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製品番号: HY-181957

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KB528

KB528 is a p300/CBP histone acetyltransferase (KAT) inhibitor with low nM IC₅₀ values against human p300 and CBP, and exhibits selectivity over other KAT family members. KB528 modulates the IRF4 transcriptional network, downregulates the expression of IRF4, MYC, CAV2 and IGLL5, and reduces the protein level of IKZF3. KB528 potently induces apoptosis in multiple myeloma cells. KB528 is applicable to research related to multiple myeloma.

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CAS 番号: 3082090-83-0
分子式: C₂₈H₂₈N₆O
分子量:464.56

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

KB528 構造式

CAS 番号: 3082090-83-0

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Epigenetic Reader Domain アイソフォーム固有の製品をすべて表示 :

Histone Acetyltransferase アイソフォーム固有の製品をすべて表示 :

IKZF Family アイソフォーム固有の製品をすべて表示 :

体外実験

KB528 (0-1 μM; 24-72 h) selectively induces apoptosis in MM1.S cells in a concentration-dependent manner after 48 h of treatment^[1].
KB528 (100 nM; 6-24 h) induces rapid loss of IKZF3 protein acetylation in MM1.S cells, followed by a transient decrease in mRNA, subsequent protein loss, and final rebound of mRNA levels.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

MM1.S cells
Concentration:

0.1, 1 and 10 μM
Incubation Time:

24, 48 and 72 h
Result:

First induced cell cycle arrest in the treatment for 24 hours, followed by apoptosis.

RT-PCR^[1]

Cell Line:

MM1.S cells
Concentration:

100 nM
Incubation Time:

24 h
Result:

Potently and almost completely downregulated the mRNA of IRF4 and its target genes and the inhibition of IKZF1 and IKZF3 is relatively mild.

Western Blot Analysis^[1]

Cell Line:

MM1.S cells
Concentration:

100 nM
Incubation Time:

6 and 14 h
Result:

Significantly reduced the levels of MYC, IRF4, and IKZF3 proteins, and notably, the protein loss of IKZF3 was more significant than the decrease in its mRNA.

化学情報

CAS 番号 3082090-83-0
分子量 464.56
分子式 C₂₈H₂₈N₆O
SMILES

N#CC1=CC=C([C@H](C)CN[C@H](C2=CC=CC=C2)[C@@H]3CNC4=C(N=CC(C5=CN(C)N=C5)=C4)O3)C=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Lenoir WF, et al. Catalytic Inhibition of p300 Preferentially Targets IRF4 Oncogenic Activity and Tumor Growth in Multiple Myeloma. Cancer Res. 2026;86(4):1010-1034. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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KB528

Epigenetic Reader Domain アイソフォーム固有の製品をすべて表示

Histone Acetyltransferase アイソフォーム固有の製品をすべて表示

IKZF Family アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

KB528 関連分類

HY-181957 関連分類