5-AIQ
Based on 1 Customer Validation
5-AIQ (5-Aminoisoquinolin-1-one) is a PARP-1 inhibitor. 5-AIQ is an important functional group in various drugs. 5-AIQ reduces the tissue injury associated with ischemia-reperfusion of the liver, it can be used for the research of the research conditions associated with ischemia-reperfusion of the liver.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.75%
- CAS 番号: 93117-08-9
- 分子式: C9H8N2O
- 分子量:160.18
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
PARP-1
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
>200 μM
Compound: 1
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Growth inhibition of human HT-29 cells after 7 days by MTS assay
Growth inhibition of human HT-29 cells after 7 days by MTS assay
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[PMID: 21417348] |
| LNCaP | IC50 |
>200 μM
Compound: 1
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Growth inhibition of human LNCAP cells after 7 days by MTS assay
Growth inhibition of human LNCAP cells after 7 days by MTS assay
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[PMID: 21417348] |
| MDA-MB-231 | IC50 |
170 μM
Compound: 1
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Growth inhibition of human MDA-MB-231 cells after 7 days by MTS assay
Growth inhibition of human MDA-MB-231 cells after 7 days by MTS assay
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[PMID: 21417348] |
体外実験
5-AIQ (5000 μg) significantly reduces the number of colonies of TA 98 without metabolic activation, and TA 98 and TA 1537 with metabolic activation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male mice[1]
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Dosage:150 and 250 mg/kg
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Administration:Oral administration; 150 and 250 mg/kg; once
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Result:Showed no increase of micronucleated polychromatic erythrocytes (MNPCE) in both 24 h and 48 h after both 125 and 250 mg/kg duration exposure as compared to the corresponding control.
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Animal Model:Anesthetised male Wistar rats with liver ischemia (for 30 minutes) and reperfusion (for 2 hours) [2]
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Dosage:3 mg/kg
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Administration:Intravenous injection; 3 mg/kg; 5 min prior to onset of liver ischemia
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Result:Reduced PARP activation and showed less staining for ICAM-1.
化学情報
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CAS 番号 93117-08-9
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性状 Solid
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分子量 160.18
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分子式 C9H8N2O
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Color Yellow to brown
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SMILES
O=C1NC=CC2=C1C=CC=C2N
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別名
5-Aminoisoquinolin-1-one
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (624.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Vinod KR, Chandra S, Sharma SK. Evaluation of 5-aminoisoquinoline (5-AIQ), a novel PARP-1 inhibitor for genotoxicity potential in vitro and in vivo. Toxicol Mech Methods. 2010 Feb;20(2):90-5. [Content Brief]
[2]. Mota-Filipe H, et al. The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat. Med Sci Monit. 2002 Nov;8(11):BR444-53. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.2431 mL | 31.2157 mL | 62.4313 mL | 156.0783 mL |
| 5 mM | 1.2486 mL | 6.2431 mL | 12.4863 mL | 31.2157 mL | |
| 10 mM | 0.6243 mL | 3.1216 mL | 6.2431 mL | 15.6078 mL | |
| 15 mM | 0.4162 mL | 2.0810 mL | 4.1621 mL | 10.4052 mL | |
| 20 mM | 0.3122 mL | 1.5608 mL | 3.1216 mL | 7.8039 mL | |
| 25 mM | 0.2497 mL | 1.2486 mL | 2.4973 mL | 6.2431 mL | |
| 30 mM | 0.2081 mL | 1.0405 mL | 2.0810 mL | 5.2026 mL | |
| 40 mM | 0.1561 mL | 0.7804 mL | 1.5608 mL | 3.9020 mL | |
| 50 mM | 0.1249 mL | 0.6243 mL | 1.2486 mL | 3.1216 mL | |
| 60 mM | 0.1041 mL | 0.5203 mL | 1.0405 mL | 2.6013 mL | |
| 80 mM | 0.0780 mL | 0.3902 mL | 0.7804 mL | 1.9510 mL | |
| 100 mM | 0.0624 mL | 0.3122 mL | 0.6243 mL | 1.5608 mL |
5-AIQ 関連分類
HY-W006566 関連分類
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