PHA 408
Based on 1 publication(s) in Google Scholar
PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation.
For research use only. We do not sell to patients.
- Purity: 99.40%
- CAS No.: 503555-55-3
- Formula: C29H27ClFN7O2
- Molecular Weight:560.02
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) PHA 408
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Biological Activity
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IKK-2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PBMC | IC50 |
39 nM
Compound: PHA-408
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Inhibition of LPS-stimulated TNFalpha release in human PBMC
Inhibition of LPS-stimulated TNFalpha release in human PBMC
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[PMID: 21236687] |
Chemical Information
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CAS No. 503555-55-3
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Appearance Solid
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Molecular Weight 560.02
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Formula C29H27ClFN7O2
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Color Off-white to light yellow
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SMILES
O=C(C1=NN(C2=CC=C(F)C=C2)C3=C1CCC4=CC=C(NC(C5=C(Cl)C=NC(N6CCN(C)CC6)=C5)=O)C=C43)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Transl Med
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. [Abstract]2018 Jul 18;10(450):eaaq1093. PMID: 30021885
Solvent & Solubility
DMSO : 50 mg/mL (89.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7857 mL | 8.9283 mL | 17.8565 mL | 44.6413 mL |
| 5 mM | 0.3571 mL | 1.7857 mL | 3.5713 mL | 8.9283 mL | |
| 10 mM | 0.1786 mL | 0.8928 mL | 1.7857 mL | 4.4641 mL | |
| 15 mM | 0.1190 mL | 0.5952 mL | 1.1904 mL | 2.9761 mL | |
| 20 mM | 0.0893 mL | 0.4464 mL | 0.8928 mL | 2.2321 mL | |
| 25 mM | 0.0714 mL | 0.3571 mL | 0.7143 mL | 1.7857 mL | |
| 30 mM | 0.0595 mL | 0.2976 mL | 0.5952 mL | 1.4880 mL | |
| 40 mM | 0.0446 mL | 0.2232 mL | 0.4464 mL | 1.1160 mL | |
| 50 mM | 0.0357 mL | 0.1786 mL | 0.3571 mL | 0.8928 mL | |
| 60 mM | 0.0298 mL | 0.1488 mL | 0.2976 mL | 0.7440 mL | |
| 80 mM | 0.0223 mL | 0.1116 mL | 0.2232 mL | 0.5580 mL |
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