Abcg2 - ATP binding cassette subfamily G member 2 Gene

Also Known as Bcrp; BCRP1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 312382

About Abcg2

Primary_assembly 4: 87,745,319-87,802,409 forward strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 312 orthologues, 9 paralogues and is associated with 38 phenotypes. Biased expression in Kidney (RPKM 256.7), Brain (RPKM 36.1) and 6 other tissues.

Summary

Enables several functions, including cytoskeletal protein binding activity; efflux transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including cellular response to lipid; embryonic process involved in female pregnancy; and urate salt excretion. Located in external side of apical plasma membrane and nucleus. Biomarker of diabetes mellitus; secondary hyperparathyroidism; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in gout; hematologic Cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Abcg2 Products (1)

mRNA Protein Name
NM_181381.2 NP_852046.1 broad substrate specificity ATP-binding cassette transporter ABCG2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables amide transmembrane transporter activity IDA
IDA: Inferred from direct assay
15255930 RGD
enables cytoskeletal protein binding IPI
IPI: Inferred from physical interaction
23403943 RGD
enables efflux transmembrane transporter activity IDA
IDA: Inferred from direct assay
15773906 RGD
enables organic anion transmembrane transporter activity IDA
IDA: Inferred from direct assay
15773906 RGD
enables xenobiotic transmembrane transporter activity IDA
IDA: Inferred from direct assay
15773906 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
18524938 RGD
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
23592396 RGD
involved in embryonic process involved in female pregnancy IDA
IDA: Inferred from direct assay
18450391 RGD
involved in export across plasma membrane IDA
IDA: Inferred from direct assay
15773906 RGD
involved in negative regulation of intestinal absorption IMP
IMP: Inferred from mutant phenotype
23333829 RGD
involved in organic anion transport IDA
IDA: Inferred from direct assay
15773906 RGD
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
15255930 RGD
involved in renal urate salt excretion IEP
IEP: Inferred from expression pattern
28679589 RGD
involved in response to 2,3,7,8-tetrachlorodibenzodioxine IEP
IEP: Inferred from expression pattern
22472606 RGD
involved in response to alcohol IEP
IEP: Inferred from expression pattern
29978425 RGD
involved in response to folic acid IEP
IEP: Inferred from expression pattern
19552531 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
28679589 RGD
involved in response to iron ion IEP
IEP: Inferred from expression pattern
15637178 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18505788 RGD
involved in transmembrane transport IMP
IMP: Inferred from mutant phenotype
16809480 RGD
involved in urate transport IMP
IMP: Inferred from mutant phenotype
22348008 RGD
involved in xenobiotic detoxification by transmembrane export across the plasma membrane IDA
IDA: Inferred from direct assay
15255930 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
18451542 RGD
located in external side of apical plasma membrane IDA
IDA: Inferred from direct assay
18619525 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Abcg2 Protein Structure

3a01204

3a01204: cl36780 (45 - 650)

  • 0
  • 200
  • 400
  • 600
  • 657 a.a.
Protein Preferred Names Protein Names

broad substrate specificity ATP-binding cassette transporter ABCG2

  • ATP binding cassette subfamily G member 2 (Junior blood group)

  • ATP-binding cassette protein G2

  • ATP-binding cassette sub-family G member 2

  • ATP-binding cassette, sub-family G (WHITE), member 2

  • ATP-binding cassette, subfamily G (WHITE), member 2

  • breast cancer resistance protein 1 homolog

  • urate exporter

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. 상품명 효과
Purity Rare Diseases
HY-10440 Vismodegib 99.97% Yes
HY-101561 Avapritinib Inhibitor 99.85% Yes
HY-109061 Lazertinib 99.87% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명 효과
Purity Phase
HY-109019 Vorolanib Inhibitor 99.78% Phase 3
HY-101570 Nedisertib 99.70% Phase 2
HY-10527C Telatinib mesylate Inhibitor 99.74% Phase 2

Pre-clinical Phase

Bioactive Molecules (59)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-10010 Ko 143 Inhibitor 99.97% Unkown
HY-11079 A-803467 Inhibitor 99.69% Unkown
HY-N2143 Fumitremorgin C Inhibitor 99.92% Unkown
HY-101453 Ceefourin 1 Inhibitor 99.72% Unkown
HY-10873 N-Desethyl Sunitinib 99.81% Unkown
HY-12757 YHO-13177 Inhibitor 99.65% Unkown
HY-D2869 Ac-H-FluNox 99.88% Unkown
HY-109061B Lazertinib mesylate 99.85% Unkown
HY-12758 YHO-13351 Inhibitor 99.16% Unkown
HY-136450 Triclabendazole sulfoxide Inhibitor 98.34% Unkown
HY-18010 PCI 29732 Inhibitor 99.59% Unkown
HY-111678 ML230 Inhibitor 99.65% Unkown
HY-100933 MY-5445 Inhibitor 99.79% Unkown
HY-113805 MC70 Inhibitor 99.50% Unkown
HY-144305 KPH2f Inhibitor 99.22% Unkown
HY-112505 Efflux inhibitor-1 Inhibitor 98.0% Unkown
HY-151432 URAT1 inhibitor 3 Inhibitor 98.02% Unkown
HY-P5391 LL-37(17-32) Inhibitor 96.71% Unkown
HY-RS00077 ABCG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W049875 Nitroxynil 98.92% Unkown
HY-183623 ProAlk01 Inducer / Unkown
HY-101570G Nedisertib (GMP) Inhibitor / Unkown
HY-109061A Lazertinib mesylate hydrate / Unkown
HY-118083 Pentamethoxymorin Inhibitor / Unkown
HY-121645 2,4-Dibromoestradiol / Unkown
HY-122416 6,8-Diprenylnaringenin Inhibitor / Unkown
HY-129301 CCTA-1523 Inhibitor / Unkown
HY-136450S Triclabendazole sulfoxide-d3 Inhibitor / Unkown
HY-136450S1 Triclabendazole sulfoxide-13C,d3 Inhibitor / Unkown
HY-13774 WK-X-34 Inhibitor / Unkown
HY-146676 UR-MB108 Inhibitor / Unkown
HY-155652 ABCG2-IN-1 Inhibitor / Unkown
HY-155653 ABCG2-IN-2 Inhibitor / Unkown
HY-156092 Antitumor photosensitizer-4 / Unkown
HY-168573 AZ99 Inhibitor / Unkown
HY-170396 ABCG2-IN-4 Inhibitor / Unkown
HY-174435 ABCB1/ABCG2-IN-1 Inhibitor / Unkown
HY-17648 MBL-II-141 Inhibitor / Unkown
HY-178100 PARP1-IN-45 Inhibitor / Unkown
HY-178386 ABCG2-IN-5 Inhibitor / Unkown
HY-181731S (R,S,R)-Altenuene-13C15 / Unkown
HY-181802 MRS8431 / Unkown
HY-181803 MRS8432 / Unkown
HY-181804 MRS8288 Inhibitor / Unkown
HY-182000 Xanthine oxidase-IN-23 / Unkown
HY-D3179 CDg13 Substrate / Unkown
HY-RS00078 Abcg2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00079 Abcg2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W082856A Butein tetramethyl ether Inhibitor / Unkown
HY-119724 ABCG2-IN-3 Inhibitor / Unkown
HY-123526 NSC265473 / Unkown
HY-136450R Triclabendazole sulfoxide (Standard) Inhibitor / Unkown
HY-149469 3,7,2',4'-Tetramethoxy-5-hydroxyflavone Inhibitor / Unkown
HY-168572 MZ82 Inhibitor / Unkown
HY-N2651 5,7,3'-Trihydroxy-4'-Methoxy-8-prenylflavanone Inhibitor / Unkown
HY-W705354 Vismodegib-d4 / Unkown
HY-W716916 Vismodegib-d7 / Unkown
HY-W754911 Avapritinib-d3 Inhibitor / Unkown
HY-W843469 1-Hydroxyacridin-9(10H)-one Control / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abcg2 NCBI NCBI:9429