Mmp3 - matrix metallopeptidase 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171045

About Mmp3

Primary_assembly 8: 4,640,416-4,653,961 forward strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 501 orthologues, 23 paralogues and is associated with 75 phenotypes. Biased expression in Adrenal (RPKM 5.6), Uterus (RPKM 4.4) and 5 other tissues.

Summary

Predicted to enable metalloendopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to interleukin-1; and response to estradiol. Located in several cellular components, including cell body; dendrite; and extracellular space. Part of protein-containing complex. Biomarker of several diseases, including abdominal aortic aneurysm; degenerative disc disease; gastric ulcer; glomerulonephritis (multiple); and primary biliary cholangitis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); carcinoma (multiple); end stage renal disease; osteoarthritis; and von Hippel-Lindau disease. Orthologous to human MMP3 (matrix metallopeptidase 3). [provided by Alliance of Genome Resources, Apr 2022]

Mmp3 Products (1)

mRNA Protein Name
NM_133523.3 NP_598207.2 stromelysin-1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
16935996 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to cell-matrix adhesion IEP
IEP: Inferred from expression pattern
12963432 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
16046515 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
15672041 RGD
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
23142217 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
17083784 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
10435007 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
19889233 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
15099024 RGD
involved in response to interleukin-1 IEP
IEP: Inferred from expression pattern
16290189 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19345799 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
16140193 RGD
involved in response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
17704356 RGD
Cellular Component GO Annotation Evidence References Source
located in cell body IDA
IDA: Inferred from direct assay
18629001 RGD
located in dendrite IDA
IDA: Inferred from direct assay
18629001 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
18439420 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
16935996 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp3 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (24 - 84)

Peptidase_M10

Peptidase_M10: pfam00413 (105 - 261)

HX

HX: cd00094 (287 - 474)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 475 a.a.
Protein Preferred Names Protein Names

stromelysin-1

  • MMP-3

  • PTR1 protein

  • SL-1

  • matrix metalloproteinase-3

  • transin-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-12170 Prinomastat 98.41% Phase 3
HY-12168 Tanomastat Inhibitor 99.74% Phase 3
HY-12270 T-5224 Inhibitor 99.59% Phase 2
HY-15768 Ilomastat Inhibitor 99.14% Phase 2
HY-N0262 Cordycepin 99.80% Phase 2
HY-112160 XL-784 free base Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (54)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13564 Batimastat Inhibitor 98.92% Unkown
HY-110397 KP-457 Inhibitor 98.88% Unkown
HY-113952 Actinonin 98.37% Unkown
HY-103444 ARP-100 Inhibitor ≥99.0% Unkown
HY-N1454 Apigenin-7-glucuronide Inhibitor 99.74% Unkown
HY-N1463 Luteolin 7-O-glucuronide Inhibitor 99.98% Unkown
HY-107394 UK 356618 Inhibitor 98.91% Unkown
HY-108672 NF157 Antagonist 99.13% Unkown
HY-P2185A NFF-3 TFA Chemical 96.32% Unkown
HY-119423 MMP Inhibitor II Inhibitor 99.7% Unkown
HY-15606 Tanaproget Agonist 99.73% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-107428 PD-166793 Inhibitor 99.21% Unkown
HY-12170A Prinomastat hydrochloride 98.53% Unkown
HY-110397G KP-457 (GMP) Inhibitor / Unkown
HY-114418 MMP3 inhibitor 1 Inhibitor 99.03% Unkown
HY-119711 NNGH Inhibitor 99.6% Unkown
HY-19485 XL-784 Inhibitor 98.25% Unkown
HY-N1940 β-Anhydroicaritin Inhibitor 99.69% Unkown
HY-W011085 CP-471474 Inhibitor 99.2% Unkown
HY-114091 PF-00356231 hydrochloride Inhibitor 99.52% Unkown
HY-114164G Murine Thrombin Activator / Unkown
HY-164826 Acetyl zingerone 99.34% Unkown
HY-13564A Batimastat sodium salt Inhibitor 99.04% Unkown
HY-137370 2-Hexynyl-5′-N-ethylcarboxamidoadenosine 99.39% Unkown
HY-169949 TAK-756 Inhibitor / Unkown
HY-P2166A MMP3 inhibitor 3 TFA Inhibitor / Unkown
HY-107617 PTIQ Inhibitor / Unkown
HY-114091A PF-00356231 Inhibitor / Unkown
HY-114164F Canine Thrombin / Unkown
HY-12168B (Rac)-Tanomastat Inhibitor / Unkown
HY-12270S T-5224-d8 / Unkown
HY-125507 F81-1144b Inhibitor / Unkown
HY-152030 Tubulin/MMP-IN-2 / Unkown
HY-153913 MMP-9-IN-7 Inhibitor / Unkown
HY-167825 Barakol / Unkown
HY-183764 COX-2/5-LOX-IN-8 Inhibitor / Unkown
HY-18694 CGS 27023A Inhibitor / Unkown
HY-18694A CGS 27023A free base Inhibitor / Unkown
HY-N16408 Berkeleyamide B Inhibitor / Unkown
HY-N16409 Berkeleyamide C Inhibitor / Unkown
HY-P2089 Dnp-PYAYWMR / Unkown
HY-P2166 MMP3 inhibitor 3 Inhibitor / Unkown
HY-P2185 NFF-3 Chemical / Unkown
HY-P3098 Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 / Unkown
HY-P3202 Matrix metalloproteinase 3 / Unkown
HY-P3699 TNO003 Substrate / Unkown
HY-P4937 NBD-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys-(DMC)-NH2 / Unkown
HY-RS08548 MMP3 Human Pre-designed siRNA Set A / Unkown
HY-RS08549 Mmp3 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08550 Mmp3 Rat Pre-designed siRNA Set A / Unkown
HY-114065 MMP3-IN-4 Inhibitor / Unkown
HY-117464 CM-352 Inhibitor / Unkown
HY-P3699A TNO003 TFA Substrate / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp3 NCBI NCBI:4314