Referencia número: HY-18061

Ochromycinone

(Synonyms: (Rac)-STA-21)

3 Cited Publications

Revisión del cliente

Based on 3 publication(s) in Google Scholar

Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity.

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Pureza: 99.61%
No. CAS: 111540-00-2
Fòrmula: C₁₉H₁₄O₄
Peso molecular:306.31

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Ochromycinone Chemical Structure

No. CAS: 111540-00-2

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (3)
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[2]

STAT3

Ver todos los productos específicos de isoformas Antibiotic :

Ver todos los productos específicos de isoformas STAT :

Cellular Effect

Cell Line	Type	Value	Description	References
HaCaT	IC₅₀	32 μM Compound: STA-21	Antiproliferative activity against human HaCaT cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HaCaT cells incubated for 48 hrs by MTT assay	[PMID: 39151117]

In Vitro

STA-21 inhibits STAT3 DNA binding activity, STAT3 dimerization, and STAT3-dependent luciferase activity. Moreover, STA-21 reduces the survival of breast carcinoma cells with constitutive STAT3 signaling but has minimal effect on the cells in which constitutive STAT3 signaling is absent^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 111540-00-2
Appearance Solid
Peso molecular 306.31
Fòrmula C₁₉H₁₄O₄
Color Light yellow to yellow
SMILES

CC(CC1=O)CC2=C1C3=C(C=C2)C(C4=C(O)C=CC=C4C3=O)=O
Synonyms

(Rac)-STA-21
Structure Classification
- Quinones
- Anthraquinones
- Phenols
- Monophenols
Initial Source
- Microorganisms
Indonesian Streptomyces sp
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (3)

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Ecotoxicol Environ Saf

Pyridaben inhibits cell cycle progression and delays early embryonic development in zebrafish (Danio rerio). [Abstract]

2024 Aug 12:283:116857. PMID: 39137465
Nutrients

Resveratrol Interferes with IL1-β-Induced Pro-Inflammatory Paracrine Interaction between Primary Chondrocytes and Macrophages. [Abstract]

2016 May 11;8(5). pii: E280. PMID: 27187448

Ochromycinone purchased from MedChemExpress. Usage Cited in: Nutrients. 2016 May 11;8(5). pii: E280. [Abstract]

Levels of p-STAT3 are determined by Western blotting and the levels of IL-6 and IL-8 are determined by ELISA assay, in MΦ cultures. Effect of treatment with IL-1β, IL-6, aIL-6 or STA21. Co, control. Representative data from one of three experiments are shown.
SSRN

2024 Apr 7.

Solvente y solubilidad

In Vitro:

DMSO : 16.67 mg/mL (54.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2647 mL

16.3233 mL

32.6467 mL

5 mM

0.6529 mL

3.2647 mL

6.5293 mL

10 mM

0.3265 mL

1.6323 mL

3.2647 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1.67 mg/mL (5.45 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (277 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Song H, et al. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4700-5. [Content Brief]

[2]. Nataliya I. Kalinovskaya, et al. New Angucyclinones from the Marine Mollusk Associated Actinomycete Saccharothrix espanaensis An 113. Natural product communications. 2008, 3(10):1611-1616.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2647 mL	16.3233 mL	32.6467 mL	81.6167 mL
	5 mM	0.6529 mL	3.2647 mL	6.5293 mL	16.3233 mL
	10 mM	0.3265 mL	1.6323 mL	3.2647 mL	8.1617 mL
	15 mM	0.2176 mL	1.0882 mL	2.1764 mL	5.4411 mL
	20 mM	0.1632 mL	0.8162 mL	1.6323 mL	4.0808 mL
	25 mM	0.1306 mL	0.6529 mL	1.3059 mL	3.2647 mL
	30 mM	0.1088 mL	0.5441 mL	1.0882 mL	2.7206 mL
	40 mM	0.0816 mL	0.4081 mL	0.8162 mL	2.0404 mL
	50 mM	0.0653 mL	0.3265 mL	0.6529 mL	1.6323 mL

Keywords

Ochromycinone

3 Cited Publications

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Ochromycinone

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Publications Citing Use of MedChemExpress (MCE) Ochromycinone

Ver todos los productos específicos de isoformas Antibiotic

Ver todos los productos específicos de isoformas STAT

Actividad biológica

Chemical Information

Publications (3)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

Ochromycinone Related Classifications

HY-18061 Related Classifications