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Cat. No.: HY-101276

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AZD-1236

Name: AZD-1236
Brand: MedChemExpress
SKU: HY-101276
Price: 200.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 Customer Validation

AZD-1236 is a dual inhibitor of MMP-9 and MMP-12. AZD-1236 selectively inhibits the activities of MMP-9 and MMP-12. AZD-1236 regulates biomarkers, reduces elastin degradation, and decreases lymphocyte levels in sputum and blood. AZD-1236 can be used for research related to chronic obstructive pulmonary disease.

For research use only. We do not sell to patients.

Purity: 98.01%
CAS No.: 459814-89-2
Formula: C₁₅H₁₉ClN₄O₅S
Molecular Weight:402.85

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

AZD-1236 Chemical Structure

CAS No.: 459814-89-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]^[2]^[3]

MMP-9

MMP-12

All MMP Isoforms :

In Vitro

AZD-1236 potently and selectively inhibits MMP-9 and MMP-12 in vitro^[2].
AZD-1236 acts as a selective inhibitor of purified human MMP-9 and MMP-12 proteins in vitro^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 459814-89-2
Appearance Solid
Molecular Weight 402.85
Formula C₁₅H₁₉ClN₄O₅S
Color White to off-white (Solid)
SMILES

C[C@@]1(NC(NC1=O)=O)CS(=O)(N2CCC(CC2)OC3=CC=C(C=N3)Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shoari A, et al. Therapeutic potential of inhibitors of gelatinases MMP-2 and MMP-9 for the treatment of breast cancer. The FEBS journal. 2026 Jul;293(13):4014-4042. [Content Brief]

[2]. Dahl R, et al. Effects of an oral MMP-9 and -12 inhibitor, AZD1236, on biomarkers in moderate/severe COPD: a randomised controlled trial. Pulmonary pharmacology & therapeutics. 2012 Apr;25(2):169-77.

[3]. Magnussen H, et al. Safety and tolerability of an oral MMP-9 and -12 inhibitor, AZD1236, in patients with moderate-to-severe COPD: a randomised controlled 6-week trial. Pulmonary pharmacology & therapeutics. 2011 Oct;24(5):563-70. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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