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Referencia número: HY-121162

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Mesembrine

(Synonyms: (+)-Mesembrine)

Mesembrine ((+)-Mesembrine) a main alkaloid that features an aryloctahydroindole skeleton. Mesembrine is a 5-HT transporter inhibitor with a K_i of 1.4 nM. Mesembrine also inhibits phosphodiesterase 4B (PDE4B) with an IC₅₀ of 7.8 μM.

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No. CAS: 468-53-1
Fòrmula: C₁₇H₂₃NO₃
Peso molecular:289.37

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Mesembrine Chemical Structure

No. CAS: 468-53-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Descripciòn

IC₅₀ & Target^[1]

PDE4B

7.8 μM (IC₅₀)

serotonin

1.4 nM (Ki)

Ver todos los productos específicos de isoformas 5-HT Receptor :

Ver todos los productos específicos de isoformas Phosphodiesterase (PDE) :

In Vitro

Mesembrine can bind to cloned human cannabinoid CB1 receptors in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 468-53-1
Peso molecular 289.37
Fòrmula C₁₇H₂₃NO₃
SMILES

O=C1CC[C@]2(C3=CC=C(OC)C(OC)=C3)CCN(C)[C@]2([H])C1
Synonyms

(+)-Mesembrine
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
Initial Source
- Plants
- other families
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (274 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. John L Krstenansky. Mesembrine alkaloids: Review of their occurrence, chemistry, and pharmacology. J Ethnopharmacol. 2017 Jan 4;195:10-19. [Content Brief]

[2]. Golo M J Meyer, et al. GC-MS, LC-MS(n), LC-high resolution-MS(n), and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high "Kanna" isolated from Sceletium tortuosum. Anal Bioanal Chem. 2015 Jan;407(3):761-78. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Mesembrine

Ver todos los productos específicos de isoformas 5-HT Receptor

Ver todos los productos específicos de isoformas Phosphodiesterase (PDE)

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Mesembrine Related Classifications

HY-121162 Related Classifications