Acyclovir sodium
Based on 23 publication(s) in Google Scholar
Acyclovir (Aciclovir) sodium is a potent, orally active antiviral agent. Acyclovir sodium has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir sodium induces cell cycle perturbation and apoptosis. Acyclovir sodium prevents bacterial infections during induction therapy for acute leukaemia.
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- Pureza: 99.82%
- No. CAS: 69657-51-8
- Fòrmula: C8H11N5NaO3
- Peso molecular:248.19
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) Acyclovir sodium
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Mol Cell. 2026 Feb 19;86(4):722-739.e8. [Abstract]
- Sci Adv. 2025 Nov 21;11(47):eadw4206. [Abstract]
- Phytomedicine. 2026 Feb:151:157802. [Abstract]
- Phytomedicine. 2024 Sep 1:134:156015. [Abstract]
- Acta Pharmacol Sin. 2024 Nov;45(11):2380-2393. [Abstract]
- EMBO J. 2025 Apr;44(7):2157-2182. [Abstract]
- Cell Rep. 2026 Mar 12;45(3):117099. [Abstract]
- Eur J Med Chem. 2023 Mar 15:250:115184. [Abstract]
- Drug Des Devel Ther. 2022 Dec 20:16:4311-4323. [Abstract]
- Front Microbiol. 2021 Jun 18:12:691008. [Abstract]
- Microchem J. 2021, 106587.
- Mol Med Rep. 2025 Jul;32(1):203. [Abstract]
- Antiviral Res. 2024 Jun 21:228:105936. [Abstract]
- Antiviral Res. 2024 Jan:221:105787. [Abstract]
- Virol J. 2025 Jul 19;22(1):249. [Abstract]
- Microb Pathog. 2026 Apr:213:108349. [Abstract]
- J Med Virol. 2023 Jan;95(1):e28226. [Abstract]
- Front Oncol. 2024 Dec 19:14:1501981. [Abstract]
- Vet Microbiol. 2026 Jun 17:320:111115. [Abstract]
- bioRxiv. 2026 May 4.
- University of Auckland. 2025.
- Biomed Pharmacother. 2023 Jun:162:114595. [Abstract]
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Actividad biológica
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HSV-1 0.85 μM (IC50) |
HSV-2 0.86 μM (IC50) |
Acyclovir (Aciclovir) sodium (3-100 µM; 24-72 hours; Jurkat, U937, and K562 leukemia cells) reduces cell viability in a dose- and time-dependent[1].
Acyclovir (Aciclovir) sodium (10-100 µM; 24-72 hours; Jurkat cells) blocks DNA synthesis, thereby arresting the cell cycle in G2/M and S phases and increasing the sub-G1 hypodiploid peak in a dose-dependent manner[1].
Acyclovir (Aciclovir) sodium (10-100 µM; 24-72 hours; Jurkat cells) induces apoptosis through activates caspase-3 and presences nuclear DNA fragmentation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat, U937 and K562 leukemia cells
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Concentration:3, 10, 30 and 100 µM
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Incubation Time:24, 48 and 72 hours
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Result:Showed a dose- and time-dependent reduction of cell viability.
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Cell Line:Jurkat cells
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Concentration:10 and 100 µM
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Incubation Time:24, 48 and 72 hours
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Result:Increased of caspase-3 activity and cleavaged the internucleosomal DNA.
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Cell Line:Jurkat cells
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Concentration:10 and 100 µM
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Incubation Time:24, 48 and 72 hours
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Result:Revealed a dose-dependent accumulation of cells in S phase after 24 and 48 h. Showed a dose-dependent increase of the sub-G1 hypodiploid peak after 72 h.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Specific-pathogen-free BALB/c mice (7-week-old) infected with HSV-1[3]
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Dosage:20 mg/kg
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Administration:Oral administration; three times daily; for 10 days
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Result:Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 69657-51-8
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Appearance Solid
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Peso molecular 248.19
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Fòrmula C8H11N5NaO3
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Color White to off-white
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SMILES
O=C1N=C(N)NC2=C1N=CN2COCCO.[Na]
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Synonyms
Aciclovir sodium; Acycloguanosine sodium
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (23)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Mol Cell
Asparagine sensing by TBK1 controls its phase separation to drive antiviral innate immune responses. [Abstract]2026 Feb 19;86(4):722-739.e8. PMID: 41653919 -
Sci Adv
Transition of pseudorabies virus from latency to reactivation state selectively triggered by pathogenic bacteria. [Abstract]2025 Nov 21;11(47):eadw4206. PMID: 41259522
Acyclovir sodium purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Nov 21;11(47):eadw4206. [Abstract]
Fluorescence microscopy images depicting N2a cells infected with different doses of HuBXY/2018-mCherry with or without Acyclovir (ACV: 200 μM) and IFN-α treatments. The images were acquired on 8 dpi.
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Phytomedicine
Inhibition of herpes simplex virus infection by Caesappanin C targeting virus gB protein and host HSP90β. [Abstract]2026 Feb:151:157802. PMID: 41544463
Acyclovir sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2026 Feb:151:157802. [Abstract]
The antiviral activity of Acyclovir (ACV) against HSV-1 in different cell cultures was evaluated using the CPE inhibition assay (MOI = 1).
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Phytomedicine
Salvianolic acid A inhibits pseudorabies virus infection by directly inactivating the virus particle. [Abstract]2024 Sep 1:134:156015. PMID: 39244942 -
Acta Pharmacol Sin
A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity. [Abstract]2024 Nov;45(11):2380-2393. PMID: 38987389
Acyclovir sodium purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Nov;45(11):2380-2393. [Abstract]
Acyclovir (2 μM). The inhibitory effect of J1 on HSV1 (MOI = 0.1) infection in Vero cells was analyzed by plaque assay.
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EMBO J
A novel biosensor for the spatiotemporal analysis of STING activation during innate immune responses to dsDNA. [Abstract]2025 Apr;44(7):2157-2182. PMID: 39984755
Acyclovir sodium purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Apr;44(7):2157-2182. [Abstract]
HeLa SIRF biosensor cells were analyzed 24 hours after being treated with a simulated method or infected with 0.5 MOI of HSV-1 virus expressing mCherry, with or without Acyclovir (50 µM).
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Cell Rep
Enucleated cells with Nectin-1 overexpression capture HSV-1 and promote viral elimination for herpes simplex encephalitis therapy. [Abstract]2026 Mar 12;45(3):117099. PMID: 41824450 -
Eur J Med Chem
Design and syntheses of a bimolecular STING agonist based on the covalent STING antagonist. [Abstract]2023 Mar 15:250:115184. PMID: 36758305 -
Drug Des Devel Ther
2022 Dec 20:16:4311-4323. PMID: 36573068 -
Front Microbiol
In vitro Studies and Clinical Observations Imply a Synergistic Effect Between Epstein-Barr Virus and Dengue Virus Infection. [Abstract]2021 Jun 18:12:691008. PMID: 34220783 -
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Mol Med Rep
Identification of metabolites associated with capecitabine‑induced hand‑foot syndrome using untargeted metabolomics in patients with cancer. [Abstract]2025 Jul;32(1):203. PMID: 40377002 -
Antiviral Res
Flexible nano-liposomes-encapsulated recombinant UL8-siRNA (r/si-UL8) based on bioengineering strategy inhibits herpes simplex virus-1 infection. [Abstract]2024 Jun 21:228:105936. PMID: 38908520 -
Antiviral Res
Pralatrexate inhibited the replication of varicella zoster virus and vesicular stomatitis virus: An old dog with new tricks. [Abstract]2024 Jan:221:105787. PMID: 38145756 -
Virol J
Small molecule UCM05 inhibits HSV-2 infection via targeting viral glycoproteins and fatty acid synthase with potentiating antiviral immunity. [Abstract]2025 Jul 19;22(1):249. PMID: 40684179 -
Microb Pathog
mTORC2-dependent autophagy inhibition regulates the replication of HSV-1 and adenovirus in viral keratitis & conjunctivitis. [Abstract]2026 Apr:213:108349. PMID: 41628839 -
J Med Virol
Small molecule RAF265 as an antiviral therapy acts against HSV-1 by regulating cytoskeleton rearrangement and cellular translation machinery. [Abstract]2023 Jan;95(1):e28226. PMID: 36251738 -
Front Oncol
Gut virome dysbiosis impairs antitumor immunity and reduces 5-fluorouracil treatment efficacy for colorectal cancer. [Abstract]2024 Dec 19:14:1501981. PMID: 39791120 -
Vet Microbiol
Pseudorabies virus EP0 recruits TECPR2 and CK2 to promote COPII accumulation and viral egress. [Abstract]2026 Jun 17:320:111115. PMID: 42322707 -
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Biomed Pharmacother
A potential anti-HIV-1 compound, Q308, inhibits HSV-2 infection and replication in vitro and in vivo. [Abstract]2023 Jun:162:114595. PMID: 36989723
Acyclovir sodium purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 Jun:162:114595. [Abstract]
Acyclovir (ACV; 2.5 μM; 48 h) significantly inhibits the expression of gD in HSV-2-infected HeLa, Vero, Beas-2B and HaCaT cells.
Solvente y solubilidad
H2O : 6.25 mg/mL (25.18 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (278 KB)
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- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Benedetti S, et, al. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells, and enhances chemotherapeutic drug cytotoxicity. Life Sci. 2018 Dec 15;215:80-85. [Content Brief]
[2]. Suzuki M, et, al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006 Nov;72(2):157-61. [Content Brief]
[3]. Li Z, et, al. Acyclovir treatment of skin lesions results in immune deviation in mice infected cutaneously with herpes simplex virus. Antivir Chem Chemother. 1999 Sep;10(5):251-7. [Content Brief]
[4]. Lönnqvist B, et, al. Oral acyclovir as prophylaxis for bacterial infections during induction therapy for acute leukaemia in adults. The Leukemia Group of Middle Sweden. Support Care Cancer. 1993 May;1(3):139-44. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.0292 mL | 20.1459 mL | 40.2917 mL | 100.7293 mL |
| 5 mM | 0.8058 mL | 4.0292 mL | 8.0583 mL | 20.1459 mL | |
| 10 mM | 0.4029 mL | 2.0146 mL | 4.0292 mL | 10.0729 mL | |
| 15 mM | 0.2686 mL | 1.3431 mL | 2.6861 mL | 6.7153 mL | |
| 20 mM | 0.2015 mL | 1.0073 mL | 2.0146 mL | 5.0365 mL | |
| 25 mM | 0.1612 mL | 0.8058 mL | 1.6117 mL | 4.0292 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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