GsMTx4
Based on 126 publication(s) in Google Scholar
GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology.
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- 純度: 99.89%
- CAS 番号: 1209500-46-8
- 分子式: C185H273N49O45S6
- 分子量:4095.84
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保管条件:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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生物活性
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化学情報
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溶剤 & 溶解度
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MedChemExpress（MCE）の使用を引用している文献 GsMTx4
More- Signal Transduct Target Ther. 2025 Aug 21;10(1):269. [Abstract]
- Cell. 2024 Jun 20;187(13):3409-3426.e24. [Abstract]
- Nat Biotechnol. 2025 Nov 10. [Abstract]
- Nat Immunol. 2026 May;27(5):949-960. [Abstract]
- Nat Immunol. 2026 Mar;27(3):543-555. [Abstract]
- Cell Res. 2026 Jan 9. [Abstract]
- Bioact Mater. 2026 Apr 3:62:846-861. [Abstract]
- Nat Commun. 2026 Feb 26;17(1):3254. [Abstract]
- Nat Commun. 2025 Sep 29;16(1):8541. [Abstract]
- Nat Commun. 2025 Jul 25;16(1):6868. [Abstract]
- Nat Commun. 2025 Mar 8;16(1):2329. [Abstract]
- Nat Commun. 2024 Aug 27;15(1):7369. [Abstract]
- Neuron. 2023 Jan 4;111(1):15-29.e8. [Abstract]
- Adv Sci (Weinh). 2026 Jul;13(39):e75355. [Abstract]
- Adv Sci (Weinh). 2026 Apr 27:e22152. [Abstract]
- Adv Sci (Weinh). 2026 Mar 4:e22936. [Abstract]
- Adv Sci (Weinh). 2025 Oct 13:e09932. [Abstract]
- Adv Sci (Weinh). 2025 Jul 26:e02052. [Abstract]
- Adv Sci (Weinh). 2024 Sep 11:e2409081. [Abstract]
- Adv Sci (Weinh). 2024 Mar;11(12):e2309133. [Abstract]
- Nat Plants. 2026 Apr 20. [Abstract]
- J Clin Invest. 2025 Jun 2;135(11):e184158. [Abstract]
- Exp Mol Med. 2026 Feb;58(1):143-160. [Abstract]
- J Nanobiotechnology. 2025 Apr 5;23(1):274. [Abstract]
- Sci Adv. 2026 Feb 6;12(6):eaeb7714. [Abstract]
- Sci Adv. 2026 Jan 16;12(3):eaea0998. [Abstract]
- Sci Adv. 2024 Oct 25;10(43):eadp4726. [Abstract]
- Cell Discov. 2022 Sep 6;8(1):84. [Abstract]
- Redox Biol. 2024 Sep 7:76:103346. [Abstract]
- Small Struct. 2025 Sep 27.
- Research (Wash D C). 2025 Jun 3:8:0718. [Abstract]
- Research (Wash D C). 2023:6:0063. [Abstract]
- Cardiovasc Diabetol. 2025 Mar 20;24(1):127. [Abstract]
- Mater Today Bio. 2026 May 29:38:103285. [Abstract]
- Mater Today Bio. 2026 Apr 22:38:103132. [Abstract]
- Mater Today Bio. 2025 Mar 8:31:101645. [Abstract]
- Mater Today Bio. 2023 Jul 20:22:100735. [Abstract]
- Acta Biomater. 2026 Jul:218:244-260. [Abstract]
- Biomater Res. 2025 Apr 9:29:0182. [Abstract]
- Genes Dis. 2024 Sep 15;12(2):101434. [Abstract]
- J Cachexia Sarcopenia Muscle. 2025 Aug;16(4):e70004. [Abstract]
- Cell Commun Signal. 2025 Jun 13;23(1):280. [Abstract]
- Int J Biol Macromol. 2025 Sep 25;330(Pt 1):147928. [Abstract]
- Small Sci. 2025 Jul 14;5(10):2500095. [Abstract]
- ACS Appl Mater Interfaces. 2025 Oct 15;17(41):56861-56876. [Abstract]
- ACS Appl Mater Interfaces. 2025 Jan 29;17(4):5866-5879. [Abstract]
- Hypertension. 2021 Sep;78(3):647-660. [Abstract]
- Regen Biomater. 2025 Jun 16:12:rbaf056. [Abstract]
- Mater Today Adv. 2023, 17: 100325.
- J Orthop Translat. 2024 Aug 13:48:146-155. [Abstract]
- Brain Behav Immun. 2025 Jul:127:341-357. [Abstract]
- Biomed Pharmacother. 2024 Jul:176:116837. [Abstract]
- J Transl Med. 2023 Oct 10;21(1):711. [Abstract]
- Cell Chem Biol. 2026 Mar 19;33(3):307-320.e4. [Abstract]
- Aging Cell. 2024 Nov 28:e14440. [Abstract]
- Cell Rep. 2025 Apr 24;44(5):115630. [Abstract]
- Cell Rep. 2025 Jan 28;44(1):115136. [Abstract]
- Clin Transl Med. 2023 Nov;13(11):e1481. [Abstract]
- Mol Med. 2025 Aug 2;31(1):272. [Abstract]
- Mol Med. 2025 Apr 22;31(1):147. [Abstract]
- Mol Med. 2025 Mar 8;31(1):90. [Abstract]
- Cell Biosci. 2023 Jan 12;13(1):7. [Abstract]
- BioChip J. 2025 Aug 1.
- Biochem Pharmacol. 2025 Aug 29;242(Pt 1):117293. [Abstract]
- Cell Prolif. 2024 Aug;57(8):e13640. [Abstract]
- Virulence. 2025 Dec;16(1):2490208. [Abstract]
- Am J Respir Cell Mol Biol. 2026 Mar 25:aanag058. [Abstract]
- Life Sci. 2026 Mar 1:388:124195. [Abstract]
- Mech Ageing Dev. 2023 Dec:216:111880. [Abstract]
- CNS Neurosci Ther. 2024 Sep;30(9):e14872. [Abstract]
- Int J Mol Sci. 2026 Jun 22;27(12):5635. [Abstract]
- Int J Mol Sci. 2023 Feb 16;24(4):4022. [Abstract]
- Int Immunopharmacol. 2025 Jul 26:163:115284. [Abstract]
- Int Immunopharmacol. 2024 Jul 14:139:112664. [Abstract]
- Invest Ophthalmol Vis Sci. 2023 Jun 1;64(7):1. [Abstract]
- Am J Physiol Cell Physiol. 2022 Oct 1;323(4):C959-C973. [Abstract]
- Neuropharmacology. 2024 Jun 15:251:109896. [Abstract]
- Arthritis Res Ther. 2023 Jul 7;25(1):117. [Abstract]
- J Physiol. 2025 Aug 28. [Abstract]
- Skelet Muscle. 2025 May 14;15(1):13. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 Sep 7;1872(1):168042. [Abstract]
- J Cell Mol Med. 2024 Dec;28(23):e70237. [Abstract]
- J Cell Mol Med. 2024 Jun;28(11):e18472. [Abstract]
- FASEB J. 2022 Aug;36(8):e22423. [Abstract]
- J Neurochem. 2022 Feb;160(3):376-391. [Abstract]
- Sci Rep. 2025 May 8;15(1):15975. [Abstract]
- Int Dent J. 2026 Jun 27;76(5):109698. [Abstract]
- Cardiovasc Toxicol. 2025 Jul 24. [Abstract]
- Bone. 2025 Jun:195:117464. [Abstract]
- Front Med. 2025 Dec 1. [Abstract]
- Am J Physiol Lung Cell Mol Physiol. 2025 Aug 1;329(2):L296-L306. [Abstract]
- Biology (Basel). 2024 May 19;13(5):357. [Abstract]
- Parasit Vectors. 2024 Feb 1;17(1):46. [Abstract]
- Am J Physiol Lung Cell Mol Physiol. 2022 May 1;322(5):L737-L760. [Abstract]
- J Gastroenterol Hepatol. 2021 Nov;36(11):3127-3139. [Abstract]
- Stem Cells Int. 2022 Jul 29:2022:6202842. [Abstract]
- Pediatr Res. 2026 Apr 24. [Abstract]
- Cancer Med. 2025 Jul;14(14):e71059. [Abstract]
- Ren Fail. 2024 Dec;46(2):2415519. [Abstract]
- Mol Pain. 2025 Dec 12:17448069251410754. [Abstract]
- Ultrasound Med Biol. 2025 Mar;51(3):494-507. [Abstract]
- Clin Exp Pharmacol Physiol. 2026 May;53(5):e70130. [Abstract]
- J Orthop Res. 2023 Aug;41(8):1792-1802. [Abstract]
- Biochem Biophys Res Commun. 2023 Jan 1:638:140-146. [Abstract]
- Arch Oral Biol. 2023 Nov:155:105798. [Abstract]
- Chin J Traumatol. 2026 Mar 7:S1008-1275(26)00041-6. [Abstract]
- University of California. 2026.
- bioRxiv. 2026 Apr 30.
- bioRxiv. 2026 Apr 3.
- Cell Biomater. 2026 Mar 6.
- bioRxiv. 2026 Jan 28.
- SSRN. 2025 Dec 12.
- Res Sq. 2025 Oct 23:rs.3.rs-7776704. [Abstract]
- Res Sq. 2025 May 28.
- SSRN. 2025 Apr 25.
- bioRxiv. 2025 Mar 26:2025.03.25.645313. [Abstract]
- bioRxiv. 2025 January 08.
- bioRxiv. 2024 November 26.
- bioRxiv. 2024 September 22.
- bioRxiv. 2024 Jun 3:2024.06.02.597001. [Abstract]
- bioRxiv. 2024 May 8:2024.05.07.592424. [Abstract]
- Preprints. 2024 Apr 17.
- Research Square Preprint. 2024 Apr 5.
- bioRxiv. 2023 Oct 9:2023.10.09.561581. [Abstract]
- bioRxiv. 2023 Jan 13:2023.01.12.523838. [Abstract]
- Research Square Print. December 8th, 2022.
Customer Validation & Images
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Flow Cytometry
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In Vivo Efficacy Study
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WB
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Cell Migration/Invasion Assay
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Cell Proliferation/Viability Assay
生物活性
MSCs[1]
GsMTx4 (5 μM) reduces Piezo1-mediated charge transfer to 38% of its initial levels in HEK293 cells transfected with Piezo1 cDNA[1].
GsMTx4 (5 μM) blocks cation-selective stretch-activated channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells[2].
GsMTx4 (2.5 μM, 16 h) significantly diminishes both the leptin-induced AMPK and MLC-2 phosphorylation in breast epithelial cells (MCF10A)[3].
GsMTx4 (500 nM, 48 h) attenuates demyelination induced by the cytotoxic lipid and psychosine (organotypic cerebellar slices)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF10A cells
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Concentration:2.5 μM
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Incubation Time:16 h
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Result:Diminished both the leptin-induced AMPK and MLC-2 phosphorylation.
GsMTx-4 (intraperitoneal injection, 270 μg/kg for a single dose) reduces mechanical allodynia induced by inflammation and by sciatic nerve injury in Von Frey test[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6 mice (toxin-induced focal demyelination of cortical brain tissue)[4]
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Dosage:3 μM for 1 μL, a single dose.
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Administration:Stereotactic injection in the left and right cerebral hemispheres (sacrificed 4 days post-injection)
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Result:Prevented the enhanced increase in microglial reactivity and microglial cell numbers induced by lysophosphatidylcholine (LPC).
Prevented LPC-mediated astrocyte toxicity by attenuating the decrease in GFAP+ cells and GFAP fluorescence intensity.
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Animal Model:Sciatic nerve injury model of male Sprague-Dawley rats[6]
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Dosage:270 μg/kg, a single dose
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Administration:Intraperitoneal injection
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Result:Reduced inflammation-evoked mechanical allodynia.
化学情報
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CAS 番号 1209500-46-8
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性状 Solid
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分子量 4095.84
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分子式 C185H273N49O45S6
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Color White to off-white
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配列
Gly-Cys-Leu-Glu-Phe-Trp-Trp-Lys-Cys-Asn-Pro-Asn-Asp-Asp-Lys-Cys-Cys-Arg-Pro-Lys-Leu-Lys-Cys-Ser-Lys-Leu-Phe-Lys-Leu-Cys-Asn-Phe-Ser-Phe-NH2 (Disulfide bridge:Cys2-Cys17, Cys9-Cys23, Cys16-Cys30)
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シーケンスの短縮
GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF-NH2 (Disulfide bridge:Cys2-Cys17, Cys9-Cys23, Cys16-Cys30)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (126)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Piezo1-mediated mechanotransduction regulates the translational activity, function and lung pathogenicity of group 2 innate lymphoid cells. [Abstract]2025 Aug 21;10(1):269. PMID: 40841361
GsMTx4 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Aug 21;10(1):269. [Abstract]
Flow cytometry analysis showing that Yoda1-induced Ca²⁺ influx is blocked by GsMTx4（0-1 μM; 120 s）.
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Cell
Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor. [Abstract]2024 Jun 20;187(13):3409-3426.e24. PMID: 38744281
GsMTx4 purchased from MedChemExpress. Usage Cited in: Cell. 2024 Jun 20;187(13):3409-3426.e24. [Abstract]
WT CD8⁺ T cells treated with DMSO or a Piezo1 inhibitor (GsMTx4, 5 μM; 2 h).
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Nat Biotechnol
Clearance of intracranial debris by ultrasound reduces inflammation and improves outcomes in hemorrhagic stroke models. [Abstract]2025 Nov 10. PMID: 41214344
GsMTx4 purchased from MedChemExpress. Usage Cited in: Nat Biotechnol. 2025 Nov 10. [Abstract]
Administration of GsMTx4 (5 μM; 5 μL) reduced the blood product clearance of UDC, as assessed by hematoma volumes across treatment groups.
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Nat Immunol
Lipid asymmetry disruption by XKR8 orchestrates neutrophil extracellular trap formation and inhibits fungal infection. [Abstract]2026 May;27(5):949-960. PMID: 41781710 -
Nat Immunol
Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging. [Abstract]2026 Mar;27(3):543-555. PMID: 41775886 -
Cell Res
Transient mechanical activation of the Piezo1 channel facilitates ex vivo expansion of hematopoietic stem cells. [Abstract]2026 Jan 9. PMID: 41507440 -
Bioact Mater
Three-dimensional printed PCL/nHA scaffolds promote soft tissue functional fibrosis to repair chest wall defect via Piezo1/Ca2+ signal during respiratory motion. [Abstract]2026 Apr 3:62:846-861. PMID: 42004622 -
Nat Commun
2026 Feb 26;17(1):3254. PMID: 41748583 -
Nat Commun
Biomimetic organo-hydrogels reveal the adipose tissue local mechanical anisotropy regulates ovarian cancer invasion. [Abstract]2025 Sep 29;16(1):8541. PMID: 41022685 -
Nat Commun
Spatiotemporal H2O2 flashes coordinate actin cytoskeletal remodeling and regulate cell migration and wound healing. [Abstract]2025 Jul 25;16(1):6868. PMID: 40715145
GsMTx4 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 25;16(1):6868. [Abstract]
GsMTx4（5 μM; 30 min）- treated BxPC3 DUOX1/2 WT cells, green lines indicate initial wound edges at t = 0 h, red lines indicate wound edges at the indicated timepoints, red arrows show area of damaged cells.
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Nat Commun
2025 Mar 8;16(1):2329. PMID: 40057496
GsMTx4 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Mar 8;16(1):2329. [Abstract]
Phospho-RAB10 (T73) signal measured by western blot in WT Henle 407 cells. The cells were treated with the PIEZO1 inhibitor GsMTx4 (10 μM; 30 min), LPS and/or the PIEZO1 agonist Yoda1, and cell lysates were collected and immunoblotted for phospho-RAB10 (T73), total RAB10, or ß-actin (loading control) .
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Nat Commun
2024 Aug 27;15(1):7369. PMID: 39191796 -
Neuron
2023 Jan 4;111(1):15-29.e8. PMID: 36368316 -
Adv Sci (Weinh)
Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse-Induced Muscle Atrophy. [Abstract]2026 Jul;13(39):e75355. PMID: 41995090 -
Adv Sci (Weinh)
Ultrasound-Activated Bifunctional Piezoelectric Hydrogel Dressings Promote Infected Wound Healing via Regulating Angiogenesis and Lymphangiogenesis. [Abstract]2026 Apr 27:e22152. PMID: 42037321 -
Adv Sci (Weinh)
Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy. [Abstract]2026 Mar 4:e22936. PMID: 41782384 -
Adv Sci (Weinh)
2025 Oct 13:e09932. PMID: 41082347 -
Adv Sci (Weinh)
PIEZO1-GPX4 Axis Mediates Mechanical Stress-Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation. [Abstract]2025 Jul 26:e02052. PMID: 40714837 -
Adv Sci (Weinh)
Enhanced Tumor-Targeted Delivery of Arginine-Rich Peptides via a Positive Feedback Loop Orchestrated by Piezo1/integrin β1 Signaling Axis. [Abstract]2024 Sep 11:e2409081. PMID: 39258781 -
Adv Sci (Weinh)
Tensile Stress-Activated and Exosome-Transferred YAP/TAZ-Notch Circuit Specifies Type H Endothelial Cell for Segmental Bone Regeneration. [Abstract]2024 Mar;11(12):e2309133. PMID: 38225729 -
Nat Plants
2026 Apr 20. PMID: 42010012 -
J Clin Invest
2025 Jun 2;135(11):e184158. PMID: 40454481 -
Exp Mol Med
Piezo1 activation in endothelial cells aggravates microvascular ischemia-reperfusion injury in limbs by enhancing ferroptosis. [Abstract]2026 Feb;58(1):143-160. PMID: 41507309 -
J Nanobiotechnology
Engineered endoplasmic reticulum-targeting nanodrugs with Piezo1 inhibition and promotion of cell uptake for subarachnoid hemorrhage inflammation repair. [Abstract]2025 Apr 5;23(1):274. PMID: 40186204 -
Sci Adv
2026 Feb 6;12(6):eaeb7714. PMID: 41637521 -
Sci Adv
Cell surface engineering with a pseudofibrotic ECM reprograms the antifibrotic activity of mesenchymal stromal cells. [Abstract]2026 Jan 16;12(3):eaea0998. PMID: 41544160 -
Sci Adv
Acute contact with profibrotic macrophages mechanically activates fibroblasts via αvβ3 integrin-mediated engagement of Piezo1. [Abstract]2024 Oct 25;10(43):eadp4726. PMID: 39441936 -
Cell Discov
A positive mechanobiological feedback loop controls bistable switching of cardiac fibroblast phenotype. [Abstract]2022 Sep 6;8(1):84. PMID: 36068215 -
Redox Biol
LOX-mediated ECM mechanical stress induces Piezo1 activation in hypoxic-ischemic brain damage and identification of novel inhibitor of LOX. [Abstract]2024 Sep 7:76:103346. PMID: 39260063 -
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Research (Wash D C)
Piezo1-Mediated Ferroptosis Delays Wound Healing in Aging Mice by Regulating the Transcriptional Activity of SLC7A11 through Activating Transcription Factor 3. [Abstract]2025 Jun 3:8:0718. PMID: 40463502 -
Research (Wash D C)
2023:6:0063. PMID: 36939442 -
Cardiovasc Diabetol
Piezo1 deletion mitigates diabetic cardiomyopathy by maintaining mitochondrial dynamics via ERK/Drp1 pathway. [Abstract]2025 Mar 20;24(1):127. PMID: 40114130 -
Mater Today Bio
Magnetic hydrogel-mediated periodic stimulation enhances mesenchymal stem cell small extracellular vesicle release. [Abstract]2026 May 29:38:103285. PMID: 42256076 -
Mater Today Bio
2026 Apr 22:38:103132. PMID: 42111771 -
Mater Today Bio
Uniform and controllable surface nano-structure on polyetheretherketone implants can regulate mechanical property to enhance soft tissue integration through Piezo1/TGF-β1 signaling axis. [Abstract]2025 Mar 8:31:101645. PMID: 40151615 -
Mater Today Bio
Hydrogel platform facilitating astrocytic differentiation through cell mechanosensing and YAP-mediated transcription. [Abstract]2023 Jul 20:22:100735. PMID: 37576868 -
Acta Biomater
Mechanically heterogeneous nanofibrous hydrogel drives Piezo1-mediated cell aggregation and collective migration. [Abstract]2026 Jul:218:244-260. PMID: 42270027 -
Biomater Res
Near-Infrared Light-Controlled Dynamic Hydrogel for Modulating Mechanosensitive Ion Channels in 3-Dimensional Environment. [Abstract]2025 Apr 9:29:0182. PMID: 40207256 -
Genes Dis
Heavy mechanical force decelerates orthodontic tooth movement via Piezo1-induced mitochondrial calcium down-regulation. [Abstract]2024 Sep 15;12(2):101434. PMID: 39759122 -
J Cachexia Sarcopenia Muscle
Unravelling the Role of PIEZO1 in Adipogenesis of Fibrogenic/Adipogenic Progenitors for Muscle Fat Infiltration After Rotator Cuff Tear. [Abstract]2025 Aug;16(4):e70004. PMID: 40726363 -
Cell Commun Signal
Activation of mechanosensitive ion channel Piezo1 linking metabolic reprogramming and pro-inflammatory responses in hepatocellular carcinoma. [Abstract]2025 Jun 13;23(1):280. PMID: 40514668 -
Int J Biol Macromol
Autophagic damage in senescent bone marrow mesenchymal stromal cells: Impact on Piezo1 expression during osteoporosis progression. [Abstract]2025 Sep 25;330(Pt 1):147928. PMID: 41015372 -
Small Sci
Built-In Electric Field Accelerates Nanotopography-Mediated Enhancement of Vascularized Osseointegration via Cav1.2/Piezo/Ca2+/PI3K Signaling. [Abstract]2025 Jul 14;5(10):2500095. PMID: 41058722 -
ACS Appl Mater Interfaces
Surficial Pore Structure on Polyetheretherketone Implants Regulates Mechanical Properties to Promote Macrophage M2 Polarization. [Abstract]2025 Oct 15;17(41):56861-56876. PMID: 41037664 -
ACS Appl Mater Interfaces
Piezoelectric Nanoarrays with Mechanical-Electrical Coupling Microenvironment for Innervated Bone Regeneration. [Abstract]2025 Jan 29;17(4):5866-5879. PMID: 39818699 -
Hypertension
Piezo1-Mediated Mechanotransduction Promotes Cardiac Hypertrophy by Impairing Calcium Homeostasis to Activate Calpain/Calcineurin Signaling. [Abstract]2021 Sep;78(3):647-660. PMID: 34333987 -
Regen Biomater
Matrix stiffness boosts PDAC chemoresistance via SCD1-dependent lipid metabolic reprogramming. [Abstract]2025 Jun 16:12:rbaf056. PMID: 40741620 -
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J Orthop Translat
Strontium zinc silicate simultaneously alleviates osteoporosis and sarcopenia in tail-suspended rats via Piezo1-mediated Ca2+ signaling. [Abstract]2024 Aug 13:48:146-155. PMID: 39229332 -
Brain Behav Immun
Mechanistic insights into the neuroprotective effects of low-intensity transcranial ultrasound stimulation in post-cardiac arrest brain injury: Modulation of the Piezo1-Dkk3/PI3K-Akt pathway. [Abstract]2025 Jul:127:341-357. PMID: 40118226 -
Biomed Pharmacother
PIEZO1 as a new target for hyperglycemic stress-induced neuropathic injury: The potential therapeutic role of bezafibrate. [Abstract]2024 Jul:176:116837. PMID: 38815290 -
J Transl Med
Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration. [Abstract]2023 Oct 10;21(1):711. PMID: 37817199 -
Cell Chem Biol
2026 Mar 19;33(3):307-320.e4. PMID: 41650963 -
Aging Cell
Piezo1 exacerbates inflammation-induced cartilaginous endplate degeneration by activating mitochondrial fission via the Ca2+/CaMKII/Drp1 axis. [Abstract]2024 Nov 28:e14440. PMID: 39610146 -
Cell Rep
Piezo1 balances the osteogenic-tenogenic plasticity of periosteal progenitor cells through the YAP pathway. [Abstract]2025 Apr 24;44(5):115630. PMID: 40286268 -
Cell Rep
2025 Jan 28;44(1):115136. PMID: 39932192 -
Clin Transl Med
H. pylori-induced NF-κB-PIEZO1-YAP1-CTGF axis drives gastric cancer progression and cancer-associated fibroblast-mediated tumour microenvironment remodelling. [Abstract]2023 Nov;13(11):e1481. PMID: 37983931 -
Mol Med
Piezo1 induces mitochondrial autophagy dysfunction leading to cartilage injury in knee osteoarthritis. [Abstract]2025 Aug 2;31(1):272. PMID: 40753437 -
Mol Med
Endothelial Piezo1 stimulates angiogenesis to offer protection against intestinal ischemia-reperfusion injury in mice. [Abstract]2025 Apr 22;31(1):147. PMID: 40263994 -
Mol Med
Piezo1 promotes intervertebral disc degeneration through the Ca2+/F-actin/Yap signaling axis. [Abstract]2025 Mar 8;31(1):90. PMID: 40057686 -
Cell Biosci
Activation of goblet cell Piezo1 alleviates mucus barrier damage in mice exposed to WAS by inhibiting H3K9me3 modification. [Abstract]2023 Jan 12;13(1):7. PMID: 36631841 -
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Biochem Pharmacol
Piezo1 promotes colitis progression by modulating the Nrf2/NF-κB/NLRP3 signaling pathway. [Abstract]2025 Aug 29;242(Pt 1):117293. PMID: 40886854 -
Cell Prolif
2024 Aug;57(8):e13640. PMID: 38556840 -
Virulence
2025 Dec;16(1):2490208. PMID: 40202859 -
Am J Respir Cell Mol Biol
Piezo1 Mediates Stretch-Induced Wnt/β-Catenin Signaling and ECM Remodeling in Aging Asthmatic Airway Smooth Muscle. [Abstract]2026 Mar 25:aanag058. PMID: 42083982 -
Life Sci
Compressive stress induces cartilage endplate degeneration through the Piezo1/YAP-TEAD/NLRP3 axis. [Abstract]2026 Mar 1:388:124195. PMID: 41506536 -
Mech Ageing Dev
Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity. [Abstract]2023 Dec:216:111880. PMID: 37839614 -
CNS Neurosci Ther
Activation of Piezo1 by intracranial hypertension induced neuronal apoptosis via activating hippo pathway. [Abstract]2024 Sep;30(9):e14872. PMID: 39328029 -
Int J Mol Sci
Activated Macrophages Promote TNF-α-Associated Tumor Cell Necroptosis in Pituitary Apoplexy Through the PIEZO1-NFATC2/REL Axis. [Abstract]2026 Jun 22;27(12):5635. PMID: 42353349 -
Int J Mol Sci
Gsmtx4 Alleviated Osteoarthritis through Piezo1/Calcineurin/NFAT1 Signaling Axis under Excessive Mechanical Strain. [Abstract]2023 Feb 16;24(4):4022. PMID: 36835440 -
Int Immunopharmacol
Piezo1 participates in sevoflurane-induced developmental neurotoxicity via neuroinflammation and synaptic damage in the hippocampus. [Abstract]2025 Jul 26:163:115284. PMID: 40716188 -
Int Immunopharmacol
The mechanosensitive Piezo1 channel exacerbates myocardial ischaemia/reperfusion injury by activating caspase-8-mediated PANoptosis. [Abstract]2024 Jul 14:139:112664. PMID: 39008937 -
Invest Ophthalmol Vis Sci
The Mechanosensitive Piezo1 Channel Mediates Mechanochemical Transmission in Myopic Eyes. [Abstract]2023 Jun 1;64(7):1. PMID: 37261388 -
Am J Physiol Cell Physiol
Mechanosensitive cation currents through TRPC6 and Piezo1 channels in human pulmonary arterial endothelial cells. [Abstract]2022 Oct 1;323(4):C959-C973. PMID: 35968892 -
Neuropharmacology
Roles of mechanosensitive ion channel PIEZO1 in the pathogenesis of brain injury after experimental intracerebral hemorrhage. [Abstract]2024 Jun 15:251:109896. PMID: 38490299 -
Arthritis Res Ther
Aberrant mechanical loading induces annulus fibrosus cells apoptosis in intervertebral disc degeneration via mechanosensitive ion channel Piezo1. [Abstract]2023 Jul 7;25(1):117. PMID: 37420255 -
J Physiol
GsMTx-4 inhibits the exercise pressor reflex and the muscle mechanoreflex primarily through TRPC inhibition. [Abstract]2025 Aug 28. PMID: 40876864 -
Skelet Muscle
GsMTx4-blocked PIEZO1 channel promotes myogenic differentiation and alleviates myofiber damage in Duchenne muscular dystrophy. [Abstract]2025 May 14;15(1):13. PMID: 40361216 -
Biochim Biophys Acta Mol Basis Dis
Piezo1 promotes M1 macrophage polarization and impairs osteogenic differentiation in bone infection. [Abstract]2025 Sep 7;1872(1):168042. PMID: 40925468 -
J Cell Mol Med
Endothelial KDM5B Regulated by Piezo1 Contributes to Disturbed Flow Induced Atherosclerotic Plaque Formation. [Abstract]2024 Dec;28(23):e70237. PMID: 39643939 -
J Cell Mol Med
Excessive load promotes temporomandibular joint chondrocyte apoptosis via Piezo1/endoplasmic reticulum stress pathway. [Abstract]2024 Jun;28(11):e18472. PMID: 38842129 -
FASEB J
2022 Aug;36(8):e22423. PMID: 35775626 -
J Neurochem
Extracellular ATP and cAMP signaling promote Piezo2-dependent mechanical allodynia after trigeminal nerve compression injury. [Abstract]2022 Feb;160(3):376-391. PMID: 34757653 -
Sci Rep
Piezo1 activation protects against sepsis-induced myocardial dysfunction in a pilot study. [Abstract]2025 May 8;15(1):15975. PMID: 40341084 -
Int Dent J
2026 Jun 27;76(5):109698. PMID: 42364415 -
Cardiovasc Toxicol
Yoda1/Piezo1 Alleviates Lipopolysaccharide-Induced Cardiac Injury via AMPK-Mediated Mitophagy. [Abstract]2025 Jul 24. PMID: 40705239 -
Bone
2025 Jun:195:117464. PMID: 40118264 -
Front Med
Sub-threshold depolarization differentially regulated by multiple ion channels plays a key role in initiation of baroreflex afferent neurotransmission evidenced from baroreceptor terminals to its cell bodies. [Abstract]2025 Dec 1. PMID: 41324839 -
Am J Physiol Lung Cell Mol Physiol
Mechanical stretch promotes sustained proliferation and inflammation in developing human airway smooth muscle. [Abstract]2025 Aug 1;329(2):L296-L306. PMID: 40668642 -
Biology (Basel)
2024 May 19;13(5):357. PMID: 38785839 -
Parasit Vectors
Blockage of mechanosensitive Piezo1 channel alleviates the severity of experimental malaria-associated acute lung injury. [Abstract]2024 Feb 1;17(1):46. PMID: 38303078 -
Am J Physiol Lung Cell Mol Physiol
Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation. [Abstract]2022 May 1;322(5):L737-L760. PMID: 35318857 -
J Gastroenterol Hepatol
2021 Nov;36(11):3127-3139. PMID: 34169583 -
Stem Cells Int
Low-Intensity Pulsed Ultrasound Enhanced Adipose-Derived Stem Cell-Mediated Angiogenesis in the Treatment of Diabetic Erectile Dysfunction through the Piezo-ERK-VEGF Axis. [Abstract]2022 Jul 29:2022:6202842. PMID: 35935181 -
Pediatr Res
Stretch, Piezo channels, and store operated calcium entry in developing human airway smooth muscle. [Abstract]2026 Apr 24. PMID: 42032191 -
Cancer Med
Piezo1/ITGB1 Synergizes With Ca2+/YAP Signaling to Propel Bladder Carcinoma Progression via a Stiffness-Dependent Positive Feedback Loop. [Abstract]2025 Jul;14(14):e71059. PMID: 40667648 -
Ren Fail
Piezo1 facilitates the initiation and progression of renal fibrosis by mediating cell apoptosis and mitochondrial dysfunction. [Abstract]2024 Dec;46(2):2415519. PMID: 39496543 -
Mol Pain
EXPRESS: Piezo1-mediated neuroexcitation via collaboration with KCa1.1 and Nav1.9 currents in myelinated Ah-type of trigeminal ganglion neurons in rats: mechanistic insights with sex-specific effects. [Abstract]2025 Dec 12:17448069251410754. PMID: 41384612 -
Ultrasound Med Biol
2025 Mar;51(3):494-507. PMID: 39632209 -
Clin Exp Pharmacol Physiol
Piezo1 Knockdown Attenuates Hypertension-Induced Cardiac Fibrosis by Inhibiting Ca2+/β-Catenin Signalling Pathway. [Abstract]2026 May;53(5):e70130. PMID: 42117520 -
J Orthop Res
Compressive stress induces spinal vertebral growth plate chondrocytes apoptosis via Piezo1. [Abstract]2023 Aug;41(8):1792-1802. PMID: 36722421 -
Biochem Biophys Res Commun
2023 Jan 1:638:140-146. PMID: 36455360 -
Arch Oral Biol
Role of mechanosensitive ion channel Piezo1 in tension-side orthodontic alveolar bone remodeling in rats. [Abstract]2023 Nov:155:105798. PMID: 37651768 -
Chin J Traumatol
Piezo1 mediates electrotaxis of alveolar epithelial cells via calcium-dependent PI3K/Akt signaling. [Abstract]2026 Mar 7:S1008-1275(26)00041-6. PMID: 41966951 -
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Res Sq
2025 Oct 23:rs.3.rs-7776704. PMID: 41282104 -
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bioRxiv
2025 Mar 26:2025.03.25.645313. PMID: 40196526 -
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bioRxiv
Ultrasonic cerebrospinal fluid clearance improves outcomes in hemorrhagic brain injury models. [Abstract]2024 Jun 3:2024.06.02.597001. PMID: 38895304 -
bioRxiv
2024 May 8:2024.05.07.592424. PMID: 38766123 -
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bioRxiv
A Cell Atlas of Thoracic Aortic Perivascular Adipose Tissue: a focus on mechanotransducers. [Abstract]2023 Oct 9:2023.10.09.561581. PMID: 37873456 -
bioRxiv
Bidirectional multiciliated cell extrusion is controlled by Notch driven basal extrusion and Piezo 1 driven apical extrusion. [Abstract]2023 Jan 13:2023.01.12.523838. PMID: 36711534 -
溶剤 & 溶解度
DMSO : 50 mg/mL (12.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (1.22 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (24.42 mM); Clear solution; Need ultrasonic
Add each solvent one by one: Saline
Solubility: 100 mg/mL (24.42 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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-
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
-
+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (300 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
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取扱説明書 (2659 KB)
参考文献
[2]. T M Suchyna, et al. Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J Gen Physiol. 2000 May;115(5):583-98. [Content Brief]
[3]. Anna Acheva, et al. Adipokine Leptin Co-operates With Mechanosensitive Ca 2 +-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells. Front Cell Dev Biol. 2021 Jan 6;8:607038. [Content Brief]
[4]. María Velasco-Estevez, et al. Inhibition of Piezo1 attenuates demyelination in the central nervous system. Glia. 2020 Feb;68(2):356-375. [Content Brief]
[5]. Medha M Pathak, et al. Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16148-53. [Content Brief]
[6]. Seung Pyo Park, et al. A tarantula spider toxin, GsMTx4, reduces mechanical and neuropathic pain. Pain. 2008 Jul;137(1):208-217. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.2442 mL | 1.2208 mL | 2.4415 mL | 6.1038 mL |
| 5 mM | 0.0488 mL | 0.2442 mL | 0.4883 mL | 1.2208 mL | |
| 10 mM | 0.0244 mL | 0.1221 mL | 0.2442 mL | 0.6104 mL |
GsMTx4 関連分類
HY-P1410 関連分類
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