Clopidol
Based on 1 Customer Validation
Clopidol (WR-61112) is an anticoccidial agent which is used as feed additive to control coccidiosis in chickens. Clopidol inhibits the sporulation of Eimeria tenella oocysts.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.78%
- CAS 番号: 2971-90-6
- 分子式: C7H7Cl2NO
- 分子量:192.04
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Plasmodium |
Coccidia |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | IC50 |
1.46 μM
Compound: 3
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Antiplasmodial activity against liver stage Plasmodium berghei infected in human HuH7 cells co-expressing GFP-Luccon treated for 1 hr prior to infection followed by 24 hrs after compound washout measured after 48 hrs post-infection by Alamar Blue assay
Antiplasmodial activity against liver stage Plasmodium berghei infected in human HuH7 cells co-expressing GFP-Luccon treated for 1 hr prior to infection followed by 24 hrs after compound washout measured after 48 hrs post-infection by Alamar Blue assay
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[PMID: 23701465] |
Clopidol is active against Plasmodium falciparum W2 (chloroquine-resistant) and FCR3 (atovaquone-resistant) strains in the low micromolar range[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2971-90-6
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性状 Solid
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分子量 192.04
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分子式 C7H7Cl2NO
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Color White to off-white
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SMILES
OC1=C(Cl)C(C)=NC(C)=C1Cl
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別名
WR-61112
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
0.1 M NaOH : 26 mg/mL (135.39 mM; ultrasonic and adjust pH to 3 with NaOH)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Pang GF, et, al. Determination of clopidol residues in chicken tissues by high-performance liquid chromatography-mass spectrometry. J Chromatogr A. 2000 Jun 16;882(1-2):85-8. [Content Brief]
[2]. Arakawa A, et, al. Effects of clopidol on sporulation and infectivity of Eimeria tenella oocysts. Vet Parasitol. 1991 Jan;38(1):55-60. [Content Brief]
[3]. Rodrigues T, et, al. Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3476-80. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 0.1 M NaOH | 1 mM | 5.2072 mL | 26.0362 mL | 52.0725 mL | 130.1812 mL |
| 5 mM | 1.0414 mL | 5.2072 mL | 10.4145 mL | 26.0362 mL | |
| 10 mM | 0.5207 mL | 2.6036 mL | 5.2072 mL | 13.0181 mL | |
| 15 mM | 0.3471 mL | 1.7357 mL | 3.4715 mL | 8.6787 mL | |
| 20 mM | 0.2604 mL | 1.3018 mL | 2.6036 mL | 6.5091 mL | |
| 25 mM | 0.2083 mL | 1.0414 mL | 2.0829 mL | 5.2072 mL | |
| 30 mM | 0.1736 mL | 0.8679 mL | 1.7357 mL | 4.3394 mL | |
| 40 mM | 0.1302 mL | 0.6509 mL | 1.3018 mL | 3.2545 mL | |
| 50 mM | 0.1041 mL | 0.5207 mL | 1.0414 mL | 2.6036 mL | |
| 60 mM | 0.0868 mL | 0.4339 mL | 0.8679 mL | 2.1697 mL | |
| 80 mM | 0.0651 mL | 0.3255 mL | 0.6509 mL | 1.6273 mL | |
| 100 mM | 0.0521 mL | 0.2604 mL | 0.5207 mL | 1.3018 mL |
Clopidol 関連分類
HY-B1088 関連分類
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