Pkm - pyruvate kinase M1/2 Gene

Also Known as PK; Pk3; Pkm2; PKM12

生物種: Rattus norvegicus

遺伝子タイプ: protein coding
遺伝子ID: 25630

About Pkm

Primary_assembly 8: 60,057,402-60,079,599 forward strand.mRatBN7.2:CM026981.1

This gene has 4 transcripts (splice variants), 229 orthologues, 5 paralogues and is associated with 10 phenotypes. Biased expression in Muscle (RPKM 9449.2), Heart (RPKM 2392.1) and 6 other tissues.

Summary

Enables several functions, including ADP binding activity; Pyruvate Kinase activity; and thyroid hormone binding activity. Involved in several processes, including ATP biosynthetic process; animal organ regeneration; and pyruvate metabolic process. Part of Pyruvate Kinase complex. Orthologous to human PKM (Pyruvate Kinase M1/2). [provided by Alliance of Genome Resources, Apr 2022]

Pkm Products (1)

mRNA Protein Name
NM_053297.2 NP_445749.1 pyruvate kinase PKM

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables ADP binding IDA
IDA: Inferred from direct assay
7040662 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
1883388 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17877381 RGD
enables protein dimerization activity IDA
IDA: Inferred from direct assay
11687968 RGD
enables pyruvate kinase activity IDA
IDA: Inferred from direct assay
1883388 RGD
enables thyroid hormone binding IDA
IDA: Inferred from direct assay
1883388 RGD
Biological Process GO Annotation Evidence 参考文献 由来
involved in animal organ regeneration IDA
IDA: Inferred from direct assay
4005043 RGD
involved in glucose metabolic process IDA
IDA: Inferred from direct assay
7929251 RGD
involved in glycolytic process IDA
IDA: Inferred from direct assay
1883388 RGD
involved in liver development IDA
IDA: Inferred from direct assay
7327170 RGD
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
10734049 RGD
involved in protein tetramerization IDA
IDA: Inferred from direct assay
11687968 RGD
involved in pyruvate biosynthetic process IDA
IDA: Inferred from direct assay
4273555 RGD
involved in pyruvate metabolic process IDA
IDA: Inferred from direct assay
10734049 RGD
involved in response to gravity IEP
IEP: Inferred from expression pattern
12165359 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
3696161 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
7929251 RGD
involved in response to muscle inactivity IEP
IEP: Inferred from expression pattern
6331066 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
7929251 RGD
involved in skeletal muscle tissue regeneration IDA
IDA: Inferred from direct assay
145474 RGD
Cellular Component GO Annotation Evidence 参考文献 由来
part of pyruvate kinase complex IDA
IDA: Inferred from direct assay
1883388 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pkm Protein Structure

Pyruvate_Kinase

Pyruvate_Kinase: cd00288 (101 - 589)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 591 a.a.
Protein Preferred Names Protein Names

pyruvate kinase PKM

  • M2 pyruvate kinase

  • pyruvate kinase isozymes M1/M2

  • pyruvate kinase muscle isozyme

  • pyruvate kinase, muscle

  • threonine-protein kinase PKM2

  • tyrosine-protein kinase PKM2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-B0404A Benserazide hydrochloride Inhibitor 99.68% Yes
HY-B0404AR Benserazide hydrochloride (Standard) Inhibitor 99.89% Unkown

Clinical Phase

Bioactive Molecules (3)
製品番号 製品名 製品効果
純度 Phase
HY-121275 Benserazide Inhibitor 98.43% Phase 4
HY-155785 MTP / Phase 4
HY-P1284A ZIP TFA Inhibitor / Phase 4

Pre-clinical Phase

Bioactive Molecules (59)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-N0822 Shikonin Inhibitor 99.80% Unkown
HY-18657 TEPP-46 Activator 99.93% Unkown
HY-103617 PKM2-IN-1 Inhibitor 99.79% Unkown
HY-19330 DASA-58 Activator 99.57% Unkown
HY-126585 SAICAR 99.57% Unkown
HY-162080 METTL1-WDR4-IN-1 Inhibitor 99.61% Unkown
HY-N7108 7-Hydroxyflavone 99.89% Unkown
HY-P1284 ZIP Inhibitor 98.56% Unkown
HY-157913 PKM2-IN-6 99.95% Unkown
HY-147368 PKM2 activator 2 Activator 99.38% Unkown
HY-167832 PT109 99.20% Unkown
HY-N4185 Licoflavone A 99.95% Unkown
HY-139667 PKM2-IN-3 Inhibitor 99.44% Unkown
HY-N2552 Vitamin K5 hydrochloride 99.25% Unkown
HY-D1456 TEPC466 99.43% Unkown
HY-N3011 Iridin 99.72% Unkown
HY-N7064 Iminostilbene Inhibitor 99.66% Unkown
HY-148324 PKM2 activator 5 Activator 96.03% Unkown
HY-148615 NPD10084 Inhibitor 99.69% Unkown
HY-155850 CIAC001 Inhibitor 99.70% Unkown
HY-W587878 Thujopsene 86.31% Unkown
HY-P1399A Pep2m, myristoylated TFA Inhibitor 99.77% Unkown
HY-126585S SAICAR-d3 96.57% Unkown
HY-132215 PF-06284674 Activator 99.69% Unkown
HY-156375 PKM2 activator 6 / Unkown
HY-162080A METTL1-WDR4-IN-1 TFA Inhibitor 99.61% Unkown
HY-179371 LIQ1 Inhibitor 97.40% Unkown
HY-D1876 ZY-2 95.77% Unkown
HY-RS10602 PKM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-119874 Alkannin Inhibitor / Unkown
HY-147397 PKM2 activator 3 Activator / Unkown
HY-149275 PKM2/PDK1-IN-1 / Unkown
HY-155216 PKM2 activator 10 Activator / Unkown
HY-155668 HMG-CoA Reductase-IN-1 Inhibitor / Unkown
HY-155849 PKM2-IN-4 Inhibitor / Unkown
HY-161519 PKM2 activator 7 Activator / Unkown
HY-168882 PKM2 modulator 1 / Unkown
HY-168883 PKM2 modulator 2 / Unkown
HY-169567 PKM2-IN-9 Inhibitor / Unkown
HY-170577 PKM2-IN-8 / Unkown
HY-172881 PKM2-IN-10 Inhibitor / Unkown
HY-178441 PKM2-IN-11 / Unkown
HY-178748 PKM2-IN-12 / Unkown
HY-180523 PKM2-IN-13 / Unkown
HY-180795 PKM2 activator 11 / Unkown
HY-182037 Multi-target kinase-IN-9 Inhibitor / Unkown
HY-183765 PARP1/PKM2-IN-1 Inhibitor / Unkown
HY-B0404AS Benserazide-d3 hydrochloride Inhibitor / Unkown
HY-B1814 Vitamin K5 / Unkown
HY-D1877 ZY-1 98.91% Unkown
HY-P1399 Pep2m, myristoylated Inhibitor / Unkown
HY-RS10603 Pkm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10604 Pkm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W753956 Iminostilbene-d10 / Unkown
HY-148313 PKM2 activator 4 Activator / Unkown
HY-162071 PKM2-IN-5 Inhibitor / Unkown
HY-168995 BAR-072 Inhibitor / Unkown
HY-169883 PKM2-IN-7 Inhibitor / Unkown
HY-180796 PKM2 agonist-1 Agonist / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Pkm NCBI NCBI:5315