosis. [Abstract]

2023 Oct 24;26(6):571. PMID: 37954118
Exp Ther Med

ChaC glutathione specific γ-glutamylcyclotransferase 1 inhibits cell viability and increases the sensitivity of prostate cancer cells to docetaxel by inducing endoplasmic reticulum stress and ferroptosis. [Abstract]

2021 Sep;22(3):997. PMID: 34345279
Lasers Surg Med

Study on the Synergistic Mechanism of Photodynamic Therapy Combined With Ferroptosis Inducer to Induce Ferroptosis in Cholangiocarcinoma. [Abstract]

2024 Dec;56(10):845-853. PMID: 39468974
Nephrology (Carlton)

2026 Jul;31(7):e70246. PMID: 42464422
Exp Anim

Diacerein alleviates endometrial fibrosis in an intrauterine adhesion model via ferroptosis inhibition. [Abstract]

2026 May 2. PMID: 42091527
In Vitro Cell Dev Biol Anim

Atorvastatin inhibits ischemia‒reperfusion-associated renal tubular cell ferroptosis by blocking the PGE2/EP4 signaling pathway. [Abstract]

2025 Mar;61(3):275-287. PMID: 39920560
Hematology

Circ_0000745 promotes acute lymphoblastic leukemia progression through mediating miR-494-3p/NET1 axis. [Abstract]

2022 Dec;27(1):11-22. PMID: 34957935
In Vitro Cell Dev Biol Anim

ACOT7 protects epidermal stem cells against lipid peroxidation. [Abstract]

2022 Aug;58(7):549-557. PMID: 36036847
Endocr Res

2026 Aug;51(3):178-192. PMID: 42381366
Neurol Res

METTL3 improves spinal cord injury-associated locomotor function via SIRT1 m6A modification and regulation of neuronal ferroptosis. [Abstract]

2025 Nov 7:1-21. PMID: 41200754
Growth Factors

VEGF ameliorates acute kidney injury by suppressing ferroptosis through activation of the ERK1/2-NRF2 pathway. [Abstract]

2025 Jul 22:1-11. PMID: 40694052
In Vivo

Mitochondrial Damage-induced Ferroptosis: The Molecular Mechanism by Which Psoralen Inhibits the Proliferation and Invasion of Non-small-cell Lung Cancer Cells. [Abstract]

2025 Sep-Oct;39(5):2681-2702. PMID: 40877163
Scand J Gastroenterol

Lysine acetyltransferase KAT2A modulates ferroptosis during colorectal cancer development. [Abstract]

2024 Apr;59(4):437-444. PMID: 38258976
Rejuvenation Res

Tangzhiqing-mediated NRF2 reduces autophagy-dependent ferroptosis to mitigate diabetes-related cognitive impairment neuronal damage. [Abstract]

2023 Jun 6. PMID: 37279293
Biol Pharm Bull

Puerarin protects against myocardial ischemia/reperfusion injury by inhibiting ferroptosis. [Abstract]

2023 Apr 1;46(4):524-532. PMID: 36696989
Biol Pharm Bull

Gastrodin Inhibits H2O2-Induced Ferroptosis through Its Antioxidative Effect in Rat Glioma Cell Line C6. [Abstract]

2020;43(3):480-487. PMID: 32115506
Curr Eye Res

HMOX1 Promotes Ferroptosis Induced by Erastin in Lens Epithelial Cell through Modulates Fe2+ Production. [Abstract]

2023 Jan;48(1):25-33. PMID: 36300537
Microbiol Immunol

Competitive Binding of Pseudomonas aeruginosa to Kelch-Like ECH-Associated Protein 1 Inhibits Nuclear Factor Erythroid 2-Related Factor 2 Ubiquitination and Suppresses Ferroptosis in Macrophages. [Abstract]

2025 Aug;69(8):418-428. PMID: 40468416
Biotech Histochem

Downregulation of acetyl-CoA carboxylase induces ferroptosis and inhibits tumor growth in oral squamous cell carcinoma. [Abstract]

2025 Sep 12:1-9. PMID: 40937588
Mol Cell Toxicol

2022.
Scienceasia

2024 Apr 13.
Masaryk University

2026.
bioRxiv

2026 May 31.
SSRN

2026 May 15.
SSRN

2026 Mar 6.
Res Sq

2026 Mar 10.
bioRxiv

2026 Mar 16.
Res Sq

2026 Mar 5.
bioRxiv

2026 Mar 31.
SSRN

2026 Mar 20.
SSRN

2026 Feb 3.
bioRxiv

2026 Feb 11.
bioRxiv

2026 Jan 21.
Biomed Pharmacother

As a novel ferroptosis inhibitor, primaquine alleviates I/R-induced retinal neuron death via increasing GSTA1 activity. [Abstract]

2026 Feb:195:118973. PMID: 41529513
Res Sq

2026 Jan 15.
SSRN

2025 Dec 2.
Res Sq

2025 Dec 3.
Seoul National University

2026.
Res Sq

Acid ceramidase modulates the lipid profile and exacerbates sensitivity to ferroptosis in senescent cells. [Abstract]

2025 Nov 28:rs.3.rs-8117957. PMID: 41356368
Res Sq

2025 Oct 28.
SSRN

2025 Nov 25.
bioRxiv

2025 Oct 3.
Res Sq

2025 Oct 6.
Authorea

2025 Sep 13.
Res Sq

2025 Sep 9.
Polytechnic University of Valencia

2025.
SSRN

2025 Sep 12.
University of Kentucky

2025.
SSRN

2025 Jul 25.
bioRxiv

2025 July 11.
Res Sq

2025 Apr 20.
Authorea

2025 Apr 18.
SSRN

2025 Jan 14.
bioRxiv

2025 March 18.
J Tradit Chin Med Sci

2025 Mar 12.
bioRxiv

2025 March 15.
Journal of Biophysical Chemistry

2025 Feb.
SSRN

2025 Jan 8.
Research Square Preprint

2024 Oct 24.
Res Sq

2024 Sep 02.
Res Sq

2024 Oct 27.
Heliyon

REV-ERBα inhibitor rescues MPTP/MPP+-induced ferroptosis of dopaminergic neuron through regulating FASN/SCD1 signaling pathway. [Abstract]

2024 Nov 15;10(23):e40388. PMID: 39654780
bioRxiv

Catabolism of extracellular glutathione supplies amino acids to support tumor growth. [Abstract]

2024 Oct 13:2024.10.10.617667. PMID: 39416022
Sci Total Environ

Voltage-dependent anion channel 1 mediates mitochondrial fission and glucose metabolic reprogramming in response to ionizing radiation. [Abstract]

2024 Oct 10:946:174246. PMID: 38955266
Heliyon

Cigarette smoke extract induces ferroptosis in human retinal pigment epithelial cells. [Abstract]

2024 Sep 24;10(20):e38151. PMID: 39498038
bioRxiv

2024 July 23.
Biomed Pharmacother

Berberine as a novel ACSL4 inhibitor to suppress endothelial ferroptosis and atherosclerosis. [Abstract]

2024 Aug:177:117081. PMID: 38971008
Biomed Pharmacother

Erastin promotes random-pattern skin flaps survival by inducing mTORC1-TFEB mediated autophagy. [Abstract]

2024 Aug:177:116918. PMID: 38878639
SSRN

2024 Jul 12.
SSRN

2024 Jul 16.
Environ Toxicol

Functional mechanism of hypoxia-like conditions mediating resistance to ferroptosis in cervical cancer cells by regulating KDM4A SUMOylation and the SLC7A11/GPX4 pathway. [Abstract]

2024 Aug;39(8):4207-4220. PMID: 38727079
Curr Res Pharmacol Drug Discov

Ferroptosis induces nucleolar stress as revealed by live-cell imaging using thioflavin T. [Abstract]

2024 Jul 8:7:100196. PMID: 39077682
Patent

US20240209353A1.
biorxiv

2024 May 27.
Biomed Pharmacother

Alpha-tocopherol inhibits ferroptosis and promotes neural function recovery in rats with spinal cord injury via downregulating Alox15. [Abstract]

2024 Jun:175:116734. PMID: 38754264
Biomed Pharmacother

Mastoparan M promotes functional recovery in stroke mice by activating autophagy and inhibiting ferroptosis. [Abstract]

2024 May:174:116560. PMID: 38583338
Heliyon

2024 Apr 26.
Biomed Pharmacother

Epigallocatechin-3-gallate confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis, apoptosis, and autophagy via modulation of 14-3-3η. [Abstract]

2024 May:174:116542. PMID: 38574620
bioRxiv

Epithelial heme oxygenase-1 enhances colonic tumorigenesis by inhibiting ferroptosis. [Abstract]

2024 Mar 8:2024.03.06.583112. PMID: 38496569
Heliyon

Artesunate induces ferroptosis by regulating MT1G and has an additive effect with doxorubicin in diffuse large B-cell lymphoma cells. [Abstract]

2024 Mar 22;10(7):e28584. PMID: 38560249
Research Square Preprint

2024 Feb 2.
Research Square Preprint

2024 Feb 20.
bioRxiv

Identifying Ferroptosis Inducers, HDAC, and RTK Inhibitor Sensitivity in Melanoma Subtypes through Unbiased Drug Target Prediction. [Abstract]

2024 Feb 12:2024.02.08.579424. PMID: 38545623
Heliyon

YAP promotes the healing of ischemic wounds by reducing ferroptosis in skin fibroblasts through inhibition of ferritinophagy. [Abstract]

2024 Jan 16;10(2):e24602. PMID: 38298641
Research Square Preprint

2023 Dec 4.
Research Square Preprint

2023 Nov 3.
Research Square Preprint

2023 Oct 6.
Research Square Preprint

2023 Sep 18.
Biomed Pharmacother

Ozone pretreatment alleviates ischemiareperfusion injury-induced myocardial ferroptosis by activating the Nrf2/Slc7a11/Gpx4 axis. [Abstract]

2023 Sep:165:115185. PMID: 37487441
Sci Total Environ

Chronic arsenic exposure induces ferroptosis via enhancing ferritinophagy in chicken livers. [Abstract]

2023 Sep 10:890:164172. PMID: 37201840
Research Square Preprint

2023 Aug 3.
bioRxiv

2023 Jul 3.
Research Square Preprint

2023 May 29.
Research Square Preprint

2023 Jun 2.
Comput Biol Med

Bioinformatics analysis of ferroptosis-related gene AKR1C3 as a potential biomarker of asthma and its identification in BEAS-2B cells. [Abstract]

2023 May:158:106740. PMID: 36996663
Biomed Pharmacother

AAV9-HGF cooperating with TGF-beta/Smad inhibitor attenuates silicosis fibrosis via inhibiting ferroptosis. [Abstract]

2023 May:161:114537. PMID: 36933378
Research Square Preprint

2023 Apr 13.
SSRN

2023 Apr 24.
bioRxiv

2023 Jan 26.
Oxid Med Cell Longev

Carbonic Anhydrase IX Controls Vulnerability to Ferroptosis in Gefitinib-Resistant Lung Cancer. [Abstract]

2023 Jan 31:2023:1367938. PMID: 36760347
Oxid Med Cell Longev

Energy-Stress-Mediated AMPK Activation Promotes GPX4-Dependent Ferroptosis through the JAK2/STAT3/P53 Axis in Renal Cancer. [Abstract]

2022 Oct 4:2022:2353115. PMID: 36246395
Research Square Print

September 1st, 2022.
Research Square Print

September 2nd, 2022.
Research Square Preprint

2022 Jul.
Research Square Print

2022 Jul.
Oxid Med Cell Longev

Vitamin C Sensitizes Pancreatic Cancer Cells to Erastin-Induced Ferroptosis by Activating the AMPK/Nrf2/HMOX1 Pathway. [Abstract]

2022 Jul 19:2022:5361241. PMID: 35915609
Research Square Print

2022 Jul.
Oxid Med Cell Longev

Treadmill Training Reduces Cerebral Ischemia-Reperfusion Injury by Inhibiting Ferroptosis through Activation of SLC7A11/GPX4. [Abstract]

2022 Jun 6:2022:8693664. PMID: 35707270
Oxid Med Cell Longev

Transcriptional Patterns of Lower-Grade Glioma Patients with Distinct Ferroptosis Levels, Immunotherapy Response, and Temozolomide Sensitivity. [Abstract]

2022 May 10;2022:9408886. PMID: 35592529
Oxid Med Cell Longev

Ferroptosis Induction Improves the Sensitivity of Docetaxel in Prostate Cancer. [Abstract]

2022 May 24:2022:4930643. PMID: 39282153
Oxid Med Cell Longev

Sorting Nexin 5 Plays an Important Role in Promoting Ferroptosis in Parkinson's Disease. [Abstract]

2022 May 5;2022:5463134. PMID: 35571244
J Oncol

Identification of a Ferroptosis-Related Prognostic Gene PTGS2 Based on Risk Modeling and Immune Microenvironment of Early-Stage Cervical Cancer. [Abstract]

2022 Apr 8:2022:3997562. PMID: 35432535
Bioengineered

Platycodin D regulates high glucose-induced ferroptosis of HK-2 cells through glutathione peroxidase 4 (GPX4). [Abstract]

2022 Mar;13(3):6627-6637. PMID: 35226829
Oxid Med Cell Longev

Ferritinophagy-Mediated Ferroptosis and Activation of Keap1/Nrf2/HO-1 Pathway Were Conducive to EMT Inhibition of Gastric Cancer Cells in Action of 2,2'-Di-pyridineketone Hydrazone Dithiocarbamate Butyric Acid Ester. [Abstract]

2022 Feb 21:2022:3920664. PMID: 35237380
Environ Toxicol

Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis. [Abstract]

2022 Feb;37(2):192-200. PMID: 34661962
Research Square Preprint

2021 Dec.
Research Square Preprint

2021 Nov.
Oxid Med Cell Longev

Effect and Mechanism of LRP6 on Cardiac Myocyte Ferroptosis in Myocardial Infarction. [Abstract]

2021 Oct 19:2021:8963987. PMID: 34712388
Research Square Preprint

2021 Jul.
Research Square Preprint

2021 Jul.
Research Square Preprint

2021 May.
Oxid Med Cell Longev

Stearoyl-CoA Desaturase 1 Potentiates Hypoxic plus Nutrient-Deprived Pancreatic Cancer Cell Ferroptosis Resistance. [Abstract]

2021 Apr 1:2021:6629804. PMID: 33868572
Research Square Preprint

2021 Apr.
Research Square Preprint

2021 Jan.
bioRxiv

2020 Dec 14.
Eur Rev Med Pharmacol Sci

Circular RNA TTBK2 regulates cell proliferation, invasion and ferroptosis via miR-761/ITGB8 axis in glioma. [Abstract]

2020 Mar;24(5):2585-2600. PMID: 32196629
bioRxiv

2019 Oct.
bioRxiv

2019 Oct 28.

Solvente y solubilidad

In Vitro:

DMSO : 12.5 mg/mL (22.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8280 mL

9.1401 mL

18.2802 mL

5 mM

0.3656 mL

1.8280 mL

3.6560 mL

10 mM

0.1828 mL

0.9140 mL

1.8280 mL

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1.25 mg/mL (2.29 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 1 mg/mL (1.83 mM); Clear solution

This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
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RP-HPLC (2659 KB)
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OR (2659 KB)
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Referencias

[1]. Li Y, et al. Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis. Hum Reprod. 2021 Mar 18;36(4):951-964. [Content Brief]

[2]. Huo H, et al. Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells. PLoS One. 2016 May 12;11(5):e0154605. [Content Brief]

[3]. Xie Y, et al. Ferroptosis: process and function. Cell Death Differ. 2016 Mar;23(3):369-79. [Content Brief]

[4]. Gai C, et al. MT1DP loaded by folate-modified liposomes sensitizes erastin-induced ferroptosis via regulating miR-365a-3p/NRF2 axis in non-small cell lung cancer cells. Cell Death Dis. 2020 Sep 14;11(9):751. [Content Brief]

[5]. Yang Y, et al. Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin. Antioxidants (Basel). 2022 Apr 4;11(4):710. [Content Brief]

[6]. Liu N, et al., Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance. Br J Cancer. 2020 Jan;122(2):279-292. [Content Brief]

[7]. Romani P, et al., Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance. Nat Cell Biol. 2022 Feb;24(2):168-180. [Content Brief]

[8]. Chen T, et al., Mitochondrial transplantation rescues neuronal cells from ferroptosis. Free Radic Biol Med. 2023 Nov 1;208:62-72. [Content Brief]

[9]. Zhu JF, et al., Ibrutinib facilitates the sensitivity of colorectal cancer cells to ferroptosis through BTK/NRF2 pathway. Cell Death Dis. 2023 Feb 23;14(2):151. [Content Brief]

[10]. Xie Y, et al., The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. Cell Rep. 2017 Aug 15;20(7):1692-1704. [Content Brief]

[11]. Doll S, et al., FSP1 is a glutathione-independent ferroptosis suppressor. Nature. 2019 Nov;575(7784):693-698. [Content Brief]

[12]. Li P, et al., Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism. Cell Death Dis. 2022 Sep 21;13(9):808. [Content Brief]

[13]. Zheng J, et al., Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines. Cell Death Dis. 2021 Jul 13;12(7):698. [Content Brief]

[14]. Wang J, et al. Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels[J]. Oncogenesis, 2024, 13(1): 31. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8280 mL	9.1401 mL	18.2802 mL	45.7005 mL
	5 mM	0.3656 mL	1.8280 mL	3.6560 mL	9.1401 mL
	10 mM	0.1828 mL	0.9140 mL	1.8280 mL	4.5700 mL
	15 mM	0.1219 mL	0.6093 mL	1.2187 mL	3.0467 mL
	20 mM	0.0914 mL	0.4570 mL	0.9140 mL	2.2850 mL

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Erastin

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Erastin

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