COIL - coilin Gene

Also Known as CLN80; p80-coilin

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 8161

About COIL

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:56,938,199-56,961,050 (from NCBI)

This gene has 2 transcripts (splice variants) and 202 orthologues. Broad expression in testis (RPKM 65.0), thyroid (RPKM 8.3) and 22 other tissues.

Summary

The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]

COIL Products (1)

mRNA Protein Name
NM_004645.3 NP_004636.1 coilin

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables identical protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12757932 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in Cajal body IDA
IDA: Inferred from direct assay
12757932 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
12757932 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
12757932 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19734146 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

coilin

  • coilin p80

COIL Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
COIL P38432 ZNF277 Homo sapiens Q8WWA6
Y2H Array
25416956
Intra
COIL P38432 MFAP1 Homo sapiens P55081
Y2H Prey Pooling
25416956
Intra
COIL P38432 CCDC57 Homo sapiens Q2TAC2-2
Validated Y2H
32296183
Intra
COIL P38432 SPANXN2 Homo sapiens Q5MJ10
Validated Y2H
32296183
Intra
COIL P38432 ADAMTS12 Homo sapiens P58397-3
Validated Y2H
32296183
Intra
COIL P38432 PDE4D Homo sapiens Q08499
Y2H Prey Pooling
25416956
Intra
COIL P38432 PDE4D Homo sapiens Q08499
Validated Y2H
25416956
Intra
COIL P38432 VRK1 Homo sapiens Q99986
Anti Tag CoIP
21920476
Intra
COIL P38432 VRK1 Homo sapiens Q99986
Peptide Array
21920476
Intra
COIL P38432 VRK1 Homo sapiens Q99986
Confocal
21920476
Intra
COIL P38432 ANKS1B Homo sapiens Q7Z6G8-2
Anti Tag CoIP
15862129
Intra
COIL P38432 ANKS1B Homo sapiens Q7Z6G8-2
Pull Down
15862129
Intra
COIL P38432 ANKS1B Homo sapiens Q7Z6G8-1
Anti Bait CoIP
15862129
Intra
COIL P38432 ANKS1B Homo sapiens Q7Z6G8-1
Pull Down
15862129
Intra
COIL P38432 DYNC2I2 Homo sapiens Q96EX3
Validated Y2H
25416956
Intra
COIL P38432 ARMCX1 Homo sapiens Q9P291
Validated Y2H
25416956
Intra
COIL P38432 ARMCX1 Homo sapiens Q9P291
Y2H Array
25416956
Intra
COIL P38432 AK6 Homo sapiens Q9Y3D8
Anti Tag CoIP
16079131
Intra
COIL P38432 AK6 Homo sapiens Q9Y3D8
Y2H
16079131
Intra
COIL P38432 AK6 Homo sapiens Q9Y3D8
Pull Down
16079131
Intra
COIL P38432 C9orf72 Homo sapiens Q96LT7
Validated Y2H
32296183
Intra
COIL P38432 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra
COIL P38432 XRCC6 Homo sapiens P12956
Pull Down
21070772
Intra
COIL P38432 PSME3 Homo sapiens P61289
Y2H Array
16713569
Intra
COIL P38432 PSME3 Homo sapiens P61289
Validated Y2H
32296183
Intra
COIL P38432 PSME3 Homo sapiens P61289
Y2H
16713569
Intra
COIL P38432 SNRPF Homo sapiens P62306
Validated Y2H
32296183
Intra
COIL P38432 SNRPF Homo sapiens P62306
Y2H Array
25416956
Intra
COIL P38432 XRCC5 Homo sapiens P13010
Pull Down
21070772
Intra
COIL P38432 XRCC5 Homo sapiens P13010
Competition Binding
21070772
Intra
COIL P38432 BYSL Homo sapiens Q13895
Validated Y2H
32296183
Intra
COIL P38432 POLR2L Homo sapiens P62875
Validated Y2H
25416956
Intra
COIL P38432 POLR2L Homo sapiens P62875
Y2H Array
25416956
Intra
COIL P38432 NKAPD1 Homo sapiens Q6ZUT1
Validated Y2H
32296183
Intra
COIL P38432 SMN1 Homo sapiens Q16637
Anti Bait CoIP
21072240
Intra
COIL P38432 SMN1 Homo sapiens Q16637
Pull Down
21070772
Intra
COIL P38432 POLR3C Homo sapiens Q9BUI4
Validated Y2H
32296183
Intra
COIL P38432 SRPK2 Homo sapiens P78362
Validated Y2H
32296183
Intra
COIL P38432 FGF12 Homo sapiens P61328
Y2H Prey Pooling
25416956
Intra
COIL P38432 PTS Homo sapiens Q03393
Y2H Array
25416956
Intra
COIL P38432 PTS Homo sapiens Q03393
Y2H Prey Pooling
25416956
Intra
COIL P38432 PTS Homo sapiens Q03393
Validated Y2H
25416956
Intra
COIL P38432 DRG1 Homo sapiens Q9Y295
Y2H Array
25416956
Intra
COIL P38432 NFU1 Homo sapiens Q9UMS0
Validated Y2H
32296183
Intra
COIL P38432 CEP70 Homo sapiens Q8NHQ1
Y2H Array
16713569
Intra
COIL P38432 CEP70 Homo sapiens Q8NHQ1
Y2H
16713569
Intra
COIL P38432 LNX1 Homo sapiens Q8TBB1
Pull Down
16713569
Intra
COIL P38432 PDLIM5 Homo sapiens Q96HC4
Y2H Array
31515488
Intra
COIL P38432 PDLIM5 Homo sapiens Q96HC4
Y2H Prey Pooling
25416956
Intra
COIL P38432 PDLIM5 Homo sapiens Q96HC4
Y2H Array
25416956
Intra
COIL P38432 PICK1 Homo sapiens Q9NRD5
Y2H
16713569
Intra
COIL P38432 PDE4D Homo sapiens Q08499-8
Validated Y2H
32296183
Intra
COIL P38432 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra
COIL P38432 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra
COIL P38432 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra
COIL P38432 ATXN1 Homo sapiens P54253
Y2H
16713569
Intra
COIL P38432 ATXN1 Homo sapiens P54253-1
IF
12757932
Cross: Cross-species interaction Intra: Intraspecies interaction

COIL 抗体

製品番号 製品名 アプリケーション 反応性
HY-P82787 Coilin Antibody (YA2532) WB Human
HY-P82787A Coilin Antibody (YA2532)(PBS only) WB Human

関連疾患

Diseases Alias
Spinal Muscular Atrophy

  • Sma

  • 5q Sma

  • Proximal Sma

  • Sma-Associated Sma

  • Spinal Amyotrophies

  • Spinal Amyotrophy

  • Spinal Muscle Degeneration

  • Spinal Muscle Wasting

  • Muscular Atrophy Spinal

  • Atrophy, Muscular, Spinal

  • Hereditary Motor Neuronopathy

  • Progressive Muscular Atrophy

  • Sma - [Spinal Muscular Atrophy]
Actinomycosis

  • Actinomycetoma

  • Boil

  • Canaliculitis

  • Actinomycotic Infection

  • Actinomycotic Madura Foot

  • Keratoactinomycosis

  • Furuncle

  • Actinomycotic Mycetema

  • Actinomycotic Mycetoma Of Foot

  • Madura Foot Due To Actinomadura

  • Actinomyces Israeli

  • Actinomycetes

  • Anaerobic Actinomyces Infection

  • Actinomycotic Infection Of Unspecified Site

  • Actinomycosis Nos

  • Actinomycotic Node

  • Actinomyces Infection

  • Actinomycotic Mycetoma

  • Mycetoma Due To Filamentous Bacteria
Muscular Atrophy

  • Muscle Wasting

  • Amyotrophia

  • Wasting - Muscle

  • Skeletal Muscle Atrophy
Differentiating Neuroblastoma
Dyskeratosis Congenita

  • Dyskeratosis Congenita Autosomal Dominant

  • Dc

  • Dkc

  • Zinsser-Engman-Cole Syndrome

  • Dyskeratosis Congenita, Autosomal Dominant

  • Autosomal Dominant Dyskeratosis Congenita

  • Dkca

  • Dyskeratosis Congenita Scoggins Type

  • Zinsser-Cole-Engman Syndrome

  • X-Linked Dyskeratosis Congenita

  • Hoyeraal-Hreidarsson Syndrome
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-B0178A Guanidine hydrochloride 98.00% Unkown

Clinical Phase

Bioactive Molecules (1)
製品番号 製品名 製品効果
純度 Phase
HY-148808 Zelasudil Inhibitor 99.48% Phase 2

Pre-clinical Phase

Bioactive Molecules (28)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P5423 GALA Inducer 99.04% Unkown
HY-135960 BO-264 99.76% Unkown
HY-18990 GSK180736A Inhibitor 98.81% Unkown
HY-146331 PC190723 Inhibitor 98.67% Unkown
HY-B0178B 6M Guanidine hydrochloride Solution 98.0% Unkown
HY-N8671 Withanoside V Inhibitor 99.9% Unkown
HY-B0178AS1 Guanidine-d5 hydrochloride 98% Unkown
HY-P11455A Lipopeptide CPE4 TFA 98.69% Unkown
HY-P11456A Lipopeptide CPK4 TFA 98.92% Unkown
HY-118046 GSK2163632A Inhibitor / Unkown
HY-118837 WF-536 Inhibitor / Unkown
HY-150536 EP39 Inhibitor / Unkown
HY-174386 STAT3-IN-43 Inhibitor / Unkown
HY-182098 DSPE-PEG1000-GALA / Unkown
HY-182098A DSPE-PEG2000-GALA / Unkown
HY-182098B DSPE-PEG3400-GALA / Unkown
HY-182098C DSPE-PEG5000-GALA / Unkown
HY-B0178AS2 Guanidine-13C hydrochloride / Unkown
HY-P10534 ccβ / Unkown
HY-P10534A ccβ acetate 98.93% Unkown
HY-P10820 N36Mut(e,g) Inhibitor / Unkown
HY-P11353 HA2 peptide Inhibitor 98.37% Unkown
HY-P11455 Lipopeptide CPE4 / Unkown
HY-P11456 Lipopeptide CPK4 / Unkown
HY-RS02958 COIL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-B0178AS Guanidine-13C,15N3 hydrochloride / Unkown
HY-RS21316 Coil Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27835 Coil Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus COIL RGD RGD:62031
Felis catus COIL VGNC VGNC:61051
Mus musculus COIL MGD MGI:104842
Bos taurus COIL VGNC VGNC:27552
Canis familiaris COIL VGNC VGNC:39454
Others COIL NCBI