Pde4b - phosphodiesterase 4B, cAMP specific Gene

Also Known as Dpde4; dunce

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18578

Summary

Enables 3',5'-cyclic-AMP phosphodiesterase activity; gamma-tubulin binding activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to epinephrine stimulus; negative regulation of adenylate cyclase-activating Adrenergic Receptor signaling pathway involved in heart process; and regulation of muscle system process. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; neutrophil chemotaxis; and neutrophil homeostasis. Located in several cellular components, including Z disc; centrosome; and synaptic vesicle. Part of gamma-tubulin complex and voltage-gated Calcium Channel complex. Is expressed in several structures, including alimentary system; ear; genitourinary system; nervous system; and respiratory system. Orthologous to human PDE4B (phosphodiesterase 4B). [provided by Alliance of Genome Resources, Apr 2022]

Pde4b Products (16)

mRNA Protein Name
NM_001177980.2 NP_001171451.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 2
NM_001177981.1 NP_001171452.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 3
NM_001177982.1 NP_001171453.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 4
NM_001177983.2 NP_001171454.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 5
NM_001374780.2 NP_001361709.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 6
NM_001404786.1 NP_001391715.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 7
NM_001404787.1 NP_001391716.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 8
NM_001404788.1 NP_001391717.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 9
NM_001404789.1 NP_001391718.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 6
NM_001404791.1 NP_001391720.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 10
NM_001404793.1 NP_001391722.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 11
NM_001404794.1 NP_001391723.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 12
NM_001404796.1 NP_001391725.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 13
NM_001404804.1 NP_001391733.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 14
NM_001404836.1 NP_001391765.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 15
NM_019840.3 NP_062814.2 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables gamma-tubulin binding IDA
IDA: Inferred from direct assay
18983980 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18983980 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
15585880 MGI
acts upstream of or within cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
11267656 MGI
acts upstream of or within leukocyte migration IMP
IMP: Inferred from mutant phenotype
15585880 MGI
acts upstream of or within neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
15585880 MGI
acts upstream of or within neutrophil homeostasis IMP
IMP: Inferred from mutant phenotype
15585880 MGI
NOT acts upstream of or within smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
14519662 MGI
Cellular Component GO Annotation Evidence References Source
located in cell periphery IDA
IDA: Inferred from direct assay
18923023 MGI
located in centrosome IDA
IDA: Inferred from direct assay
18983980 MGI
located in cytosol IDA
IDA: Inferred from direct assay
23008439 MGI
located in dendritic spine IDA
IDA: Inferred from direct assay
18983980 MGI
located in excitatory synapse IDA
IDA: Inferred from direct assay
18983980 MGI
part of gamma-tubulin complex IDA
IDA: Inferred from direct assay
18983980 MGI
located in membrane IDA
IDA: Inferred from direct assay
23008439 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
18983980 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
18983980 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153192 Nerandomilast Inhibitor 99.99% Unkown
HY-15455 Roflumilast Inhibitor 99.98% Yes
HY-153192A Nerandomilast dihydrate Inhibitor 99.93% Unkown

Clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Phase
HY-10469 GSK256066 Inhibitor 98.69% Phase 2
HY-117960 Orismilast Inhibitor 99.88% Phase 2
HY-155830 Morcamilast Inhibitor 98.92% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.94% Phase 2
HY-108047 MK-0873 Inhibitor 95.0% Phase 2
HY-144683 PF-07038124 Inhibitor / Phase 2
HY-111167 AN-2898 Inhibitor / Phase 2
HY-106003 GSK356278 Inhibitor 99.82% Phase 1
HY-131707 LEO 39652 Inhibitor 99.40% Phase 1
HY-201403 LY2775240 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (53)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122942 Moracin M 98.99% Unkown
HY-128358 MR-L2 Activator 98.63% Unkown
HY-115687 PDE4B-IN-2 Inhibitor 99.59% Unkown
HY-119190 PF-06445974 Inhibitor 98.59% Unkown
HY-16900A (R)-(-)-Rolipram Inhibitor 99.91% Unkown
HY-144683A PF-07038124 hydrochloride Inhibitor 99.26% Unkown
HY-103050 ML-030 Inhibitor 99.28% Unkown
HY-139178 KVA-D-88 Inhibitor 99.81% Unkown
HY-100246 CI-1044 Inhibitor 98.02% Unkown
HY-147830 PDE4B-IN-3 Inhibitor 99.37% Unkown
HY-206852 PF-06445974 precursor 99.67% Unkown
HY-70069 GSK256066 Trifluoroacetate Inhibitor 99.83% Unkown
HY-117977 FCPR03 Inhibitor 99.82% Unkown
HY-153192B (S)-Nerandomilast Inhibitor 98.69% Unkown
HY-153192C (rac)-Nerandomilast Inhibitor 99.65% Unkown
HY-181418 HY-072808 Inhibitor 98.75% Unkown
HY-121162 Mesembrine Inhibitor / Unkown
HY-180878 PDE4B modulator-1 98.28% Unkown
HY-114052 NVP-ABE171 Inhibitor / Unkown
HY-115913 PDE4-IN-6 Inhibitor / Unkown
HY-144684 PDE4-IN-8 Inhibitor / Unkown
HY-146201 PDE4B/7A-IN-1 99.63% Unkown
HY-146202 PDE4B/7A-IN-2 / Unkown
HY-147950 PDE4-IN-10 Inhibitor / Unkown
HY-159654 PDE4-IN-19 Inhibitor / Unkown
HY-161851 MDL3 Inhibitor / Unkown
HY-162582 Z19153 Inhibitor / Unkown
HY-162583 PDE4-IN-17 Inhibitor / Unkown
HY-168558 PDE4B/D-IN-4 Inhibitor / Unkown
HY-16900G Rolipram (GMP) Inhibitor / Unkown
HY-172365 P7–2302 Inhibitor / Unkown
HY-172776 Phosphodiesterase-IN-3 Inhibitor / Unkown
HY-172870 PDE4B-IN-4 Inhibitor / Unkown
HY-174339 Neuroprotective agent 12 / Unkown
HY-174383 PDE3/4-IN-2 Inhibitor 99.75% Unkown
HY-175832 PDE4B-IN-5 Inhibitor / Unkown
HY-176520 PDE4-IN-29 Inhibitor / Unkown
HY-176524S PDE3/4-IN-3 Inhibitor / Unkown
HY-179503 PDE/TRPA1/CHIT1-IN-1 Inhibitor / Unkown
HY-179504 PDE4B-IN-6 Inhibitor / Unkown
HY-180803 LH17 Inhibitor / Unkown
HY-181088 PDE3/4-IN-4 Inhibitor / Unkown
HY-181549 PDE4-IN-32 Inhibitor / Unkown
HY-181646 PDE4-IN-34 Inhibitor / Unkown
HY-181762 Multitarget AD-IN-6 Inhibitor / Unkown
HY-181770 PDE4B-IN-7 Inhibitor / Unkown
HY-181774 PDE4/5-IN-1 Inhibitor / Unkown
HY-182060 PDE4B/D-IN-5 / Unkown
HY-RS10223 PDE4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-119799 UK-500001 Inhibitor / Unkown
HY-N11262 Sudachitin / Unkown
HY-RS16654 Pde4b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23089 Pde4b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde4b NCBI NCBI:5142