AG73
AG73 is a polypeptide. AG73 is derived from the G domain of the Laminin α1 chain. AG73 binds heparin, Syndecan-1 and Syndecan-4. AG73 promotes the adhesion of various cells, induces the differentiation of salivary gland acinar cells, stimulates neurite outgrowth, secretion of matrix metalloproteinases and angiogenesis. AG73 retains its angiogenic activity when conjugated to chitosan membranes. AG73 can be used in the research of melanoma and ischemic injury.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 170655-66-0
- 分子式: C64H120N24O17
- 分子量:1497.82
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
AG73 (200 μg/mL) completely inhibits the formation of cellular networks by mouse melanoma (B16F10) cells on Matrigel[1].
AG73 binds to immobilized biotinylated heparin with a Kd of 6.4 μM[1].
AG73 (1-100 μg/mL; 2 days) stimulates angiogenesis sprouting from 13-day-incubated chick embryo aortic rings in a dose-dependent manner[2].
AG73 (0.1-100 μg; 18 h) promotes axonal growth in 71% of PC12 cells when used at a substrate coating concentration of 100 μg[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
AG73 (1 mg/mL per mouse; s.c.; single dose) promotes vessel cell migration and angiogenesis in vivo, resulting in a mean of 55 endothelial cells per field in the subcutaneous Cultrex BME plug assay[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:unspecified strain (fertilized eggs)[2]
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Dosage:0.5 μg per coverslip
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Administration:topical application; single dose
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Result:Induced a positive angiogenic response (vessels radiating from the coverslip center) in 55.5% of treated eggs.
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Animal Model:unspecified strain[2]
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Dosage:1 mg/mL per mouse
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Administration:s.c.; single dose
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Result:Showed an intermediate color between the poorly vascularized control/AG73T plugs and the ECGS-treated positive control plugs.
Confirmed significantly more migrated endothelial cells, with a mean of ~55 endothelial cells per field.
化学情報
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CAS 番号 170655-66-0
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分子量 1497.82
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分子式 C64H120N24O17
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配列
Arg-Lys-Arg-Leu-Gln-Val-Gln-Leu-Ser-Ile-Arg-Thr
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シーケンスの短縮
RKRLQVQLSIRT
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Hoffman MP, et al. Cell type-specific differences in glycosaminoglycans modulate the biological activity of a heparin-binding peptide (RKRLQVQLSIRT) from the G domain of the laminin alpha1 chain. J Biol Chem. 2001;276(25):22077-22085. [Content Brief]
[2]. Mochizuki M, et al. Angiogenic activity of syndecan-binding laminin peptide AG73 (RKRLQVQLSIRT). Arch Biochem Biophys. 2007;459(2):249-255. [Content Brief]
[3]. Weeks BS, et al. Laminin-1 and the RKRLQVQLSIRT laminin-1 alpha1 globular domain peptide stimulate matrix metalloproteinase secretion by PC12 cells. Exp Cell Res. 1998;243(2):375-382. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AG73 関連分類
HY-P11777 関連分類
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