2. Gene
  3. Hdac4 - histone deacetylase 4 Gene

Hdac4 - histone deacetylase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as HD4; 4932408F19Rik

Gene ID: 208727 | Gene type: protein coding

About Hdac4

Chromosome 1: 91,856,501-92,123,421 reverse strand.GRCm39:CM000994.3

This gene has 12 transcripts (splice variants), 263 orthologues, 10 paralogues and is associated with 40 phenotypes. Ubiquitous expression in adrenal adult (RPKM 12.3), ovary adult (RPKM 1.9) and 28 other tissues.

Summary

Enables several functions, including chromatin binding activity; protein deacetylase activity; and transcription corepressor activity. Involved in regulation of nucleobase-containing compound metabolic process and response to denervation involved in regulation of muscle adaptation. Acts upstream of or within several processes, including negative regulation of osteoblast differentiation; osteoblast development; and regulation of cardiac muscle contraction by calcium ion signaling. Located in several cellular components, including actomyosin; cytosol; and neuromuscular junction. Is expressed in several structures, including alimentary system; early embryo; ganglia; hand; and telencephalon. Used to study eating disorder. Human ortholog(s) of this gene implicated in ataxia telangiectasia; chromosome 2q37 deletion syndrome; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4). [provided by Alliance of Genome Resources, Apr 2022]

Hdac4 Products(1)

mRNA Protein Name
NM_207225.2 NP_997108.1 histone deacetylase 4

Hdac4 Protein Structure

ClassIIa_HDAC4_Gln-rich-N

ClassIIa_HDAC4_Gln-rich-N: cd10162 (89 - 150)

HDAC4

HDAC4: cd10006 (645 - 1048)

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  • 1076 a.a.
Protein Preferred Names Protein Names

histone deacetylase 4

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15149 Romidepsin Inhibitor 99.98% Unkown
HY-13322 Pracinostat Inhibitor 99.82% Yes
Clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-10528 Tasquinimod Modulator 99.94% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842 Givinostat Inhibitor 98.05% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor / Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-10223 CUDC-101 Inhibitor 99.19% Phase 1
Pre-clinical Phase
Bioactive Molecules (35)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18361 TMP195 Inhibitor 99.57% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-18360 TMP269 Inhibitor 98.05% Unkown
HY-13428 Tubacin Inhibitor 95.50% Unkown
HY-16699 Nexturastat A Inhibitor 99.03% Unkown
HY-115475 SW-100 Inhibitor 99.59% Unkown
HY-119939 CHDI-390576 Inhibitor 98.07% Unkown
HY-19350 BML-210 Inhibitor 98.06% Unkown
HY-123295 HDAC3-IN-T247 Inhibitor 98.94% Unkown
HY-12954 PTACH Inhibitor 99.65% Unkown
HY-149285 NT160 Inhibitor 99.58% Unkown
HY-146153 HDAC-IN-40 Inhibitor 98.71% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-150109 Purinostat mesylate Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-149372 HDAC6-IN-17 Inhibitor / Unkown
HY-151263 G4/HDAC-IN-1 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-163143 HDAC8-IN-6 Inhibitor / Unkown
HY-149208 HDAC-IN-53 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-157740 XSJ-10 Inhibitor / Unkown
HY-150503 KH-259 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-146159 PI3K/HDAC-IN-2 Inhibitor / Unkown
HY-162377 HDAC-IN-70 Inhibitor / Unkown
HY-151897 HDAC-IN-49 Inhibitor / Unkown
HY-151896 HDAC6-IN-14 Inhibitor / Unkown
HY-149721 HDAC4-IN-1 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac4 NCBI NCBI:9759