PDE4B - Pde4b phosphodiesterase 4B Gene

Also Known as Pde4B1; Pde4B2; Pde4B3; Pde4B4; Pde4b5; PDE4/IVb; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24626

Summary

Enables 3',5'-cyclic-AMP phosphodiesterase activity. Involved in response to heat. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Orthologous to human PDE4B (phosphodiesterase 4B). [provided by Alliance of Genome Resources, Apr 2022]

PDE4B Products (2)

mRNA Protein Name
NM_001398935.1 NP_001385864.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 1
NM_017031.3 NP_058727.3 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
12441002 RGD
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15242814 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

  • 3',5'-cyclic AMP phosphodiesterase

  • DPDE4

  • Phosphodiesterase 4B, cAMP-specific (dunce

  • phosphodiesterase 4B, cAMP specific

  • phosphodiesterase type 4B5

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153192 Nerandomilast Inhibitor 99.99% Unkown
HY-15455 Roflumilast Inhibitor 99.98% Yes
HY-153192A Nerandomilast dihydrate Inhibitor 99.93% Unkown

Clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Phase
HY-10469 GSK256066 Inhibitor 98.69% Phase 2
HY-117960 Orismilast Inhibitor 99.88% Phase 2
HY-155830 Morcamilast Inhibitor 98.92% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.94% Phase 2
HY-108047 MK-0873 Inhibitor 95.0% Phase 2
HY-144683 PF-07038124 Inhibitor / Phase 2
HY-111167 AN-2898 Inhibitor / Phase 2
HY-106003 GSK356278 Inhibitor 99.82% Phase 1
HY-131707 LEO 39652 Inhibitor 99.40% Phase 1
HY-201403 LY2775240 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (53)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122942 Moracin M 98.99% Unkown
HY-128358 MR-L2 Activator 98.63% Unkown
HY-115687 PDE4B-IN-2 Inhibitor 99.59% Unkown
HY-119190 PF-06445974 Inhibitor 98.59% Unkown
HY-16900A (R)-(-)-Rolipram Inhibitor 99.91% Unkown
HY-144683A PF-07038124 hydrochloride Inhibitor 99.26% Unkown
HY-103050 ML-030 Inhibitor 99.28% Unkown
HY-139178 KVA-D-88 Inhibitor 99.81% Unkown
HY-100246 CI-1044 Inhibitor 98.02% Unkown
HY-147830 PDE4B-IN-3 Inhibitor 99.37% Unkown
HY-206852 PF-06445974 precursor 99.67% Unkown
HY-70069 GSK256066 Trifluoroacetate Inhibitor 99.83% Unkown
HY-117977 FCPR03 Inhibitor 99.82% Unkown
HY-153192B (S)-Nerandomilast Inhibitor 98.69% Unkown
HY-153192C (rac)-Nerandomilast Inhibitor 99.65% Unkown
HY-181418 HY-072808 Inhibitor 98.75% Unkown
HY-121162 Mesembrine Inhibitor / Unkown
HY-180878 PDE4B modulator-1 98.28% Unkown
HY-114052 NVP-ABE171 Inhibitor / Unkown
HY-115913 PDE4-IN-6 Inhibitor / Unkown
HY-144684 PDE4-IN-8 Inhibitor / Unkown
HY-146201 PDE4B/7A-IN-1 99.63% Unkown
HY-146202 PDE4B/7A-IN-2 / Unkown
HY-147950 PDE4-IN-10 Inhibitor / Unkown
HY-159654 PDE4-IN-19 Inhibitor / Unkown
HY-161851 MDL3 Inhibitor / Unkown
HY-162582 Z19153 Inhibitor / Unkown
HY-162583 PDE4-IN-17 Inhibitor / Unkown
HY-168558 PDE4B/D-IN-4 Inhibitor / Unkown
HY-16900G Rolipram (GMP) Inhibitor / Unkown
HY-172365 P7–2302 Inhibitor / Unkown
HY-172776 Phosphodiesterase-IN-3 Inhibitor / Unkown
HY-172870 PDE4B-IN-4 Inhibitor / Unkown
HY-174339 Neuroprotective agent 12 / Unkown
HY-174383 PDE3/4-IN-2 Inhibitor 99.75% Unkown
HY-175832 PDE4B-IN-5 Inhibitor / Unkown
HY-176520 PDE4-IN-29 Inhibitor / Unkown
HY-176524S PDE3/4-IN-3 Inhibitor / Unkown
HY-179503 PDE/TRPA1/CHIT1-IN-1 Inhibitor / Unkown
HY-179504 PDE4B-IN-6 Inhibitor / Unkown
HY-180803 LH17 Inhibitor / Unkown
HY-181088 PDE3/4-IN-4 Inhibitor / Unkown
HY-181549 PDE4-IN-32 Inhibitor / Unkown
HY-181646 PDE4-IN-34 Inhibitor / Unkown
HY-181762 Multitarget AD-IN-6 Inhibitor / Unkown
HY-181770 PDE4B-IN-7 Inhibitor / Unkown
HY-181774 PDE4/5-IN-1 Inhibitor / Unkown
HY-182060 PDE4B/D-IN-5 / Unkown
HY-RS10223 PDE4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-119799 UK-500001 Inhibitor / Unkown
HY-N11262 Sudachitin / Unkown
HY-RS16654 Pde4b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23089 Pde4b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PDE4B NCBI NCBI:5142