Smad2 - SMAD family member 2 Gene

Also Known as Madh2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29357

Summary

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; SMAD binding activity; and enzyme binding activity. Predicted to contribute to DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including adrenal gland development; regulation of gene expression; and transforming growth factor beta receptor signaling pathway. Located in cytoplasm and nucleus. Part of protein-containing complex. Used to study hepatocellular carcinoma. Biomarker of colon Cancer and myocardial infarction. Human ortholog(s) of this gene implicated in Lynch syndrome; cervical cancer; and ovarian Cancer. Orthologous to human SMAD2 (Smad Family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Smad2 Products (4)

mRNA Protein Name
NM_001277450.1 NP_001264379.1 mothers against decapentaplegic homolog 2
NM_019191.2 NP_062064.1 mothers against decapentaplegic homolog 2
NM_001277450.1 NP_001264379.1 mothers against decapentaplegic homolog 2
NM_019191.2 NP_062064.1 mothers against decapentaplegic homolog 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16362038 RGD
Biological Process GO Annotation Evidence References Source
involved in SMAD protein signal transduction IMP
IMP: Inferred from mutant phenotype
22073128 RGD
involved in adrenal gland development IDA
IDA: Inferred from direct assay
12844345 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
32065356 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
33409963 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15987742 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22073128 RGD
involved in signal transduction involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22073128 RGD
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
22073128 RGD
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
16959941 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mothers against decapentaplegic homolog 2

  • SMAD 2

  • mad-related protein 2

  • mothers against DPP homolog 2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99720 Luspatercept Inhibitor 98.92% Unkown
HY-P99590A Sotatercept (mIgG2a) Inhibitor 99.93% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-P5542 Vicatertide Inhibitor 99.24% Phase 3
HY-N2037A Higenamine hydrochloride 99.34% Phase 1
HY-183067 TAS1440 98.03% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99351 Andecaliximab Inhibitor 98.57% Phase 3

Pre-clinical Phase

Bioactive Molecules (60)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-116084 Trimethylamine N-oxide Activator 98.0% Unkown
HY-126675A AS2863619 98.02% Unkown
HY-100830 NCB-0846 Inhibitor 99.61% Unkown
HY-N2037 Higenamine 99.31% Unkown
HY-108915 Trimethylamine N-oxide dihydrate Activator 99.86% Unkown
HY-116084S Trimethylamine N-oxide-d9 Activator 99.76% Unkown
HY-124447 BTYNB 98.0% Unkown
HY-N6985 Baccatin III 99.82% Unkown
HY-N6013 Aloin (mixture of A&B) 99.36% Unkown
HY-132187 Sphingosylphosphorylcholine 99.50% Unkown
HY-N3266 Methyl rosmarinate 99.89% Unkown
HY-100448A Butaprost 99.85% Unkown
HY-126675 AS2863619 free base 99.87% Unkown
HY-100444 SIS3 free base Inhibitor 98.02% Unkown
HY-144043 ALK5-IN-8 Inhibitor 98.21% Unkown
HY-18766 EW-7195 Inhibitor 98.84% Unkown
HY-122856 AZ12601011 Inhibitor 99.78% Unkown
HY-123900 AZ12799734 Inhibitor 98.67% Unkown
HY-N0363 (+)-Columbianetin 99.04% Unkown
HY-N4107 Phyllanthin Inhibitor 99.97% Unkown
HY-118528A TP0427736 hydrochloride Inhibitor 99.91% Unkown
HY-N0363A (+)-Columbianetin acetate 99.83% Unkown
HY-P10363 Tiger17 Activator 98.47% Unkown
HY-100830A NCB-0970 Control 98.81% Unkown
HY-161398 TGFβRII-IN-3 99.51% Unkown
HY-171878 BI-4659 Inhibitor 99.78% Unkown
HY-N0136B (-)-Taxifolin Inhibitor 98.98% Unkown
HY-P11223 CMF9 Inhibitor 98.65% Unkown
HY-RS13393 SMAD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117511 HJC0123 99.06% Unkown
HY-P10359A TAT-QFNP12 acetate Inhibitor 95.90% Unkown
HY-P4890A Relaxin H3 (human) TFA / Unkown
HY-RS17208 Smad2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-116084S1 Trimethylamine-N-oxide-13C3 Activator / Unkown
HY-10321G PD173074 (GMP) Inhibitor / Unkown
HY-107614G 1-Oleoyl lysophosphatidic acid sodium (GMP) Activator / Unkown
HY-120973 Butaprost free acid / Unkown
HY-126675G AS2863619 (GMP) / Unkown
HY-162404 (14S,15R)-14-Deoxyoxacyclododecindione Inhibitor / Unkown
HY-162405 STAT6-IN-12 Inhibitor / Unkown
HY-168607 ALK5-IN-83 Inhibitor / Unkown
HY-170578 SIRT2-IN-17 Inhibitor / Unkown
HY-172108 TGFβRI-IN-7 Inhibitor / Unkown
HY-181430 PXS 25 Inhibitor / Unkown
HY-181431 PXS 64 Inducer / Unkown
HY-183067A TAS1440 benzoate / Unkown
HY-P10359 TAT-QFNP12 Inhibitor / Unkown
HY-P11827 C11 peptide-1 Inhibitor / Unkown
HY-P4890 Relaxin H3 (human) / Unkown
HY-W108953 Myristoyl tetrapeptide-12 Activator / Unkown
HY-W722562 Trimethylamine oxide-15N 99.93% Unkown
HY-Y1269D Ammonium chloride, for molecular biology / Unkown
HY-118528 TP0427736 Inhibitor / Unkown
HY-12273G DMH-1 (GMP) Inhibitor / Unkown
HY-124595 MPT0B098 Inhibitor / Unkown
HY-N0363AR (+)-Columbianetin acetate (Standard) / Unkown
HY-N0363R (+)-Columbianetin (Standard) / Unkown
HY-N2037AS1 Higenamine-d4-1 hydrochloride / Unkown
HY-N6013R Aloin (mixture of A&B) (Standard) / Unkown
HY-RS23660 Smad2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99720A Luspatercept (mIgG2a) Inhibitor 99.9% Unkown
HY-P992410 MEDI-579 Inhibitor / Unkown
HY-P992108 Efadirelaxin alfa Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smad2 NCBI NCBI:4087