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Rock1 - Rho-associated coiled-coil containing protein kinase 1 Gene

Also Known as Rock-I; 1110055K06Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19877

About Rock1

Chromosome 18: 10,064,401-10,182,045 reverse strand.GRCm39:CM001011.3

This gene has 8 transcripts (splice variants), 212 orthologues, 5 paralogues and is associated with 26 phenotypes. Ubiquitous expression in bladder adult (RPKM 7.8), placenta adult (RPKM 6.) and 28 other tissues.

Summary

Predicted to enable Rho-dependent protein serine/threonine kinase activity; aspartic-type endopeptidase inhibitor activity; and small GTPase binding activity. Involved in several processes, including glomerular visceral epithelial cell migration; positive regulation of focal adhesion assembly; and response to angiotensin. Acts upstream of or within several processes, including apical constriction; bleb assembly; and negative regulation of neuron apoptotic process. Located in several cellular components, including cytoplasmic stress granule; lamellipodium; and ruffle. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and skeletal muscle. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Rock1 Products (1)

mRNA	Protein	Name
NM_009071.2	NP_033097.1	rho-associated protein kinase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16741948	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	16249236	MGI
involved in actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	15464581	MGI
acts upstream of or within apical constriction	IGI IGI: Inferred from genetic interaction	21685893	MGI
acts upstream of or within bleb assembly	IMP IMP: Inferred from mutant phenotype	17135244	MGI
involved in blood vessel diameter maintenance	IMP IMP: Inferred from mutant phenotype	29353861	MGI
involved in epithelial to mesenchymal transition	IGI IGI: Inferred from genetic interaction	15464581	MGI
involved in mRNA destabilization	IMP IMP: Inferred from mutant phenotype	29353861	MGI
acts upstream of motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15071095	MGI
involved in myoblast migration	IMP IMP: Inferred from mutant phenotype	17654484	MGI
acts upstream of or within negative regulation of motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15071095	MGI
involved in podocyte cell migration	IMP IMP: Inferred from mutant phenotype	30115939	MGI
involved in positive regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	17654484	MGI
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	30115939	MGI
acts upstream of or within regulation of actin filament-based process	IGI IGI: Inferred from genetic interaction	21685893	MGI
involved in regulation of synapse maturation	IDA IDA: Inferred from direct assay	30826947	MGI
involved in regulation of synapse maturation	IMP IMP: Inferred from mutant phenotype	30826947	MGI
involved in response to angiotensin	IGI IGI: Inferred from genetic interaction	28679962	MGI
involved in response to transforming growth factor beta	IGI IGI: Inferred from genetic interaction	28679962	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	30826947	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	30826947	MGI
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	27430620	MGI
located in cytoskeleton	IDA IDA: Inferred from direct assay	16741948	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	16741948	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16741948	MGI
located in ruffle	IDA IDA: Inferred from direct assay	16741948	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rock1 Protein Structure

STKc_ROCK1

Smc

HR1_ROCK1

ROCK_SBD

PH_ROCK

C1_ROCK1

0
300
600
900
1200
1354 a.a.

Protein Preferred Names	Protein Names
rho-associated protein kinase 1	Rho-associated coiled-coil forming kinase 1 p160 ROCK-1 p160ROCK rho-associated, coiled-coil-containing protein kinase 1 rho-associated, coiled-coil-containing protein kinase I

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10583	Y-27632 dihydrochloride	Inhibitor	99.98%	Unkown
HY-10341	Fasudil Hydrochloride	Inhibitor	99.97%	Yes
HY-15307	Belumosudil	Inhibitor	99.83%	Yes
HY-10341A	Fasudil	Inhibitor	99.98%	Yes
HY-15685	Ripasudil	Inhibitor	99.95%	Unkown
HY-15307A	Belumosudil mesylate	Inhibitor	99.89%	Yes
HY-13911A	Hydroxyfasudil hydrochloride	Inhibitor	98.88%	Unkown
HY-13911	Hydroxyfasudil	Inhibitor	98.78%	Unkown
HY-10341C	Fasudil dihydrochloride	Inhibitor	99.98%	Yes
HY-10341B	Fasudil hydrochloride semihydrate	Inhibitor	/	Unkown
HY-15685A	Ripasudil free base	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-109191	Sovesudil	Inhibitor	99.91%	Phase 3
HY-15687A	SAR407899	Inhibitor	99.67%	Phase 2
HY-16758A	Verosudil hydrochloride	Inhibitor	/	Phase 2
HY-16071	AT13148	Inhibitor	99.20%	Phase 1

Pre-clinical Phase

Bioactive Molecules (45)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10071	Y-27632	Inhibitor	99.91%	Unkown
HY-15392	Chroman 1	Inhibitor	98.97%	Unkown
HY-15556	GSK269962A	Inhibitor	99.75%	Unkown
HY-11000	GSK429286A	Inhibitor	98.27%	Unkown
HY-119937	ROCK inhibitor-2	Inhibitor	99.92%	Unkown
HY-15755	RKI-1447	Inhibitor	98.02%	Unkown
HY-13300	SR-3677	Inhibitor	99.23%	Unkown
HY-10319	BAY-549	Inhibitor	99.46%	Unkown
HY-108518	SB-772077B dihydrochloride	Inhibitor	99.33%	Unkown
HY-15392A	Chroman 1 dihydrochloride	Inhibitor	98.13%	Unkown
HY-12437	BDP5290	Inhibitor	98.90%	Unkown
HY-18990	GSK180736A	Inhibitor	98.81%	Unkown
HY-15556A	GSK269962A hydrochloride	Inhibitor	99.73%	Unkown
HY-15687	SAR407899 hydrochloride	Inhibitor	99.14%	Unkown
HY-16758	Verosudil	Inhibitor	98.22%	Unkown
HY-162596	NRL-1049	Inhibitor	99.96%	Unkown
HY-132302	Hu7691	Inhibitor	99.91%	Unkown
HY-149266	THK01	Inhibitor	99.80%	Unkown
HY-14362	GSK-25	Inhibitor	98.33%	Unkown
HY-110339	RKI-1447 dihydrochloride	Inhibitor	99.94%	Unkown
HY-Q22471	ROCK1-IN-1	Inhibitor	99.14%	Unkown
HY-109191A	Sovesudil hydrochloride	Inhibitor	99.45%	Unkown
HY-100270	Rho-Kinase-IN-1	Inhibitor	99.91%	Unkown
HY-125221	DJ4	Inhibitor	99.25%	Unkown
HY-122011	PF-4950834	Inhibitor	99.60%	Unkown
HY-126275	HSD1590	Inhibitor	99.00%	Unkown
HY-14227	LIMK-IN-1	Inhibitor	99.33%	Unkown
HY-178821	ROCK2-IN-12	Inhibitor	98.02%	Unkown
HY-N12378	β-Patchoulene	Inhibitor	96.88%	Unkown
HY-107209	RKI-1313	Inhibitor	98.2%	Unkown
HY-132302A	Hu7691 free base	Inhibitor	/	Unkown
HY-172177	ROCK/HDAC-IN-2	Inhibitor	/	Unkown
HY-181582	LASSBio-2382	Inhibitor	/	Unkown
HY-187204	RX-044	Inhibitor	/	Unkown
HY-164809	Desisopropyle-belumosudil	Inhibitor	/	Unkown
HY-181583	LASSBio-2389	Inhibitor	/	Unkown
HY-N15301A	Nocarnickelamide B TFA	Inhibitor	/	Unkown
HY-13300A	SR-3677 dihydrochloride	Inhibitor	/	Unkown
HY-178013	ROCK2-IN-11	Inhibitor	/	Unkown
HY-175843	ROCK2-IN-10	Inhibitor	/	Unkown
HY-W047432	5-Nitro-1H-indazole-3-carbonitrile	Inhibitor	/	Unkown
HY-168650	ROCK/HDAC-IN-1	Inhibitor	/	Unkown
HY-187203	RX-021	Inhibitor	/	Unkown
HY-123939	JAK1/3-IN-1	Inhibitor	/	Unkown
HY-N15301	Nocarnickelamide B	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rock1	NCBI	NCBI:6093