CDK8-IN-7
CDK8-IN-7 (compound 12) is a potent and selective cyclin-dependent kinase 8 (CDK8) inhibitor with an Kd of 3.5 nM. CDK8-IN-7 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC50s of 5.9, 4.8, 5.4, 16.2, 12.5-25 µM, respectively. CDK8-IN-7 has the potential for the research of AML-cancer.
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- CAS 番号: 2415156-30-6
- 分子式: C30H40N2
- 分子量:428.65
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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CDK8 3.5 nM (Kd) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| H9c2 | EC50 |
12.5 μM
Compound: 12
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Cytotoxicity against rat H9c2 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay
Cytotoxicity against rat H9c2 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay
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[PMID: 32245563] |
| MOLM-13 | EC50 |
5.9 μM
Compound: 12
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Cytotoxicity against human MOLM13 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay
Cytotoxicity against human MOLM13 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay
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[PMID: 32245563] |
| MV4-11 | EC50 |
5.4 μM
Compound: 12
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Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay
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[PMID: 32245563] |
| NRK | EC50 |
16.2 μM
Compound: 12
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Cytotoxicity against rat NRK cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay
Cytotoxicity against rat NRK cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay
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[PMID: 32245563] |
| OCI-AML-3 | EC50 |
4.8 μM
Compound: 12
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Cytotoxicity against human OCI-AML3 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay
Cytotoxicity against human OCI-AML3 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay
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[PMID: 32245563] |
化学情報
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CAS 番号 2415156-30-6
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分子量 428.65
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分子式 C30H40N2
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SMILES
C[C@@]12C(C3=CC=CC4=C3C=CN=C4)=CC[C@@]1([H])[C@]5([H])CC[C@@]6([H])C[C@H](N(C)C)CC[C@]6(C)[C@@]5([H])CC2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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