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製品番号: HY-163374

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Cdc7-IN-20

Cdc7-IN-20 (EP-05) is an orally effective and selective Cdc7 inhibitor with IC₅₀ and K_i values of 0.93 and 0.11 nM, respectively. Cdc7-IN-20 has antitumor activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₅H₁₆N₄OS
分子量:300.38

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Cdc7-IN-20 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cdc7-IN-20 (EP-05) is an orally effective and selective Cdc7 inhibitor with IC₅₀ and K_i values of 0.93 and 0.11 nM, respectively. Cdc7-IN-20 has antitumor activity^[1].

CDK アイソフォーム固有の製品をすべて表示 :

体外実験

Cdc7-IN-20 (0.5, 1, 2 μM, 24 h) can inhibit the proliferation of COLO 205 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

COLO 205
Concentration:

0.5, 1, 2 μM
Incubation Time:

24 h
Result:

Inhibited the phosphorylation at Ser53 and Ser40 of MCM2 in a dose-dependent manner.

体内実験

Cdc7-IN-20 (2, 4, 8 mg/kg, orally, for 3 consecutive days) has an antitumor effect in COLO 205 xenograft mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

COLO 205 xenograft mice model^[1]
Dosage:

2, 4, 8 mg/kg
Administration:

p.o. for 3 consecutive days
Result:

Inhibit the expression of p-MCM2 protein.

化学情報

分子量 300.38
分子式 C₁₅H₁₆N₄OS
SMILES

O=C1NC(C(N)C(C)C)=NC2=C1SC(C3=CC=NC=C3)=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Fu M, et al. Discovery of a potent and selective cell division cycle 7 inhibitor from 6-(3-fluoropyridin-4-yl) thieno [3, 2-d] pyrimidin-4 (3H)-one derivatives as an orally active antitumor agent. Acta Pharmaceutica Sinica. B, 2024, 14(2): 893.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
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Cdc7-IN-20

CDK アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Cdc7-IN-20 関連分類

HY-163374 関連分類