CDK8-IN-1
Based on 1 Customer Validation
CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.19%
- CAS 番号: 1629633-48-2
- 分子式: C11H8F3N3O
- 分子量:255.20
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Kinase Inhibitor Library
HY-L009
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Blood Cancer Compound Library
HY-L079
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Cancer Stem Cells Compound Library
HY-L135
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Heterocyclic Compound Library
HY-L138
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Highly Selective Inhibitors Library
HY-L158
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Serine/Threonine Kinase Inhibitor Library
HY-L164
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Anti-Hematopathy Compound Library
HY-L171
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Anti-Ovarian Cancer Compound Library
HY-L173
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Protein Kinase Compound Library
HY-L196
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Cell Proliferation Compound Library
HY-L201
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
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High-Efficiency Gene Editing Compound Library
HY-L244
生物活性
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CDK8 3 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| AGS | IC50 |
0.27 μM
Compound: 16
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Antiproliferative activity against human AGS cells after 72 hrs by MTT assay
Antiproliferative activity against human AGS cells after 72 hrs by MTT assay
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[PMID: 28802632] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1629633-48-2
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性状 Solid
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分子量 255.20
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分子式 C11H8F3N3O
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Color White to light brown
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SMILES
NC(C1=C(C(F)(F)F)C(C2=CC=NC=C2)=CN1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (391.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
純度とドキュメンテーション
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データシート (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9185 mL | 19.5925 mL | 39.1850 mL | 97.9624 mL |
| 5 mM | 0.7837 mL | 3.9185 mL | 7.8370 mL | 19.5925 mL | |
| 10 mM | 0.3918 mL | 1.9592 mL | 3.9185 mL | 9.7962 mL | |
| 15 mM | 0.2612 mL | 1.3062 mL | 2.6123 mL | 6.5308 mL | |
| 20 mM | 0.1959 mL | 0.9796 mL | 1.9592 mL | 4.8981 mL | |
| 25 mM | 0.1567 mL | 0.7837 mL | 1.5674 mL | 3.9185 mL | |
| 30 mM | 0.1306 mL | 0.6531 mL | 1.3062 mL | 3.2654 mL | |
| 40 mM | 0.0980 mL | 0.4898 mL | 0.9796 mL | 2.4491 mL | |
| 50 mM | 0.0784 mL | 0.3918 mL | 0.7837 mL | 1.9592 mL | |
| 60 mM | 0.0653 mL | 0.3265 mL | 0.6531 mL | 1.6327 mL | |
| 80 mM | 0.0490 mL | 0.2449 mL | 0.4898 mL | 1.2245 mL | |
| 100 mM | 0.0392 mL | 0.1959 mL | 0.3918 mL | 0.9796 mL |
CDK8-IN-1 関連分類
HY-103492 関連分類
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