Cot-IN-4
Cot-IN-4 (compound 32) is a potent cancer osaka thyroid (COT) kinase inhibitor with an IC50 of 6 nM. Cot-IN-4 inhibits the phosphorylation of ERK (IC50: 60 nM) and inhibits TNFα release (IC50: 60 nM). Cot-IN-4 also inhibits the formation of the pro-inflammatory cytokine IL-1β (IC50: 0.2 μM) in Uric acid (HY-B2130)-stimulated macrophages. Cot-IN-4 can be used for the study of inflammatory diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1984784-10-2
- 分子式: C30H28N8O
- 分子量:516.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
[1]|
MAP3K8/COT/Tpl2 |
ERK |
IL-1β |
TNF-α |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PBMC | IC50 |
0.2 μM
Compound: rac-32
|
Antiinflammatory activity in human PBMC assessed as inhibition of uric acid induced-IL-1beta formation stimulated with MSU crystals after 3 hrs in presence of ATP
Antiinflammatory activity in human PBMC assessed as inhibition of uric acid induced-IL-1beta formation stimulated with MSU crystals after 3 hrs in presence of ATP
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[PMID: 27502541] |
化学情報
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CAS 番号 1984784-10-2
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分子量 516.60
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分子式 C30H28N8O
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SMILES
CC(CN1CCOCC1)NC2=CC=C3C(C=CC(N4C=NC5=C4C6=C(N=C5)C=NC(C7=CC=NC=C7)=C6)=C3)=N2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Cot-IN-4 関連分類
HY-178726 関連分類
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