ND-336
Based on 1 publication(s) in Google Scholar
ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-14, with Kis of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 97.16%
- No. CAS: 1807453-83-3
- Fòrmula: C16H18ClNO3S2
- Peso molecular:371.90
-
Almacenamiento:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-15827
NSC 405020MMP14 Inhibitor -
HY-12169
MarimastatMMP Inhibitor -
HY-15768
IlomastatMMP Inhibitor -
HY-100211
TAPI-2MMP/TACE/ADAM Inhibitor -
HY-118694
TAPI-0TACE/MMP Inhibitor -
HY-100359
CL-82198MMP-13 Inhibitor -
HY-103444
ARP-100MMP-2 Inhibitor -
HY-130391
MMP12-IN-3MMP12 Inhibitor -
HY-119307
ApratastatTACE/MMPs Inhibitor -
HY-120793
CMC2.24Ras/MMPs Inhibitor -
HY-12169R
Marimastat (Standard)MMP Inhibitor -
HY-12354
SB-3CTMMP2/9 Inhibitor
Publications Citing Use of MedChemExpress (MCE) ND-336
More
Actividad biológica
Descripciòn
IC50 & Target
[1]|
MMP-2 85 nM (Ki) |
MMP-9 150 nM (Ki) |
MMP-14 120 nM (Ki) |
In Vivo
ND-336 (0.05-0.01 mg; topical application; daily for 14 day) accelerates diabetic wound healing[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female diabetic db/db mice[1]
-
Dosage:0.05, 0.025, and 0.01 mg
-
Administration:Topical application; daily for 14 day
-
Result:Healed 1.2- to 1.6-fold faster than those treated with ND-322 than those treated with vehicle.
- Mitochondrial membrane-potential fluorescent assay
- Human pluripotent stem cell endothelial-cell differentiation
- Vascular/Branching Fractal Analysis
- Cell migration
- Mitochondrial membrane-potential and mitochondrial mass staining
- Endothelial Tube Formation Assay
- Research Protocol for Inflammation-related Diseases
- Cell-Exclusion Zone Migration Assay
- Endothelial Cell Migration/Angiogenic Sprouting Assay
Chemical Information
-
No. CAS 1807453-83-3
-
Appearance Solid
-
Peso molecular 371.90
-
Fòrmula C16H18ClNO3S2
-
Color White to off-white
-
SMILES
NCC1=CC=C(OC2=CC=C(C=C2)S(CC3SC3)(=O)=O)C=C1.Cl
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
-
Journal Impact Factor
-
Most Recent
Solvente y solubilidad
In Vitro:
DMSO : 30 mg/mL (80.67 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (271 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Gao M, et al. Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy. Proc Natl Acad Sci U S A. 2015;112(49):15226-15231. [Content Brief]
[2]. Nguyen TT, et al. Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing. J Med Chem. 2018;61(19):8825-8837. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6889 mL | 13.4445 mL | 26.8889 mL | 67.2224 mL |
| 5 mM | 0.5378 mL | 2.6889 mL | 5.3778 mL | 13.4445 mL | |
| 10 mM | 0.2689 mL | 1.3444 mL | 2.6889 mL | 6.7222 mL | |
| 15 mM | 0.1793 mL | 0.8963 mL | 1.7926 mL | 4.4815 mL | |
| 20 mM | 0.1344 mL | 0.6722 mL | 1.3444 mL | 3.3611 mL | |
| 25 mM | 0.1076 mL | 0.5378 mL | 1.0756 mL | 2.6889 mL | |
| 30 mM | 0.0896 mL | 0.4481 mL | 0.8963 mL | 2.2407 mL | |
| 40 mM | 0.0672 mL | 0.3361 mL | 0.6722 mL | 1.6806 mL | |
| 50 mM | 0.0538 mL | 0.2689 mL | 0.5378 mL | 1.3444 mL | |
| 60 mM | 0.0448 mL | 0.2241 mL | 0.4481 mL | 1.1204 mL | |
| 80 mM | 0.0336 mL | 0.1681 mL | 0.3361 mL | 0.8403 mL |
ND-336 Related Classifications
HY-124373 Related Classifications
Powered by Bioz