Chalepensin
Based on 1 Customer Validation
Chalepensin is a nematicide and CYP inhibitor. Chalepensin inhibits CYP2A6, CYP1A1, CYP1A2, CYP2A13, CYP2C9, CYP2D6, CYP2E1, and CYP3A4 to varying degrees, with IC50 values of 82.3 μM, 2.86 μM, 3.01 μM, 0.21 μM, 6.58 μM, 1.67 μM, 61.1 μM, and 61.7 μM, respectively. Chalepensin potently and selectively kills third-stage infective larvae of Strongyloides venezuelensis.
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- Pureza: 98.98%
- No. CAS: 13164-03-9
- Fòrmula: C16H14O3
- Peso molecular:254.28
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Almacenamiento:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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CYP2A6 82.3 μM (IC50) |
CYP1A1 2.86 μM (IC50) |
CYP1A2 3.01 μM (IC50) |
CYP2A13 0.21 μM (IC50) |
CYP2C9 6.58 μM (IC50) |
CYP2D6 1.67 μM (IC50) |
CYP2E1 61.1 μM (IC50) |
CYP3A4 61.7 μM (IC50) |
Chalepensin inhibits CYP1A1, CYP1A2, CYP2A13, CYP2C9, CYP2D6, CYP2E1, and CYP3A4 to varying degrees[1].
Chalepensin (1-50 μM; 24-72 h) potently and selectively kills third-stage infective larvae (L3) of *Strongyloides venezuelensis*, with an LC50 of 3.4 µM at 72 h and a selectivity index of 990.0, exhibiting activity comparable to that of ivermectin[2].
Chalepensin (1-60 μM; 24-72 h) potently and selectively kills parthenogenetic adult females of *Onchocerca volvulus*, with an LC50 of 16.8 μM at 72 h and a selectivity index of 200.4; this compound exhibits superior activity to graveoline and comparable activity to ivermectin at low concentrations[2].
Chalepensin (10 μM-6 mM; 72 h) exhibits extremely low cytotoxicity against Vero cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:African green monkey kidney epithelial (Vero, ATCC CCL-81) cells
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Concentration:10 μM-6 mM
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Incubation Time:72 h
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Result:Showed minimal cytotoxicity to Vero cells with an IC50 of 3365.9 μM at 72 h.
Chemical Information
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No. CAS 13164-03-9
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Appearance Solid
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Peso molecular 254.28
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Fòrmula C16H14O3
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Color White to off-white
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SMILES
O=C1C(C(C)(C)C=C)=CC2=CC3=C(OC=C3)C=C2O1
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Ueng YF, et al. Mechanism-based inhibition of CYP1A1 and CYP3A4 by the furanocoumarin chalepensin. Drug Metab Pharmacokinet. 2013;28(3):229-238. [Content Brief]
[2]. Rodríguez-Garza NE, et al. Antiparasitic Activity of Chalepensin and Graveoline Isolated from Ruta chalepensis L.: In Vitro Evaluation Against Strongyloides venezuelensis. Pathogens. 2025 Apr 25;14(5):419. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Chalepensin Related Classifications
HY-N8382 Related Classifications
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