EC-70124
EC-70124 is an orally active multikinase inhibitor targeting IKKβ and JAK2. EC-70124 blocks IkB phosphorylation and STAT3 (Tyr705) activation, suppressing NF-κB nuclear translocation and STAT3 transcriptional activity. EC-70124 reduces tumor growth and cancer stem cell (CSC) populations in prostate cancer cells and xenograft models. EC-70124 is promising for research of prostate cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1185908-92-2
- 分子式: C26H19N3O5
- 分子量:453.45
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
|
JAK2 |
NF-κB |
IKKβ |
STAT3 |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-13 | IC50 |
13 nM
Compound: EC-70124
|
Antiproliferative activity against human MOLM-13 cells expressing FLT3-ITD mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay
Antiproliferative activity against human MOLM-13 cells expressing FLT3-ITD mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay
|
[PMID: 32659083] |
| MOLM-16 | IC50 |
27 nM
Compound: EC-70124
|
Antiproliferative activity against human MOLM16 cells expressing FLT3-ITD mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay
Antiproliferative activity against human MOLM16 cells expressing FLT3-ITD mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay
|
[PMID: 32659083] |
| MV4-11 | IC50 |
12.27 nM
Compound: EC-70124
|
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell proliferation measured after 24 hrs by MTT assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell proliferation measured after 24 hrs by MTT assay
|
[PMID: 32659083] |
化学情報
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CAS 番号 1185908-92-2
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分子量 453.45
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分子式 C26H19N3O5
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SMILES
C[C@]12N3C4=C(C5=CC=CC=C53)C(C(NC6=O)=O)=C6C7=C4N([C@](C[C@@H]([C@H]2O)O)([H])O1)C8=CC=CC=C78
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
EC-70124 関連分類
HY-124067 関連分類
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