Bufothionine
Bufothionine is an alkaloid. Bufothionine can be isolated from Cinobufacini. Bufothionine induces mitochondria-mediated Apoptosis. Bufothionine significantly reduces serum IL-6 concentration, suppresses p-Stat3tyr705, p-Stat3ser727 and Jak2 expressions. Bufothionine upregulates Atg5, Atg7 and LC3Ⅱ expressions. Bufothionine induces Autophagy. Bufothionine suppresses PIM3 expression. Bufothionine relieves symptoms of H22-tumor-bearing mice and exerts anti-inflammation activity. Bufothionine exerts anti-cancer activities against gastric cancer.
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- CAS 番号: 475-39-8
- 分子式: C12H14N2O4S
- 分子量:282.32
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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JAK2 |
p-STAT3 |
PIM3 |
IL-6 |
化学情報
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CAS 番号 475-39-8
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分子量 282.32
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分子式 C12H14N2O4S
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SMILES
O=S([O-])(OC1=CC=C2NC=C3C2=C1[N+](C)(CC3)C)=O
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Structure Classification
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Initial Source
toad
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Kong WS, et al. Bufothionine induces autophagy in H22 hepatoma-bearing mice by inhibiting JAK2/STAT3 pathway, a possible anti-cancer mechanism of cinobufacini. J Ethnopharmacol. 2021 Apr 24;270:113848. [Content Brief]
[2]. Wang G, et al. Bufothionine exerts anti-cancer activities in gastric cancer through Pim3. Life Sci. 2019 Sep 1;232:116615. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Bufothionine 関連分類
HY-N13352 関連分類
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