Smo - smoothened, frizzled class receptor Gene

Also Known as bnb; Smoh; smoothened; E130215L21Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 319757

About Smo

Chromosome 6: 29,735,502-29,761,364 forward strand.GRCm39:CM000999.3

This gene has 2 transcripts (splice variants), 204 orthologues, 15 paralogues and is associated with 40 phenotypes. Broad expression in ovary adult (RPKM 53.2), limb E14.5 (RPKM 37.8) and 25 other tissues.

Summary

Predicted to enable patched binding activity. Involved in several processes, including animal organ development; regulation of animal organ morphogenesis; and regulation of gene expression. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regionalization. Located in 9+0 non-motile cilium; ciliary membrane; and cytoplasm. Is expressed in several structures, including 1st branchial arch; 4-cell stage embryo; alimentary system; central nervous system; and genitourinary system. Used to study medulloblastoma and pulmonary emphysema. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human Smo (smoothened, Frizzled class receptor). [provided by Alliance of Genome Resources, Apr 2022]

Smo Products (1)

mRNA	Protein	Name
NM_176996.5	NP_795970.3	smoothened homolog precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables oxysterol binding	IDA IDA: Inferred from direct assay	23831757	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21659505	MGI
enables protein kinase A catalytic subunit binding	IPI IPI: Inferred from physical interaction	33886552	MGI
enables protein sequestering activity	IDA IDA: Inferred from direct assay	33886552	MGI

Biological Process GO Annotation	Evidence	Références	Source
involved in alpha-tubulin acetylation	IMP IMP: Inferred from mutant phenotype	27793670	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	22987639	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	16571630	MGI
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	35353806	MGI
acts upstream of or within astrocyte activation	IMP IMP: Inferred from mutant phenotype	23680462	MGI
acts upstream of or within atrial septum morphogenesis	IGI IGI: Inferred from genetic interaction	22898775	MGI
acts upstream of or within cell development	IMP IMP: Inferred from mutant phenotype	12403705	MGI
acts upstream of or within cell fate specification	IMP IMP: Inferred from mutant phenotype	18590716	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12403705	MGI
involved in cellular response to cholesterol	IEP IEP: Inferred from expression pattern	21931618	MGI
acts upstream of or within central nervous system development	IGI IGI: Inferred from genetic interaction	12435628	MGI
acts upstream of or within central nervous system neuron differentiation	IMP IMP: Inferred from mutant phenotype	16571630	MGI
acts upstream of or within cerebellar cortex morphogenesis	IMP IMP: Inferred from mutant phenotype	16571625	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	23680462	MGI
acts upstream of or within dentate gyrus development	IMP IMP: Inferred from mutant phenotype	18297065	MGI
involved in determination of left/right asymmetry in lateral mesoderm	IMP IMP: Inferred from mutant phenotype	11517919	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	12421714	MGI
acts upstream of or within developmental growth	IMP IMP: Inferred from mutant phenotype	16571630	MGI
acts upstream of or within digestive tract development	IMP IMP: Inferred from mutant phenotype	19619492	MGI
acts upstream of or within dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	16571630	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IMP IMP: Inferred from mutant phenotype	18590716	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	15755804	MGI
acts upstream of or within embryonic organ development	IGI IGI: Inferred from genetic interaction	24302887	MGI
acts upstream of epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	17199044	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	12403705	MGI
acts upstream of or within epithelial-mesenchymal cell signaling	IMP IMP: Inferred from mutant phenotype	19304890	MGI
involved in forebrain morphogenesis	IMP IMP: Inferred from mutant phenotype	11517919	MGI
acts upstream of or within gene expression	IDA IDA: Inferred from direct assay	23201751	MGI
acts upstream of hair follicle development	IMP IMP: Inferred from mutant phenotype	17199044	MGI
acts upstream of or within hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	17199044	MGI
involved in heart looping	IMP IMP: Inferred from mutant phenotype	11517919	MGI
acts upstream of or within heart morphogenesis	IGI IGI: Inferred from genetic interaction	16687132	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IDA IDA: Inferred from direct assay	23680462	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	17881493	MGI
acts upstream of or within left/right axis specification	IMP IMP: Inferred from mutant phenotype	9636176	MGI
acts upstream of or within mammary gland epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	17199044	MGI
involved in mesenchymal to epithelial transition involved in metanephric renal vesicle formation	IMP IMP: Inferred from mutant phenotype	16396903	MGI
involved in midgut development	IMP IMP: Inferred from mutant phenotype	11517919	MGI
acts upstream of or within multicellular organism growth	IGI IGI: Inferred from genetic interaction	18590716	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	18590716	MGI
acts upstream of or within myoblast migration	IGI IGI: Inferred from genetic interaction	22987639	MGI
acts upstream of or within negative regulation of DNA binding	IGI IGI: Inferred from genetic interaction	16396903	MGI
involved in negative regulation of DNA binding	IMP IMP: Inferred from mutant phenotype	16396903	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	24548465	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16571630	MGI
acts upstream of or within negative regulation of epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	17199044	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16396903	MGI
acts upstream of or within negative regulation of hair follicle development	IMP IMP: Inferred from mutant phenotype	17199044	MGI
involved in negative regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	33886552	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19304890	MGI
acts upstream of or within neural crest cell migration	IGI IGI: Inferred from genetic interaction	16687132	MGI
acts upstream of neuroblast proliferation	IGI IGI: Inferred from genetic interaction	16543460	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	12403705	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	11748145	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	14973297	MGI
acts upstream of or within pancreas morphogenesis	IMP IMP: Inferred from mutant phenotype	20185815	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	15107405	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	24548465	MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	16396903	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19124651	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	12403705	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23680462	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16396903	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	19304890	MGI
involved in positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	24548465	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IGI IGI: Inferred from genetic interaction	16543460	MGI
involved in positive regulation of organ growth	IMP IMP: Inferred from mutant phenotype	24548465	MGI
acts upstream of or within positive regulation of protein import into nucleus	IGI IGI: Inferred from genetic interaction	17043310	MGI
acts upstream of or within positive regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	16459297	MGI
acts upstream of positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11517919	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15906375	MGI
acts upstream of protein import into nucleus	IGI IGI: Inferred from genetic interaction	17043310	MGI
acts upstream of or within protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	19952108	MGI
acts upstream of or within protein stabilization	IDA IDA: Inferred from direct assay	19124651	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	18590716	MGI
involved in regulation of heart morphogenesis	IMP IMP: Inferred from mutant phenotype	11517919	MGI
involved in regulation of localization	IMP IMP: Inferred from mutant phenotype	21209331	MGI
acts upstream of or within regulation of somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	17199044	MGI
acts upstream of or within response to inositol	IDA IDA: Inferred from direct assay	34093381	MGI
acts upstream of or within skeletal muscle fiber development	IMP IMP: Inferred from mutant phenotype	22987639	MGI
acts upstream of or within smoothened signaling pathway	IDA IDA: Inferred from direct assay	35353806	MGI
acts upstream of or within smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	17043310	MGI
acts upstream of or within smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	15107405	MGI
involved in smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	11517919	MGI
involved in somite development	IMP IMP: Inferred from mutant phenotype	11517919	MGI
involved in spinal cord dorsal/ventral patterning	IMP IMP: Inferred from mutant phenotype	21209331	MGI
acts upstream of or within thalamus development	IMP IMP: Inferred from mutant phenotype	19357274	MGI
acts upstream of or within type B pancreatic cell development	IMP IMP: Inferred from mutant phenotype	20185815	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	15294868	MGI
involved in ventral midline determination	IMP IMP: Inferred from mutant phenotype	11517919	MGI

Cellular Component GO Annotation	Evidence	Références	Source
located in 9+0 non-motile cilium	IDA IDA: Inferred from direct assay	26996322	MGI
is active in Golgi apparatus	IDA IDA: Inferred from direct assay	35353806	MGI
located in Golgi apparatus	IDA IDA: Inferred from direct assay	35353806	MGI
located in centriole	IDA IDA: Inferred from direct assay	29038301	MGI
located in ciliary membrane	IDA IDA: Inferred from direct assay	22179047	MGI
located in cilium	IDA IDA: Inferred from direct assay	16136078	MGI
is active in cilium	IMP IMP: Inferred from mutant phenotype	27793670	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	18488998	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	35353806	MGI
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	35353806	MGI
located in late endosome	IDA IDA: Inferred from direct assay	35353806	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	21931618	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Smo Protein Structure

CRD_SMO

7tmF_SMO_homolog

0
200
400
600
793 a.a.

Protein Preferred Names	Protein Names
smoothened homolog	bent body

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (6)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-16582A	Sonidegib	Antagonist	99.98%	Yes
HY-16391	Glasdegib	Inhibitor	99.65%	Yes
HY-B0603	Fluticasone	Agonist	98.70%	Yes
HY-16582	Sonidegib diphosphate	Antagonist	99.97%	Yes
HY-B0877	Halcinonide	Agonist	98.29%	Unkown
HY-16391A	Glasdegib maleate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-13654	IPI-269609	Inhibitor	/	Phase 4
HY-16587	Saridegib	Inhibitor	99.95%	Phase 3
HY-13242	Taladegib	Inhibitor	99.92%	Phase 2
HY-13809	BMS-833923	Inhibitor	99.82%	Phase 2
HY-18636	LEQ506	Inhibitor	98.92%	Phase 1

Pre-clinical Phase

Bioactive Molecules (59)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-12848	SAG	Agonist	99.79%	Unkown
HY-17024	Cyclopamine	Inhibitor	99.97%	Unkown
HY-15108	Purmorphamine	Activator	99.94%	Unkown
HY-100224	SANT-1	Antagonist	99.87%	Unkown
HY-12848B	SAG hydrochloride	Agonist	99.91%	Unkown
HY-12848C	SAG dihydrochloride	Agonist	98.23%	Unkown
HY-15483	DY131	Inhibitor	99.72%	Unkown
HY-100535	KAAD-Cyclopamine	Antagonist	≥96.0%	Unkown
HY-12316	20(S)-Hydroxycholesterol	Activator	99.63%	Unkown
HY-15108G	Purmorphamine (GMP)	Agonist	/	Unkown
HY-12317	GSA-10	Agonist	≥98.0%	Unkown
HY-13459	PF-5274857	Antagonist	99.31%	Unkown
HY-15412	HhAntag		99.40%	Unkown
HY-N0247	Saikosaponin B1	Inhibitor	99.42%	Unkown
HY-151115	JNJ-1289	Inhibitor	98.06%	Unkown
HY-12848R	SAG (Standard)	Agonist	99.56%	Unkown
HY-137115	BODIPY-Cyclopamine		98.91%	Unkown
HY-113965	CUR61414	Inhibitor	≥99.0%	Unkown
HY-115566	S1PL-IN-1	Antagonist	99.9%	Unkown
HY-100036	MK-4101	Antagonist	99.16%	Unkown
HY-117407	ALLO-2	Antagonist	99.72%	Unkown
HY-108508	SMANT hydrochloride	Inhibitor	99.90%	Unkown
HY-18287	MRT-83	Antagonist	99.27%	Unkown
HY-120499	AZD8542	Antagonist	99.49%	Unkown
HY-100224G	SANT-1 (GMP)	Antagonist	/	Unkown
HY-110240	IHR-1	Antagonist	98.05%	Unkown
HY-108507	MRT-10	Antagonist	98.99%	Unkown
HY-12316R	20(S)-Hydroxycholesterol (Standard)	Activator	98.69%	Unkown
HY-145387	MRT-81	Antagonist	99.85%	Unkown
HY-18287A	MRT-83 hydrochloride	Antagonist	99.60%	Unkown
HY-162372	Hedgehog IN-6	Inhibitor	/	Unkown
HY-150567	SMO-IN-3	Inhibitor	/	Unkown
HY-147743	SMO-IN-1	Inhibitor	/	Unkown
HY-147670	TPB15	Inhibitor	/	Unkown
HY-147744	AZD7254	Inhibitor	/	Unkown
HY-13242A	Taladegib hydrochloride	Inhibitor	/	Unkown
HY-162273	Antibacterial agent 189		/	Unkown
HY-183335	SMO-IN-6	Inhibitor	/	Unkown
HY-153499	SMO-IN-4	Antagonist	/	Unkown
HY-177291	LAB687	Antagonist	/	Unkown
HY-145918	MRT-14	Antagonist	99.04%	Unkown
HY-12848A	(Rac)-SAG	Agonist	/	Unkown
HY-13459A	PF-5274857 hydrochloride	Antagonist	/	Unkown
HY-12848S	SAG-d3	Inhibitor	99.85%	Unkown
HY-16391S1	Glasdegib-d4	Inhibitor	/	Unkown
HY-110326	Smo antagonist M25	Antagonist	/	Unkown
HY-16391B	Glasdegib hydrochloride	Inhibitor	/	Unkown
HY-131016	IHR-Cy3	Antagonist	/	Unkown
HY-159893	SMO-IN-5	Inhibitor	/	Unkown
HY-148440	RL-0070933	Modulator	/	Unkown
HY-117903A	MRT-92	Antagonist	/	Unkown
HY-184378	MDB5	Inhibitor	/	Unkown
HY-W338819	Clobetasol	Agonist	/	Unkown
HY-16587A	Saridegib hydrochloride	Inhibitor	/	Unkown
HY-W700539	N1-Acetyl triethylenetetramine	Inhibitor	/	Unkown
HY-123752	MS-0022	Antagonist	/	Unkown
HY-150564	SMO-IN-2	Inhibitor	98.12%	Unkown
HY-133974	7-keto-25-Hydroxycholesterol	Activator	/	Unkown
HY-12848G	SAG (GMP)	Agonist	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P990418	Anti-FZD7 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smo	NCBI	NCBI:6608