Smo - smoothened, frizzled class receptor Gene

Mus musculus

Also known as bnb; Smoh; smoothened; E130215L21Rik

Gene ID: 319757 | Gene type: protein coding

About Smo

Chromosome 6: 29,735,502-29,761,364 forward strand.GRCm39:CM000999.3

This gene has 2 transcripts (splice variants), 204 orthologues, 15 paralogues and is associated with 40 phenotypes. Broad expression in ovary adult (RPKM 53.2), limb E14.5 (RPKM 37.8) and 25 other tissues.

Summary

Predicted to enable patched binding activity. Involved in several processes, including animal organ development; regulation of animal organ morphogenesis; and regulation of gene expression. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regionalization. Located in 9+0 non-motile cilium; ciliary membrane; and cytoplasm. Is expressed in several structures, including 1st branchial arch; 4-cell stage embryo; alimentary system; central nervous system; and genitourinary system. Used to study medulloblastoma and pulmonary emphysema. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human Smo (smoothened, Frizzled class receptor). [provided by Alliance of Genome Resources, Apr 2022]

Smo Products(1)

mRNA	Protein	Name
NM_176996.5	NP_795970.3	smoothened homolog precursor

Smo Protein Structure

CRD_SMO

7tmF_SMO_homolog

0
200
400
600
793 a.a.

Protein Preferred Names

Protein Names

smoothened homolog

bent body

Related Agents

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16582A	Sonidegib	Antagonist	99.91%	Yes
HY-16391	Glasdegib	Inhibitor	99.31%	Yes
HY-16582	Sonidegib diphosphate	Antagonist	99.73%	Yes
HY-B0877	Halcinonide	Agonist	99.56%	Unkown
HY-B0603	Fluticasone	Agonist	/	Unkown
HY-16391A	Glasdegib maleate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16587	Saridegib	Inhibitor	99.87%	Phase 3
HY-13809	BMS-833923	Inhibitor	98.11%	Phase 2
HY-13242	Taladegib	Inhibitor	99.57%	Phase 2

Pre-clinical Phase

Bioactive Molecules (39)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12848	SAG	Agonist	99.79%	Unkown
HY-17024	Cyclopamine	Inhibitor	99.97%	Unkown
HY-15108	Purmorphamine	Activator	99.89%	Unkown
HY-12848B	SAG hydrochloride	Agonist	99.63%	Unkown
HY-15483	DY131	Inhibitor	99.88%	Unkown
HY-12848C	SAG dihydrochloride	Agonist	/	Unkown
HY-12316	20(S)-Hydroxycholesterol	Activator	98.70%	Unkown
HY-12317	GSA-10	Agonist	98.01%	Unkown
HY-13459	PF-5274857	Antagonist	98.89%	Unkown
HY-N0836	Jervine	Inhibitor	98.03%	Unkown
HY-145387	MRT-81	Antagonist	98.87%	Unkown
HY-18636	LEQ506	Inhibitor	98.15%	Unkown
HY-N0247	Saikosaponin B1	Inhibitor	99.42%	Unkown
HY-15412	HhAntag		98.70%	Unkown
HY-100036	MK-4101	Antagonist	98.31%	Unkown
HY-117407	ALLO-2	Antagonist	99.72%	Unkown
HY-113965	CUR61414	Inhibitor	99.04%	Unkown
HY-18287	MRT-83	Antagonist	99.16%	Unkown
HY-18287A	MRT-83 hydrochloride	Antagonist	99.60%	Unkown
HY-108507	MRT-10	Antagonist	98.99%	Unkown
HY-15108G	Purmorphamine (GMP)	Agonist	/	Unkown
HY-150567	SMO-IN-3	Inhibitor	/	Unkown
HY-147744	AZD7254	Inhibitor	/	Unkown
HY-162372	Hedgehog IN-6	Inhibitor	/	Unkown
HY-145918	MRT-14	Antagonist	98.91%	Unkown
HY-131016	IHR-Cy3	Antagonist	/	Unkown
HY-12848A	(Rac)-SAG	Agonist	/	Unkown
HY-110240	IHR-1	Antagonist	98.05%	Unkown
HY-147743	SMO-IN-1	Inhibitor	/	Unkown
HY-150564	SMO-IN-2	Inhibitor	/	Unkown
HY-153499	SMO-IN-4	Antagonist	/	Unkown
HY-108508	SMANT hydrochloride	Inhibitor	99.90%	Unkown
HY-12848S	SAG-d3	Inhibitor	99.85%	Unkown
HY-147670	TPB15	Inhibitor	/	Unkown
HY-13459A	PF-5274857 hydrochloride	Antagonist	/	Unkown
HY-148440	RL-0070933	Modulator	/	Unkown
HY-120499	AZD8542	Antagonist	/	Unkown
HY-12316R	20(S)-Hydroxycholesterol (Standard)	Activator	/	Unkown
HY-162273	Antibacterial agent 189		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smo	NCBI	NCBI:6608
Rattus norvegicus	Smo	NCBI	NCBI:25273

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