製品番号: HY-N0096

Rotundine

(別名: (-)-Tetrahydropalmatine; L-Tetrahydropalmatine)

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC₅₀s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of 5-HT_1A with an IC₅₀ of 370 nM.

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純度: 99.96%
CAS 番号: 483-14-7
分子式: C₂₁H₂₅NO₄
分子量:355.43

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Rotundine 構造式

CAS 番号: 483-14-7

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体内実験
- 臨床実験
化学情報
Publications (1)
溶剤 & 溶解度
- 体外
プロトコル
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

5-HT_1A Receptor

D₁ Receptor

166 nM (IC₅₀)

D₂ Receptor

1400 nM (IC₅₀)

D₃ Receptor

3300 nM (IC₅₀)

5-HT_1A Receptor

370 nM (IC₅₀)

5-HT Receptor アイソフォーム固有の製品をすべて表示 :

Dopamine Receptor アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
THP-1	IC₅₀	22.78 nM Compound: 1	Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrs Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrs	[PMID: 23199480]

体内実験

Rotundine (l-THP) possesses a blocking effect on dopamine D₁ and D2 receptors. On day 1 and 7, there is no difference in locomotor counts between the Rotundine groups (6.25, 12.5, and 18.75 mg/kg) and saline group. Locomotor counts are greatly increased in the oxycodone group compare with the saline group. Rotundine at doses of 6.25, 12.5, and 18.75 mg/kg antagonizes hyperactivity induced by oxycodone. Rotundine (6.25, 12.5 mg/kg) does not affect the magnitude of sensitization, but there is a marked difference between oxycodone+oxycodone group and Rotundine (18.75 mg/kg)+oxycodone+oxycodone group, indicating that Rotundine (18.75 mg/kg) greatly inhibits the development of oxycodone sensitization^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 483-14-7
性状 Solid
分子量 355.43
分子式 C₂₁H₂₅NO₄
Color White to off-white
SMILES

COC1=CC=C2C(CN3CCC4=CC(OC)=C(OC)C=C4[C@]3([H])C2)=C1OC
別名

(-)-Tetrahydropalmatine; L-Tetrahydropalmatine
Structure Classification
- Alkaloids
- Isoquinoline Alkaloids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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RNA Biol

Comprehensive profiling and molecular characterization of alternative splicing regulation in synaptic remodelling associated with neuropathic pain induced by chronic constrictive injury in a rat model. [Abstract]

2026 May 15. PMID: 42137963

溶剤 & 溶解度

体外:

DMF : 100 mg/mL (281.35 mM; Need ultrasonic)

DMSO : ≥ 100 mg/mL (281.35 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8135 mL

14.0675 mL

28.1349 mL

5 mM

0.5627 mL

2.8135 mL

5.6270 mL

10 mM

0.2813 mL

1.4067 mL

2.8135 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

プロトコル

Animal Administration^[2]

Kunming mice, initially weighing 18 to 22 g are used in this study. Four groups of mice are given Rotundine (l-THP) (6.25, 12.5, and 18.75 mg/kg) or saline, respectively, once per day for 7 consecutive days, followed by a 5 d withdrawal period. On d 13, all animals are challenged with saline. On day 1, 7, and 13, after 40-min treatment with Rotundine or saline, the mice are put into the test boxes and locomotor activity is monitored for 60 min^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang JB, et al. l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction. Future Med Chem. 2012 Feb;4(2):177-86. [Content Brief]

[2]. Liu YL, et al. Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice. Acta Pharmacol Sin. 2005 May;26(5):533-8. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMF / DMSO	1 mM	2.8135 mL	14.0675 mL	28.1349 mL	70.3373 mL
	5 mM	0.5627 mL	2.8135 mL	5.6270 mL	14.0675 mL
	10 mM	0.2813 mL	1.4067 mL	2.8135 mL	7.0337 mL
	15 mM	0.1876 mL	0.9378 mL	1.8757 mL	4.6892 mL
	20 mM	0.1407 mL	0.7034 mL	1.4067 mL	3.5169 mL
	25 mM	0.1125 mL	0.5627 mL	1.1254 mL	2.8135 mL
	30 mM	0.0938 mL	0.4689 mL	0.9378 mL	2.3446 mL
	40 mM	0.0703 mL	0.3517 mL	0.7034 mL	1.7584 mL
	50 mM	0.0563 mL	0.2813 mL	0.5627 mL	1.4067 mL
	60 mM	0.0469 mL	0.2345 mL	0.4689 mL	1.1723 mL
	80 mM	0.0352 mL	0.1758 mL	0.3517 mL	0.8792 mL
	100 mM	0.0281 mL	0.1407 mL	0.2813 mL	0.7034 mL

Keywords

Rotundine

1 Cited Publications

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Rotundine

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MedChemExpress（MCE）の使用を引用している文献 Rotundine

5-HT Receptor アイソフォーム固有の製品をすべて表示

Dopamine Receptor アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

プロトコル

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Rotundine 関連分類

HY-N0096 関連分類