Sirt3 - sirtuin 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 293615

About Sirt3

Primary_assembly 1: 195,942,073-195,964,808 reverse strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 198 orthologues, 6 paralogues and is associated with 13 phenotypes. Biased expression in Liver (RPKM 142.2), Adrenal (RPKM 122.2) and 9 other tissues.

Summary

Enables enzyme binding activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; negative regulation of Reactive Oxygen Species metabolic process; and positive regulation of Insulin secretion. Located in mitochondrion. Used to study non-alcoholic fatty liver disease. Biomarker of congestive heart failure; myocardial infarction; obesity; and prediabetes syndrome. Orthologous to human SIRT3 (Sirtuin 3). [provided by Alliance of Genome Resources, Apr 2022]

Sirt3 Products (1)

mRNA Protein Name
NM_001106313.2 NP_001099783.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
24505357 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
23397292 RGD
involved in negative regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
23397292 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
23397292 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sirt3 Protein Structure

SIRT1

SIRT1: cd01408 (73 - 307)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

NAD-dependent protein deacetylase sirtuin-3, mitochondrial

  • SIRT3L mitochondrial

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0130 Perindopril 99.85% Yes
HY-B0130A Perindopril erbumine 99.98% Yes

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-123033A Nicotinamide riboside chloride Activator 99.90% Phase 4
HY-123033C Nicotinamide riboside malate Activator 98.04% Phase 4
HY-123033B Nicotinamide riboside tartrate Activator 98.07% Phase 4
HY-123033 Nicotinamide riboside Activator / Phase 4

Pre-clinical Phase

Bioactive Molecules (36)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108331 3-TYP Inhibitor 99.90% Unkown
HY-113402 Gamma-glutamylcysteine Activator 98.53% Unkown
HY-100578 AGK2 Inhibitor 99.43% Unkown
HY-158426 2-APQC Agonist 99.70% Unkown
HY-15510 Tenovin-6 Inhibitor 98.00% Unkown
HY-N1511 Ganoderic acid D Activator 99.89% Unkown
HY-N2110 Phellopterin Agonist 99.94% Unkown
HY-119575 Tetramethyluric acid Activator 99.63% Unkown
HY-16616 SIRT-IN-2 Inhibitor 98.08% Unkown
HY-136199 SIRT1-IN-1 Inhibitor 98.15% Unkown
HY-N2673 5-Heptadecylresorcinol Activator 99.83% Unkown
HY-16605 SIRT6-IN-6 Inhibitor 98.59% Unkown
HY-163987 SIRT3 activator 2 Activator 98.94% Unkown
HY-15510B Tenovin-6 Hydrochloride Inhibitor 98.88% Unkown
HY-173572 SKLB-11A Agonist 99.40% Unkown
HY-161920 SIRT3-IN-1 Inhibitor 98.47% Unkown
HY-124113 4'-Bromo-resveratrol Inhibitor 99.94% Unkown
HY-16615 SIRT-IN-1 Inhibitor 98.14% Unkown
HY-111329 JGB1741 Inhibitor 99.37% Unkown
HY-19339 Tenovin-3 Degrader 98.0% Unkown
HY-150727 SIRT5 inhibitor 4 Inhibitor 98.37% Unkown
HY-136855 MitoPBN Modulator 95.00% Unkown
HY-P3364A Ac-QPKK(Ac)-AMC acetate Substrate 99.38% Unkown
HY-151519 SIRT2-IN-9 Inhibitor 99.45% Unkown
HY-118343 AC-93253 Inhibitor 99.3% Unkown
HY-111303 CHIC35 Inhibitor / Unkown
HY-155784 SPC-180002 Inhibitor / Unkown
HY-170402 SIRT6-IN-4 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-146013 Sirt1/2-IN-1 Inhibitor / Unkown
HY-114906 SIRT1/2/3-IN-2 Inhibitor / Unkown
HY-160944 hsa62 Inhibitor / Unkown
HY-160617 SIRT2-IN-14 Inhibitor / Unkown
HY-184173 OXPHOS-IN-3 Inhibitor / Unkown
HY-118109 SIRT3-IN-2 Inhibitor / Unkown
HY-W109401 SIRT-IN-6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirt3 NCBI NCBI:23410