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Referencia número: HY-N12503

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Patuletin

Patuletin is a flavonol, that can be isolated from the flowers of Tagetes patula. Patuletin shows anti-proliferative activity against cancer cells. Patuletin causes significant nuclear fragmentation and has a great capacity to induce caspase-3 activation.

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No. CAS: 519-96-0
Fòrmula: C₁₆H₁₂O₈
Peso molecular:332.26

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Patuletin Chemical Structure

No. CAS: 519-96-0

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Actividad biológica

Descripciòn

IC₅₀ & Target

Caspase 3

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Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	10.1 μg/mL Compound: 11	Antioxidant activity in human HL60 cells assessed as reduction of cytochrome-c release Antioxidant activity in human HL60 cells assessed as reduction of cytochrome-c release	[PMID: 10650074]

In Vitro

Patuletin (0-100 μg/mL, 24 h) shows anti-proliferative activity against cancer cells^[2].
Patuletin induces apoptosis in the CaSki, MDA-MB-231, and SK-Lu-1 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:

CaSki, MDA-MB-231 and SK-Lu-1
Concentration:

6, 12, 25, 50 and 100 μg/mL
Incubation Time:

24 h
Result:

Showed a dose-dependent proliferation inhibition, with IC₅₀ values of 37, 86, and 18 μg/mL for CaSki, MDA-MB-231 and SK-Lu-1 cells, respectively.

Chemical Information

No. CAS 519-96-0
Peso molecular 332.26
Fòrmula C₁₆H₁₂O₈
SMILES

O=C1C(O)=C(C2=CC(O)=C(O)C=C2)OC3=CC(O)=C(C(O)=C13)OC
Structure Classification
- Flavonoids
- Flavonols
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Zane A , et al. Flavonols in Spinach Leaves[J]. Journal of Organic Chemistry, 1961, 26(11).

[2]. Alvarado-Sansininea JJ, et al. Quercetagetin and Patuletin: Antiproliferative, Necrotic and Apoptotic Activity in Tumor Cell Lines. Molecules. 2018 Oct 9;23(10):2579. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
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Patuletin

Ver todos los productos específicos de isoformas Caspase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Patuletin Related Classifications

HY-N12503 Related Classifications