GG13
GG13 is an anti-inflammatory peptide. GG13 reduces the expression of STAT1, NOS2, COX2, and CD40. GG13 decreases the expression and secretion of iNOS and TNF-α proteins. GG13 is applicable to the research of inflammatory diseases.
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- Fòrmula: C48H76N16O17
- Peso molecular:1149.21
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Help & FAQs
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
COX-2 |
STAT1 |
iNOS |
NOS2 |
In Vitro
GG13 (25-400 μg/mL; 20 h) promotes the proliferation of RAW264.7 macrophages without reducing cell viability[1].
GG13 (50-400 μg/mL; 12 h) inhibits LPS-stimulated NO production in RAW264.7 macrophages in a concentration-dependent manner, with an inhibition rate of 68.81% at 200 μg/mL and 73.53% at 400 μg/mL[1].
GG13 downregulates the expression of key pro-inflammatory proteins STAT1, NOS2, COX2 and CD40 in LPS-stimulated RAW264.7 macrophages, a finding confirmed by label-free proteomic analysis[1].
GG13 (50-200 μg/mL; 12 h) inhibits TNF-α secretion in LPS-stimulated RAW264.7 macrophages in a concentration-dependent manner, with an inhibition rate of 40.25% at the concentration of 200 μg/mL[1].
GG13 (50-200 μg/mL; 12 h) reduces the expression of pro-inflammatory iNOS and TNF-α proteins in LPS-stimulated RAW264.7 macrophages in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 macrophages
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Concentration:25-400 μg/mL
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Incubation Time:20 h
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Result:Enhanced cell proliferation across all tested concentrations without significantly affecting cell viability, relative to untreated control cells.
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Cell Line:LPS-stimulated RAW264.7 macrophages
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Concentration:50-200 μg/mL
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Incubation Time:12 h pre-incubation, followed by 8 h LPS co-incubation
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Result:Inhibited TNF-α secretion in a concentration-dependent manner (p < 0.001).
Reduced TNF-α secretion by 40.25% at 200 μg/mL.
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Cell Line:LPS-stimulated RAW264.7 macrophages
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Concentration:50-200 μg/mL
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Incubation Time:12 h pre-incubation, followed by 8 h LPS co-incubation
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Result:Reduced the expression of iNOS and TNF-α proteins significantly in a concentration-dependent manner (p < 0.01).
Chemical Information
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Peso molecular 1149.21
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Fòrmula C48H76N16O17
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Sequence
Gly-Pro-Gly-Ala-Pro-Ala-Asp-Pro-Gly-Arg-Pro-Thr-Gly
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Sequence Shortening
GPGAPADPGRPTG
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GG13 Related Classifications
HY-P11915 Related Classifications
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