Hdac4 - histone deacetylase 4 Gene

Also Known as HD4; 4932408F19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 208727

About Hdac4

Chromosome 1: 91,856,501-92,123,421 reverse strand.GRCm39:CM000994.3

This gene has 12 transcripts (splice variants), 263 orthologues, 10 paralogues and is associated with 40 phenotypes. Ubiquitous expression in adrenal adult (RPKM 12.3), ovary adult (RPKM 1.9) and 28 other tissues.

Summary

Enables several functions, including chromatin binding activity; protein deacetylase activity; and transcription corepressor activity. Involved in regulation of nucleobase-containing compound metabolic process and response to denervation involved in regulation of muscle adaptation. Acts upstream of or within several processes, including negative regulation of osteoblast differentiation; osteoblast development; and regulation of cardiac muscle contraction by calcium ion signaling. Located in several cellular components, including actomyosin; cytosol; and neuromuscular junction. Is expressed in several structures, including alimentary system; early embryo; ganglia; hand; and telencephalon. Used to study eating disorder. Human ortholog(s) of this gene implicated in ataxia telangiectasia; chromosome 2q37 deletion syndrome; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4). [provided by Alliance of Genome Resources, Apr 2022]

Hdac4 Products (1)

mRNA Protein Name
NM_207225.2 NP_997108.1 histone deacetylase 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
16260608 MGI
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
10748098 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
24768298 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14576337 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
17468767 MGI
enables protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
18250163 MGI
enables transcription corepressor activity IGI
IGI: Inferred from genetic interaction
15990875 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of cell population proliferation IDA
IDA: Inferred from direct assay
15537544 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15537544 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16260608 MGI
acts upstream of or within negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
14576337 MGI
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
15537544 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15537544 MGI
involved in negative regulation of glycolytic process IMP
IMP: Inferred from mutant phenotype
19109424 MGI
involved in negative regulation of miRNA transcription IGI
IGI: Inferred from genetic interaction
24675724 MGI
involved in negative regulation of miRNA transcription IMP
IMP: Inferred from mutant phenotype
24675724 MGI
acts upstream of or within negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
15990875 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17873280 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15537544 MGI
acts upstream of or within osteoblast development IMP
IMP: Inferred from mutant phenotype
15990875 MGI
acts upstream of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
15990875 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19109424 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19109424 MGI
acts upstream of or within regulation of cardiac muscle contraction by calcium ion signaling IMP
IMP: Inferred from mutant phenotype
18250163 MGI
acts upstream of or within regulation of skeletal muscle fiber development IGI
IGI: Inferred from genetic interaction
17786239 MGI
acts upstream of or within regulation of skeletal muscle fiber differentiation IGI
IGI: Inferred from genetic interaction
17786239 MGI
involved in response to denervation involved in regulation of muscle adaptation IMP
IMP: Inferred from mutant phenotype
19109424 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
15537544 MGI
Cellular Component GO Annotation Evidence References Source
located in actomyosin IDA
IDA: Inferred from direct assay
18250163 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
22318228 MGI
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
19109424 MGI
located in cytosol IDA
IDA: Inferred from direct assay
17761942 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
17873280 MGI
located in nucleus IDA
IDA: Inferred from direct assay
22318228 MGI
located in nucleus IMP
IMP: Inferred from mutant phenotype
19109424 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac4 Protein Structure

ClassIIa_HDAC4_Gln-rich-N

ClassIIa_HDAC4_Gln-rich-N: cd10162 (89 - 150)

HDAC4

HDAC4: cd10006 (645 - 1048)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1076 a.a.
Protein Preferred Names Protein Names

histone deacetylase 4

Hdac4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Hdac4 Q6NZM9 Runx2 Mus musculus Q08775
Anti Tag CoIP
15537544
Intra
Hdac4 Q6NZM9 Runx2 Mus musculus Q08775
EMSA
15537544
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15149 Romidepsin Inhibitor 99.98% Unkown
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-10528 Tasquinimod Modulator 99.70% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1

Pre-clinical Phase

Bioactive Molecules (61)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18361 TMP195 Inhibitor 99.82% Unkown
HY-13428 Tubacin Inhibitor 98.71% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-18360 TMP269 Inhibitor 98.16% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Unkown
HY-19350 BML-210 Inhibitor 98.04% Unkown
HY-119939 CHDI-390576 Inhibitor 98.10% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-123295 HDAC3-IN-T247 Inhibitor 98.91% Unkown
HY-169259 HDAC9-IN-1 Inhibitor 95.13% Unkown
HY-135714 Bavarostat Inhibitor 99.51% Unkown
HY-149285 NT160 Inhibitor 99.58% Unkown
HY-W039803 HDAC4 ligand-2 Ligand / Unkown
HY-149721 HDAC4-IN-1 Inhibitor 98.11% Unkown
HY-146153 HDAC-IN-40 Inhibitor 98.71% Unkown
HY-12954 PTACH Inhibitor 99.65% Unkown
HY-148624 CHDI-00484077 Inhibitor 98.38% Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-149208 HDAC-IN-53 Inhibitor 95.73% Unkown
HY-184524 PROTAC HDAC4 Degrader-2 / Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-181086 FLT3/HDAC-IN-3 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-178022 HDAC6-IN-63 Inhibitor / Unkown
HY-151896 HDAC6-IN-14 Inhibitor / Unkown
HY-151263 G4/HDAC-IN-1 Inhibitor / Unkown
HY-149372 HDAC6-IN-17 Inhibitor / Unkown
HY-146159 PI3K/HDAC-IN-2 Inhibitor / Unkown
HY-150503 KH-259 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-180214 HDAC6-IN-69 Inhibitor / Unkown
HY-179227 HDAC6 ligand-7 Inhibitor / Unkown
HY-170379 HDAC-IN-84 Inhibitor / Unkown
HY-162630 HDAC6-IN-44 Inhibitor / Unkown
HY-163143 HDAC8-IN-6 Inhibitor / Unkown
HY-151897 HDAC-IN-49 Inhibitor / Unkown
HY-179321 PROTAC HDAC4 Degrader-1 Degrader / Unkown
HY-184705 HDAC-IN-105 Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-169400 HDACs/EZH2-IN-1 Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-172159 FF2039 Inhibitor / Unkown
HY-181579 HDAC6-IN-74 Inhibitor / Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-182747 HDAC6-IN-79 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-P2044 Azumamide E Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac4 NCBI NCBI:9759