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PD98059

407 Cited Publications
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Based on 407 publication(s) in Google Scholar

PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 µM) and MEK2 (IC50 of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 μM) and AHR transformation (IC50 of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy.

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  • Pureza: 99.27%
  • No. CAS: 167869-21-8
  • Fòrmula: C16H13NO3
  • Peso molecular:267.28
  • Almacenamiento:

    4°C, protect from light

    * In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

  • PD98059 Chemical Structure
    PD98059 Chemical Structure
  • Experimental Validation Results for PD98059
  • Experimental Validation Results for PD98059
  • Experimental Validation Results for PD98059
  • Experimental Validation Results for PD98059
  • Experimental Validation Results for PD98059
  • Experimental Validation Results for PD98059
  • Experimental Validation Results for PD98059
  • Experimental Validation Results for PD98059
  • Experimental Validation Results for PD98059
  • Experimental Validation Results for PD98059
  • Experimental Validation Results for PD98059
  • Experimental Validation Results for PD98059
  • Experimental Validation Results for PD98059
  • Experimental Validation Results for PD98059
  • Experimental Validation Results for PD98059
  • Experimental Validation Results for PD98059
  • Experimental Validation Results for PD98059
  • Experimental Validation Results for PD98059
  • Experimental Validation Results for PD98059
No. CAS: 167869-21-8
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  • PD98059 Chemical Structure
    PD98059 Chemical Structure
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  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 10;16(1):576. [Abstract]

    Customer Validation
     CSA of iAMs after AngII exposure in the presence or absence of the ERK-pathway inhibitor PD98059 (50 µM; pretreatment for 2h), with and without EF-1 (32 µM, n = 20 cell areas for all groups). The results showed that the anti-hypertrophic effect of EF-1 was blocked following inhibition of the ERK1/2 pathway by PD98059.

  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 Mar:116:109763. [Abstract]

    Customer Validation
     PD98059 (0,10,30 μM; 24 h) inhibits the expression of p-ERK, Nrf2, Hif-1α, and IL-17D in NCM460 cells.

  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2019 Apr:22:101133. [Abstract]

    Customer Validation
     The effects of inhibitor PD98059 on the phosphorylated-ERK1/2, total ERK1/2, Thr181-phosphorylated tau, Thr205-phosphorylated tau, total tau and ROS production in different groups with or without Aβ25-35/FGF21.

  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: Mol Cell. 2018 Feb 1;69(3):480-492.e7. [Abstract]

    Customer Validation
     ERK is important for Nur77 phosphorylation. MV3 cells are pretreated with different kinase inhibitors (PD98059, 40 μM; SB202190, 20 μM; SP600125, 25 μM) before 3 hr of glucose starvation.

  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: World J Gastroenterol. 2018 Feb 21;24(7):819-832. [Abstract]

    Customer Validation
     HSCs are pretreated with AICAR (500 μM), LY294002 (20 μM), PD98059 (10 μM), or Rapamycin (100 nM) for 2 h and then incubated with or without CoCl2 (150 μM) for 12 h. Expression levels of HIF-1α and VEGF are measured by Western blot analysis;

  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2018 Jun 27;66(25):6317-6325. [Abstract]

    Customer Validation
     HepG2 cells are pre-incubated with 20 µM SB203580, SP600125 and PD98059 for 1 h and then treated with tangeretin(20µM) for 24 h.

  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2018 Mar;75(6):1117-1132. [Abstract]

    Customer Validation
     Sertoli cells (SC) are pretreated with the PD98059 for 1 h followed by a 24-h treatment with MC-LR. Expression levels of MMP-8, c-Jun, c-Fos, p-ERK, ERK, p-JNK, and JNK are determined by western blotting.

  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2018 Jul;75(14):2627-2641. [Abstract]

    Customer Validation
     RAW264.7 macrophages are pre-treated with the inhibitor of ERK, JNK, P38, P65, and AKT signal pathway.Western blot analyzes the non- and phosphorylation of ERK, JNK, P38, P65, and AKT.

  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: Toxicology. 2018 Dec 1:410:222-230. [Abstract]

    Customer Validation
     SH-SY5Y cells are pretreated with MEK inhibitor PD98059 (10 μM) for 1 h, then incubated with NaF (60 mg/L) for 24 h. Representative images of western blotting for BDNF, TrkB and p-ERK1/2 in SH-SY5Y cells.

  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: Sci Rep. 2018 Feb 12;8(1):2848. [Abstract]

    Customer Validation
     The expression of EGFR, p-EGFR, ERK, p-ERK and FOS in four groups (from left to right: 50 μM PD98059, 30 min; control; pretreatment with 50 μM PD98059, 30 min, then intervened with 0.1 mg/L BER 15 min; 0.1 mg/L BER for 15 min) are examined using western blot.

  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: Mol Cell Biochem. 2018 Feb;439(1-2):117-129. [Abstract]

    Customer Validation
     Protein expression levels of E-cadherin N-cadherin, p-ERK, ERK, TGF-β1, p-Smad2, and p-Smad3 in each group are analyzed by western blotting.

  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: Mol Oncol. 2018 Mar;12(3):305-321. [Abstract]

    Customer Validation
     Western blot analysis of the expression level of EGFR, Sp1, total and phosphorylated Erk1/2 proteins in cell lysates from two breast cancer cells pretreated with PD98059 and then stimulated with TGF-β for the indicated times

  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Jan 1;495(1):781-786. [Abstract]

    Customer Validation
     Representative images of migrated cells. HUVECs are pretreated with PD98059 (10 μM), SCH772984 (500 nM) or mock control for 2 h, and seeded in upper chambers of transwell inserts. VEGF (100 ng/ml), Scg3 (1 μg/ml) or PBS in medium with reduced FBS is added to bottom chambers in the presence or absence of the inhibitor. After culturing for 4 or 20 h, cells migrated to the lower surface of transwell membrane are stained with DAPI.

  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):253-259. [Abstract]

    Customer Validation
     The expression of p-ERK1/2, ERK1/2, AGCAN and COL2 detected by Western blot in degenerated NP cells treated with or without rhLIF (100 ng/ml) and PD98059 (0 μM, 25 μM, 50 μM) for 48 h.

  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Feb:98:36-44. [Abstract]

    Customer Validation
     Resveratrol (RES) inhibits epithelial-mesenchymal transition (EMT) and extracellular matrix (ECM) remodeling of renal cell carcinoma (RCC) cells via the Akt and ERK1/2 signaling pathway. RCC cell lines are treated with RES (0, 50, 100 μM) and 50 μM PD98059 for 24 h. Levels of Akt, p-Akt, ERK1/2, p-ERK1/2 proteins are examined by Western blot.

  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: Mol Immunol. 2017 Jul:87:161-170. [Abstract]

    Customer Validation
     Effect of TLR2 on autophagy activation via ERK1/2 signaling pathway activation in MG-infected RAW264.7 cells. RAW264.7 cells transfected with TLR2 siRNA/control siRNA is then infected with MG for 30 min prior to PD98059. The expression levels of Beclin1, LC3-II/I, p-JNK, p-ERK1/2 and p-p38 are examined by Western blot.

  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: Hum Mol Genet. 2017 Sep 15;26(18):3553-3563. [Abstract]

    Customer Validation
     Immunofluorescence analysis for expression of the I-cell marker ΔNP63 on proximal sections of ureters explanted from E12.5 wildtype (control) embryos and cultured for 6 d in the presence of solvent (DMSO) (A), the AKT inhibitor (AKT-i) MK2206 (B), the P38 inhibitor (P38-i) SB203580 (C), the ERK1/2 inhibitor (ERK1/2-i) PD98059 (D) or combinations as indicated (E and F).

  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2017 Apr;13(4):1353-1359. [Abstract]

    Customer Validation
     Hippocampal neuron lysates are subjected to western blotting to evaluate Nrf2 levels and the phosphorylation of ERK in the presence and absence of PD98059.

  • 1/16

    PD98059 purchased from MedChemExpress. Usage Cited in: Biomed Res. 2017; 28 (8): 3383-3386

    Customer Validation
     Effects of various protease inhibitors on HO-1 and P-gp protein expressions.

  • PD98059