2C07
2C07 is a mutant Ras (K-RasM72C, H-RasM72C) inhibitor. 2C07 blocks the activation of PI3K through allosteric Ras modification. 2C07 binds to the modified switch II pocket (S-IIG) of Ras in both GDP- and GTP-bound states, stabilizes the GDP-bound state, disrupts the polar interactions of the canonical GTP-bound state, and inhibits SOS binding and nucleotide exchange. 2C07 can be used in cancer-related research.
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- CAS 番号: 2230185-95-0
- 分子式: C19H25F3N4O2S2
- 分子量:462.55
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
2C07 selectively binds to the engineered Cys72 residue in truncated K-RasM72C GDP and truncated H-RasM72C GppNHp with βME50 values of 2.53 mM and 1.10 mM, respectively, and does not modify wild-type Ras constructs[1].
2C07 binds to the switch-II groove (S-IIG) of truncated K-RasM72C GDP and truncated H-RasM72C in both GDP and GppNHp states, inducing a modified switch-II pocket conformation and, in the GppNHp state, altering switch I positioning and Mg2+ coordination[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2230185-95-0
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分子量 462.55
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分子式 C19H25F3N4O2S2
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SMILES
O=C(NCCCSSCCN(C)C)C1=C(N(N=C1)C2=CC=C(C=C2)OC)C(F)(F)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
2C07 関連分類
HY-114894 関連分類
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