country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-187396

Copy Link Print Information

FD1-C10-CB

FD1-C10-CB is a PROTAC degrader targeting the BRD4 protein. FD1-C10-CB binds to FEM1B to form a ternary complex with BRD4, achieving FEM1B-dependent degradation of BRD4 via the ubiquitin-proteasome system. FD1-C10-CB binds to CD36 to mediate endocytic cellular delivery, thereby enhancing its degrading activity. FD1-C10-CB mediates protein degradation through the Cullin-dependent ubiquitin-proteasome pathway, rather than the lysosomal autophagy pathway. FD1-C10-CB induces a decrease in BRD4 protein levels, and its degrading activity is competitively inhibited by FL47 or JQ1. FD1-C10-CB can be used in the research of breast cancer and osteosarcoma.
(Pink: BRD4 ligand (HY-78695); Blue: FEM1B E3 ligase ligand; Black: linker).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₆₄H₈₅Cl₂N₉O₉S
分子量:1227.39

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

FD1-C10-CB 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

FD1-C10-CB is a PROTAC degrader targeting the BRD4 protein. FD1-C10-CB binds to FEM1B to form a ternary complex with BRD4, achieving FEM1B-dependent degradation of BRD4 via the ubiquitin-proteasome system. FD1-C10-CB binds to CD36 to mediate endocytic cellular delivery, thereby enhancing its degrading activity. FD1-C10-CB mediates protein degradation through the Cullin-dependent ubiquitin-proteasome pathway, rather than the lysosomal autophagy pathway. FD1-C10-CB induces a decrease in BRD4 protein levels, and its degrading activity is competitively inhibited by FL47 or JQ1. FD1-C10-CB can be used in the research of breast cancer and osteosarcoma^[1]. (Pink: BRD4 ligand (HY-78695); Blue: FEM1B E3 ligase ligand; Black: linker).

IC₅₀ & Target

^[1]

BRD4

PROTACs アイソフォーム固有の製品をすべて表示 :

Epigenetic Reader Domain アイソフォーム固有の製品をすべて表示 :

体外実験

Anti-cancerOthers

Anti-cancer

FD1-C10-CB effectively degrades BRD4 in MDA-MB-231 and HOS cells with greater efficacy than FD1^[1].

Others

FD1-C10-CB (10 μM; unspecified time course) mediates FEM1B-dependent BRD4 degradation in HEK293T cells via the ubiquitin-proteasome system, with enhanced activity relative to FD1 that relies on CD36-mediated endocytosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HEK293T cells, FEM1B-knockout HEK293T cells
Concentration:

10 μM (inhibitor/competitor experiments); multiple concentrations (dose-dependent analysis)
Incubation Time:

1-24 h
Result:

Induced concentration- and time-dependent degradation of BRD4, with significantly improved DC₅₀ and Dₘₐₓ values compared to the parent compound FD1.
Abrogated BRD4 degradation in FEM1B-knockout cells.
Inhibited BRD4 degradation when co-administered with proteasome inhibitor MG132, neddylation inhibitor MLN4924, CD36 inhibitor SMS121, and excess FL47 or JQ1.
Left BRD4 degradation unaffected by lysosomal inhibitors bafilomycin A1 or chloroquine.

Related Protocols :

化学情報

分子量 1227.39
分子式 C₆₄H₈₅Cl₂N₉O₉S
SMILES

ClCC(N1CCN(CCCNC([C@]23C[C@@H]4C[C@@H](C[C@@](C(NC5=CC(OCCNC(C[C@H]6C7=NN=C(C)N7C(SC(C)=C8C)=C8C(C9=CC=C(Cl)C=C9)=N6)=O)=CC(OC(CCCCCCCCCCC(OC(C)(C)C)=O)=O)=C5)=O)(C4)C3)C2)=O)CC1)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Xu L, et al. Structure-Guided Discovery of Novel Dual-Site FEM1B Ligands and Assessment of Their Use in Targeted Protein Degradation. Journal of medicinal chemistry. 2026 Jul 15. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

FD1-C10-CB

PROTACs アイソフォーム固有の製品をすべて表示

Epigenetic Reader Domain アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

FD1-C10-CB 関連分類

HY-187396 関連分類

Bioz

Keywords

最近チェックした製品

IC₅₀ & Target