TLR7 - toll like receptor 7 Gene

Canis lupus familiaris (sub-species: familiaris)

Gene ID: 491743 | Gene type: protein coding

About TLR7

Primary_assembly X: 9,285,506-9,311,834 forward strand.ROS_Cfam_1.0:CM025138.1

This gene has 2 transcripts (splice variants), 197 orthologues and 19 paralogues.

TLR7 Products(1)

mRNA	Protein	Name
NM_001048124.2	NP_001041589.1	toll-like receptor 7

TLR7 Protein Structure

LRR_RI

LRR_8

LRR_RI

PPP1R42

LRR_RI

LRR_12

LRR_RI

LRR

LRR_RI

PCC

TIR

0
200
400
600
800
1000
1054 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 7

Related Agents

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0180	Imiquimod	Agonist	99.96%	Unkown
HY-B1370	Hydroxychloroquine sulfate	Inhibitor	99.99%	Yes
HY-B0180A	Imiquimod hydrochloride	Agonist	99.77%	Yes
HY-B0180B	Imiquimod maleate	Agonist	99.92%	Yes
HY-B1370B	(R)-Hydroxychloroquine	Inhibitor	/	Unkown
HY-B1370A	(S)-Hydroxychloroquine	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Phase
HY-W008634	Bropirimine	Agonist	99.94%	Phase 3
HY-13740	Resiquimod	Agonist	99.95%	Phase 2
HY-134581	Enpatoran	Inhibitor	99.80%	Phase 2
HY-15601	Vesatolimod	Agonist	99.90%	Phase 2
HY-134581A	Enpatoran hydrochloride	Inhibitor	99.42%	Phase 2
HY-108472	Loxoribine	Agonist	99.94%	Phase 2
HY-13740G	Resiquimod (GMP)	Agonist	/	Phase 2
HY-111269	AZD8848	Agonist	99.14%	Phase 2
HY-100176	PF-4878691	Agonist	99.89%	Phase 2
HY-118250	GSK2245035	Agonist	99.79%	Phase 2
HY-139575	Guretolimod	Agonist	/	Phase 2
HY-177617	Bazlitoran	Agonist	/	Phase 2
HY-177617A	Bazlitoran sodium	Agonist	/	Phase 2
HY-13655A	Isatoribine	Agonist	/	Phase 2
HY-109104	Telratolimod	Agonist	98.85%	Phase 1
HY-111786	LHC-165	Agonist	98.0%	Phase 1
HY-178166	ETI41	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (89)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0201	Atractylenolide I	Antagonist	99.98%	Unkown
HY-124603	AT791	Inhibitor	98.77%	Unkown
HY-128799	CL097	Agonist	99.90%	Unkown
HY-160229	ssRNA40 sodium	Activator	98.34%	Unkown
HY-12756A	E6446 dihydrochloride	Antagonist	99.29%	Unkown
HY-103697	Gardiquimod		99.91%	Unkown
HY-12756	E6446	Antagonist	98.78%	Unkown
HY-103698	TLR7/8 agonist 1	Agonist	98.42%	Unkown
HY-139323	TLR7/8-IN-1	Inhibitor	99.92%	Unkown
HY-103698A	TLR7/8 agonist 1 dihydrochloride	Agonist	99.70%	Unkown
HY-135905	CL264	Inhibitor	98.63%	Unkown
HY-110120	DSR-6434	Agonist	99.32%	Unkown
HY-128799A	CL097 hydrochloride	Agonist	99.96%	Unkown
HY-111582	BBIQ	Agonist	99.81%	Unkown
HY-130797	TLR7/8 agonist 3	Agonist	99.96%	Unkown
HY-B1370R	Hydroxychloroquine sulfate (Standard)	Inhibitor	99.96%	Unkown
HY-117602	TLR7 agonist 3	Agonist	99.90%	Unkown
HY-160227A	ORN 06 sodium	Activator	95.05%	Unkown
HY-153879	C12-TLRa	Ligand	99.0%	Unkown
HY-111358	TLR7 agonist 1	Agonist	98.19%	Unkown
HY-159102	PVP-037.2	Agonist	99.18%	Unkown
HY-156174	E104	Inhibitor	99.38%	Unkown
HY-139017	TLR7/8 agonist 4	Agonist	99.18%	Unkown
HY-131945	CU-115	Antagonist	99.63%	Unkown
HY-150736	ODN 20844	Inhibitor	96.14%	Unkown
HY-13740S	Resiquimod-d5	Agonist	98.33%	Unkown
HY-138139B	AXC-715 trihydrochloride	Agonist	99.76%	Unkown
HY-110207	SM-324405	Agonist	98.52%	Unkown
HY-103697A	Gardiquimod diTFA		99.0%	Unkown
HY-115400	1V209	Agonist	99.67%	Unkown
HY-145885	TLR7/8 agonist 6	Agonist	98.93%	Unkown
HY-138139A	AXC-715 hydrochloride	Agonist	99.89%	Unkown
HY-156693A	MTvkPABC-P5 TFA	Agonist	98.78%	Unkown
HY-176774	L07-2	Agonist	99.83%	Unkown
HY-157793	SMU-L11	Agonist	99.64%	Unkown
HY-145960A	MC-Val-Cit-PAB-Amide-TLR7 agonist 4 formic	Agonist	97.70%	Unkown
HY-158694A	TLR7 agonist 20 hydrochloride	Agonist	99.86%	Unkown
HY-164485	INI-4001	Activator	/	Unkown
HY-145961	TLR7 agonist 4	Agonist	98.87%	Unkown
HY-153543	TLR7/8 agonist 8	Agonist	98.69%	Unkown
HY-178037	TLR9 antagonist 1	Antagonist	/	Unkown
HY-179474	TSI-13-57	Inhibitor	98.73%	Unkown
HY-153071	TLR7 agonist 6	Agonist	98.08%	Unkown
HY-10018	Toll-like receptor modulator	Modulator	99.36%	Unkown
HY-145960	MC-Val-Cit-PAB-Amide-TLR7 agonist 4	Agonist	99.39%	Unkown
HY-150744	ODN 24888	Inhibitor	/	Unkown
HY-150158	TMX-201		≥95.0%	Unkown
HY-101589	Sotirimod	Agonist	99.90%	Unkown
HY-139017A	TLR7/8 agonist 4 TFA	Agonist	/	Unkown
HY-141454	TLR8 agonist 2	Agonist	/	Unkown
HY-141454A	TLR8 agonist 2 hydrochloride	Agonist	/	Unkown
HY-147215	UC-1V150	Agonist	/	Unkown
HY-179047	SMU-L11-R	Agonist	/	Unkown
HY-162725	TLR7 agonist 24	Agonist	/	Unkown
HY-158694	TLR7 agonist 20	Agonist	/	Unkown
HY-163670	TLR7 agonist 21	Inhibitor	/	Unkown
HY-179209	TLR9-IN-2	Inhibitor	/	Unkown
HY-145886	TLR7/8 antagonist 1	Antagonist	/	Unkown
HY-168159	TLR7 agonist 27	Agonist	/	Unkown
HY-153544	TLR7/8 agonist 9	Inhibitor	/	Unkown
HY-179007	TLR7 agonist 31	Agonist	/	Unkown
HY-121496	3M-011	Agonist	/	Unkown
HY-153070	TLR7 agonist 5	Agonist	/	Unkown
HY-183079	ENDO12	Inhibitor	/	Unkown
HY-156175	TLR7 agonist 14	Agonist	/	Unkown
HY-153073	TLR7 agonist 8	Agonist	/	Unkown
HY-163398	TLR7-IN-1	Inhibitor	/	Unkown
HY-168157	TLR7 agonist 26	Agonist	/	Unkown
HY-176553	KBD4466	Inhibitor	/	Unkown
HY-162845	TLR7/8 agonist 11	Agonist	/	Unkown
HY-175782	SMU-R39	Antagonist	/	Unkown
HY-160227	ORN 06	Activator	/	Unkown
HY-153072	TLR7 agonist 7	Agonist	/	Unkown
HY-162115	TLR7 agonist 17	Agonist	/	Unkown
HY-181796	TLR7 antagonist-1	Antagonist	/	Unkown
HY-169057	BI1543673	Inhibitor	/	Unkown
HY-169017	MTT5	Agonist	98.49%	Unkown
HY-178169	ETI60	Inhibitor	/	Unkown
HY-173070	TLR7 agonist 29	Agonist	/	Unkown
HY-152726	TLR7 agonist 9	Agonist	/	Unkown
HY-179336	TLR7/8 agonist 14	Agonist	/	Unkown
HY-117686	AZ12441970	Agonist	/	Unkown
HY-170899	TLR7 agonist 28	Agonist	/	Unkown
HY-111582G	BBIQ (GMP)	Agonist	/	Unkown
HY-159919	UM-3006	Agonist	/	Unkown
HY-159914	AYK004-B1	Agonist	/	Unkown
HY-159916	AYK004	Agonist	/	Unkown
HY-177300	TLR7/8 agonist 13	Agonist	/	Unkown
HY-165632	Creatine ethyl ester	Activator	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991956	ABB071	Inhibitor	/	Unkown
HY-P992348	DS-7011a	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	TLR7	NCBI	NCBI:51284
Mus musculus	TLR7	NCBI	NCBI:170743

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